In this thesis, we consider the solution of high-dimensional optimization problems with an underlying low-rank tensor structure. Due to the exponentially increasing computational complexity in the number of dimensions—the so-called curse of dimensionality—they present a considerable computational challenge and become infeasible even for moderate problem sizes. Multilinear algebra and tensor numerical methods have a wide range of applications in the fields of data science and scientific computing. Due to the typically large problem sizes in practical settings, efficient methods, which exploit low-rank structures, are essential. In this thesis, we consider an application each in both of these fields. Tensor completion, or imputation of unknown values in partially known multiway data is an important problem, which appears in statistics, mathematical imaging science and data science. Under the assumption of redundancy in the underlying data, this is a well-defined problem and methods of mathematical optimization can be applied to it. Due to the fact that tensors of fixed rank form a Riemannian submanifold of the ambient high-dimensional tensor space, Riemannian optimization is a natural framework for these problems, which is both mathematically rigorous and computationally efficient. We present a novel Riemannian trust-region scheme, which compares favourably with the state of the art on selected application cases and outperforms known methods on some test problems. Optimization problems governed by partial differential equations form an area of scientific computing which has applications in a variety of areas, ranging from physics to financial mathematics. Due to the inherent high dimensionality of optimization problems arising from discretized differential equations, these problems present computational challenges, especially in the case of three or more dimensions. An even more challenging class of optimization problems has operators of integral instead of differential type in the constraint. These operators are nonlocal, and therefore lead to large, dense discrete systems of equations. We present a novel solution method, based on separation of spatial dimensions and provably low-rank approximation of the nonlocal operator. Our approach allows the solution of multidimensional problems with a complexity which is only slightly larger than linear in the univariate grid size; this improves the state of the art for a particular test problem problem by at least two orders of magnitude.

Gegenstand der Dissertation ist die Geschichte und Manifestation des Nationaltheaters in Japan, der Transfer einer europäischen Kulturinstitution nach und deren Umsetzungsprozess in Japan, welcher mit der Modernisierung Japans ab Mitte des 19. Jahrhunderts begann und erst hundert Jahre später mit der Eröffnung des ersten Nationaltheaters 1966 endete. Dazu werden theaterhistorische Entwicklungen, Veränderungen in der Theaterproduktion und -architektur in Bezug auf die Genese eines japanischen Nationaltheaters beleuchtet. Das Ergebnis zeigt, dass sich die Institution Nationaltheater in seiner japanischen kulturellen Translation bzw. Manifestation wesentlich von den vom Land selbst als Model anvisierten Pendants in Europa in Inhalt, Organisations- und Produktionsstruktur unterscheidet. Kulturell übersetzt wurde allein die Hülle der europäischen Institution. Das erste Nationaltheater in Japan manifestiert sich als eine von der Regierung im Rahmen des Denkmalschutzgesetztes initiierte und bestimmte, spezifisch japanische Variante eines Nationaltheaters, die unter dem Management von staatlichen Angestellten und Beamten den Erhalt traditioneller Künste in dafür ausgerichteten Bühnen zur Aufgabe hat. Nationaltheaterensemble gibt es nicht, die Produktionen werden mit Schauspielern kommerzieller Theaterunternehmen realisiert. Der lange Prozess dieser Genese liegt in der nicht vorhandenen Theaterförderung seitens der Regierung und der eher zurückhaltenden Haltung der Theaterwelt gegenüber einem staatlich betriebenen Theater begründet. Das Hüllen-Konzept des ersten Nationaltheaters diente, genau wie dessen Management durch Beamte, als Prototyp für die fünf weiteren bis 2004 eröffneten Nationaltheater in Japan, welche als Spartentheater der spezifisch japanischen Vielfalt an Theaterformen, auch in ihrer Bühnenarchitektur Rechnung tragen.

Avant de mettre en place le conseil de coopération dans une classe, il faut en préparer l’organisation, le contenu et la méthode. Cet article fournit des indications sur sa mise en place et propose des méthodes concrètes pour le mener à bien.

Die Praxishefte Demokratische Schulkultur erscheinen halbjährlich und bieten Schulleitungen und Schulpersonal theoretische Grundlagen und praxisorientierte Anleitungen zur demokratiepädagogischen Schulentwicklung. Jedes Themenheft ist jeweils einer demokratiepädagogischen Bauform oder strategischen Frage der Schulentwicklung gewidmet. Die Praxishefte werden allen Luxemburger Schulen als Printausgabe zur Verfügung gestellt und online mit zusätzlichen Materialien und in französischer Fassung vorgehalten.

Les carnets paraissent biannuellement et offrent aux dirigeant(e)s des écoles ainsi qu’au personnel des fondements théoriques et du matériel pratique pour la mise en œuvre d’un développement scolaire démocratique. Chaque publication traite d’une méthode de l’éducation à la démocratie ou d’une question stratégique du développement scolaire. Les carnets en langue allemande sont mis à disposition des écoles luxembourgeoises en version imprimée. Tous le matériel ainsi que la version en langue française sont disponibles en ligne.

The article considers the question whether poets lie against the background of the possible difference between poetical and discursive knowledge. Starting from Plato’s thesis, namely that poets lie, the article refers to Rorty, who, in contrast to Plato and with the example of Nabokov, recognizes in poetry a special kind of knowledge. It is opposed to discursive knowledge, which is closely related to prose. In the second part Parmenides’ didactic poem “On Nature” is seen as an example of proposing discursive truth in poetic words. Heidegger read Parmenides’ poem as a case for the evidence of truth in non-ambiguous poetical words (cf. the example “a-letheia” – un-concealedness, truth). Popper, however, interpreted the same text very differently, namely as a critical reference to the principal ambiguity of the word in human language and as the first known instance of the presentation of the deductive method. In this context the works of Nietzsche and Solov’ev are seen as opposed to each other, as Nietzsche in “Zarathustra” identified philosophical and poetical knowledge, whereas Solov’ev in his main work kept them separate from each other. The last part of the article studies the relation of poetical and discursive knowledge in poems of Gennadij Ajgi with their closeness to the dream, of Vera Stepanova with the intriguing opening to the co-presence of the Poetical I and the Other in one and the same word and of Durs Grünbein, who exposes the ambiguity of poetical language as a means to show that even untruth can open a way to come to truth. Then the lie of poetical words can be their way to say the truth.

The relationship between poetry and cognition appears, at first glance, as hardly compelling as that of art and science, of feeling and thinking, or even of intuition and analysis. For this reason, its analysis is fundamentally concerned with questions from philosophical and literary criticism perspectives: Which forms of “cognition” are possible in poetry? In what way and in what forms can poetry also be a medium of generation and/or mediation of cognition, experience or even knowledge and truth? And which processes, matters, or “information” are thereby privileged? Are there subgenres of poetry, for example historical poetry, reflective poetry or didactic poetry, that are especially relevant as regards cognitive functions? And can cognition also be mediated through aura, Stimmung or experience?

Walter Benjamin developed his concept of the “aura” on the basis of the poetry of Baudelaire and applied this term to objects of art, nature, and man. Georg Picht transformed Benjamin’s aura-concept into a method of pre-rational knowledge forms, whose mediums includes foremost music, but also poetry and art. In modern nature poetry the varieties of aura cognition can be determined and described with the help of Benjamin’s and Picht’s concepts: Gennadij Ajgi creates poetic equivalents for the experience of nature-aura; Keijiro Suga makes a diagnosis of aura of areas of natural sites or landscapes and their historical transformation through war and nuclear catastrophe (Fukushima); Christian Lehnert translates auratic communication with nature in poetic conversations.

Cet article analyse les pratiques quotidiennes des habitants de Sarre, de Lorraine, du Luxembourg, de Rhénanie-Palatinat et de Wallonie effectuées dans les régions voisines. L’hypothèse est l’existence d’une réalité de vie transfrontalière dans la Grande Région à partir des pratiques transfrontalières de ses habitants. Dans une telle perspective socio-constructiviste, on ne demande pas ce qu'est la Grande Région SaarLorLux, mais comment elle est constituée ou comment elle se manifeste dans la vie quotidienne de ses habitants. Pour donner des éléments de réponse, seront analysées les pratiques transfrontalières les plus courantes, notamment le fait de faire des achats et du shopping, se détendre dans la nature/faire du tourisme, fréquenter des manifestations culturelles et rendre visite à des amis et à la famille. Les considérations se basent sur trois études empiriques récentes dans l’espace d'analyse, qui sont mises en rapport et contextualisées socio-culturellement et socio-économiquement dans le but de relever l'organisation spatiale, les motivations ainsi que d'autres facteurs contextuels des pratiques transfrontalières dans la Grande Région SaarLorLux. Dans cette approche, les flux de mobilité et les préférences spatiales sont reconstruits à partir des pratiques quotidiennes qui donnent un aperçu des réalités de vie transfrontalière dans la Grande Région SaarLorLux.

Can we learn something from poetry? Can poems convey to their readers insight, knowledge, orientation, understanding or even wisdom? The paper assumes that general answers to these questions are possible but often lacking in substance. Instead, it is worthwhile to consider (a) different types of cognitive achievements and (b) sub-genres of poetry to which specific cognitive achievements have been attributed in certain aesthetic traditions as well as in literary criticism. For this purpose, the paper introduces a modern descriptive vocabulary for various types of cognitive significance and advocates an orientation to the concept of “knowledge” instead of more vague terms like “insight” or “understanding”. In a second step, the paper deals with three sub-genres of lyric poetry, whose cognitive value has repeatedly been claimed in aesthetic traditions as well as in literary studies: “didactic poetry”, “philosophical poetry” (Germ. „Gedankenlyrik“) and “poetry of moods”. By means of concrete examples, the paper shows how each of the three sub-genres privileges a certain type of cognitive significance or a certain “mechanism” of knowledge communication. In a third step, the paper points out which basic features of poetry, such as fictionality, argumentativeness, and literariness, are essential and which are irrelevant to the different types of cognitive significance. Finally, the paper discusses (a) whether the three sub-genres of lyric poetry can be defined without reference to their cognitive functions and (b) whether it would be more appropriate to postulate corresponding practices of reading lyric poetry that are linked but not restricted to these sub-genres of lyric poetry and therefore can basically be applied to every poem.

C’est la participation des citoyen(ne)s engagé(e)s qui fait vivre la démocratie. À cette fin, il est nécessaire de familiariser le plus tôt possible les enfants et les adolescents aux méthodes démocratiques. Le conseil de coopération est un outil d’éducation à la démocratie qui offre aux élèves de nombreuses possibilités pour expérimenter la participation et renforcer leurs compétences démocratiques.

Lyrik gilt vielfach als hermetisch, gefühlszentriert oder ästhetisch überdeterminiert. Daher ist das Verhältnis von Lyrik und Erkenntnis auf den ersten Blick so wenig zwingend wie das von Kunst und Wissenschaft, von Fühlen und Denken oder auch von Intuition und Analyse. Die Beiträge des Bandes widmen sich aus philosophischer und literaturwissenschaftlicher Perspektive Praktiken und Formen, die sich in der Lyrik, insbesondere in der Gegenwartslyrik, möglicher Erkenntnisfunktionen bedienen. Dabei geht es um grundsätzliche Fragen zum Verhältnis von Lyrik und Erkenntnis: Welche Formen von ‚Erkenntnis‘ sind in der Lyrik überhaupt möglich? Inwiefern und mit welchen Formen kann Lyrik auch ein Mittel der Generierung und/oder Vermittlung von Erkenntnis, Erfahrung oder gar Wissen und Wahrheit sein und welche Verfahren, Inhalte oder ‚Informationen‘ werden dabei bevorzugt? Gibt es Subgenres der Lyrik, beispielsweise Geschichtslyrik, Gedankenlyrik oder Lehrdichtung, die im Hinblick auf Erkenntnisfunktionen besonders relevant sind? Und kann Erkenntnis auch durch Aura, Stimmung oder Erlebnis vermittelt werden?

Background: Increasing exposure to engineered inorganic nanoparticles takes actually place in both terrestric and aquatic ecosystems worldwide. Although we already know harmful effects of AgNP on the soil bacterial community, information about the impact of the factors functionalization, concentration, exposure time, and soil texture on the AgNP effect expression are still rare. Hence, in this study, three soils of different grain size were exposed for up to 90 days to bare and functionalized AgNP in concentrations ranging from 0.01 to 1.00 mg/kg soil dry weight. Effects on soil microbial community were quantified by various biological parameters, including 16S rRNA gene, photometric, and fluorescence analyses. Results: Multivariate data analysis revealed significant effects of AgNP exposure for all factors and factor combinations investigated. Analysis of individual factors (silver species, concentration, exposure time, soil texture) in the unifactorial ANOVA explained the largest part of the variance compared to the error variance. In depth analysis of factor combinations revealed even better explanation of variance. For the biological parameters assessed in this study, the matching of soil texture and silver species, and the matching of soil texture and exposure time were the two most relevant factor combinations. The factor AgNP concentration contributed to a lower extent to the effect expression compared to silver species, exposure time and physico–chemical composition of soil. Conclusions: The factors functionalization, concentration, exposure time, and soil texture significantly impacted the effect expression of AgNP on the soil microbial community. Especially long-term exposure scenarios are strongly needed for the reliable environmental impact assessment of AgNP exposure in various soil types.

In dem Beitrag wird ein praxissoziologischer Ansatz für die Beschreibung und Analyse der grenzüberschreitenden Zusammenarbeit vorgestellt. Dafür wird zunächst die Entwicklung der Kooperationsforschung, ihre charakteristischen Orientierungen sowie die Grundzüge praxistheoretischen Denkens skizziert. Darauf aufbauend wird die heuristische Denkfigur der grenzüberschreitenden Praxisformation erarbeitet, die mit Prämissen herkömmlicher Kooperationsforschung bricht. Sie wird am Beispiel von vier Herausforderungen der grenzüberschreitenden Zusammenarbeit weiter ausdifferenziert, um schließlich zu einer alternativen Perspektivierung der grenzüberschreitenden Zusammenarbeit zu gelangen. Es folgt ein Ausblick, der auf die forschungspraktischen Besonderheiten des vorgestellten Ansatzes eingeht mit Blick auf eine künftige praxissoziologische und multidisziplinär anschlussfähige Kooperationsforschung.

Urban flooding cannot be avoided entirely and in all areas, particularly in coastal cities. Therefore adaptation to the growing risk is necessary. Geographical Information Systems (GIS) based knowledge on risk informs location-based approach to adaptation to climate risk. It allows managing city- wide coordination of adaptation measures, reducing adverse impacts of local strategies on neighbouring areas to the minimum. Quantitative assessments dominate GIS applications in flood risk management, for instance to demonstrate the distribution of people and assets in a flood prone area. Qualitative, participatory approaches to GIS are on the rise but have not been applied in the context of flooding yet. The overarching research question of this working paper is: what can GIS, and what can it not say about relationships / social relations in adaptation to urban flood risk? The use of GIS in risk mapping has exposed environmental injustices. Applications of GIS further allow model- ling future flood risk in function of demographic and land use changes, and combining it with decision support systems (DSS). While such GIS applications provide invaluable information for urban planners steering adaptation they however fall short on revealing the social relations that shape individual and household adaptation decisions. The relevance of networked social relations in adaptation to flood risk has been demonstrated in case studies, and extensively in the literature on organizational learning and adaptation to change. The purpose of this literature review is to identify the type of social relations that shape adaptive capacities towards urban flood risk which can- not be identified in a conventional GIS application.

In der kleinen ostfriesischen Kirchengemeinde W. hat sich im Jahr 1969 ein plötzlicher Todesfall ereignet. Fremdverschulden wird ausgeschlossen. Jemand, der die Hintergründe des Todesfalls aufklären will, stößt allenthalben auf – bisweilen gar aggressives – Schweigen. Eine Geschichte über individuelle und kollektive Schuld, lutherische Kirchenmusik und den Wert, den wir der Kultur und der Tradition beimessen. Ausgezeichnet mit dem Borsla-Preis 2019.

Feedback in der Schule? Das bedeutet häufig eine kurze Rückmeldung der Lehrer*innen an die Schüler*innen zu deren Mitarbeit. Dabei bietet eine etablierte Feedbackkultur im Unterricht breite Möglichkeiten, demokratisches Handeln zu üben und die Unterrichtsqualität zu verbessern, und muss keineswegs nur einseitig ausfallen.

This paper provides an overview of five major shifts in urban water supply governance in relation to changing paradigms in the water sector as a whole and in water-related research: i) the municipal hydraulic paradigm in the Global North; ii) its travel to cities in the Global South; iii) the shift from government to governance; iv) the (private) utility model and v) its contestation. The articulation of each shift in the Ghanaian context is described from the creation of the first water supply system during colonial time to the recent contestation against private corporate sector participation. Current challenges are outlined together with new pathways for researching urban water governance. The paper is based on a literature review conducted in 2015 and serves as a background study for further research within the WaterPower project.

This doctoral thesis includes five studies that deal with the topics work, well-being, and family formation, as well as their interaction. The studies aim to find answers to the following questions: Do workers’ personality traits determine whether they sort into jobs with performance appraisals? Does job insecurity result in lower quality and quantity of sleep? Do public smoking bans affect subjective well-being by changing individuals’ use of leisure time? Can risk preferences help to explain non-traditional family forms? And finally, are differences in out-of-partnership birth rates between East and West Germany driven by cultural characteristics that have evolved in the two separate politico-economic systems? To answer these questions, the following chapters use basic economic subjects such as working conditions, income, and time use, but also employ a range of sociological and psychological concepts such as personality traits and satisfaction measures. Furthermore, all five studies use data from the German Socio-Economic Panel (SOEP), a representative longitudinal panel of private households in Germany, and apply state-of-the-art microeconometric methods. The findings of this doctoral thesis are important for individuals, employers, and policymakers. Workers and employers benefit from knowing the determinants of occupational sorting, as vacancies can be filled more accurately. Moreover, knowing which job-related problems lead to lower well-being and potentially higher sickness absence likely increases efficiency in the workplace. The research on smoking bans and family formation in chapters 4, 5, and 6 is particularly interesting for policymakers. The results on the effects of smoking bans on subjective well-being presented in chapter 4 suggest that the impacts of tobacco control policies could be weighed more carefully. Additionally, understanding why women are willing to take the risks associated with single motherhood can help to improve policies targeting single mothers.

Der vorliegende Sammelband geht auf die UniGR-Fachtagung Edu.GR - Europa leben lernen / Edu.GR - Apprendre à vivre l’Europe zurück, die am 20. September 2018 an der Universität Trier stattfand. Die Beiträge befassen sich aus unterschiedlichen Perspektiven – so aus Sicht der Bildungswissenschaften, der Fachdidaktiken, der Sozialwissenschaften und der Bildungspraxis – mit der Frage der Gestaltung Europas am Beispiel der Großregion. Vorgestellt und diskutiert werden neben Konzepten transnationaler Bildung auch empirische Analysen des Denkens und Handelns der Beteiligten in grenzregionalen (Aus-)Bildungskontexten sowie ausgewählte Beispiele transnationaler Bildungspraxis.

Reisebilder aus Ägypten: wortreich beschrieben, fotografisch und filmisch dokumentiert. Der Artikel skizziert die Orientbilder deutscher Reisender im 19. Jahrhundert. Illustriert durch aktuelle Fotografien der Verfasserin.

Liste der ersten Filme, die in Ägypten gedreht wurden = Anhang zu Deeken, Annette: Dokumentarische Reise-Bilder aus Ägypten um 1900

Willi Huttig gehört zu den Photographen, die auf der legendären Photoausstellung "Family of man" der Weltöffentlichkeit präsentiert wurden. Er ist gleichwohl ein Unbekannter in der Photogeschichte. Hier eine Spurensuche.

Die Implementierung eines Klassenrats ist mit der Hoffnung verbunden, die demokratischen Kompetenzen von Schüler*innen zu stärken. Welche Kompetenzen die Teilnehmer*innen mithilfe dieser demokratiepädagogischen Methode tatsächlich erwerben und wie sich der Klassenrat auf die Klassengemeinschaft auswirkt, hat eine empirische Studie1 am Lycée Nic Biever in Dudelange untersucht.

Thema dieser Dissertation ist das deutsche Selbstbildnis im 17. Jahrhundert. Ziel der Arbeit war es, das deutsche Selbstbildnis als eigene Gattung zu etablieren. Hierzu wurden die Selbstbildnisse deutscher Maler des 17. Jahrhunderts ausgewählt, gilt doch diese Zeit noch immer als ‚totes Jahrhundert‘. Grundlage der Untersuchung war eine Sammlung von 148 Objekten, die einer grundlegenden Analyse unterzogen wurden. Das früheste Selbstbildnis in dieser Sammlung stammt von 1600, das späteste wurde um 1700 angefertigt. Künstler aus dem gesamten Alten Reich, ob aus Schlesien und Böhmen, Nord-oder Süddeutschland oder aus den österreichischen wie schweizerischen Landen sind hier vertreten. Die Selbstbildnisse stammen von Malern in der gesamten breite ihrer Karriere. So sind gleichermaßen Selbstbildnisse von Gesellen wie Meistern, von Hofmalern bis hin zu Freimeistern vertreten. Besonders wichtig war es, nicht nur Selbstbildnisse im Gemälde oder Kupferstich in die Untersuchung aufzunehmen, sondern auch Stammbucheinträge. Die ausführliche Betrachtung und Gegenüberstellung der deutschen Selbstbildnisse mit denen ihrer europäischen Kollegen hat gezeigt, dass auch deutsche Maler den gängigen Darstellungstypen wie etwa dem virtuoso folgten. Aber die deutschen Maler imitierten nicht nur, sondern experimentierten und gingen mit ihren Vorbildern spielerisch um. Daneben folgten sie natürlich auch den Trends der Selbstinszenierung. Sie drückten in ihren Selbstbildnissen ihren Wunsch nach sozialer und gesellschaftlicher Emanzipation des gesamten Berufsstandes aus. So war das deutsche Selbstbildnis eigenständiger Ausdruck des Aufbruches deutscher Künstler in eine neue Zeit.

La participation des élèves ne devrait pas se limiter à l’implication dans l’organisation et l’évaluation des cours. Une culture de tâches participative offre de nombreuses possibilités pour pratiquer et analyser la participation démocratique à l’aide d’actions réelles ou simulées dans l’apprentissage technique.

Many combinatorial optimization problems on finite graphs can be formulated as conic convex programs, e.g. the stable set problem, the maximum clique problem or the maximum cut problem. Especially NP-hard problems can be written as copositive programs. In this case the complexity is moved entirely into the copositivity constraint. Copositive programming is a quite new topic in optimization. It deals with optimization over the so-called copositive cone, a superset of the positive semidefinite cone, where the quadratic form x^T Ax has to be nonnegative for only the nonnegative vectors x. Its dual cone is the cone of completely positive matrices, which includes all matrices that can be decomposed as a sum of nonnegative symmetric vector-vector-products. The related optimization problems are linear programs with matrix variables and cone constraints. However, some optimization problems can be formulated as combinatorial problems on infinite graphs. For example, the kissing number problem can be formulated as a stable set problem on a circle. In this thesis we will discuss how the theory of copositive optimization can be lifted up to infinite dimension. For some special cases we will give applications in combinatorial optimization.

Competitive analysis is a well known method for analyzing online algorithms. Two online optimization problems, the scheduling problems and the list accessing problems, are considered in the thesis of Yida Zhu in the respect of this method. For both problems, several existing online and offline algorithms are studied. Their performances are compared with the performances of corresponding offline optimal algorithms. In particular, the list accessing algorithm BIT is carefully reviewed. The classical proof of its worst case performance get simplified by adapting the knowledge about the optimal offline algorithm. With regard to average case analysis, a new closed formula is developed to determine the performance of BIT on specific class of instances. All algorithm considered in this thesis are also implemented in Julia. Their empirical performances are studied and compared with each other directly.

With the advent of high­throughput sequencing (HTS), profiling immunoglobulin (IG) repertoires has become an essential part of immunological research. The dissection of IG repertoires promises to transform our understanding of the adaptive immune system dynamics. Advances in sequencing technology now also allow the use of the Ion Torrent Personal Genome Machine (PGM) to cover the full length of IG mRNA transcripts. The applications of this bench­top scale HTS platform range from identification of new therapeutic antibodies to the deconvolution of malignant B cell tumors. In the context of this thesis, the usability of the PGM is assessed to investigate the IG heavy chain (IGH) repertoires of animal models. First, an innovate bioinformatics approach is presented to identify antigendriven IGH sequences from bulk sequenced bone marrow samples of transgenic humanized rats, expressing a human IG repertoire (OmniRatTM). We show, that these rats mount a convergent IGH CDR3 response towards measles virus hemagglutinin protein and tetanus toxoid, with high similarity to human counterparts. In the future, databases could contain all IGH CDR3 sequences with known specificity to mine IG repertoire datasets for past antigen exposures, ultimately reconstructing the immunological history of an individual. Second, a unique molecular identifier (UID) based HTS approach and network property analysis is used to characterize the CLL­like CD5+ B cell expansion of A20BKO mice overexpressing a natural short splice variant of the CYLD gene (A20BKOsCYLDBOE). We could determine, that in these mice, overexpression of sCYLD leads to unmutated subvariant of CLL (U­CLL). Furthermore, we found that this short splice variant is also seen in human CLL patients highlighting it as important target for future investigations. Third, the UID based HTS approach is improved by adapting it to the PGM sequencing technology and applying a custom­made data processing pipeline including the ImMunoGeneTics (IMGT) database error detection. Like this, we were able to obtain correct IGH sequences with over 99.5% confidence and correct CDR3 sequences with over 99.9% confidence. Taken together, the results, protocols and sample processing strategies described in this thesis will improve the usability of animal models and the Ion Torrent PGM HTS platform in the field if IG repertoire research.

Abstract: Thermal infrared (TIR) multi-/hyperspectral and sun-induced fluorescence (SIF) approaches together with classic solar-reflective (visible, near-, and shortwave infrared reflectance (VNIR)/SWIR) hyperspectral remote sensing form the latest state-of-the-art techniques for the detection of crop water stress. Each of these three domains requires dedicated sensor technology currently in place for ground and airborne applications and either have satellite concepts under development (e.g., HySPIRI/SBG (Surface Biology and Geology), Sentinel-8, HiTeSEM in the TIR) or are subject to satellite missions recently launched or scheduled within the next years (i.e., EnMAP and PRISMA (PRecursore IperSpettrale della Missione Applicativa, launched on March 2019) in the VNIR/SWIR, Fluorescence Explorer (FLEX) in the SIF). Identification of plant water stress or drought is of utmost importance to guarantee global water and food supply. Therefore, knowledge of crop water status over large farmland areas bears large potential for optimizing agricultural water use. As plant responses to water stress are numerous and complex, their physiological consequences affect the electromagnetic signal in different spectral domains. This review paper summarizes the importance of water stress-related applications and the plant responses to water stress, followed by a concise review of water-stress detection through remote sensing, focusing on TIR without neglecting the comparison to other spectral domains (i.e., VNIR/SWIR and SIF) and multi-sensor approaches. Current and planned sensors at ground, airborne, and satellite level for the TIR as well as a selection of commonly used indices and approaches for water-stress detection using the main multi-/hyperspectral remote sensing imaging techniques are reviewed. Several important challenges are discussed that occur when using spectral emissivity, temperature-based indices, and physically-based approaches for water-stress detection in the TIR spectral domain. Furthermore, challenges with data processing and the perspectives for future satellite missions in the TIR are critically examined. In conclusion, information from multi-/hyperspectral TIR together with those from VNIR/SWIR and SIF sensors within a multi-sensor approach can provide profound insights to actual plant (water) status and the rationale of physiological and biochemical changes. Synergistic sensor use will open new avenues for scientists to study plant functioning and the response to environmental stress in a wide range of ecosystems.

Harvesting of silage maize in late autumn on waterlogged soils may result in several ecological problems such as soil compaction and may subsequently be a major threat to soil fertility in Europe. It was hypothesized that perennial energy crops might reduce the vulnerability for soil compaction through earlier harvest dates and improved soil stability. However, the performance of such crops to be grown on soil that are periodically waterlogged and implications for soil chemical and microbial properties are currently an open issue. Within the framework of a two-year pot experiment we investigated the potential of the cup plant (Silphium perfoliatum L.), Jerusalem artichoke (Helianthus tuberosus), giant knotweed (Fallopia japonicum X bohemica), tall wheatgrass (Agropyron elongatum), and reed canary grass (Phalaris arundinacea) for cultivation under periodically waterlogged soil conditions during the winter half year and implications for soil chemical and biological properties. Examined perennial energy crops coped with periodical waterlogging and showed yields 50% to 150% higher than in the control which was never faced with waterlogging. Root formation was similar in waterlogged and non-waterlogged soil layers. Soil chemical and microbial properties clearly responded to different soil moisture treatments. For example, dehydrogenase activity was two to four times higher in the periodically waterlogged treatment compared to the control. Despite waterlogging, aerobic microbial activity was significantly elevated indicating morphological and metabolic adaptation of the perennial crops to withstand waterlogged conditions. Thus, our results reveal first evidence of a site-adapted biomass production on periodical waterlogged soils through the cultivation of perennial energy crops and for intense plant microbe interactions.

Partizipativer Unterricht, der nicht nur aus punktuell erlebter Teilnahme besteht, ist — wie Charlotte Keuler es im Leitartikel des vorliegenden Heftes formuliert — durch die Herausforderungen, vor die uns unsere globalisierte Welt stellt, in vielerlei Hinsicht unabdingbar geworden. Kommunikationsfähigkeit, interkulturelle Kompetenz, Wissensmanagement und andere oft zitierte „soft skills“ sind Schlüsselkompetenzen des 21. Jahrhunderts.

L’apprentissage par le projet - plus que toute autre forme d’enseignement - permet aux élèves de participer de manière autonome à l’organisation des cours. Les apprenant(e)s ne s’exercent pas seulement dans l’action autonome et responsable, mais jouent, eux aussi, un rôle actif dans la société.

A huge number of clinical studies and meta-analyses have shown that psychotherapy is effective on average. However, not every patient profits from psychotherapy and some patients even deteriorate in treatment. Due to this result and the restricted generalization of clinical studies to clinical practice, a more patient-focused research strategy has emerged. The question whether a particular treatment works for an individual case is the focus of this paradigm. The use of repeated assessments and the feedback of this information to therapists is a major ingredient of patient-focused research. Improving patient outcomes and reducing dropout rates by the use of psychometric feedback seems to be a promising path. Therapists seem to differ in the degree to which they make use of and profit from such feedback systems. This dissertation aims to better understand therapist differences in the context of patient-focused research and the impact of therapists on psychotherapy. Three different studies are included, which focus on different aspects within the field: Study I (Chapter 5) investigated how therapists use psychometric feedback in their work with patients and how much therapists differ in their usage. Data from 72 therapists treating 648 patients were analyzed. It could be shown that therapists used the psychometric feedback for most of their patients. Substantial variance in the use of feedback (between 27% and 52%) was attributable to therapists. Therapists were more likely to use feedback when they reported being satisfied with the graphical information they received. The results therefore indicated that not only patient characteristics or treatment progress affected the use of feedback. Study II (Chapter 6) picked up on the idea of analyzing systematic differences in therapists and applied it to the criterion of premature treatment termination (dropout). To answer the question whether therapist effects occur in terms of patients’ dropout rates, data from 707 patients treated by 66 therapists were investigated. It was shown that approximately six percent of variance in dropout rates could be attributed to therapists, even when initial impairment was controlled for. Other predictors of dropout were initial impairment, sex, education, personality styles, and treatment expectations. Study III (Chapter 7) extends the dissertation by investigating the impact of a transfer from one therapist to another within ongoing treatments. Data from 124 patients who agreed to and experienced a transfer during their treatment were analyzed. A significant drop in patient-rated as well as therapist-rated alliance levels could be observed after a transfer. On average, there seemed to be no difficulties establishing a good therapeutic alliance with the new therapist, although differences between patients were observed. There was no increase in symptom severity due to therapy transfer. Various predictors of alliance and symptom development after transfer were investigated. Impacts on clinical practice were discussed. Results of the three studies are discussed and general conclusions are drawn. Implications for future research as well as their utility for clinical practice and decision-making are presented.

Sollten Plastikverpackungen verboten werden? Was spricht gegen eine Wahlberechtigung ab 14 Jahren? Wie sollte die EU mit möglichen Auswirkungen des Brexits umgehen? – Auch solche Fragen haben im Klassenrat ihre Berechtigung, denn ihre Diskussion bietet besondere Chancen für demokratische Lernprozesse.

It is well-known that katabatic winds can be detected as warm signatures in the surface temperature over the slopes of the Antarctic ice sheets. For appropriate synoptic forcing and/or topographic channeling, katabatic surges occur, which result in warm signatures also over adjacent ice shelves. Moderate Resolution Imaging Spectroradiometer (MODIS) ice surface temperature (IST) data are used to detect warm signatures over the Antarctic for the winter periods 2002–2017. In addition, high-resolution (5 km) regional climate model data is used for the years of 2002 to 2016. We present a case study and a climatology of wind-induced IST anomalies for the Ross Ice Shelf and the eastern Weddell Sea. The IST anomaly distributions show maxima around 10–15K for the slopes, but values of more than 25K are also found. Katabatic surges represent a strong climatological signal with a mean warm anomaly of more than 5K on more than 120 days per winter for the Byrd Glacier and the Nimrod Glacier on the Ross Ice Shelf. The mean anomaly for the Brunt Ice Shelf is weaker, and exceeds 5K on about 70 days per winter. Model simulations of the IST are compared to the MODIS IST, and show a very good agreement. The model data show that the near-surface stability is a better measure for the response to the wind than the IST itself.

Die Trierer Quellen- und Studienhefte zur historisch-politischen Bildung veröffentlichen Ergebnisse aktueller Forschungsprojekte und Materialien für den historisch-politischen Unterricht aus der Arbeit des Arbeitsbereichs Didaktik der Gesellschaftswissenschaften.