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The influence of the dopamine agonist Ritalin-® on performance in a card sorting task involving a monetary reward component was tested in 43 healthy male participants. It was investigated whether Ritalin-® would have differential behavioral effects as a function of the participants' parental bonding experiences and the personality variable "Novelty Seeking". When activity and performance accuracy were stimulated my monetary reward, Ritalin-® reduced activity in response to reward and added to the reward-induced increase in performance accuracy. However, performance accuracy after drug challenge was improved only in the low care participants. In the high care participants, it was contrarily impaired. This observation suggests that the successful therapeutic administration of Ritalin-® in ADHD may be influenced by early life parental care. Suggesting an association between the personality dimension of "Novelty Seeking" and the dopamine system, high "Novelty Seeking" scores positively correlated with sensitivity to Ritalin-® challenge.
Fibromyalgia is a disorder of unknown etiology characterized by widespread, chronic musculoskeletal pain of at least three month duration and pressure hyperalgesia at specific tender points on clinical examination. The disorder is accompanied by a multitude of additional symptoms such as fatigue, sleep disturbances, morning stiffness, depression, and anxiety. In terms of biological disturbances, low cortisol concentrations have been repeatedly observed in blood and urine samples of fibromyalgia patients, both under basal and stress-induced conditions. The aim of this dissertation was to investigate the presence of low cortisol concentrations (hypocortisolism) and potential accompanying alterations on sympathetic and immunological levels in female fibromyalgia patients. Beside the expected hypocortisolism, a higher norepinephrine secretion and lower natural killer cell levels were found in the patient group compared to a control group consisting of healthy, age-matched women. In addition, an increased activity of some pro-inflammatory markers was observed thus leading to alterations in the balance of pro-/anti-inflammatory activity. The results underline the relevance of simultaneous investigations of interacting bodily systems for a better understanding of underlying biological mechanisms in stress-related disorders.
The subject of this thesis is hypercyclic, mixing, and chaotic C0-semigroups on Banach spaces. After introducing the relevant notions and giving some examples the so called hypercyclicity criterion and its relation with weak mixing is treated. Some new equivalent formulations of the criterion are given which are used to derive a very short proof of the well-known fact that a C0-semigroup is weakly mixing if and only if each of its operators is. Moreover, it is proved that under some "regularity conditions" each hypercyclic C0-semigroup is weakly mixing. Furthermore, it is shown that for a hypercyclic C0-semigroup there is always a dense set of hypercyclic vectors having infinitely differentiable trajectories. Chaotic C0-semigroups are also considered. It is proved that they are always weakly mixing and that in certain cases chaoticity is already implied by the existence of a single periodic point. Moreover, it is shown that strongly elliptic differential operators on bounded C^1-domains never generate chaotic C0-semigroups. A thorough investigation of transitivity, weak mixing, and mixing of weighted compositioin operators follows and complete characterisations of these properties are derived. These results are then used to completely characterise hypercyclicity, weak mixing, and mixing of C0-semigroups generated by first order partial differential operators. Moreover, a characterisation of chaos for these C0-semigroups is attained. All these results are achieved on spaces of p-integrable functions as well as on spaces of continuous functions and illustrated by various concrete examples.
The allergic contact dermatitis (ACD) to small molecular weight compounds is a common inflammatory skin reaction. ACD is restricted to industrialized countries, has an enormous sociomedical and socioeconomic impact. About 2,800 compounds from the six million chemicals known in our environment are believed to have allergic, and to a lesser degree also contact-sensitizing or immunogenic properties causing allergic contact dermatitis. ACD results from T cell responses to harmless, low molecular weight chemicals (haptens) applied to the skin. Haptens are not directly recognized by the cells of the immune system. They need to be presented by subsets of antigen presenting cells to the cells of the immune system. In this regard, epidermal Langerhans cells (LC) and the cells into which they mature (dendritic cells) are believed to play a pivotal role in the sensitization process for ACD. LC are able to bind the haptens, internalize them, and present them to naive T cells and induce thereby the development of effector T cells. They are so-called professional antigen presenting cells. This process is initiated and maintained by the release of several mediators, which are released by various cells after their contact with the haptens. One of the first proteins secreted into the environment is interleukin (IL)-1ß. This cytokine is produced and secreted minutes after an antigen enters the cell. It is commonly believed that the large amounts of this protein and other cytokines such as granulocyte-colony stimulation factor (GM-CSF) and tumor necrosis factor alpha (TNF-ï¡) needed for the initiation and activation of ACD are coming first from other cells residing in the skin, e.g., keratinocytes, monocytes and macrophages. These cytokines provide the danger signals needed for the activation of the Langerhans cell (LC), which then produce via a positive feedback loop various cytokines themselves. In addition, other proteins such as chemokines influence the generation of danger signals, migration, homing of T cells in the local lymph nodes as well as the recruitment of T cells into the skin. Thus, a small molecular compounds or hapten needs to be able to induce danger signals in order to become immunogenic. In this study, we investigated whether para-phenylenediamine (PPD), an arylamine and common contact allergen, is able to induce danger signals and likely provide the signals needed for an initiation of an immune response[162, 163]. PPD is used as an antioxidant, an ingredient of hair dyes, intermediate of dyestuff, and PPD is found in chemicals used for photographic processing. But up to date, it has not been clearly demonstrated if PPD itself is a sensitizing agent. Thus, this study aimed on the potential of PPD to provide the danger signals by studying IL-1β, TNF-ï¡, and monocyte chemoattractant proteins (MCP-1) in human monocytes, peripheral blood mononuclear cells (PBMC) from healthy volunteers, and also in two human monocyte cell lines namely U937, and THP-1. This study found that PPD decreased dose- and time-dependently the expression and release of three relevant mediators involved in the generation of danger signals. Namely, PPD reduced the mRNA and protein levels for IL-1ß, TNF-ï¡, and MCP-1 in primary human monocytes from various donors. These findings were extended and validated by investigations using the cell line U937. The data were highly specific for PPD, and no such results were gained for its known auto oxidation product called Bandrowski- base or for meta-phenylenediamine (MPD), and ortho-phenylenediamine (OPD). Therefore, we can speculate that this effect is likely to be dependent on the para-substitution. Based on these results we conclude that PPD itself is not able to mount a cascade for the induction of danger signals. It should be mentioned that it is still possible that PPD induces danger signals for sensitization by other unknown processes. Therefore, more research is still needed focusing on this subject especially in professional antigen presenting cells in order to solve the still open question whether PPD itself sensitizes naive T cells or if PPD is solely an allergen. Independently we found unexpectedly that PPD as well as other haptens such as 2, 4-Dinitrochlorobenzene, nickelsulfate, as well as some terpenoide increased clearly the expression of CC chemokin receptor 2 (CCR2), the receptor for the chemokine MCP-1. Up to date, the main importance for the CCR2 receptor comes from results demonstrating that CCR2 is critical for the migration of monocytes after encounter with bacterial lipopolysaccharides. Under these circumstances the receptor disappears from the cell surface and is down regulated. An up regulation of CCR2 has not been reported for haptens, and deserves further investigations.
The fragmentation of landscapes has an important impact on the conservation of biodiversity. The genetic diversity is an important factor for a population- viability, influenced by the landscape structure. However, different species with differing ecological demands react rather differently on the same landscape pattern. To address this feature, we studied ten xerothermophilous butterfly species with differing habitat requirements (habitat specialists with low dispersal power in contrast to habitat generalists with low dispersal power and habitat generalists with higher dispersal power). We analysed allozyme loci for about 10 populations (Ã 40 individuals) of each species in a western German study region with adjoining areas in Luxemburg and north-eastern France. The genetic diversity and genetic differentiation between local populations was discussed under conservation genetic aspects. For generalists we detected a more or less panmictic structure and for species with lower abundance and sedentarily behaviour the effect of isolation by distance. On the other hand, the isolation of specialists was mostly reflected by strong genetic differentiation patterns between the investigated populations. Parameters of genetic diversity were mostly significantly higher in generalists, compared to specialists. Substructures within populations as an answer of low intrapatch migration, low population densities and high population fluctuations could be shown as well. Aspects of landscape history (the historical distribution of habitats resulting of the presence of limestone areas) and the changes of extensive sheep pasturing and the loss of potential habitats in the last few decades (recent fragmentation) are discussed against the gained genetic data-set of the ten butterflies.
It has been the overall aim of this research work to assess the potential of hyperspectral remote sensing data for the determination of forest attributes relevant to forest ecosystem simulation modeling and forest inventory purposes. A number of approaches for the determination of structural and chemical attributes from hyperspectral remote sensing have been applied to the collected data sets. Many of the methods to be found in the literature were up to now just applied to broadband multispectral data, applied to vegetation canopies other than forests, reported to work on the leaf level or with modelled data, not validated with ground truth data, or not systematically compared to other methods. Attributes that describe the properties of the forest canopy and that are potentially open to remote sensing were identified, appropriate methods for their retrieval were implemented and field, laboratory and image data (HyMap sensor) were acquired over a number of forest plots. The study on structural attributes compared statistical and physical approaches. In the statistical section, linear predictive models between vegetation indices derived from HyMap data and field measurements of structural forest stand attributes were systematically evaluated. The study demonstrates that for hyperspectral image data, linear regression models can be applied to quantify leaf area index and crown volume with good accuracy. For broadband multispectral data, the accuracy was generally lower. The physically-based approach used the invertible forest reflectance model (INFORM), a combination of well established sub-models FLIM, SAIL and LIBERTY. The model was inverted with HyMap data using a neural network approach. In comparison to the statistical approach, it could be shown that the reflectance model inversion works equally well. In opposition to empirically derived prediction functions that are generally limited to the local conditions at a certain point in time and to a specified sensor type, the calibrated reflectance model can be applied more easily to different optical remote sensing data acquired over central European forests. The study on chemical forest attributes evaluated the information content of HyMap data for the estimation of nitrogen, chlorophyll and water concentration. A number of needle samples of Norway spruce were analysed for their total chlorophyll, nitrogen and water concentrations. The chemical data was linked to needle spectra measured in the laboratory and canopy spectra measured by the HyMap sensor. Wavebands selected in statistical models were often located in spectral regions that are known to be important for chlorophyll detection (red edge, green peak). Predictive models were applied on the HyMap image to compute maps of chlorophyll concentration and nitrogen concentration. Results of map overlay operations revealed coherence between total chlorophyll and zones of stand development stage and between total chlorophyll and zones of soil type. Finally, it can be stated that the hyperspectral remote sensing data generally contains more information relevant to the estimation of the forest attributes compared to multispectral data. Structural forest attributes, except biomass, can be determined with good accuracy from a hyperspectral sensor type like HyMap. Among the chemical attributes, chlorophyll concentration can be determined with good accuracy and nitrogen concentration with moderate accuracy. For future research, additional dimensions have to be taken into account, for instance through exploitation of multi-view angle data. Additionally, existing forest canopy reflectance models should be further improved.
In past years, desertification and land degradation have been acknowledged as a major threat to human welfare world-wide, and their environmental and societal implications have sparked the formulation of the UN Convention to Combat Desertification (UNCCD). Any measure taken against desertification, or the design of dedicated early warning systems, must take into account both the spatial and temporal dimensions of process driving factors. Equally important, past and present reactions of ecosystems to physical and socio-economical disturbances or management interventions need to be understood. In this context, remote sensing and geoinformation processing support the required assessment, monitoring and modelling approaches, and hence provide an essential contribution to the scientific component of the struggle against desertification. Supported by DG Research of the European Commission, the Remote Sensing Department of the University of Trier convened RGLDD to promote scientific exchange between specialists working on the interface of remote sensing, geoinformation processing, desertification/land degradation research and its socio-economic implications. Although targeted at the scientific community, contributions with application perspectives were of crucial importance and both an overview of the current state of the art as well as operational opportunities were presented. Hosted at the Robert-Schuman Haus in Trier, the conference gained widespread attention and attracted an international audience from all parts of the world, which underlines the global dimension of land degradation and desertification processes. Based on a rigorous review of submitted abstracts, more than 100 contributions were accepted for oral and poster presentation, which are found in these proceedings edition in full paper form. Please note: This document is optimised for screen resolution, to receive a high-resolution version please contact the editors.