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Interaction between the Hypothalamic-Pituitary-Adrenal Axis and the Circadian Clock System in Humans (2018)

Yurtsever, Türkan

Rotation of the Earth creates day and night cycles of 24 h. The endogenous circadian clocks sense these light/dark rhythms and the master pacemaker situated in the suprachiasmatic nucleus of the hypothalamus entrains the physical activities according to this information. The circadian machinery is built from the transcriptional/translational feedback loops generating the oscillations in all nucleated cells of the body. In addition, unexpected environmental changes, called stressors, also challenge living systems. A response to these stimuli is provided immediately via the autonomic-nervous system and slowly via the hypothalamus"pituitary"adrenal (HPA) axis. When the HPA axis is activated, circulating glucocorticoids are elevated and regulate organ activities in order to maintain survival of the organism. Both the clock and the stress systems are essential for continuity and interact with each other to keep internal homeostasis. The physiological interactions between the HPA axis and the circadian clock system are mainly addressed in animal studies, which focus on the effects of stress and circadian disturbances on cardiovascular, psychiatric and metabolic disorders. Although these studies give opportunity to test in whole body, apply unwelcome techniques, control and manipulate the parameters at the high level, generalization of the results to humans is still a debate. On the other hand, studies established with cell lines cannot really reflect the conditions occurring in a living organism. Thus, human studies are absolutely necessary to investigate mechanisms involved in stress and circadian responses. The studies presented in this thesis were intended to determine the effects of cortisol as an end-product of the HPA axis on PERIOD (PER1, PER2 and PER3) transcripts as circadian clock genes in healthy humans. The expression levels of PERIOD genes were measured under baseline conditions and after stress in whole blood. The results demonstrated here have given better understanding of transcriptional programming regulated by pulsatile cortisol at standard conditions and short-term effects of cortisol increase on circadian clocks after acute stress. These findings also draw attention to inter-individual variations in stress response as well as non-circadian functions of PERIOD genes in the periphery, which need to be examined in details in the future.

The prosodic marking of rhetorical questions in Standard Chinese (2022)

Zahner-Ritter, Katharina ; Chen, Yiya ; Dehé, Nicole ; Braun, Bettina

The present study investigates the prosody of information-seeking (ISQs) and rhetorical questions (RQs) in Standard Chinese, in polar and wh-questions. Like in other languages, ISQs and RQs in Standard Chinese can have the same surface structure, allowing for a direct prosodic comparison between illocution types (ISQ vs RQ). Since Standard Chinese has lexical tone, the use of f0 as a cue to illocution type may be restricted. We investigate the prosodic differences between ISQs and RQs as well as the interplay of prosodic cues to RQs. In terms of f0, results showed that RQs were lower in f0, with the f0 range on the first word being expanded followed by f0 compression. RQs were further longer in duration and more often realized with non-modal voice quality (glottalized voice) as compared to ISQs. These prosodic cues were largely manipulated in tandem (illocutionary pairs with larger durational differences also showed larger differences in mean f0; voice quality, in turn, seemed to be an additional cue). We suggest three possible explanations (assertive force, focus, speaker attitude) that unite the present findings on RQs in Standard Chinese with the findings on RQs in other, non-tonal languages.

Three Kinds of Rising-Falling Contours in German wh-Questions: Evidence From Form and Function (2022)

Zahner-Ritter, Katharina ; Einfeldt, Marieke ; Wochner, Daniela ; James, Angela ; Dehé, Nicole ; Braun, Bettina

The intonational realization of utterances is generally characterized by regional as well as inter- and intra-speaker variability in f0. Category boundaries thus remain “fuzzy” and it is non-trivial how the (continuous) acoustic space maps onto (discrete) pitch accent categories. We focus on three types of rising-falling contours, which differ in the alignment of L(ow) and H(igh) tones with respect to the stressed syllable. Most of the intonational systems on German have described two rising accent categories, e.g., L+H* and L*+H in the German ToBI system. L+H* has a high-pitched stressed syllable and a low leading tone aligned in the pre-tonic syllable; L*+H a low-pitched stressed syllable and a high trailing tone in the post-tonic syllable. There are indications for the existence of a third category which lies between these two categories, with both L and H aligned within the stressed syllable, henceforth termed (LH)*. In the present paper, we empirically investigate the distinctiveness of three rising-falling contours [L+H*, (LH)*, and L*+H, all with a subsequent low boundary tone] in German wh-questions. We employ an approach that addresses both the form and the function of the contours, also taking regional variation into account. In Experiment 1 (form), we used a delayed imitation paradigm to test whether Northern and Southern German speakers can imitate the three rising-falling contours in wh-questions as distinct contours. In Experiment 2 (function), we used a free association task to investigate whether listeners interpret the pragmatic meaning of the three contours differently. Imitation results showed that German speakers—both from the North and the South—reproduced the three contours. There was a small but significant effect of regional variety such that contours produced by speakers from the North were slightly more distinct than those by speakers from the South. In the association task, listeners from both varieties attributed distinct meanings to the (LH)* accent as opposed to the two ToBI accents L+H* and L*+H. Combined evidence from form and function suggests that three distinct contours can be found in the acoustic and perceptual space of German rising-falling contours.

How experience with tone in the native language affects the L2 acquisition of pitch accents (2022)

Zahner-Ritter, Katharina ; Zhao, Tianyi ; Einfeldt, Marieke ; Braun, Bettina

This paper tested the ability of Mandarin learners of German, whose native language has lexical tone, to imitate pitch accent contrasts in German, an intonation language. In intonation languages, pitch accents do not convey lexical information; also, pitch accents are sparser than lexical tones as they only associate with prominent words in the utterance. We compared two kinds of German pitch-accent contrasts: (1) a “non-merger” contrast, which Mandarin listeners perceive as different and (2) a “merger” contrast, which sounds more similar to Mandarin listeners. Speakers of a tone language are generally very sensitive to pitch. Hypothesis 1 (H1) therefore stated that Mandarin learners produce the two kinds of contrasts similarly to native German speakers. However, the documented sensitivity to tonal contrasts, at the expense of processing phrase-level intonational contrasts, may generally hinder target-like production of intonational pitch accents in the L2 (Hypothesis 2, H2). Finally, cross-linguistic influence (CLI) predicts a difference in the realization of these two contrasts as well as improvement with higher proficiency (Hypothesis 3, H3). We used a delayed imitation paradigm, which is well-suited for assessing L2-phonetics and -phonology because it does not necessitate access to intonational meaning. We investigated the imitation of three kinds of accents, which were associated with the sentence-final noun in short wh-questions (e.g., Wer malt denn Mandalas, lit: “Who draws PRT mandalas?” “Who likes drawing mandalas?”). In Experiment 1, 28 native speakers of Mandarin participated (14 low- and 14 high-proficient). The learners’ productions of the two kinds of contrasts were analyzed using General Additive Mixed Models to evaluate differences in pitch accent contrasts over time, in comparison to the productions of native German participants from an earlier study in our lab. Results showed a more pronounced realization of the non-merger contrast compared to German natives and a less distinct realization of the merger contrast, with beneficial effects of proficiency, lending support to H3. Experiment 2 tested low-proficient Italian learners of German (whose L1 is an intonation language) to contextualize the Mandarin data and further investigate CLI. Italian learners realized the non-merger contrast more target-like than Mandarin learners, lending additional support to CLI (H3).

Hybrid and Quality Aware Federations of Linked Data Fragment Interfaces and Traditional RESTfulWeb APIs (2026)

Zeimetz, Tobias

This thesis presents four contributions in the domains of schema/ontology alignment and query processing. First, we present a novel alignment approach, denoted as FiLiPo (Finding Linkage Points), to align the schema of RDF knowledge bases with the response schema of RESTful Web APIs. FiLiPo only requires knowledge about a knowledge base (e.g., class names) but no prior knowledge about the Web APIs’ data structure. It uses fifteen different string similarity metrics to find an alignment between the schema of a knowledge base and that of aWeb API. Next, a benchmark system named ETARA (Evaluation Toolkit for API and RDF Alignment) is introduced that was created with the goal to simulate RESTful Web APIs and is able to cover all important characteristics of Web APIs, i.e., latency, timeouts, rate limits and, furthermore, provides configurable response structures (e.g., JSON or XML). Additionally, it was designed to support researchers during the development of alignment systems. Afterward, the alignments determined by FiLiPo are used to create a hybrid and federated query processor named TunA (Tunable Query Optimizer forWeb APIs and User Preferences), which allows SPARQL queries combining knowledge bases and RESTful Web APIs and is tunable towards user preferences, i.e., coverage, reliability and execution time. The primary goal of TunA is to return a query result that satisfies the user’s preferences in terms of data quality, even when using unreliable data sources by performing a majority vote over multiple sources. Lastly, we present a federated query processor, denoted as ORAQL (Overlap and Reliability Aware Query Processing Layer), which uses overlap information to reduce the number of selected sources that are available in a federation. The goal is to reduce redundant data and, hence, improve the query execution speed. Therefore, ORAQL uses a profile feature that provides information about the overlap between all data sources of a federation. Furthermore, we extend the quality estimation of TunA to cover Triple Pattern Fragment interfaces to ensure a user-provided reliability goal.

Regional climate simulations in the Weddell Sea region (Antarctic): Model verification and evaluation of low-level jets (2023)

Zentek, Rolf

This cumulative thesis encompass three studies focusing on the Weddell Sea region in the Antarctic. The first study produces and evaluates a high quality data set of wind measurements for this region. The second study produces and evaluates a 15 year regional climate simulation for the Weddell Sea region. And the third study produces and evaluates a climatology of low level jets (LLJs) from the simulation data set. The evaluations were done in the attached three publications and the produced data sets are published online. In 2015/2016, the RV Polarstern undertook an Antarctic expedition in the Weddell Sea. We operated a Doppler wind lidar on board during that time running different scan patterns. The resulting data was evaluated, corrected, processed and we derived horizontal wind speed and directions for vertical profiles with up to 2 km height. The measurements cover 38 days with a temporal resolution of 10-15 minutes. A comparisons with other radio sounding data showed only minor differences. The resulting data set was used alongside other measurements to evaluate temperature and wind of simulation data. The simulation data was produced with the regional climate model CCLM for the period of 2002 to 2016 for the Weddell Sea region. Only smaller biases were found except for a strong warm bias during winter near the surface of the Antarctic Plateau. Thus we adapted the model setup and were able to remove the bias in a second simulation. This new simulation data was then used to derive a climatology of low level jets (LLJs). Statistics of occurrence frequency, height and wind speed of LLJs for the Weddell Sea region are presented along other parameters. Another evaluation with measurements was also performed in the last study.

Verification of the regional atmospheric model CCLM v5.0 with conventional data and lidar measurements in Antarctica (2020)

Zentek, Rolf ; Heinemann, Günther

The nonhydrostatic regional climate model CCLM was used for a long-term hindcast run (2002–2016) for the Weddell Sea region with resolutions of 15 and 5 km and two different turbulence parametrizations. CCLM was nested in ERA-Interim data and used in forecast mode (suite of consecutive 30 h long simulations with 6 h spin-up). We prescribed the sea ice concentration from satellite data and used a thermodynamic sea ice model. The performance of the model was evaluated in terms of temperature and wind using data from Antarctic stations, automatic weather stations (AWSs), an operational forecast model and reanalyses data, and lidar wind profiles. For the reference run we found a warm bias for the near-surface temperature over the Antarctic Plateau. This bias was removed in the second run by adjusting the turbulence parametrization, which results in a more realistic representation of the surface inversion over the plateau but resulted in a negative bias for some coastal regions. A comparison with measurements over the sea ice of the Weddell Sea by three AWS buoys for 1 year showed small biases for temperature around ±1 K and for wind speed of 1 m s−1. Comparisons of radio soundings showed a model bias around 0 and a RMSE of 1–2 K for temperature and 3–4 m s−1 for wind speed. The comparison of CCLM simulations at resolutions down to 1 km with wind data from Doppler lidar measurements during December 2015 and January 2016 yielded almost no bias in wind speed and a RMSE of ca. 2 m s−1. Overall CCLM shows a good representation of temperature and wind for the Weddell Sea region. Based on these encouraging results, CCLM at high resolution will be used for the investigation of the regional climate in the Antarctic and atmosphere–ice–ocean interactions processes in a forthcoming study.

Analysis of the performance of a ship-borne scanning wind lidar in the Arctic and Antarctic (2018)

Zentek, Rolf ; Kohnemann, Svenja ; Heinemann, Günther

In the present study a non-motion-stabilized scanning Doppler lidar was operated on board of RV Polarstern in the Arctic (June 2014) and Antarctic (December 2015– January 2016). This is the first time that such a system measured on an icebreaker in the Antarctic. A method for a motion correction of the data in the post-processing is presented. The wind calculation is based on vertical azimuth display (VAD) scans with eight directions that pass a quality control. Additionally a method for an empirical signal-tonoise ratio (SNR) threshold is presented, which can be calculated for individual measurement set-ups. Lidar wind profiles are compared to total of about 120 radiosonde profiles and also to wind measurements of the ship. The performance of the lidar measurements in comparison with radio soundings generally shows small root mean square deviation (bias) for wind speed of around 1ms-1(0.1ms-1) and for wind direction of around 10 (1). The post-processing of the non-motion-stabilized data shows comparably high quality to studies with motion-stabilized systems. Two case studies show that a flexible change in SNR threshold can be beneficial for special situations. Further the studies reveal that short-lived low-level jets in the atmospheric boundary layer can be captured by lidar measurements with a high temporal resolution in contrast to routine radio soundings. The present study shows that a non-motionstabilized Doppler lidar can be operated successfully on an icebreaker. It presents a processing chain including quality control tests and error quantification, which is useful for further measurement campaigns.

Competitive Analysis of Scheduling Problems and List Accessing Problems (2019)

Zhu, Yida

Competitive analysis is a well known method for analyzing online algorithms. Two online optimization problems, the scheduling problems and the list accessing problems, are considered in the thesis of Yida Zhu in the respect of this method. For both problems, several existing online and offline algorithms are studied. Their performances are compared with the performances of corresponding offline optimal algorithms. In particular, the list accessing algorithm BIT is carefully reviewed. The classical proof of its worst case performance get simplified by adapting the knowledge about the optimal offline algorithm. With regard to average case analysis, a new closed formula is developed to determine the performance of BIT on specific class of instances. All algorithm considered in this thesis are also implemented in Julia. Their empirical performances are studied and compared with each other directly.

Optimal Control of Partial Integro-Differential Equations and Analysis of the Gaussian Kernel (2018)

Zimmer, Lukas Aaron

An important field of applied mathematics is the simulation of complex financial, mechanical, chemical, physical or medical processes with mathematical models. In addition to the pure modeling of the processes, the simultaneous optimization of an objective function by changing the model parameters is often the actual goal. Models in fields such as finance, biology or medicine benefit from this optimization step. While many processes can be modeled using an ordinary differential equation (ODE), partial differential equations (PDEs) are needed to optimize heat conduction and flow characteristics, spreading of tumor cells in tissue as well as option prices. A partial integro-differential equation (PIDE) is a parital differential equation involving an integral operator, e.g., the convolution of the unknown function with a given kernel function. PIDEs occur for example in models that simulate adhesive forces between cells or option prices with jumps. In each of the two parts of this thesis, a certain PIDE is the main object of interest. In the first part, we study a semilinear PIDE-constrained optimal control problem with the aim to derive necessary optimality conditions. In the second, we analyze a linear PIDE that includes the convolution of the unknown function with the Gaussian kernel.

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