The object of the current Thematic Issue is not to focus on the individuals (the cross-border commuters) but on the organization of the cross-border labor markets. We move from a micro perspective to a macro perspective in order to underline the diversity of the cross-border labor markets (at the French borders, for example) and shed light on the many aspects that impact cross-border supply or demand. Trying to understand the whole system that goes beyond the cross-border flows, the question we address in this thematic issue is about the organization of the labor markets: is the system organized in a cross-border way? Or do the borders still prevent a genuinely integrated cross-border labor market?

In recent decades, Border Studies have gained importance and have seen a noticeable increase in development. This manifests itself in an increased institutionalization, a differentiation of the areas of research interest and a conceptual reorientation that is interested in examining processes. So far, however, little attention has been paid to questions about (inter)disciplinary self-perception and methodological foundations of Border Studies and the associated consequences for research activities. This thematic issue addresses these desiderata and brings together articles that deal with their (inter)disciplinary foundations as well as method(olog)ical and practical research questions. The authors also provide sound insights into a disparate field of work, disclose practical research strategies, and present methodologically sophisticated systematizations.

While women's evolving contribution to entrepreneurship is irrefutable, in almost all nations, gender disparity is an existing reality of entrepreneurship. Social and economic outcomes make women entrepreneurship an important area for scholars and governments. In attempts to find reasons for this gender disparity, academic scholars evaluated various factors and recognised perceptual variables as having outstanding explanatory value in understanding women's entrepreneurship. To advance our knowledge of gender disparity in entrepreneurship, the present study explores the influence of entrepreneurial perceptual variables on women's entrepreneurship and considers the critical role of country-level institutional contexts on the women's entrepreneurial propensity. Therefore, this study examines the impact of perceptual variables in different nations. It also offers connections between entrepreneurial perceptions, women entrepreneurship, and institutional contexts as a critical topic for future studies. Drawing on the importance of perceptual factors, this dissertation investigates whether and how their perception of entrepreneurial networks influences the individuals' decision to initiate a new venture. Prior scholars considered exposure to entrepreneurial role models as one of the most influential factors on the women's inclination towards entrepreneurship; thus, a systemized analysis makes it possible to identify existing research gaps related to this perception. Hence, to draw a clear picture of the relationship between entrepreneurial role models and entrepreneurship, this dissertation provides a systemized overview of prior studies. Subsequently, Chapter 2 structures the existing literature on entrepreneurial role models and reveals that past literature has focused on the different types of role models, the stage of life at which the exposure to role models occurs, and the context of the exposure. Current discourse argues that the women's lower access to entrepreneurial role models negatively influences their inclination towards entrepreneurship. Additionally, although the research on women entrepreneurship has proliferated in recent years, little is known about how entrepreneurial perceptual variables form women's propensity towards entrepreneurship in various institutional contexts. The work of Koellinger et al. (2013), hereafter KMS, is one of the most influential papers that investigated the influence of perceptual variables, and it showed that a lower rate of women entrepreneurship is associated with a lower level of their entrepreneurial network, perceived entrepreneurial capability, and opportunity evaluation and with a higher fear of entrepreneurial failure. Thus, this dissertation replicates the work of KMS. Chapter 3 explicitly investigates the influence of the above perceptions on women's entrepreneurial propensity. This research has drawn data from the Global Entrepreneurship Monitor, a cross-national individual-level data set (2001-2006) covering 236,556 individuals across 17 countries. The results of this chapter suggest that gender disparities in entrepreneurial propensity are conditioned by differences in entrepreneurial perceptual variables. Women's lower levels of perceived entrepreneurial capability, entrepreneurial role models and opportunity evaluation and their higher fear of failure lead to lower entrepreneurial propensity. To extend and generalise the relationship between perceptions and women's entrepreneurial propensity, in Chapter 4, two studies are conducted based on replicated research. Extension 1 generalises the results of KMS by using the same analysis on more recent data. Accordingly, this research implemented the same analysis on 372,069 individuals across the same countries (2011-2016). The recent data show that although gender disparity became significantly weaker, the gender gap is still in men's favour. However, similarly to the replicated study, this research revealed that perceptual factors explain a larger part of the gender disparity. To strengthen prior empirical evidence, in extension 2, utilising a sample of 1,029,863 individuals from 71 countries (2011-2016), the study conducted the same measures and analysis in a more global setting. By including developing countries, gender disparity in entrepreneurial propensity decreased significantly. The study revealed that the relative significance of the influences of perceptions' differs significantly across nations; however, perceptions have a worldwide effect. Moreover, this research found that the ratio of nascent women entrepreneurs in less developed countries to those in more developed nations is 2. More precisely, a higher level of economic development negatively influences the impact of perceptions on women's entrepreneurial propensity. Whereas prior scholars increasingly underlined the importance of perceptions in explaining a large part of gender disparities in entrepreneurship, most of the prior investigations focused on nascent (early-stage) entrepreneurship, and evidence on the relationship between perceptions and other types of self-employment, such as innovative entrepreneurship, is scant. Innovation is a confirmed key driver of a firm's sustainability, higher competitive capability, and growth. Therefore, Chapter 5 investigates the influence of perceptions on women's innovative entrepreneurship. The chapter points out that entrepreneurial perceptions are the main determinants of the women's decision to offer a new product or service. This chapter also finds that women's innovative entrepreneurship is associated with the country's specific economic setting. Overall, by underlining the critical role of institutional contexts, this dissertation provides considerable insights into the interaction between perceptions and women entrepreneurship, and its results have implications for policymakers and practitioners, who may find it helpful to consider women entrepreneurship in systemized challenges. Formal and informal barriers affect women's entrepreneurial perceptions and can differ from one country to the other. In this sense, it is crucial to design operational plans to mitigate formal and stereotypical challenges, and thus, more women will be able to start a business, particularly in developing countries in which women significantly comprise a smaller portion of the labour markets. This type of policy could write the "rules of the game" such that these rules enhance the women's propensity towards entrepreneurship.

Many combinatorial optimization problems on finite graphs can be formulated as conic convex programs, e.g. the stable set problem, the maximum clique problem or the maximum cut problem. Especially NP-hard problems can be written as copositive programs. In this case the complexity is moved entirely into the copositivity constraint. Copositive programming is a quite new topic in optimization. It deals with optimization over the so-called copositive cone, a superset of the positive semidefinite cone, where the quadratic form x^T Ax has to be nonnegative for only the nonnegative vectors x. Its dual cone is the cone of completely positive matrices, which includes all matrices that can be decomposed as a sum of nonnegative symmetric vector-vector-products. The related optimization problems are linear programs with matrix variables and cone constraints. However, some optimization problems can be formulated as combinatorial problems on infinite graphs. For example, the kissing number problem can be formulated as a stable set problem on a circle. In this thesis we will discuss how the theory of copositive optimization can be lifted up to infinite dimension. For some special cases we will give applications in combinatorial optimization.

Structured Eurobonds are a prominent topic in the discussions how to complete the monetary and fiscal union. This work sheds light on several issues going hand in hand with the introduction of common bonds. At first a crucial question is on the optimal construction, e.g. what is the optimal common liability. Other questions that arise belong to the time after the introduction. The impact on several exchnage rates is examined in this work. Finally an approximation bias in forward-looking DSGE models is quantified which would lead to an adjustment of central bank interest rates and therefore has an impact on the other two topics.

This dissertation focuses on the link between labour market institutions and precautionary savings. It is evaluated whether private households react to changes in social insurance provision such as the income replacement in case of unemployment by increased savings for precautionary reasons. The dissertation consists of three self-contained chapters, each focusing on slightly different aspects of the topic. The first chapter titled "Precautionary saving and the (in)stability of subjective earnings uncertainty" empirically looks at the influence of future income uncertainty on household saving behavior. Numerous cross-section studies on precautionary saving use subjective expectations regarding the income variance one year ahead as a proxy for income uncertainty. Using such proxies observed only at one point in time, however, may give rise to biased estimates for precautionary wealth if expectations are not stable over time. Survey data from the Dutch DNB Household Survey suggest that subjective future income distributions are not stable over the mid-term. Moreover, in this study I contrast estimates of precautionary wealth using the variation coefficient observed at one point in time with those using a simple mid-term average. Estimates of precautionary wealth based on the average are about 40% to 80% higher than the estimates using the variation coefficient observed only once. In addition to that, wealth accumulation for precautionary reasons is estimated for different parts of the income distribution. The share of precautionary wealth is highest for households at the center of the income distribution. By linking saving behaviour with unemployment insurance, the following chapters then shed some light on an issue that has largely been neglected in the literature on labour market institutions so far. Whereas the third chapter models the relevance of unemployment insurance for income uncertainty and intertemporal decision making during institutional reform processes, chapter 4 seeks to establish empirically a relationship between saving behavior and unemployment insurance. Social insurance, especially unemployment insurance, provides agents with income insurance against not marketable income risks. Since the early 1990s, reform measures like more activating policies as suggested by the OECD Jobs Study in 1994 have been observed in Europe. In the third chapter it is argued that such changes in unemployment insurance reduce public insurance and increase income uncertainty. Moreover, a simple three period model is discussed which shows a link between a welfare state reform and agents' saving decisions as one possible reaction of agents to self-insure against income risk. Two sources of uncertainty seem to be important in this context: (1) uncertain results of the reform process concerning the replacement rate, and (2) uncertainty regarding the timing of information about the content of the reform. It can be shown that the precautionary motive for saving explains an increased accumulation of capital in times of reform activities. In addition to that, early information about the expected replacement rate increases agents' utility and reduces under and oversaving. Following the argument of the previous chapters, that an important feature of labour market institutions in modern welfare states is to provide cash transfers as income replacement in case of unemployment, it is hypothesised that unemployment benefits reduce the motive to save for precautionary reasons. Based on consumer sentiment data from the European Commission's Consumer Survey, chapter four finally provides some evidence that aggregate saving intentions are significantly influenced by unemployment benefits. It can be shown that higher benefits lower the intention to save.

This paper provides an overview of five major shifts in urban water supply governance in relation to changing paradigms in the water sector as a whole and in water-related research: i) the municipal hydraulic paradigm in the Global North; ii) its travel to cities in the Global South; iii) the shift from government to governance; iv) the (private) utility model and v) its contestation. The articulation of each shift in the Ghanaian context is described from the creation of the first water supply system during colonial time to the recent contestation against private corporate sector participation. Current challenges are outlined together with new pathways for researching urban water governance. The paper is based on a literature review conducted in 2015 and serves as a background study for further research within the WaterPower project.

This report presents the results of a stakeholder mapping exercise carried out in the WaterPower project. The mapping was conducted for the following main research areas of the project: water supply, land use planning and management, wetland management and climate change adaptation/disaster risk reduction. The report gives an overview of the stakeholders that play a role in these respective areas and identifies those who have concomitant responsibilities in different sectors. It represents the first step towards further involvement of stakeholders in the WaterPower project.

External capital plays an important role in financing entrepreneurial ventures, due to limited internal capital sources. An important external capital provider for entrepreneurial ventures are venture capitalists (VCs). VCs worldwide are often confronted with thousands of proposals of entrepreneurial ventures per year and must choose among all of these companies in which to invest. Not only do VCs finance companies at their early stages, but they also finance entrepreneurial companies in their later stages, when companies have secured their first market success. That is why this dissertation focuses on the decision-making behavior of VCs when investing in later-stage ventures. This dissertation uses both qualitative as well as quantitative research methods in order to provide answer to how the decision-making behavior of VCs that invest in later-stage ventures can be described. Based on qualitative interviews with 19 investment professionals, the first insight gained is that for different stages of venture development, different decision criteria are applied. This is attributed to different risks and goals of ventures at different stages, as well as the different types of information available. These decision criteria in the context of later-stage ventures contrast with results from studies that focus on early-stage ventures. Later-stage ventures possess meaningful information on financials (revenue growth and profitability), the established business model, and existing external investors that is not available for early-stage ventures and therefore constitute new decision criteria for this specific context. Following this identification of the most relevant decision criteria for investors in the context of later-stage ventures, a conjoint study with 749 participants was carried out to understand the relative importance of decision criteria. The results showed that investors attribute the highest importance to 1) revenue growth, (2) value-added of products/services for customers, and (3) management team track record, demonstrating differences when compared to decision-making studies in the context of early-stage ventures. Not only do the characteristics of a venture influence the decision to invest, additional indirect factors, such as individual characteristics or characteristics of the investment firm, can influence individual decisions. Relying on cognitive theory, this study investigated the influence of various individual characteristics on screening decisions and found that both investment experience and entrepreneurial experience have an influence on individual decision-making behavior. This study also examined whether goals, incentive structures, resources, and governance of the investment firm influence decision making in the context of later-stage ventures. This study particularly investigated two distinct types of investment firms, family offices and corporate venture capital funds (CVC), which have unique structures, goals, and incentive systems. Additional quantitative analysis showed that family offices put less focus on high-growth firms and whether reputable investors are present. They tend to focus more on the profitability of a later-stage venture in the initial screening. The analysis showed that CVCs place greater importance on product and business model characteristics than other investors. CVCs also favor later-stage ventures with lower revenue growth rates, indicating a preference for less risky investments. The results provide various insights for theory and practice.

Stress position in English words is well-known to correlate with both their morphological properties and their phonological organisation in terms of non-segmental, prosodic categories like syllable structure. While two generalisations capturing this correlation, directionality and stratification, are well established, the exact nature of the interaction of phonological and morphological factors in English stress assignment is a much debated issue in the literature. The present study investigates if and how directionality and stratification effects in English can be learned by means of Naive Discriminative Learning, a computational model that is trained using error-driven learning and that does not make any a-priori assumptions about the higher-level phonological organisation and morphological structure of words. Based on a series of simulation studies we show that neither directionality nor stratification need to be stipulated as a-priori properties of words or constraints in the lexicon. Stress can be learned solely on the basis of very flat word representations. Morphological stratification emerges as an effect of the model learning that informativity with regard to stress position is unevenly distributed across all trigrams constituting a word. Morphological affix classes like stress-preserving and stress-shifting affixes are, hence, not predefined classes but sets of trigrams that have similar informativity values with regard to stress position. Directionality, by contrast, emerges as spurious in our simulations; no syllable counting or recourse to abstract prosodic representations seems to be necessary to learn stress position in English.

A basic assumption of standard small area models is that the statistic of interest can be modelled through a linear mixed model with common model parameters for all areas in the study. The model can then be used to stabilize estimation. In some applications, however, there may be different subgroups of areas, with specific relationships between the response variable and auxiliary information. In this case, using a distinct model for each subgroup would be more appropriate than employing one model for all observations. If no suitable natural clustering variable exists, finite mixture regression models may represent a solution that „lets the data decide“ how to partition areas into subgroups. In this framework, a set of two or more different models is specified, and the estimation of subgroup-specific model parameters is performed simultaneously to estimating subgroup identity, or the probability of subgroup identity, for each area. Finite mixture models thus offer a fexible approach to accounting for unobserved heterogeneity. Therefore, in this thesis, finite mixtures of small area models are proposed to account for the existence of latent subgroups of areas in small area estimation. More specifically, it is assumed that the statistic of interest is appropriately modelled by a mixture of K linear mixed models. Both mixtures of standard unit-level and standard area-level models are considered as special cases. The estimation of mixing proportions, area-specific probabilities of subgroup identity and the K sets of model parameters via the EM algorithm for mixtures of mixed models is described. Eventually, a finite mixture small area estimator is formulated as a weighted mean of predictions from model 1 to K, with weights given by the area-specific probabilities of subgroup identity.

One of the most essential hypotheses of usage-based theories and many constructionist approaches to language is that language entails the piecemeal learning of constructions on the basis of general cognitive mechanisms and exposure to the target language in use (Ellis 2002; Tomasello 2003). However, there is still a considerable lack of empirical research on the emergence and mental representation of constructions in second language (L2) acquisition. One crucial question that arises, for instance, is whether L2 learners’ knowledge of a construction corresponds to a native-like mapping of form and meaning and, if so, to what extent this representation is shaped by usage. For instance, it is unclear how learners ‘build’ constructional knowledge, i.e. which pieces of frequency-, form- and meaning-related information become relevant for the entrenchment and schematisation of a L2 construction. To address these issues, the English catenative verb construction was used as a testbed phenomenon. This idiosyncratic complex construction is comprised of a catenative verb and a non-finite complement clause (see Huddleston & Pullum 2002), which is prototypically a gerund-participial (henceforth referred to as ‘target-ing’ construction) or a to-infinitival complement (‘target-to’ construction): (1) She refused to do her homework. (2) Laura kept reading love stories. (3) *He avoids to listen to loud music. This construction is particularly interesting because learners often show choices of a complement type different from those of native speakers (e.g. Gries & Wulff 2009; Martinez‐Garcia & Wulff 2012) as illustrated in (3) and is commonly claimed to be difficult to be taught by explicit rules (see e.g. Petrovitz 2001). By triangulating different types of usage data (corpus and elicited production data) and analysing these by multivariate statistical tests, the effects of different usage-related factors (e.g. frequency, proficiency level of the learner, semantic class of verb, etc.) on the representation and development of the catenative verb construction and its subschemas (i.e. target-to and target-ing construction) were examined. In particular, it was assessed whether they can predict a native-like form-meaning pairing of a catenative verb and non-finite complement. First, all studies were able to show a robust effect of frequency on the complement choice. Frequency does not only lead to the entrenchment of high-frequency exemplars of the construction but is also found to motivate a taxonomic generalisation across related exemplars and the representation of a more abstract schema. Second, the results indicate that the target-to construction, due to its higher type and token frequency, has a high degree of schematicity and productivity than the target-ing construction for the learners, which allows for analogical comparisons and pattern extension with less entrenched exemplars. This schema is likely to be overgeneralised to (less frequent) target-ing verbs because the learners perceive formal and semantic compatibility between the unknown/infrequent verb and this pattern. Furthermore, the findings present evidence that less advanced learners (A2-B2) make more coarse-grained generalisations, which are centred around high-frequency and prototypical exemplars/low-scope patterns. In the case of high-proficiency learners (C1-C2), not only does the number of native-like complement choices increase but relational information, such as the semantic subclasses of the verb, form-function contingency and other factors, becomes also relevant for a target-like choice. Thus, the results suggests that with increasing usage experience learners gradually develop a more fine-grained, interconnected representation of the catenative verb construction, which gains more resemblance to the form-meaning mappings of native speakers. Taken together, these insights highlight the importance for language learning and teaching environments to acknowledge that L2 knowledge is represented in the form of highly interconnected form-meaning pairings, i.e. constructions, that can be found on different levels of abstraction and complexity.

The article offers a concise view on the constitution of the Baltic state of Latvia. After an introduction focusing on constitutional history, the author explores basic principles and human rights in the text of the constitution and explains the main constitutional bodies and their functions in legislative, executive and judiciary. Chapters on citizenship and religious rights round up this introduction to the Latvian Constitution.

This working paper outlines analytical pathways that could contribute to deepening the understanding of water inequalities in cities of the Global South. It brings together the status quo of research on water inequalities in Accra, the capital of Ghana, and studies on Environmental Justice. In doing so, it argues for the need to analytically distinguish between the terms ‘(in)equality’ and ‘(in)justice’. Studying everyday water practices and per- spectives on water (in)justice of different stakeholders would be a suitable entry point for an in-depth ethnographic study that analytically separates water inequalities and water injustices but considers their interlinkages. The working paper is based on a literature review conducted in 2015 in the scope of the WaterPower project.

Behavioural traces from interactions with digital technologies are diverse and abundant. Yet, their capacity for theory-driven research is still to be constituted. In the present cumulative dissertation project, I deliberate the caveats and potentials of digital behavioural trace data in behavioural and social science research. One use case is online radicalisation research. The three studies included, set out to discern the state-of-the-art of methods and constructs employed in radicalization research, at the intersection of traditional methods and digital behavioural trace data. Firstly, I display, based on a systematic literature review of empirical work, the prevalence of digital behavioural trace data across different research strands and discern determinants and outcomes of radicalisation constructs. Secondly, I extract, based on this literature review, hypotheses and constructs and integrate them to a framework from network theory. This graph of hypotheses, in turn, makes the relative importance of theoretical considerations explicit. One implication of visualising the assumptions in the field is to systematise bottlenecks for the analysis of digital behavioural trace data and to provide the grounds for the genesis of new hypotheses. Thirdly, I provide a proof-of-concept for incorporating a theoretical framework from conspiracy theory research (as a specific form of radicalisation) and digital behavioural traces. I argue for marrying theoretical assumptions derived from temporal signals of posting behaviour and semantic meaning from textual content that rests on a framework from evolutionary psychology. In the light of these findings, I conclude by discussing important potential biases at different stages in the research cycle and practical implications.

Objective Our study investigated body image representations in female patients with anorexia nervosa and healthy controls using a size estimation with pictures of their own body. We also explored a method to reduce body image distortions through right hemispheric activation. Method Pictures of participants’ own bodies were shown on the left or right visual fields for 130 ms after presentation of neutral, positive, or negative word primes, which could be self-relevant or not, with the task of classifying the picture as “thinner than”, “equal to”, or “fatter than” one’s own body. Subsequently, activation of the left- or right hemispheric through right- or left-hand muscle contractions for 3 min., respectively. Finally, participants completed the size estimation task again. Results The distorted “fatter than” body image was found only in patients and only when a picture of their own body appeared on the right visual field (left hemisphere) and was preceded by negative self-relevant words. This distorted perception of the patients’ body image was reduced after left-hand muscle contractions (right hemispheric activation). Discussion To reduce body image distortions it is advisable to find methods that help anorexia nervosa patients to increase their self-esteem. The body image distortions were ameliorated after right hemispheric activation. A related method to prevent distorted body-image representations in these patients may be Eye Movement Desensitization and Reprocessing (EMDR) therapy.

There is no longer any doubt about the general effectiveness of psychotherapy. However, up to 40% of patients do not respond to treatment. Despite efforts to develop new treatments, overall effectiveness has not improved. Consequently, practice-oriented research has emerged to make research results more relevant to practitioners. Within this context, patient-focused research (PFR) focuses on the question of whether a particular treatment works for a specific patient. Finally, PFR gave rise to the precision mental health research movement that is trying to tailor treatments to individual patients by making data-driven and algorithm-based predictions. These predictions are intended to support therapists in their clinical decisions, such as the selection of treatment strategies and adaptation of treatment. The present work summarizes three studies that aim to generate different prediction models for treatment personalization that can be applied to practice. The goal of Study I was to develop a model for dropout prediction using data assessed prior to the first session (N = 2543). The usefulness of various machine learning (ML) algorithms and ensembles was assessed. The best model was an ensemble utilizing random forest and nearest neighbor modeling. It significantly outperformed generalized linear modeling, correctly identifying 63.4% of all cases and uncovering seven key predictors. The findings illustrated the potential of ML to enhance dropout predictions, but also highlighted that not all ML algorithms are equally suitable for this purpose. Study II utilized Study I’s findings to enhance the prediction of dropout rates. Data from the initial two sessions and observer ratings of therapist interventions and skills were employed to develop a model using an elastic net (EN) algorithm. The findings demonstrated that the model was significantly more effective at predicting dropout when using observer ratings with a Cohen’s d of up to .65 and more effective than the model in Study I, despite the smaller sample (N = 259). These results indicated that generating models could be improved by employing various data sources, which provide better foundations for model development. Finally, Study III generated a model to predict therapy outcome after a sudden gain (SG) in order to identify crucial predictors of the upward spiral. EN was used to generate the model using data from 794 cases that experienced a SG. A control group of the same size was also used to quantify and relativize the identified predictors by their general influence on therapy outcomes. The results indicated that there are seven key predictors that have varying effect sizes on therapy outcome, with Cohen's d ranging from 1.08 to 12.48. The findings suggested that a directive approach is more likely to lead to better outcomes after an SG, and that alliance ruptures can be effectively compensated for. However, these effects were reversed in the control group. The results of the three studies are discussed regarding their usefulness to support clinical decision-making and their implications for the implementation of precision mental health.

This study focuses on the representation of British South Asian identities in contemporary British audiovisual media. It attempts to answer the question, whether these identities are represented as hybrid, heterogeneous and ambivalent, or whether these contemporary representations follow in the tradition of colonial and postcolonial racialism. Racialised depictions of British South Asians have been the norm not only in the colonial but also in the postcolonial era until the rise of the Black British movement, whose successes have been also acknowledged in the field of representation. However these achievements have to be scrutinized again, especially in the context of the post 9/11 world, rising Islamophobia, and new forms of institutionalized discrimination on the basis of religion. Since the majority of British Muslims are of South Asian origin, this study tries to answer the question whether the marker of religious origin is racial belonging, i.e. skin colour, and old stereotypes associated with the racialised representation are being perpetuated into current depictions through an examination of the varied genre of popular audio visual media texts.

The glucocorticoid (GC) cortisol, main mediator of the hypothalamic-pituitary-adrenal axis, has many implications in metabolism, stress response and the immune system. GC function is mediated mainly via the glucocorticoid receptor (GR) which binds as a transcription factor to glucocorticoid response elements (GREs). GCs are strong immunosuppressants and used to treat inflammatory and autoimmune diseases. Long-term usage can lead to several irreversible side effects which make improved understanding indispensable and warrant the adaptation of current drugs. Several large scale gene expression studies have been performed to gain insight into GC signalling. Nevertheless, studies at the proteomic level have not yet been made. The effects of cortisol on monocytes and macrophages were studied in the THP-1 cell line using 2D fluorescence difference gel electrophoresis (2D DIGE) combined with MALDI-TOF mass spectrometry. More than 50 cortisol-modulated proteins were identified which belonged to five functional groups: cytoskeleton, chaperones, immune response, metabolism, and transcription/translation. Multiple GREs were found in the promoters of their corresponding genes (+10 kb/-0.2 kb promoter regions including all alternative promoters available within the Database for Transcription Start Sites (DBTSS)). High quality GREs were observed mainly in cortisol modulated genes, corroborating the proteomics results. Differential regulation of selected immune response related proteins were confirmed by qPCR and immuno-blotting. All immune response related proteins (MX1, IFIT3, SYWC, STAT3, PMSE2, PRS7) which were induced by LPS were suppressed by cortisol and belong mainly to classical interferon target genes. Mx1 has been selected for detailed expression analysis since new isoforms have been identified by proteomics. FKBP51, known to be induced by cortisol, was identified as the strongest differentially expressed protein and contained the highest number of strict GREs. Genomic analysis of five alternative FKBP5 promoter regions suggested GC inducibility of all transcripts. 2D DIGE combined with 2D immunoblotting revealed the existence of several previously unknown FKBP51 isoforms, possibly resulting from these transcripts. Additionally multiple post-translational modifications were found, which could lead to different subcellular localization in monocytes and macrophages as seen by confocal microscopy. Similar results were obtained for the different cellular subsets of human peripheral blood mononuclear cells (PBMCs). FKBP51 was found to be constitutively phosphorylated with up to 8 phosphosites in CD19+ B lymphocytes. Differential Co-immunoprecipitation for cytoplasm and nucleus allowed us to identify new potential interaction partners. Nuclear FKBP51 was found to interact with myosin 9, whereas cytosolic FKBP51 with TRIM21 (synonym: Ro52, Sjögren`s syndrome antigen). The GR has been found to interact with THOC4 and YB1, two proteins implicated in mRNA processing and transcriptional regulation. We also applied proteomics to study rapid non-genomic effects of acute stress in a rat model. The nuclear proteome of the thymus was investigated after 15 min restraint stress and compared to the non-stressed control. Most of the identified proteins were transcriptional regulators found to be enriched in the nucleus probably to assist gene expression in an appropriate manner. The proteomic approach allowed us to further understand the cortisol mediated response in monocytes/macrophages. We identified several new target proteins, but we also found new protein variants and post-translational modifications which need further investigation. Detailed study of FKBP51 and GR indicated a complex regulation network which opened a new field of research. We identified new variants of the anti-viral response protein MX1, displaying differential expression and phosphorylation in the cellular compartments. Further, proteomics allowed us to follow the very early effects of acute stress, which happen prior to gene expression. The nuclear thymocyte proteome of restraint stressed rats revealed an active preparation for subsequent gene expression. Proteomics was successfully applied to study differential protein expression, to identify new protein variants and phosphorylation events as well as to follow translocation. New aspects for future research in the field of cortisol-mediated immune modulation have been added.

Attitudes are "the most distinctive and indispensable concept in contemporary social psychology" (Allport, 1935, p. 798). This outstanding position of the attitude concept in social cognitive research is not only reflected in the innumerous studies focusing on this concept but also in the huge number of theoretical approaches that have been put forth since then. Yet, it is still an open question, what attitudes actually are. That is, the question of how attitude objects are represented in memory cannot be unequivocally answered until now (e.g., Barsalou, 1999; Gawronski, 2007; Pratkanis, 1989, Chapter 4). In particular, researchers strongly differ with respect to their assumptions on the content, format and structural nature of attitude representations (Ferguson & Fukukura, 2012). This prevailing uncertainty on what actually constitutes our likes and dislikes is strongly dovetailed with the question of which processes result in the formation of these representations. In recent years, this issue has mainly been addressed in evaluative conditioning research (EC). In a standard EC-paradigm a neutral stimulus (conditioned stimulus, CS) is repeatedly paired with an affective stimulus (unconditioned stimulus, US). The pairing of stimuli then typically results in changes in the evaluation of the CS corresponding to the evaluative response of the US (De Houwer, Baeyens, & Field, 2005). This experimental approach on the formation of attitudes has primarily been concerned with the question of how the representations underlying our attitudes are formed. However, which processes operate on the formation of such an attitude representation is not yet understood (Jones, Olson, & Fazio, 2010; Walther, Nagengast, & Trasselli, 2005). Indeed, there are several ideas on how CS-US pairs might be encoded in memory. Notwithstanding the importance of these theoretical ideas, looking at the existing empirical work within the research area of EC (for reviews see Hofmann, De Houwer, Perugini, Baeyens, & Crombez, 2010; De Houwer, Thomas, & Baeyens, 2001) leaves one with the impression that scientists have skipped the basic processes. Basic processes hereby especially refer to the attentional processes being involved in the encoding of CSs and USs as well as the relation between them. Against the background of this huge gap in current research on attitude formation, the focus of this thesis will be to highlight the contribution of selective attention processes to a better understanding of the representation underlying our likes and dislikes. In particular, the present thesis considers the role of selective attention processes for the solution of the representation issue from three different perspectives. Before illustrating these different perspectives, Chapter 1 is meant to envision the omnipresence of the representation problem in current theoretical as well as empirical work on evaluative conditioning. Likewise, it emphasizes the critical role of selective attention processes for the representation question in classical conditioning and how this knowledge might be used to put forth the uniqueness of evaluative conditioning as compared to classical conditioning. Chapter 2 then considers the differential influence of attentional resources and goal-directed attention on attitude learning. The primary objective of the presented experiment was thereby to investigate whether attentional resources and goal-directed attention exert their influence on EC via changes in the encoding of CS-US relations in memory (i.e., contingency memory). Taking the findings from this experiment into account, Chapter 3 focuses on the selective processing of the US relative to the CS. In particular, the two experiments presented in this chapter were meant to explore the moderating influence of the selective processing of the US in its relation to the CS on EC. In Chapter 4 the important role of the encoding of the US in relation to the CS, as outlined in Chapter 3, is illuminated in the context of different retrieval processes. Against the background of the findings from the two presented experiments, the interplay between the encoding of CS-US contingencies and the moderation of EC via different retrieval processes will be discussed. Finally, a general discussion of the findings, their theoretical implications and future research lines will be outlined in Chapter 5.

Mankind has dramatically influenced the nitrogen (N) fluxes between soil, vegetation, water and atmosphere " the global N cycle. Increasing intensification of agricultural land use, caused by the growing demand for agricultural products, has had major impacts on ecosystems worldwide. Particularly nitrogenous gases such as ammonia (NH3) have increased mainly due to industrial livestock farming. Countries with high N deposition rates require a variety of deposition measurements and effective N monitoring networks to assess N loads. Due to high costs, current "conventional"-deposition measurement stations are not widespread and therefore provide only a patchy picture of the real extent of the prevailing N deposition status over large areas. One tool that allows quantification of the exposure and the effects of atmospheric N impacts on an ecosystem is the use of bioindicators. Due to their specific physiology and ecology, especially lichens and mosses are suitable to reflect the atmospheric N input at ecosystem level. The present doctoral project began by investigating the general ability of epiphytic lichens to qualify and quantify N deposition by analysing both lichens and total N and δ15N along a gradient of different N emission sources and severity. The results showed that this was a viable monitoring method, and a grid-based monitoring system with nitrophytic lichens was set up in the western part of Germany. Finally, a critical appraisal of three different monitoring techniques (lichens, mosses and tree bark) was carried out to compare them with national relevant N deposition assessment programmes. In total 1057 lichen samples, 348 tree bark samples, 153 moss samples and 24 deposition water samples, were analysed in this dissertation at different investigation scales in Germany.The study identified species-specific ability and tolerance of various epiphytic lichens to accumulate N. Samples of tree bark were also collected and N accumulation ability was detected in connection with the increased intensity of agriculture, and according to the presence of reduced N compounds (NHx) in the atmosphere. Nitrophytic lichens (Xanthoria parietina, Physcia spp.) have the strongest correlations with high agriculture-related N deposition. In addition, the main N sources were revealed with the help of δ15N values along a gradient of altitude and areas affected by different types of land use (NH3 density classes, livestock units and various deposition types). Furthermore, in the first nationwide survey of Germany to compare lichens, mosses and tree bark samples as biomonitors for N deposition, it was revealed that lichens are clearly the most meaningful monitor organisms in highly N affected regions. Additionally, the study shows that dealing with different biomonitors is a difficult task due to their variety of N responses. The specific receptor surfaces of the indicators and therefore their different strategies of N uptake are responsible for the tissue N concentration of each organism group. It was also shown that the δ15N values depend on their N origin and the specific N transformations in each organism system, so that a direct comparison between atmosphere and ecosystems is not possible.In conclusion, biomonitors, and especially epiphytic lichens may serve as possible alternatives to get a spatially representative picture of the N deposition conditions. Furthermore, bioindication with lichens is a cost-efficient alternative to physico-chemical measurements to comprehensively assess different prevailing N doses and sources of N pools on a regional scale. They can at least support on-site deposition instruments by qualification and quantification of N deposition.

Let K be a compact subset of the complex plane. Then the family of polynomials P is dense in A(K), the space of all continuous functions on K that are holomorphic on the interior of K, endowed with the uniform norm, if and only if the complement of K is connected. This is the statement of Mergelyan's celebrated theorem. There are, however, situations where not all polynomials are required to approximate every f ϵ A(K) but where there are strict subspaces of P that are still dense in A(K). If, for example, K is a singleton, then the subspace of all constant polynomials is dense in A(K). On the other hand, if 0 is an interior point of K, then no strict subspace of P can be dense in A(K). In between these extreme cases, the situation is much more complicated. It turns out that it is mostly determined by the geometry of K and its location in the complex plane which subspaces of P are dense in A(K). In Chapter 1, we give an overview of the known results. Our first main theorem, which we will give in Chapter 3, deals with the case where the origin is not an interior point of K. We will show that if K is a compact set with connected complement and if 0 is not an interior point of K, then any subspace Q ⊂ P which contains the constant functions and all but finitely many monomials is dense in A(K). There is a close connection between lacunary approximation and the theory of universality. At the end of Chapter 3, we will illustrate this connection by applying the above result to prove the existence of certain universal power series. To be specific, if K is a compact set with connected complement, if 0 is a boundary point of K and if A_0(K) denotes the subspace of A(K) of those functions that satisfy f(0) = 0, then there exists an A_0(K)-universal formal power series s, where A_0(K)-universal means that the family of partial sums of s forms a dense subset of A_0(K). In addition, we will show that no formal power series is simultaneously universal for all such K. The condition on the subspace Q in the main result of Chapter 3 is quite restrictive, but this should not be too surprising: The result applies to the largest possible class of compact sets. In Chapter 4, we impose a further restriction on the compact sets under consideration, and this will allow us to weaken the condition on the subspace Q. The result that we are going to give is similar to one of those presented in the first chapter, namely the one due to Anderson. In his article “Müntz-Szasz type approximation and the angular growth of lacunary integral functions”, he gives a criterion for a subspace Q of P to be dense in A(K) where K is entirely contained in some closed sector with vertex at the origin. We will consider compact sets with connected complement that are -- with the possible exception of the origin -- entirely contained in some open sector with vertex at the origin. What we are going to show is that if K\{0} is contained in an open sector of opening angle 2α and if Λ is some subset of the nonnegative integers, then the span of {z → z^λ : λ ϵ Λ} is dense in A(K) whenever 0 ϵ Λ and some Müntz-type condition is satisfied. Conversely, we will show that if a similar condition is not satisfied, then we can always find a compact set K with connected complement such that K\{0} is contained in some open sector of opening angle 2α and such that the span of {z → z^λ : λ ϵ Λ} fails to be dense in A(K).

This thesis deals with REITs, their capital structure and the effects on leverage that regulatory requirements might have. The data used results from a combination of Thomson Reuters data with hand-collected data regarding the REIT status, regulatory information and law variables. Overall, leverage is analysed across 20 countries in the years 2007 to 2018. Country specific data, manually extracted from yearly EPRA reportings, is merged with company data in order to analyse the influence of different REIT restrictions on a firm's leverage. Observing statistically significant differences in means across NON-REITs and REITs, causes motivation for further investigations. My results show that variables beyond traditional capital structure determinants impact the leverage of REITs. I find that explicit restrictions on leverage and the distribution of profits have a significant effect on leverage decisions. This supports the notion that the restrictions from EPRA reportings are mandatory. I test for various combinations of regulatory variables that show both in isolation as well as in combination significant effects on leverage. My main result is the following: Firms that operate under regulation that specifies a maximum leverage ratio, in addition to mandatory high dividend distributions, have on average lower leverage ratios. Further the existence of sanctions has a negative effect on REITs' leverage ratios, indicating that regulation is binding. The analysis clearly shows that traditional capital structure determinants are of second order relevance. This relationship highlights the impact on leverage and financing decisions caused by regulation. These effects are supported by further analysis. Results based on an event study show that REITs have statistically lower leverage ratios compared to NON-REITs. Based on a structural break model, the following effect becomes apparent: REITs increase their leverage ratios in years prior REIT status. As a consequence, the ex ante time frame is characterised by a bunker and adaption process, followed by the transformation in the event. Using an event study and a structural break model, the analysis highlights the dominance of country-specific regulation.

In recent years, the establishment of new makerspaces in Germany has increased significantly. The underlying phenomenon of the Maker Movement is a cultural and technological movement focused on making physical and digital products using open source principles, collaborative production, and individual empowerment. Because of its potential to democratize the innovation and production process, empower individuals and communities, and enable innovators to solve problems at the local level, the Maker Movement has received considerable attention in recent years. Despite numerous indicators, little is known about the phenomenon and its individual members, especially in Germany. Initial research suggests that the Maker Movement holds great potential for innovation and entrepreneurship. However, there is still a gap in understanding how Makers discover, evaluate and exploit entrepreneurial opportunities. Moreover, there is still controversy - both among policy makers and within the maker community itself - about the impact the maker movement has and can have on innovation and entrepreneurship in the future. This dissertation uses a mixed-methods approach to explore these questions. In addition to a quantitative analysis of maker characteristics, the results show that social impact, market size, and property rights have significant effects on the evaluation of entrepreneurial opportunities. The findings within this dissertation expand research in the field of the Maker Movement and offer multiple implications for practice. This dissertation provides the first quantitative data on makers in makerspaces in Germany, their characteristics and motivations. In particular, the relationship between the Maker Movement and entrepreneurship is explored in depth for the first time. This is complemented by the presentation of different identity profiles of the individuals involved. In this way, policy-makers can develop a better understanding of the movement, its personalities and values, and consider them in initiatives and formats.

Spatially explicit information about forest cover is fundamental for operational forest management and forest monitoring. Although open-satellite-based earth observation data in a spatially high resolution (i.e., Sentinel-2, ≤10 m) can cover some information needs, spatially very high-resolution imagery (i.e., aerial imagery, ≤2 m) is needed to generate maps at a scale suitable for regional and local applications. In this study, we present the development, implementation, and evaluation of a Geographic Object-Based Image Analysis (GEOBIA) framework to stratify forests (needleleaved, broadleaved, non-forest) in Luxembourg. The framework is exclusively based on open data and free and open-source geospatial software. Although aerial imagery is used to derive image objects with a 0.05 ha minimum size, Sentinel-2 scenes of 2020 are the basis for random forest classifications in different single-date and multi-temporal feature setups. These setups are compared with each other and used to evaluate the framework against classifications based on features derived from aerial imagery. The highest overall accuracies (89.3%) have been achieved with classification on a Sentinel-2-based vegetation index time series (n = 8). Similar accuracies have been achieved with classification based on two (88.9%) or three (89.1%) Sentinel-2 scenes in the greening phase of broadleaved forests. A classification based on color infrared aerial imagery and derived texture measures only achieved an accuracy of 74.5%. The integration of the texture measures into the Sentinel-2-based classification did not improve its accuracy. Our results indicate that high resolution image objects can successfully be stratified based on lower spatial resolution Sentinel-2 single-date and multi-temporal features, and that those setups outperform classifications based on aerial imagery only. The conceptual framework of spatially high-resolution image objects enriched with features from lower resolution imagery facilitates the delivery of frequent and reliable updates due to higher spectral and temporal resolution. The framework additionally holds the potential to derive additional information layers (i.e., forest disturbance) as derivatives of the features attached to the image objects, thus providing up-to-date information on the state of observed forests.