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COVID-19 infection in CVID patients: What we know so far

  • Introduction:In patients with common variable immunodeficiency (CVID),immunological response is compromised. Knowledge about COVID‐19 in CVIDpatients is sparse. We, here, synthesize current research addressing the level ofthreat COVID‐19posestoCVIDpatientsandthebest‐known treatments. Method:Review of 14 publications. Results:The number of CVID patients with moderate to severe (~29%) andcritical infection courses (~10%), and the number of fatal cases (~13%), areincreased compared to the general picture of COVID‐19 infection. However,this might be an overestimate. Systematic cohort‐wide studies are lacking, andasymptomatic or mild cases among CVID patients occur that can easily remainunnoticed. Regular immunoglobulin replacement therapy was administered inalmost all patients, potentially explaining why the numbers of critical and fatalcases were not higher. In addition, the application of convalescent plasma wasdemonstrated to have positive effects. Conclusions:COVID‐19 poses an elevated threat to CVID patients. However,only systematic studies can provide robust information on the extent of thisthreat. Regular immunoglobulin replacement therapy is beneficial to combatCOVID‐19 in CVID patients, and best treatment after infection includes theuse of convalescent plasma in addition to common medication.
Author:Stefan LöttersORCiD, Alisha Jung, Niels Weifenbach
Parent Title (English):Immunity, Inflammation and Disease
Place of publication:Hoboken
Document Type:Article
Date of completion:2021/05/12
Date of publication:2021/05/12
Publishing institution:Universität Trier
Contributing corporation:The publication was funded by the Open Access Fund of Universität Trier and the German Research Foundation (DFG)
Release Date:2022/03/14
Tag:SARS‐CoV‐2; common variable immunodeficiency; convalescent plasma; immunoglobulin replacement
GND Keyword:Immundefekt; Immunglobulintherapie; Plasmaersatz; SARS-CoV-2
Volume (for the year ...):2021
Issue / no.:Band 9, Heft 3
Number of pages:3
First page:632
Last page:634
Institutes:Fachbereich 6 / Raum- und Umweltwissenschaften
Dewey Decimal Classification:9 Geschichte und Geografie / 91 Geografie, Reisen / 910 Geografie, Reisen
Licence (German):License LogoCC BY: Creative-Commons-Lizenz 4.0 International

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