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Auf der Grundlage einer Fragebogenstudie wurden unterschiedliche Elemente eines förderlichen Umgangs mit Gesundheitsinformationen betrachtet und ihre Zusammenhänge mit personspezifischen Merkmalen analysiert. Als zentrale Aspekte der Informationsprozesse wurden die drei Elemente Gesundheitsinformationskompetenz, Gesundheitsinteresse und gesundheitsspezifische Informationsgewohnheiten konzeptuell voneinander getrennt. Auf der Basis des bisherigen Forschungsstands wurde zunächst ein theoretisches Modell des Umgangs mit Gesundheitsinformationen entwickelt, das die Bedeutung der Kompetenz und des Interesses für gesundheitsbezogene Informationsgewohnheiten hervorhebt, individuelle Ausprägungen dieser drei Elemente mit soziodemografischen Faktoren, Persönlichkeitseigenschaften, Überzeugungen und dem Gesundheitszustand in Beziehung setzt sowie Verbindungen zu gesundheitsrelevanten Verhaltensweisen beschreibt. Dieses Modell wurde anschließend an einer Stichprobe von 352 Berufsschülerinnen und -schülern aus drei Berufsbereichen (Wirtschaft/Verwaltung, Technik und Gesundheit) empirisch überprüft. Über multiple Regressionsanalysen wurden bedeutsame Prädiktoren für die drei Hauptelemente Kompetenz, Interesse und Informationsgewohnheiten identifiziert, über logistische Regressionen und Korrelationen ihre Zusammenhänge mit dem Gesundheitsverhalten überprüft. Darüber hinaus wurden lineare Strukturgleichungsmodelle zur Vorhersage des Informationsverhaltens entwickelt. Die Ergebnisse bestätigen die konzeptionelle Trennung der drei Faktoren, die jeweils mit unterschiedlichen Prädiktoren verbunden waren. Auf der Basis der Befunde werden Ansatzpunkte für die weitere Forschung und die Förderung eines kompetenten Umgangs mit Gesundheitsinformationen diskutiert.
Die publikationsbasierte Dissertation untersucht die Bedeutung sozialer Bewegungen für die Entwicklung der Sozialen Arbeit am Ende des 19. und den ersten Jahrzehnten des 20. Jahrhunderts als Profession und Disziplin in den USA und in Deutschland. Dabei wird die entstehende Soziale Arbeit als ‚Formbildung‘ sozialer Bewegungen verstanden und gefragt, wie sich die Bewegungen in die sich etablierende und institutionalisierende Profession und Wissenschaft Soziale Arbeit einschreiben, welche Anliegen dabei verfolgt werden und wie dadurch Wissen in der Sozialen Arbeit auch über nationalstaatliche Grenzen hinweg zirkuliert.
Die Untersuchung konzentriert sich auf Prozesse der Pädagogisierung, also unterschiedliche ‚Formbildungen des Pädagogischen‘, die die Bewegungsanliegen zum Thema von Aufklärung, (Selbst)Bildung und Pädagogik machen, und auf solche der Verwissenschaftlichung, die sich auf den Aufbau einer Wissensgrundlage zur Bearbeitung von sozialen Problemen richten und dabei alternative Formen der Wissensproduktion ausbilden. Diese Prozesse werden in drei Teilstudien – zur Charity Organization Movement und der Settlement House Movement in den USA sowie der bürgerlichen Frauenbewegung in Deutschland – in sieben Einzelbeiträgen näher untersucht. Im Mittelpunkt stehen dabei die Handlungsmethoden und das Praxisverständnis sowie Forschungskonzepte und –projekte exemplarisch ausgewählter sozialbewegter Initiativen der Sozialen Arbeit. Dabei werden unter anderem nicht-intendierte Effekte untersucht, die zum Beispiel in Konservierungen normativer Vorstellungen und Ideologien in als demokratisierend angelegten Ansätzen, aber auch in ‚differenzverstärkenden‘ Effekten bestehen können.
Das Ideal einer lebendigen Demokratie mit engagierten Bürger/innen lässt nach Wegen suchen, um die Partizipationsbereitschaft nachkommender Generationen zu fördern. Ausgehend von der Prämisse, dass das Wohlbefinden einen zentralen Motivator darstellt, der sich auch bei jungen Menschen mithilfe der Konzepte der Positiven Psychologie gezielt fördern lässt (Brohm & Endres, 2015), nähert sich der vorliegende Beitrag den beiden folgenden Forschungsfragen: Erstens, lässt sich ein Zusammenhang zwischen dem Wohlbefinden Jugendlicher und ihrer politischen Partizipationsbereitschaft respektive ihrem politischen Interesse empirisch nachweisen? Zweitens, in welchen Kontexten und in welchem Maße erleben Jugendliche Wohlbefinden in der Auseinandersetzung mit politischen Themen, Akteur/innen und Prozessen?
Da bisherige bundesweite und regionale Studien zu den Themen Jugend, Politik und politisch-gesellschaftlicher Teilhabe nur in bedingtem Maße Rückschlüsse auf die fünf Elemente des Wohlbefindens nach Seligman (2012) zuließen, wurde im Vorfeld des vorliegenden Beitrags eine schriftliche Befragung von 100 Jugendlichen aus dem saarländischen Landkreis Saarlouis durchgeführt.
Die Befragten charakterisieren sich mehrheitlich als allgemein aufgeschlossen und interessiert, doch es gelingt der Politik und ihren Mittler/innen nur eingeschränkt, dieses Potenzial in aktive politische Teilhabe zu übersetzen. Unter anderem persönliche Kontakte zu politisch Engagierten und eigene Erfahrungen in politischen Verbänden erweisen sich indes als positiv und korrelieren mit dem politischen Interesse und der Offenheit der Jugendlichen gegenüber politischer Partizipation.
A huge number of clinical studies and meta-analyses have shown that psychotherapy is effective on average. However, not every patient profits from psychotherapy and some patients even deteriorate in treatment. Due to this result and the restricted generalization of clinical studies to clinical practice, a more patient-focused research strategy has emerged. The question whether a particular treatment works for an individual case is the focus of this paradigm. The use of repeated assessments and the feedback of this information to therapists is a major ingredient of patient-focused research. Improving patient outcomes and reducing dropout rates by the use of psychometric feedback seems to be a promising path. Therapists seem to differ in the degree to which they make use of and profit from such feedback systems. This dissertation aims to better understand therapist differences in the context of patient-focused research and the impact of therapists on psychotherapy. Three different studies are included, which focus on different aspects within the field:
Study I (Chapter 5) investigated how therapists use psychometric feedback in their work with patients and how much therapists differ in their usage. Data from 72 therapists treating 648 patients were analyzed. It could be shown that therapists used the psychometric feedback for most of their patients. Substantial variance in the use of feedback (between 27% and 52%) was attributable to therapists. Therapists were more likely to use feedback when they reported being satisfied with the graphical information they received. The results therefore indicated that not only patient characteristics or treatment progress affected the use of feedback.
Study II (Chapter 6) picked up on the idea of analyzing systematic differences in therapists and applied it to the criterion of premature treatment termination (dropout). To answer the question whether therapist effects occur in terms of patients’ dropout rates, data from 707 patients treated by 66 therapists were investigated. It was shown that approximately six percent of variance in dropout rates could be attributed to therapists, even when initial impairment was controlled for. Other predictors of dropout were initial impairment, sex, education, personality styles, and treatment expectations.
Study III (Chapter 7) extends the dissertation by investigating the impact of a transfer from one therapist to another within ongoing treatments. Data from 124 patients who agreed to and experienced a transfer during their treatment were analyzed. A significant drop in patient-rated as well as therapist-rated alliance levels could be observed after a transfer. On average, there seemed to be no difficulties establishing a good therapeutic alliance with the new therapist, although differences between patients were observed. There was no increase in symptom severity due to therapy transfer. Various predictors of alliance and symptom development after transfer were investigated. Impacts on clinical practice were discussed.
Results of the three studies are discussed and general conclusions are drawn. Implications for future research as well as their utility for clinical practice and decision-making are presented.
When do anorexic patients perceive their body as too fat? Aggravating and ameliorating factors
(2019)
Objective
Our study investigated body image representations in female patients with anorexia nervosa
and healthy controls using a size estimation with pictures of their own body. We also
explored a method to reduce body image distortions through right hemispheric activation.
Method
Pictures of participants’ own bodies were shown on the left or right visual fields for 130 ms
after presentation of neutral, positive, or negative word primes, which could be self-relevant
or not, with the task of classifying the picture as “thinner than”, “equal to”, or “fatter than”
one’s own body. Subsequently, activation of the left- or right hemispheric through right- or
left-hand muscle contractions for 3 min., respectively. Finally, participants completed the
size estimation task again.
Results
The distorted “fatter than” body image was found only in patients and only when a picture of
their own body appeared on the right visual field (left hemisphere) and was preceded by
negative self-relevant words. This distorted perception of the patients’ body image was
reduced after left-hand muscle contractions (right hemispheric activation).
Discussion
To reduce body image distortions it is advisable to find methods that help anorexia nervosa
patients to increase their self-esteem. The body image distortions were ameliorated after
right hemispheric activation. A related method to prevent distorted body-image representations
in these patients may be Eye Movement Desensitization and Reprocessing (EMDR)
therapy.
Academic achievement is a central outcome in educational research, both in and outside higher education, has direct effects on individual’s professional and financial prospects and a high individual and public return on investment. Theories comprise cognitive as well as non-cognitive influences on achievement. Two examples frequently investigated in empirical research are knowledge (as a cognitive determinant) and stress (as a non-cognitive determinant) of achievement. However, knowledge and stress are not stable, what raises questions as to how temporal dynamics in knowledge on the one hand and stress on the other contribute to achievement. To study these contributions in the present doctoral dissertation, I used meta-analysis, latent profile transition analysis, and latent state-trait analysis. The results support the idea of knowledge acquisition as a cumulative and long-term process that forms the basis for academic achievement and conceptual change as an important mechanism for the acquisition of knowledge in higher education. Moreover, the findings suggest that students’ stress experiences in higher education are subject to stable, trait-like influences, as well as situational and/or interactional, state-like influences which are differentially related to achievement and health. The results imply that investigating the causal networks between knowledge, stress, and academic achievement is a promising strategy for better understanding academic achievement in higher education. For this purpose, future studies should use longitudinal designs, randomized controlled trials, and meta-analytical techniques. Potential practical applications include taking account of students’ prior knowledge in higher education teaching and decreasing stress among higher education students.
With the advent of highthroughput sequencing (HTS), profiling immunoglobulin (IG) repertoires has become an essential part of immunological research. The dissection of IG repertoires promises to transform our understanding of the adaptive immune system dynamics. Advances in sequencing technology now also allow the use of the Ion Torrent Personal Genome Machine (PGM) to cover the full length of IG mRNA transcripts. The applications of this benchtop scale HTS platform range from identification of new therapeutic antibodies to the deconvolution of malignant B cell tumors. In the context of this thesis, the usability of the PGM is assessed to investigate the IG heavy chain (IGH) repertoires of animal models. First, an innovate bioinformatics approach is presented to identify antigendriven IGH sequences from bulk sequenced bone marrow samples of transgenic humanized rats, expressing a human IG repertoire (OmniRatTM). We show, that these rats mount a convergent IGH CDR3 response towards measles virus hemagglutinin protein and tetanus toxoid, with high similarity to human counterparts. In the future, databases could contain all IGH CDR3 sequences with known specificity to mine IG repertoire datasets for past antigen exposures, ultimately reconstructing the immunological history of an individual. Second, a unique molecular identifier (UID) based HTS approach and network property analysis is used to characterize the CLLlike CD5+ B cell expansion of A20BKO mice overexpressing a natural short splice variant of the CYLD gene (A20BKOsCYLDBOE). We could determine, that in these mice, overexpression of sCYLD leads to unmutated subvariant of CLL (UCLL). Furthermore, we found that this short splice variant is also seen in human CLL patients highlighting it as important target for future investigations. Third, the UID based HTS approach is improved by adapting it to the PGM sequencing technology and applying a custommade data processing pipeline including the ImMunoGeneTics (IMGT) database error detection. Like this, we were able to obtain correct IGH sequences with over 99.5% confidence and correct CDR3 sequences with over 99.9% confidence. Taken together, the results, protocols and sample processing strategies described in this thesis will improve the usability of animal models and the Ion Torrent PGM HTS platform in the field if IG repertoire research.
Early life adversity (ELA) poses a high risk for developing major health problems in adulthood including cardiovascular and infectious diseases and mental illness. However, the fact that ELA-associated disorders first become manifest many years after exposure raises questions about the mechanisms underlying their etiology. This thesis focuses on the impact of ELA on startle reflexivity, physiological stress reactivity and immunology in adulthood.
The first experiment investigated the impact of parental divorce on affective processing. A special block design of the affective startle modulation paradigm revealed blunted startle responsiveness during presentation of aversive stimuli in participants with experience of parental divorce. Nurture context potentiated startle in these participants suggesting that visual cues of childhood-related content activates protective behavioral responses. The findings provide evidence for the view that parental divorce leads to altered processing of affective context information in early adulthood.
A second investigation was conducted to examine the link between aging of the immune system and long-term consequences of ELA. In a cohort of healthy young adults, who were institutionalized early in life and subsequently adopted, higher levels of T cell senescence were observed compared to parent-reared controls. Furthermore, the results suggest that ELA increases the risk of cytomegalovirus infection in early childhood, thereby mediating the effect of ELA on T cell-specific immunosenescence.
The third study addresses the effect of ELA on stress reactivity. An extended version of the Cold Pressor Test combined with a cognitive challenging task revealed blunted endocrine response in adults with a history of adoption while cardiovascular stress reactivity was similar to control participants. This pattern of response separation may best be explained by selective enhancement of central feedback-sensitivity to glucocorticoids resulting from ELA, in spite of preserved cardiovascular/autonomic stress reactivity.