Refine
Year of publication
- 2010 (56) (remove)
Document Type
- Doctoral Thesis (38)
- Article (14)
- Conference Proceedings (3)
- Retro digitized Object (1)
Language
- German (35)
- English (16)
- French (4)
- Multiple languages (1)
Has Fulltext
- yes (56)
Keywords
- Frankreich (5)
- Reisebericht (5)
- Germany (4)
- Treves (4)
- Deutschland (3)
- Physiologische Psychologie (3)
- Rezeption (3)
- Tourismus (3)
- Travel (3)
- 19th century (2)
Institute
- Universitätsbibliothek (16)
- Raum- und Umweltwissenschaften (13)
- Psychologie (10)
- Geschichte, mittlere und neuere (4)
- Mathematik (3)
- Wirtschaftswissenschaften (3)
- Informatik (2)
- Politikwissenschaft (2)
- Allgemeine Sprach- und Literaturwissenschaft (1)
- Fachbereich 2 (1)
- Kunstgeschichte (1)
- Rechtswissenschaft (1)
- Soziologie (1)
The visualization of relational data is at the heart of information visualization. The prevalence of visual representations for this kind of data is based on many real world examples spread over many application domains: protein-protein interaction networks in the field of bioinformatics, hyperlinked documents in the World Wide Web, call graphs in software systems, or co-author networks are just four instances of a rich source of relational datasets. The most common visual metaphor for this kind of data is definitely the node-link approach, which typically suffers from visual clutter caused by many edge crossings. Many sophisticated algorithms have been developed to layout a graph efficiently and with respect to a list of aesthetic graph drawing criteria. Relations between objects normally change over time. Visualizing the dynamics means an additional challenge for graph visualization researchers. Applying the same layout algorithms for static graphs to intermediate states of dynamic graphs may also be a strategy to compute layouts for an animated graph sequence that shows the dynamics. The major drawback of this approach is the high cognitive effort for a viewer of the animation to preserve his mental map. To tackle this problem, a sophisticated layout algorithm has to inspect the whole graph sequence and compute a layout with as little changes as possible between subsequent graphs. The main contribution and ultimate goal of this thesis is the visualization of dynamic compound weighted multi directed graphs as a static image that targets at visual clutter reduction and at mental map preservation. To achieve this goal, we use a radial space-filling visual metaphor to represent the dynamics in relational data. As a side effect the obtained pictures are very aesthetically appealing. In this thesis we firstly describe static graph visualizations for rule sets obtained by extracting knowledge from software archives under version control. In a different work we apply animated node-link diagrams to code-developer relationships to show the dynamics in software systems. An underestimated visualization paradigm is the radial representation of data. Though this kind of data has a long history back to centuries-old statistical graphics, only little efforts have been done to fully explore the benefits of this paradigm. We evaluated a Cartesian and a radial counterpart of a visualization technique for visually encoding transaction sequences and dynamic compound digraphs with both an eyetracking and an online study. We found some interesting phenomena apart from the fact that also laymen in graph theory can understand the novel approach in a short time and apply it to datasets. The thesis is concluded by an aesthetic dimensions framework for dynamic graph drawing, future work, and currently open issues.
During and after application, pesticides enter the atmosphere by volatilisation and by wind erosion of particles on which the pesticide is sorbed. Measurements at application sites revealed that sometimes more than half of the amount applied is lost into the atmosphere within a few days. The atmosphere is an important part of the hydrologic cycle that can transport pesticides from their point of application and deposit them into aquatic and terrestrial ecosystems far from their point of use. In the region of Trier pesticides are widely used. In order to protect crops from pests and increase crop yields in the viniculture, six to eight pesticide applications take place between May and August. The impact that these applications have on the environmental pollution of the region is not yet well understood. The present study was developed to characterize the atmospheric presence, temporal patterns, transport and deposition of a variety of pesticides in the atmosphere of the area of Trier. To this purpose, rain samples were weekly collected at eight sites during the growing seasons 2000, 2001 and 2002, and air samples (gas and particle phases) were collected during the growing season 2002. Multiresidue analysis methods were developed to determine multiple classes of pesticides in rain water, particle- and gas-phase samples. Altogether 24 active ingredients and 3 metabolites were chosen as representative substances, focussing mainly on fungicides. Twenty-four of the 27 measured pesticides were detected in the rain samples; seventeen pesticides were detected in the air samples. The most frequently detected pesticides and at the highest concentrations, both in rain and air, were compounds belonging to the class of fungicides. The insecticide methyl parathion was also detected in several rain samples as well as two substances that are banned in Germany, such as the herbicides atrazine and simazine. Concentration levels varied during the growing season with the highest concentrations being measured in the late spring and summer months, coinciding with application times and warmer months. Concentration levels measured in the rain samples were, generally, in the order of rnng l-1. Though average concentrations for single substances were less than 100 ng l-1, total concentrations were considerable and in some instances well above the EU drinking water quality standard of 500 ng l-1 for total pesticides. Compared to the amounts applied for pest control, the amounts deposited by rain resulted between 0,004% and 0,10% of the maximum application rates. These low pesticide inputs from precipitation to surface-water bodies is not of concern in vinicultural areas where the impact of other sources, such as superficial runoff inputs from the treated areas and cleaning of field crop sprayers, is more important. However, the potential impacts of these aerial pesticide inputs to non-target sites, such as organic crops, and sensitive ecosystems are as yet not known. Concentration levels in the air samples were in the order of ng m-3 at sites close to the fields were pesticides were applied, while lower values, in the order of pg m-3, were detected at the site located further away from fields where applications were performed. The measured air concentration levels found in this study do not represent a concern for human health in terms of acute risk. Inhalation toxicity studies have shown that an acute potential risk only arises at air concentrations in the range of g m-3. Finally, it must be kept in mind that only a small number of chemicals that were applied in the area were analysed for in this study. In order to gain a better evaluation of the local atmospheric load of pesticides, a wider spectrum of applied substances (including metabolites) needs to be investigated.
N-acetylation by N-acetyltransferase 1 (NAT1) is an important biotransformation pathway of the human skin and it is involved in the deactivation of the arylamine and well-known contact allergen para-phenylenediamine (PPD). Here, NAT1 expression and activity were analyzed in antigen presenting cells (monocyte-derived dendritic cells, MoDCs, a model for epidermal Langerhans cells) and human keratinocytes. The latter were used to study exogenous and endogenous NAT1 activity modulations. Within this thesis, MoDCs were found to express metabolically active NAT1. Activities were between 23.4 and 26.6 nmol/mg/min and thus comparable to peripheral blood mononuclear cells. These data suggest that epidermal Langerhans cells contribute to the cutaneous N-acetylation capacity. Keratinocytes, which are known for their efficient N-acetylation, were analyzed in a comparative study using primary keratinocytes (NHEK) and different shipments of the immortalized keratinocyte cell line HaCaT, in order to investigate the ability of the cell line to model epidermal biotransformation. N-acetylation of the substrate para-aminobenzoic acid (PABA) was 3.4-fold higher in HaCaT compared to NHEK and varied between the HaCaT shipments (range 12.0"44.5 nmol/mg/min). Since B[a]P induced cytochrome p450 1 (CYP1) activities were also higher in HaCaT compared to NHEK, the cell line can be considered as an in vitro tool to qualitatively model epidermal metabolism, regarding NAT1 and CYP1. The HaCaT shipment with the highest NAT1 activity showed only minimal reduction of cell viability after treatment with PPD and was subsequently used to study interactions between NAT1 and PPD in keratinocytes. Treatment with PPD induced expression of cyclooxygenases (COX) in HaCaT, but in parallel, PPD N-acetylation was found to saturate with increasing PPD concentration. This saturation explains the presence of the PPD induced COX induction despite the high N-acetylation capacities. A detailed analysis of the effect of PPD on NAT1 revealed that the saturation of PPD N-acetylation was caused by a PPD-induced decrease of NAT1 activity. This inhibition was found in HaCaT as well as in primary keratinocytes after treatment with PPD and PABA. Regarding the mechanism, reduced NAT1 protein level and unaffected NAT1 mRNA expression after PPD treatment adduced clear evidences for substrate-dependent NAT1 downregulation. These results expand the existing knowledge about substrate-dependent NAT1 downregulation to human epithelial skin cells and demonstrate that NAT1 activity in keratinocytes can be modulated by exogenous factors. Further analysis of HaCaT cells from different shipments revealed an accelerated progression through the cell cycle in HaCaT cells with high NAT1 activities. These findings suggest an association between NAT1 and proliferation in keratinocytes as it has been proposed earlier for tumor cells. In conclusion, N-acetylation capacity of MoDCs as well as keratinocytes contribute to the overall N-acetylation capacity of human skin. NAT1 activity of keratinocytes and consequently the detoxification capacities of human skin can be modulated by the presence of exogenous NAT1 substrates and endogenous by the cell proliferation status of keratinocytes.
Aggression is one of the most researched topics in psychology. This is understandable, since aggression behavior does a lot of harm to individuals and groups. A lot is known already about the biology of aggression, but one system that seems to be of vital importance in animals has largely been overlooked: the hypothalamic-pituitary-adrenal (HPA) axis. Menno Kruk and Jószef Haller and their research teams developed rodent models of adaptive, normal, and abnormal aggressive behavior. They found the acute HPA axis (re)activity, but also chronic basal levels to be causally relevant in the elicitation and escalation of aggressive behavior. As a mediating variable, changes in the processing of relevant social information is proposed, although this could not be tested in animals. In humans, not a lot of research has been done, but there is evidence for both the association between acute and basal cortisol levels in (abnormal) aggression. However, not many of these studies have been experimental of nature. rnrnOur aim was to add to the understanding of both basal chronic levels of HPA axis activity, as well as acute levels in the formation of aggressive behavior. Therefore, we did two experiments, both with healthy student samples. In both studies we induced aggression with a well validated paradigm from social psychology: the Taylor Aggression Paradigm. Half of the subjects, however, only went through a non-provoking control condition. We measured trait basal levels of HPA axis activity on three days prior. We took several cortisol samples before, during, and after the task. After the induction of aggression, we measured the behavioral and electrophysiological brain response to relevant social stimuli, i.e., emotional facial expressions embedded in an emotional Stroop task. In the second study, we pharmacologically manipulated cortisol levels 60min before the beginning of the experiment. To do that, half of the subjects were administered 20mg of hydrocortisone, which elevates circulating cortisol levels (cortisol group), the other half was administered a placebo (placebo group). Results showed that acute HPA axis activity is indeed relevant for aggressive behavior. We found in Study 1 a difference in cortisol levels after the aggression induction in the provoked group compared to the non-provoked group (i.e., a heightened reactivity of the HPA axis). However, this could not be replicated in Study 2. Furthermore, the pharmacological elevation of cortisol levels led to an increase in aggressive behavior in women compared to the placebo group. There were no effects in men, so that while men were significantly more aggressive than women in the placebo group, they were equally aggressive in the cortisol group. Furthermore, there was an interaction of cortisol treatment with block of the Taylor Aggression Paradigm, in that the cortisol group was significantly more aggressive in the third block of the task. Concerning basal HPA axis activity, we found an effect on aggressive behavior in both studies, albeit more consistently in women and in the provoked and non-provoked groups. However, the effect was not apparent in the cortisol group. After the aggressive encounter, information processing patterns were changed in the provoked compared to the non-provoked group for all facial expressions, especially anger. These results indicate that the HPA axis plays an important role in the formation of aggressive behavior in humans, as well. Importantly, different changes within the system, be it basal or acute, are associated with the same outcome in this task. More studies are needed, however, to better understand the role that each plays in different kinds of aggressive behavior, and the role information processing plays as a possible mediating variable. This extensive knowledge is necessary for better behavioral interventions.
Stress is a common phenomenon for animals living in the wild, but also for humans in modern societies. Originally, the body's stress response is an adaptive reaction to a possibly life-threatening situation, and it has been shown to impact on energy distribution and metabolism, thereby increasing the chance of survival. However, stress has also been shown to impact on mating behaviour and reproductive strategies in animals and humans. This work deals with the effect of stress on reproductive behavior. Up to now, research has only focused on the effects of stress on reproduction in general. The effects of stress on reproduction may be looked at from two points of view. First, stress affects reproductive functioning by endocrine (e.g. glucocorticoid) actions on the reproductive system. However, stress can also influence reproductive behavior, i.e. mate choice and mating preferences. Animals and humans do not mate randomly, but exhibit preferences towards mating partners. One factor by which animals and humans choose their mating partners is similarity vs. dissimilarity: Similar mates usually carry more of one's own genes and the cooperation between similar mates is, at least theoretically, less hampered by expressing diverse behaviors. By mating with dissimilar mates on the other hand one may acquire new qualities for oneself, but also for one's offspring, useful to cope with environmental challenge. In humans we usually find a preference for similar mates. Due to the high costs of breeding, variables like cooperation and life-long partnerships may play a greater role than the acquaintance of new qualities.The present work focuses on stress effects on mating preferences of humans and will give a first answer to the question whether stress may affect our preference for similar mates. Stress and mating preferences are at the centre of this work. Thus, in the first Chapter I will give an introduction on stress and mating preferences and link these topics to each other. Furthermore, I will give a short summary of the studies described in Chapter II - Chapter IV and close the chapter with a general discussion of the findings and directions for further research on stress and mating preferences. Human mating behavior is complex, and many aspects of it may not relate to biology but social conventions and education. This work will not focus on those aspects but rather on cognitive and affective processing of erotic and sexually-relevant stimuli, since we assume that these aspects of mating behaviour are likely related to psychobiological stress mechanisms. Therefore, a paradigm is needed that measures such aspects of mating preferences in humans. The studies presented in Chapter II and Chapter III were performed in order to develop such a paradigm. In these studies we show that affective startle modulation may be used to indicate differences in sexual approach motivation to potential mating partners with different similarity levels to the participant. In Chapter IV, I will describe a study that aimed to investigate the effects of stress on human mating preferences. We showed that stress reverses human mating preferences: While unstressed individuals show a preference for similar mates, stressed individuals seem to prefer dissimilar mates. Overall, the studies presented in this work showed that affective startle modulation can be employed to measure mating preferences in humans and that these mating preferences are influenced by stress.
Abstracts book of oral presentations and poster contributions for the mid-term conference of the Interreg IVB NWE project ForeStClim. The international conference took place in Nancy (France) from 20. to 22. September 2010. The topics of the conference sessions were as follows:rnSession 1: Projecting forest sites and stand shiftsrnSession 2: Climate change and water: modelling across spatial and temporal scalesrnSession 3: Addressing climate change in practical silvicultural decision support
Überblicksdarstellung zur deutschsprachigen Casanova-Rezeption mit Schwerpunkt 20. Jahrhundert (in französischer Sprache).
Tropospheric ozone (O3) is known to have various detrimental effects on plants, such as visible leaf injury, reduced growth and premature senescence. Flux models offer the determination of the harmful ozone dose entering the plant through the stomata. This dose can then be related to phytotoxic effects mentioned above to obtain dose-response relationships, which are a helpful tool for the formulation of abatement strategies of ozone precursors. rnOzone flux models are dependant on the correct estimation of stomatal conductance (gs). Based on measurements of gs, an ozone flux model for two white clover clones (Trifolium repens L. cv Regal; NC-S (ozone-sensitive) and NC-R (ozone-resistant)) differing in their sensitivity to ozone was developed with the help of artificial neural networks (ANNs). White clover is an important species of various European grassland communities. The clover plants were exposed to ambient air at three sites in the Trier region (West Germany) during five consecutive growing seasons (1997 to 2001). The response parameters visible leaf injury and biomass ratio of NC-S/NC-R clone were regularly assessed. gs-measurements of both clones functioned as output of the ANN-based gs model, while corresponding climate parameters (i.e. temperature, vapour pressure deficit (VPD) and photosynthetic active radiation (PAR)) and various ozone concentration indices were inputs. The development of the model was documented in detail and various model evaluation techniques (e.g. sensitivity analysis) were applied. The resulting gs model was used as a basis for ozone flux calculations, which were related to above mentioned response parameters. rnThe results showed that the ANNs were capable of revealing and learning the complex relationship between gs and key meteorological parameters and ozone concentration indices. The dose-response relationships between ozone fluxes and visible leaf injury were reasonably strong, while those between ozone fluxes and NC-S/NC-R biomass ratio were fairly weak. The results were discussed in detail with respect to the suitability of the chosen experimental methods and model type.
Während deutsche Einwanderer sich nur bedingt gegen die Institution der Sklaverei aussprachen, zeigten sie in ihrer Sicht auf African Americans ein weit höheres Maß an Geschlossenheit in ihrer ablehnenden Haltung. Um die Divergenz zwischen der Wahrnehmung von Sklaverei und African Americans sinnvoll zu kontextualisieren und zu erklären, erscheint die Kategorie der race als erhellende Untersuchungseinheit, welche hilft, die einseitige Wahrnehmung auf der menschlichen im Vergleich zur institutionellen Ebene zu beleuchten. Da der Begriff race weit weniger ideologisch belastet ist als der Begriff des Rassismus, bietet er ein Instrument, welches die nötige Offenheit für verschiedene Erklärungsansätze besitzt. Als Arbeitsgrundlage dient dabei die Definition von Stephen Cornell und Douglas Hartman. Die Autoren betonen besonders stark den menschlichen Ursprung der Kategorie race, ein für diese Untersuchung besonders wichtiger Aspekt, weil er auf die soziale Eingebundenheit des Konzepts verweist. Als solches handelt es sich bei race um eine historische Einheit, die Diskussionen und Wandlungen unterworfen war. Menschen schufen diese Kategorie als distinktes Merkmal für eine Gruppe von Menschen, die sie so eindeutig als von sich selbst unterschiedlich darstellten und damit eine möglichst große und eindeutige Differenz schufen. Diese Vorüberlegungen bilden die Basis für den Kontext, in dem die deutschen Einwanderer ihre Unterschiedlichkeit zu schwarzen Menschen wahrnahmen und davon ausgehend diese als Menschen beurteilten, was häufig mit einer Bewertung der Institution der Sklaverei einherging, der viele der in Amerika lebenden African Americans unterworfen waren. Die Divergenz zwischen dem Selbst und dem Gegenüber schlägt sich dabei in den komplementären Konzepten von blackness und whiteness nieder. Im Zusammenhang mit den deutschen Immigranten spielen diese beiden Perspektiven eine wichtige Rolle, weil so die Denkmuster der Deutschen zum Teil aus ihrem Fokus auf das Anderssein ihres Gegenübers, also der blackness, und zum Teil aus dem Gefühl der eigenen besonderen Stellung, also der whiteness, zu erklären sind. Deutsche Einwanderer schlossen sich Argumentationsmustern aus der Literatur oder der Populärwissenschaft in unterschiedlichen Ausprägung sowohl direkt auch indirekt an, was darauf hindeutet, dass sie wohl mit Gedanken um die Thematik blackness bereits schon in der alten Heimat in variierender Intensität konfrontiert worden waren und damit ihre Äußerungen zu schwarzen Menschen, welche sie nach ihrer Ankunft in den USA trafen, auch auf Vorstellungen beruhten, die sie vor einem direkten Kontakt mit Schwarzen geformt hatten. In Anlehnung an die Diskussionen innerhalb der USA zu schwarzen Menschen wurde Blackness für die deutschen Einwanderer zu einer gesellschaftlichen Kategorie, mit der sie sich in unterschiedlichen Intensitätsgraden auseinandersetzten mussten, weil sie potentiell enorme Auswirkungen auf die verschiedensten Aspekte des Lebens haben konnte. Die Institution der Sklaverei als eine auf race basierende Arbeitsform spielte dabei eine wichtige Rolle, weil hier eine institutionalisierte Manifestation der rassistischen Hierarchisierung in der amerikanischen Gesellschaft existierte. Innerhalb dieser hierarchisierten Gesellschaft stellte die Distanzierung von schwarzen Menschen und, damit einhergehend, die Integration in die Gruppe der weißen Amerikaner eine grundlegende Tendenz dar. Die Kategorie whiteness gewann also enorm an Wichtigkeit für die Einwanderer, wobei die sich daraus ergebenden Folgen etwa in wirtschaftlicher Hinsicht nicht unbedingt der Realität entsprechen mussten, sondern auch auf subjektive Wahrnehmungen beschränkt sein konnten. Vor diesem Hintergrund erklärt sich die hohe Zahl der deutschen Immigranten, die eine latente Abneigung oder sogar offene Abscheu gegenüber African Americans zeigte. Dieser Anreiz zur Differenzierung in Weiße und Schwarze war im Zusammenhang mit der Diskussion um die Institution der Sklaverei nicht gegeben, denn dabei ging es vor allem den intellektuellen Deutschen primär um abstrakte Ideen wie Freiheit und Gleichheit, die sie dann ohne oder nur mit geringem Bezug zu schwarzen Menschen diskutierten. Solange also die Distanz zu African Americans und damit die Zugehörigkeit zur Kategorie whiteness gewahrt blieb, konnten die Deutschen ihre Meinungen gegen die Sklaverei äußern. Es ging dann nicht um das Wohl der Schwarzen, sondern um die Institution und die damit verbundenen abstrakten Prinzipien.