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Surveys are commonly tailored to produce estimates of aggregate statistics with a desired level of precision. This may lead to very small sample sizes for subpopulations of interest, defined geographically or by content, which are not incorporated into the survey design. We refer to subpopulations where the sample size is too small to provide direct estimates with adequate precision as small areas or small domains. Despite the small sample sizes, reliable small area estimates are needed for economic and political decision making. Hence, model-based estimation techniques are used which increase the effective sample size by borrowing strength from other areas to provide accurate information for small areas. The paragraph above introduced small area estimation as a field of survey statistics where two conflicting philosophies of statistical inference meet: the design-based and the model-based approach. While the first approach is well suited for the precise estimation of aggregate statistics, the latter approach furnishes reliable small area estimates. In most applications, estimates for both large and small domains based on the same sample are needed. This poses a challenge to the survey planner, as the sampling design has to reflect different and potentially conflicting requirements simultaneously. In order to enable efficient design-based estimates for large domains, the sampling design should incorporate information related to the variables of interest. This may be achieved using stratification or sampling with unequal probabilities. Many model-based small area techniques require an ignorable sampling design such that after conditioning on the covariates the variable of interest does not contain further information about the sample membership. If this condition is not fulfilled, biased model-based estimates may result, as the model which holds for the sample is different from the one valid for the population. Hence, an optimisation of the sampling design without investigating the implications for model-based approaches will not be sufficient. Analogously, disregarding the design altogether and focussing only on the model is prone to failure as well. Instead, a profound knowledge of the interplay between the sample design and statistical modelling is a prerequisite for implementing an effective small area estimation strategy. In this work, we concentrate on two approaches to address this conflict. Our first approach takes the sampling design as given and can be used after the sample has been collected. It amounts to incorporate the survey design into the small area model to avoid biases stemming from informative sampling. Thus, once a model is validated for the sample, we know that it holds for the population as well. We derive such a procedure under a lognormal mixed model, which is a popular choice when the support of the dependent variable is limited to positive values. Besides, we propose a three pillar strategy to select the additional variable accounting for the design, based on a graphical examination of the relationship, a comparison of the predictive accuracy of the choices and a check regarding the normality assumptions.rnrnOur second approach to deal with the conflict is based on the notion that the design should allow applying a wide variety of analyses using the sample data. Thus, if the use of model-based estimation strategies can be anticipated before the sample is drawn, this should be reflected in the design. The same applies for the estimation of national statistics using design-based approaches. Therefore, we propose to construct the design such that the sampling mechanism is non-informative but allows for precise design-based estimates at an aggregate level.
A huge number of clinical studies and meta-analyses have shown that psychotherapy is effective on average. However, not every patient profits from psychotherapy and some patients even deteriorate in treatment. Due to this result and the restricted generalization of clinical studies to clinical practice, a more patient-focused research strategy has emerged. The question whether a particular treatment works for an individual case is the focus of this paradigm. The use of repeated assessments and the feedback of this information to therapists is a major ingredient of patient-focused research. Improving patient outcomes and reducing dropout rates by the use of psychometric feedback seems to be a promising path. Therapists seem to differ in the degree to which they make use of and profit from such feedback systems. This dissertation aims to better understand therapist differences in the context of patient-focused research and the impact of therapists on psychotherapy. Three different studies are included, which focus on different aspects within the field:
Study I (Chapter 5) investigated how therapists use psychometric feedback in their work with patients and how much therapists differ in their usage. Data from 72 therapists treating 648 patients were analyzed. It could be shown that therapists used the psychometric feedback for most of their patients. Substantial variance in the use of feedback (between 27% and 52%) was attributable to therapists. Therapists were more likely to use feedback when they reported being satisfied with the graphical information they received. The results therefore indicated that not only patient characteristics or treatment progress affected the use of feedback.
Study II (Chapter 6) picked up on the idea of analyzing systematic differences in therapists and applied it to the criterion of premature treatment termination (dropout). To answer the question whether therapist effects occur in terms of patients’ dropout rates, data from 707 patients treated by 66 therapists were investigated. It was shown that approximately six percent of variance in dropout rates could be attributed to therapists, even when initial impairment was controlled for. Other predictors of dropout were initial impairment, sex, education, personality styles, and treatment expectations.
Study III (Chapter 7) extends the dissertation by investigating the impact of a transfer from one therapist to another within ongoing treatments. Data from 124 patients who agreed to and experienced a transfer during their treatment were analyzed. A significant drop in patient-rated as well as therapist-rated alliance levels could be observed after a transfer. On average, there seemed to be no difficulties establishing a good therapeutic alliance with the new therapist, although differences between patients were observed. There was no increase in symptom severity due to therapy transfer. Various predictors of alliance and symptom development after transfer were investigated. Impacts on clinical practice were discussed.
Results of the three studies are discussed and general conclusions are drawn. Implications for future research as well as their utility for clinical practice and decision-making are presented.
The goal of this work is to compare operators that are defined on probably varying Hilbert spaces. Distance concepts for operators as well as convergence concepts for such operators are explained and examined. For distance concepts we present three main notions. All have in common that they use space-linking operators that connect the spaces. At first, we look at unitary maps and compare the unitary orbits of the operators. Then, we consider isometric embeddings, which is based on a concept of Joachim Weidmann. Then we look at contractions but with more norm equations in comparison. The latter idea is based on a concept of Olaf Post called quasi-unitary equivalence. Our main result is that the unitary and isometric distances are equal provided the operators are both self-adjoint and have 0 in their essential spectra. In the third chapter, we focus specifically on the investigation of these distance terms for compact operators or operators in p-Schatten classes. In this case, the interpretation of the spectra as null sequences allows further distance investigation. Chapter four deals mainly with convergence terms of operators on varying Hilbert spaces. The analyses in this work deal exclusively with concepts of norm resolvent convergence. The main conclusion of the chapter is that the generalisation for norm resolvent convergence of Joachim Weidmann and the generalisation of Olaf Post, called quasi-unitary equivalence, are equivalent to each other. In addition, we specify error bounds and deal with the convergence speed of both concepts. Two important implications of these convergence notions are that the approximation is spectrally exact, i.e., the spectra converge suitably, and that the convergence is transferred to the functional calculus of the bounded functions vanishing at infinity.
In order to investigate the psychobiological consequences of acute stress under laboratory conditions, a wide range of methods for socially evaluative stress induction have been developed. The present dissertation is concerned with evaluating a virtual reality (VR)-based adaptation of one of the most widely used of those methods, the Trier Social Stress Test (TSST). In the three empirical studies collected in this dissertation, we aimed to examine the efficacy and possible areas of application of the adaptation of this well-established psychosocial stressor in a virtual environment. We found that the TSST-VR reliably incites the activation of the major stress effector systems in the human body, albeit in a slightly less pronounced way than the original paradigm. Moreover, the experience of presence is discussed as one potential factor of influence in the origin of the psychophysiological stress response. Lastly, we present a use scenario for the TSST-VR in which we employed the method to investigate the effects of acute stress on emotion recognition performance. We conclude that, due to its advantages concerning versatility, standardization and economic administration, the paradigm harbors enormous potential not only for psychobiological research, but other applications such as clinical practice as well. Future studies should further explore the underlying effect mechanisms of stress in the virtual realm and the implementation of VR-based paradigms in different fields of application.
Optimal Control of Partial Integro-Differential Equations and Analysis of the Gaussian Kernel
(2018)
An important field of applied mathematics is the simulation of complex financial, mechanical, chemical, physical or medical processes with mathematical models. In addition to the pure modeling of the processes, the simultaneous optimization of an objective function by changing the model parameters is often the actual goal. Models in fields such as finance, biology or medicine benefit from this optimization step.
While many processes can be modeled using an ordinary differential equation (ODE), partial differential equations (PDEs) are needed to optimize heat conduction and flow characteristics, spreading of tumor cells in tissue as well as option prices. A partial integro-differential equation (PIDE) is a parital differential equation involving an integral operator, e.g., the convolution of the unknown function with a given kernel function. PIDEs occur for example in models that simulate adhesive forces between cells or option prices with jumps.
In each of the two parts of this thesis, a certain PIDE is the main object of interest. In the first part, we study a semilinear PIDE-constrained optimal control problem with the aim to derive necessary optimality conditions. In the second, we analyze a linear PIDE that includes the convolution of the unknown function with the Gaussian kernel.
Die vorliegende Arbeit versucht an dem Beispiel der Umsetzung der Vorschriften des § 301 SGB V - Datenaustausch zwischen stationären Einrichtungen und den Krankenkassen - zum einen die Probleme zum anderen aber auch die Lösungsmöglich-keiten eines Datenaustausches in einem sehr heterogenen Umfeld (-Krankenhäuser, Rehabilitationseinrichtungen und Kostenträgern) zu beschreiben. Ziel des Lösungsansatzes ist es gleichzeitig, neben der Erhebung und Weiterleitung der Daten von dem stationären Leistungserbringer an die jeweilige Krankenkasse (gesetzlicher Auftrag) die erhobenen Daten für weitere Analysen - intern wie extern - zu nutzen. Hierbei wird zum einen der Fokus auf die innerbetriebliche Nutzung der Daten gelegt - Kostenrechnung speziell Kostenträgerrechnung - zum anderen wird auch die Frage des externen Betriebsvergleiches (§ 5 BPflV) beleuchtet. Insgesamt wird gezeigt, dass für die weitere Entwicklung des Gesundheitswesens ein in sich einheitliches Datenmodell zwingend notwendig ist um die seit vielen Jahren immer wieder eingeforderte Transparenz des Gesundheitswesen herzustellen. Dies gilt insbesondere für die sektorenübergreifende - ambulant / stationär - Datenzusammenführung. Die Arbeit beschreibt die Fragen und Probleme sowohl der Informatik als auch der Gesundheitsökonomie und zeigt in Form des neu erarbeiteten Referenzmodells einen Lösungsansatz auf. Das Datenmodell enthält auch die notwendigen Informationen für ein DRG-System. Insofern ist eine Änderung des Datenmodells durch die aktuelle Einführung eines deutschen DRG - Systems nicht notwendig.
Competitive analysis is a well known method for analyzing online algorithms.
Two online optimization problems, the scheduling problems and the list accessing problems, are considered in the thesis of Yida Zhu in the respect of this method.
For both problems, several existing online and offline algorithms are studied. Their performances are compared with the performances of corresponding offline optimal algorithms.
In particular, the list accessing algorithm BIT is carefully reviewed.
The classical proof of its worst case performance get simplified by adapting the knowledge about the optimal offline algorithm.
With regard to average case analysis, a new closed formula is developed to determine the performance of BIT on specific class of instances.
All algorithm considered in this thesis are also implemented in Julia.
Their empirical performances are studied and compared with each other directly.
Die Aufgabe der vorliegenden Arbeit lag darin, anhand der Quelle von Luthers Tischreden zu zeigen, welche Art von Kunstwerken Martin Luther erwähnt und welche Funktion diese in den Colloquia hatten. Sie untersucht das Corpus der über 7000 Tischreden systematisch auf Äußerungen, die im Zusammenhang mit Kunstwerken im weitesten Sinne stehen. Es erfolgte eine textkritische Bearbeitung der Tischreden. Der Anspruch der Arbeit war, diese Bildwerke zu identifizieren und in ihren historischen bzw. kunsthistorischen Kontext zu stellen. Da viele Parallelstellen gefunden und herangezogen werden konnten, ließen sich zahlreiche Irrtümer aufdecken und Fehldeutungen korrigieren. Der Fokus lag dabei nach der Auswertung und der anschließenden Beschäftigung mit den Stellen auf Luthers geradezu leitmotivisch auftretendem Thema der Superbia. Diesem Themenbereich der Todsünden wurde in der Lutherforschung bisher nur wenig Beachtung geschenkt, denn die sie galt für die Reformation als unwesentlich. Es konnte aber in dieser Arbeit dargelegt werden, wie wichtig die Todsünden und vor allem die Superbia in Luthers Tischreden und in seinem Gesamtwerk sind. Darüber hinaus hat sich die Arbeit mit der Performanz der Bilder in Luthers Werk beschäftigt. Sie leistet zudem einen Beitrag zu der Fragestellung, mit welcher Intention Luther seine eigenen Porträts in Auftrag gegeben hat. So wird dargelegt, wie Luther seine Bildstrategien verfolgt. Die Arbeit hat ferner gezeigt, wie wichtig für die effektive, interdisziplinär nutzbare Auswertung der Tischreden als Quelle eine digitale Ausgabe wäre, die mit Metadaten versehen ist und dadurch nach semantischen Kriterien durchsucht werden kann.
This cumulative thesis encompass three studies focusing on the Weddell Sea region in the Antarctic. The first study produces and evaluates a high quality data set of wind measurements for this region. The second study produces and evaluates a 15 year regional climate simulation for the Weddell Sea region. And the third study produces and evaluates a climatology of low level jets (LLJs) from the simulation data set. The evaluations were done in the attached three publications and the produced data sets are published online.
In 2015/2016, the RV Polarstern undertook an Antarctic expedition in the Weddell Sea. We operated a Doppler wind lidar on board during that time running different scan patterns. The resulting data was evaluated, corrected, processed and we derived horizontal wind speed and directions for vertical profiles with up to 2 km height. The measurements cover 38 days with a temporal resolution of 10-15 minutes. A comparisons with other radio sounding data showed only minor differences.
The resulting data set was used alongside other measurements to evaluate temperature and wind of simulation data. The simulation data was produced with the regional climate model CCLM for the period of 2002 to 2016 for the Weddell Sea region. Only smaller biases were found except for a strong warm bias during winter near the surface of the Antarctic Plateau. Thus we adapted the model setup and were able to remove the bias in a second simulation.
This new simulation data was then used to derive a climatology of low level jets (LLJs). Statistics of occurrence frequency, height and wind speed of LLJs for the Weddell Sea region are presented along other parameters. Another evaluation with measurements was also performed in the last study.
This thesis presents four contributions in the domains of schema/ontology alignment and query processing. First, we present a novel alignment approach, denoted as FiLiPo (Finding Linkage Points), to align the schema of RDF knowledge bases with the response schema of RESTful Web APIs. FiLiPo only requires knowledge about a knowledge base (e.g., class names) but no prior knowledge about the
Web APIs’ data structure. It uses fifteen different string similarity metrics to find an alignment between the schema of a knowledge base and that of aWeb API.
Next, a benchmark system named ETARA (Evaluation Toolkit for API and RDF Alignment) is introduced that was created with the goal to simulate RESTful Web APIs and is able to cover all important characteristics of Web APIs, i.e., latency, timeouts, rate limits and, furthermore, provides configurable response structures (e.g., JSON or XML). Additionally, it was designed to support researchers during
the development of alignment systems.
Afterward, the alignments determined by FiLiPo are used to create a hybrid and federated query processor named TunA (Tunable Query Optimizer forWeb APIs and User Preferences), which allows SPARQL queries combining knowledge bases and RESTful Web APIs and is tunable towards user preferences, i.e., coverage, reliability and execution time. The primary goal of TunA is to return a query result that satisfies the user’s preferences in terms of data quality, even when using unreliable data sources by performing a majority vote over multiple sources.
Lastly, we present a federated query processor, denoted as ORAQL (Overlap and Reliability Aware Query Processing Layer), which uses overlap information to reduce the number of selected sources that are available in a federation. The goal is to reduce redundant data and, hence, improve the query execution speed. Therefore, ORAQL uses a profile feature that provides information about the overlap between all data sources of a federation. Furthermore, we extend the quality estimation of TunA to cover Triple Pattern Fragment interfaces to ensure a user-provided reliability goal.