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Environmental exposures during susceptible early-life developmental periods can have the ability to model and shape individuals immunological responses in adulthood. This has been partly demonstrated in animal models, highlighting the long-term consequences of early-life exposure to bacterial infection in adulthood but the mechanisms driving and maintaining the immune early life programming are not yet fully understood. In this thesis, we investigated the epigenetic mechanisms, mainly DNA methylation, controlling the establishment/maintenance of early-life programming by bacterial and viral exposure in mice. Initially, it was important to carefully consider the sequencing method which would deliver a genome-wide DNA methylation profile of high quality to be able to identify LPS-programming specific methylation signature. For this purpose, we investigated the cutting pattern of restriction enzymes used for reduced representation CpG sequencing in order to control the number of dynamically regulated CpG sites interrogated. CpGs in CGI and shelf/shore could be enriched by the enzymes MspI, HhaI and BstUI, particularly in gene bodies for all genomic regions, promoters (TSS1500, TSS200), intra- (1st exon, gene body, 3’UTR, 5’UTR) and inter-genic regions. The enzyme HpyCH4IV mainly enriched CpG elements in the open sea for all genomic elements. This study allowed us to make an informed decision about the enzymes best fitted to identify DNA methylation patterns associated with LPS and H1N1-programming.
To understand the mechanisms controlling the establishment/maintenance of early-life programming in mice, we characterised LPS-programmed lymphocytes in vivo and in vitro. A single exposure to LPS at post-natal day 14 elicited stable, sex specific, long-term hypo
responsiveness of both the in-vivo and ex-vivo immune response to a homotypic LPS re-exposure in adulthood. In addition, both the HPA and HPG axes were concurrently programmed with blunted corticosterone after an acute stress and reduced circulating testosterone levels. Genome wide DNA methylation analysis identified a similar number of hyper- and hypo-methylated loci in LPS-programmed mice, spread across the genome specifically in intragenic regions. The programming associated phenotype was trans-generationally inherited in an oscillatory manner to the two subsequent generations. This suggests compensation efforts from the offspring phenotype to match and best adapt to their living environment. Several sperm miRNAs were found differentially expressed in LPS-programmed males, suggesting a probable route for the transmission of programming to next generations. Next, we adopted a similar approach to investigate the consequences of neonatal exposure to influenza virus. Viral respiratory tract infections are highly prevalent during early-life and have a long-lasting, profound, impact on both neurodevelopment and the subsequent risk for developing allergy and asthma. Little is known about the long-term effects on the innate immune system. BALB/c mice exposed to Influenza A (H1N1, A/Puerto Rico/8/1934) at PND14 had increased serum IL-6, MIP-β and RANTES (p<0.05) when re-exposed to H1N1 in adulthood, confirming long-term immune programing.
Similar effects were observed after re-stimulating H1N1 programed mice with polyI:C and homotypic polyI:C programming and re-stimulation, suggesting preferential programming of the innate immune system. Reduced-representation epigenome sequencing identified a network of
methylation changes common to both early life polyI:C and H1N1 programming, leaving a mechanistic ‘trace’ that remained visible throughout life. Taken together our data suggest that neonatal exposure to infections induces an early activation of the innate immune system which coincides with cellular developmental peaks, hence epigenetically and transcriptionally programming cellular functions until adulthood. Early-life infection with either LPS or H1N1 was shown to lead to profound DNA methylation and transcriptional re-programming of immune cells. The pathway and network analysis of differentially methylated genes revealed that the immune system was at the centre of a number of transcriptionally modified clusters, in accordance with the diverse consequences of early-life LPS programming on the immune, neurological and hormonal systems.
« Je n’ai rien à cacher... quoique ?! » Un guide pratique pour mener des discussions en classe
(2020)
L’interaction entre les grands volumes de données (big data) et l’intelligence artificielle ouvre de nouveaux horizons, et cela également dans le domaine de la sécurité publique. De plus en plus de villes dans le monde entier y ont recours et installent des caméras à reconnaissance faciale. Tout le monde n’est pas d’accord avec cette pratique. Comment peut-on discuter avec les jeunes du débat social actuel sur la sécurité publique et la vie privée ?
Cet article présente une méthode qui permet aux enseignant(e)s de se faire une idée de l’expérience que les élèves ont des médias numériques et de leur maîtrise du numérique. Elle demande peu de préparation et n’exige pas de connaissances préalables de la part des enseignant(e)s. Cet exercice permet de détendre l’atmosphère en classe et de déterminer dans quelle mesure les élèves réfléchissent déjà à l’usage qu’ils/elles font des médias numériques.
Les médias numériques peuvent contribuer à aborder les contenus de l’enseignement de façon motivante et compréhensible et à développer les capacités d’action démocratique des élèves. L’application « KonterBUNT. Einschreiten für Demokratie » (Intervenir pour la démocratie) aide les jeunes à appendre à réagir aux propos méprisants.
Aider les jeunes à s’exprimer constitue un volet important de l’éducation à la démocratie. Dans ce contexte, une des méthodes consiste à laisser les jeunes concevoir les médias qu’ils/elles connaissent le mieux. Cet article examine essentiellement comment mettre en relation le travail de projet créatif avec les médias numériques, et plus précisément, le smartphone.
Les outils numériques offrent un large éventail de possibilités pour favoriser la participation démocratique dans les écoles et la société, pour participer aux processus d’élaboration des politiques et pour organiser le travail des comités scolaires, les processus de développement et les projets. Afin de permettre aux élèves d’employer les outils de façon efficace, leur utilisation à l’école et dans l’enseignement doit être testée et faire l’objet d’une réflexion.
Pour pouvoir développer une compétence médiatique, les élèves ont besoin d’une réflexion, mais également d’une pratique personnelle des médias afin de devenir des producteur(trice)s et des concepteur(trice)s d’offres médiatiques. Ce compte rendu pratique relate la réalisation d’un programme télévisé d’une heure avec des élèves du Lycée de Garçons Esch.
La numérisation a des répercussions non négligeables sur tous les aspects de la vie. La mise en réseau technique et la conversion de données analogiques en données numériques sont à l’origine d’énormes quantités de données. Il est possible d’identifier des régularités dans leur mise en rapport et leur traitement, et de générer des applications dont les conséquences sociales, éthiques, politiques, juridiques, professionnelles et économiques sont encore difficiles à évaluer.
mateneen - Démocratie à l'école 04/2020 : L'éducation à la démocratie dans la société numérique
(2020)
Les carnets paraissent deux fois par an et offrent aux dirigeant(e)s des écoles ainsi qu’au personnel des fondements théoriques et du matériel pratique pour la mise en oeuvre d’un développement scolaire démocratique. Chaque publication traite d’une méthode de l’éducation à la démocratie ou d’une question stratégique du développement scolaire. Les carnets en langue allemande sont mis à la disposition des écoles luxembourgeoises en version imprimée. L’ensemble du matériel ainsi que la version en langue française sont disponibles en ligne.
With two-thirds to three-quarters of all companies, family firms are the most common firm type worldwide and employ around 60 percent of all employees, making them of considerable importance for almost all economies. Despite this high practical relevance, academic research took notice of family firms as intriguing research subjects comparatively late. However, the field of family business research has grown eminently over the past two decades and has established itself as a mature research field with a broad thematic scope. In addition to questions relating to corporate governance, family firm succession and the consideration of entrepreneurial families themselves, researchers mainly focused on the impact of family involvement in firms on their financial performance and firm strategy. This dissertation examines the financial performance and capital structure of family firms in various meta-analytical studies. Meta-analysis is a suitable method for summarizing existing empirical findings of a research field as well as identifying relevant moderators of a relationship of interest.
First, the dissertation examines the question whether family firms show better financial performance than non-family firms. A replication and extension of the study by O’Boyle et al. (2012) based on 1,095 primary studies reveals a slightly better performance of family firms compared to non-family firms. Investigating the moderating impact of methodological choices in primary studies, the results show that outperformance holds mainly for large and publicly listed firms and with regard to accounting-based performance measures. Concerning country culture, family firms show better performance in individualistic countries and countries with a low power distance.
Furthermore, this dissertation investigates the sensitivity of family firm performance with regard to business cycle fluctuations. Family firms show a pro-cyclical performance pattern, i.e. their relative financial performance compared to non-family firms is better in economically good times. This effect is particularly pronounced in Anglo-American countries and emerging markets.
In the next step, a meta-analytic structural equation model (MASEM) is used to examine the market valuation of public family firms. In this model, profitability and firm strategic choices are used as mediators. On the one hand, family firm status itself does not have an impact on firms‘ market value. On the other hand, this study finds a positive indirect effect via higher profitability levels and a negative indirect effect via lower R&D intensity. A split consideration of family ownership and management shows that these two effects are mainly driven by family ownership, while family management results in less diversification and internationalization.
Finally, the dissertation examines the capital structure of public family firms. Univariate meta-analyses indicate on average lower leverage ratios in family firms compared to non-family firms. However, there is significant heterogeneity in mean effect sizes across the 45 countries included in the study. The results of a meta-regression reveal that family firms use leverage strategically to secure their controlling position in the firm. While strong creditor protection leads to lower leverage ratios in family firms, strong shareholder protection has the opposite effect.
In dem Gebiet der Informationsextraktion angesiedelt kombiniert diese Arbeit mehrere Verfahren aus dem Bereich des maschinellen Lernens. Sie stellt einen neuen Algorithmus vor, der teil-überwachtes Lernen mit aktivem Lernen verknüpft. Ausgangsbasis ist die Analyse der Daten, indem sie in mehrere Sichten aufgeteilt werden. Hier werden die Eingaben verschiedener Personen unterteilt. Jeweils getrennt voneinander erzeugt der Algorithmus mittels Klassifizierern Modelle, die aus den individuellen Auszeichnungen der Personen aufgebaut werden. Um die dafür benötigte Datenmenge zu erhalten wird Crowdsourcing genutzt, dass es ermöglicht eine große Anzahl an Personen zu erreichen. Die Personen erhalten die Aufgabe, Texte zu annotieren. Einerseits wird dies initial für einen historischen Textkorpus vorgenommen. Dabei wird aufgeführt, welche Schritte notwendig sind, um die Annotationsaufgabe in Crowdsourcing-Portalen zur Bearbeitung anzubieten und durchzuführen. Andererseits wird ein aktueller Datensatz von Kurznachrichten genutzt. Der Algorithmus wird auf diese Beispieldatensätze angewandt. Durch Experimente wird die Ermittlung der optimalen Parameterauswahl durchgeführt. Außerdem werden die Ergebnisse mit den Resultaten bisheriger Algorithmen verglichen.
In current times, the coronavirus is spreading and taking its toll all over the world. Inspite of having developed into a global pandemic, COVID-19 is oftentimes met with local national(ist) reactions. Many states pursue iso-lationist politics by closing and enforcing borders and by focusing entirely on their own functioning in this mo-ment of crisis. This nationalist/nationally-oriented rebordering politics goes hand in hand with what might be termed ‘linguistic rebordering,’ i.e. the attempts of constructing the disease as something foreign-grown and by apportioning the blame to ‘the other.’ This paper aims at laying bare the interconnectedness of these geopoliti-cal and linguistic/discursive rebordering politics. It questions their efficacy and makes a plea for cross-border solidarity.
Die Praxishefte Demokratische Schulkultur erscheinen halbjährlich und bieten Schulleitungen und Schulpersonal theoretische Grundlagen und praxisorientierte Anleitungen zur demokratiepädagogischen Schulentwicklung.
Jedes Themenheft ist jeweils einer demokratiepädagogischen Bauform oder strategischen Frage der Schulentwicklung gewidmet. Die Praxishefte werden allen Luxemburger Schulen als Printausgabe zur Verfügung gestellt und online mit zusätzlichen Materialien und in französischer Fassung vorgehalten.
"Ich habe nichts zu verstecken ... oder doch?!" - Ein Praxisleitfaden zur Diskussion in der Klasse
(2020)
Durch das Zusammenspiel von Big Data und künstlicher Intelligenz eröffnen sich ganz neue Möglichkeiten, auch im Bereich der öffentlichen Sicherheit. Immer mehr Städte weltweit machen davon Gebrauch und setzen auf Kameras mit computergesteuerter Gesichtserkennung. Nicht jeder ist damit einverstanden. Wie kann man die aktuelle gesellschaftliche Debatte um öffentliche Sicherheit und Privatsphäre mit Jugendlichen besprechen?
Der Beitrag stellt eine Möglichkeit vor, wie man mit einem Impuls, ohne größere Vorbereitungen und ohne Vorwissen, einen ersten Überblick über die Erfahrungen und den Umgang der Schüler*innen mit digitalen Medien gewinnen kann. Die Übung lockert die Unterrichtsatmosphäre auf und lässt erkennen, inwiefern die Klasse ihren Umgang mit digitalen Medien bereits reflektiert.
Digitale Medien können dabei helfen, Unterrichtsinhalte auf motivierende und anschauliche Weise zu thematisieren und demokratische Handlungskompetenzen von Schüler*innen zu trainieren. Die App „KonterBUNT. Einschreiten für Demokratie“ unterstützt Jugendliche bei der Auseinandersetzung mit menschenverachtenden Parolen.
Jugendliche zu unterstützen, sich auszudrücken, ist ein wichtiger Bereich der Demokratiebildung. Eine der Möglichkeiten dafür ist es, sie die Medien gestalten zu lassen, die sie am besten kennen. Der vorliegende Artikel beschäftigt sich vor allem mit der Frage, wie man kreative und themenbezogene Projektarbeit mit digitalen Medien – genauer: dem Smartphone – verbinden kann.
Digitale Tools bieten vielfältige Möglichkeiten, demokratische Beteiligung in Schule und Gesellschaft zu unterstützen, an politischen Entscheidungsprozessen zu partizipieren und schulische Gremienarbeit, Entwicklungsprozesse und Projekte zu organisieren. Damit Schüler*innen die Tools kompetent nutzen können, sollte ihre Anwendung in Schule und Unterricht erprobt und reflektiert werden.
Damit Schüler*innen Medienkompetenz entwickeln, bedarf es neben der Reflexion auch eigener Medienpraxis, in der sie zu Produzent*innen und Gestalter*innen von Medienangeboten werden. Der Praxisbericht stellt die Entwicklung einer einstündigen Fernsehsendung mit Schüler*innen am Lycée de Garçons in Esch vor.
Digitalisierung wirkt sich in radikaler Weise auf alle Lebensbereiche aus. Durch die technische Vernetzung und die Umwandlung analoger in digitale Daten entstehen umfassende Datenmengen. Aus ihrer Verknüpfung und Verarbeitung lassen sich Regelmäßigkeiten erkennen und Anwendungen generieren, deren soziale, ethische, politische, rechtliche, arbeitsweltliche und ökonomische Folgen heute noch nicht ansatzweise abzuschätzen sind.
The object of the current Thematic Issue is not to focus on the individuals (the cross-border commuters) but on the organization of the cross-border labor markets. We move from a micro perspective to a macro perspective in order to underline the diversity of the cross-border labor markets (at the French borders, for example) and shed light on the many aspects that impact cross-border supply or demand. Trying to understand the whole system that goes beyond the cross-border flows, the question we address in this thematic issue is about the organization of the labor markets: is the system organized in a cross-border way? Or do the borders still prevent a genuinely integrated cross-border labor market?
Hypothalamic-pituitary-adrenal (HPA) axis-related genetic variants influence the stress response
(2020)
The physiological stress system includes the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic-adrenal-medullary system (SAM). Parameters representing these systems such as cortisol, blood pressure or heart rate define the physiological reaction in response to a stressor. The main objective of the studies described in this thesis was to understand the role of the HPA-related genetic factors in these two systems. Genetic factors represent one of the components causing individual variations in physiological stress parameters. Five genes involved in the functioning of the HPA axis regarding stress responses are examined in this thesis. They are: corticotropin-releasing hormone (CRH), the glucocorticoid receptor (GR), the mineralocorticoid receptor (MR), the 5-hydroxytryptamine-transporter-linked polymorphic region (5-HTTLPR) in the serotonin transporter (5-HTT) and the brain-derived neurotrophic factor (BDNF) gene. Two hundred thirty-two healthy participants were genotyped. The influence of genetic factors on physiological parameters, such as post-awakening cortisol and blood pressure was assessed, as well as the influence of genetic factors on stress reactivity in response to a socially evaluated cold pressor test (SeCPT). Three studies tested the HPA-related genes each on three different levels. The first study examined the influences of genotypes and haplotypes of these five genes on physiological as well as psychological stress indicators (Chapter 2). The second study examined the effects of GR variants (genotypes and haplotypes) and promoter methylation level on both the SAM system and the HPA axis stress reactivity (Chapter 3). The third study comprised the characterization of CRH promoter haplotypes in an in-vitro study and the association of the CRH promoter with stress indicators in vivo (Chapter 4).
In order to investigate the psychobiological consequences of acute stress under laboratory conditions, a wide range of methods for socially evaluative stress induction have been developed. The present dissertation is concerned with evaluating a virtual reality (VR)-based adaptation of one of the most widely used of those methods, the Trier Social Stress Test (TSST). In the three empirical studies collected in this dissertation, we aimed to examine the efficacy and possible areas of application of the adaptation of this well-established psychosocial stressor in a virtual environment. We found that the TSST-VR reliably incites the activation of the major stress effector systems in the human body, albeit in a slightly less pronounced way than the original paradigm. Moreover, the experience of presence is discussed as one potential factor of influence in the origin of the psychophysiological stress response. Lastly, we present a use scenario for the TSST-VR in which we employed the method to investigate the effects of acute stress on emotion recognition performance. We conclude that, due to its advantages concerning versatility, standardization and economic administration, the paradigm harbors enormous potential not only for psychobiological research, but other applications such as clinical practice as well. Future studies should further explore the underlying effect mechanisms of stress in the virtual realm and the implementation of VR-based paradigms in different fields of application.
Entrepreneurship has become an essential phenomenon all over the world because it is a major driving force behind the economic growth and development of a country. It is widely accepted that entrepreneurship development in a country creates new jobs, pro-motes healthy competition through innovation, and benefits the social well being of individuals and societies. The policymakers in both developed and developing countries focus on entrepreneurship because it helps to alleviate impediments to economic development and social welfare. Therefore, policymakers and academic researchers consider the promotion of entrepreneurship as essential for the economy and research-based support is needed for further development of entrepreneurship activities.
The impact of entrepreneurial activities on economic and social development also varies from country to country. The effect of entrepreneurial activities on economic and social development also varies from country to country because the level of entrepreneur-ship activities also varies from one region to another or one country to another. To under-stand these variations, policymakers have investigated the determinants of entrepreneur-ship at different levels, such as the individual, industry, and country levels. Moreover, entrepreneurship behavior is influenced by various personal and environmental level factors. However, these personal-level factors cannot be separated from the surrounding environment.
The link between religion and entrepreneurship is well established and can be traced back to Weber (1930). Researchers have analyzed the relationship between religion and entrepreneurship from various perspectives, and the research related to religion and entrepreneurship is diversified and scattered across disciplines. This dissertation tries to explain the link between religion and entrepreneurship, specifically Islamic religion and entrepreneurship. Technically this dissertation comprises three parts. The first part of this dissertation consists of two chapters that discuss the definition and theories of entrepreneurship (Chapter 2) and the theoretical relationship between religion and entrepreneur-ship (Chapter 3).
The second part of this dissertation (Chapter 4) provides an overview of the field with a purpose to gain a better understanding of the field’s current state of knowledge to bridge the different views and perspectives. In order to provide an overview of the field, a systematic literature search leading to a descriptive overview of the field based on 270 articles published in 163 journals Subsequently, bibliometric methods are used to identify thematic clusters, the most influential authors and articles, and how they are connected.
The third part of this dissertation (Chapter 5) empirically evaluates the influence of Islamic values and Islamic religious practices on entrepreneurship intentions within the Islamic community. Using the theory of planned behavior as a theoretical lens, we also take into account that the relationship between religion and entrepreneurial intentions can be mediated by individual’s attitude towards entrepreneurship. A self-administrative questionnaire was used to collect the responses from a sample of 1895 Pakistani university students. A structured equation modeling was adopted to perform a nuanced assessment of the relationship between Islamic values and practices and entrepreneurship intentions and to account for mediating effect of attitude towards entrepreneurship.
The research on religion and entrepreneurship has increased sharply during the last years and is scattered across various academic disciplines and fields. The analysis identifies and characterize the most important publications, journals, and authors in the area and map the analyzed religions and regions. The comprehensive overview of previous studies allows us to identify research gaps and derive avenues for future research in a substantiated way. Moreover, this dissertation helps the research scholars to understand the field in its entirety, identify relevant articles, and to uncover parallels and differences across religions and regions. Besides, the study reveals a lack of empirical research related to specific religions and specific regions. Therefore, scholars can take these regions and religions into consideration when conducting empirical research.
Furthermore, the empirical analysis about the influence of Islamic religious values and Islamic religious practices show that Islamic values served as a guiding principle in shaping people’s attitudes towards entrepreneurship in an Islamic community; they had an indirect influence on entrepreneurship intention through attitude. Similarly, the relationship between Islamic religious practices and the entrepreneurship intentions of students was fully mediated by the attitude towards entrepreneurship. Furthermore, this dissertation contributes to prior research on entrepreneurship in Islamic communities by applying a more fine-grained approach to capture the link between religion and entrepreneurship. Moreover, it contributes to the literature on entrepreneurship intentions by showing that the influence of religion on entrepreneurship intentions is mainly due to religious values and practices, which shape the attitude towards entrepreneurship and thereby influence entrepreneurship intentions in religious communities. The entrepreneur-ship research has put a higher emphasis on assessing the influence of a diverse set of con-textual factors. This dissertation introduces Islamic values and Islamic religious practices as critical contextual factors that shape entrepreneurship in countries that are characterized by the Islamic religion.
Why they rebel peacefully: On the violence-reducing effects of a positive attitude towards democracy
(2020)
Under the impression of Europe’s drift into Nazism and Stalinism in the first half of the 20th century, social psychological research has focused strongly on dangers inherent in people’s attachment to a political system. The dissertation at hand contributes to a more differentiated perspective by examining violence-reducing aspects of political system attachment in four consecutive steps: First, it highlights attachment to a social group as a resource for violence prevention on an intergroup level. The results suggest that group attachment fosters self-control, a well-known protective factor against violence. Second, it demonstrates violence-reducing influences of attachment on a societal level. The findings indicate that attachment to a democracy facilitate peaceful and prevent violent protest tendencies. Third, it introduces the concept of political loyalty, defined as a positive attitude towards democracy, in order to clarify the different approaches of political system attachment. A set of three studies show the reliability and validity of a newly developed political loyalty questionnaire that distinguishes between affective and cognitive aspects. Finally, the dissertation differentiates former findings with regard to protest tendencies using the concept of political loyalty. A set of two experiments show that affective rather than cognitive aspects of political loyalty instigate peaceful protest tendencies and prevent violent ones. Implications of this dissertation for political engagement and peacebuilding as well as avenues for future research are discussed.
This dissertation details how Zeami (ca. 1363 - ca.1443) understood his adoption of the heavenly woman dance within the historical conditions of the Muromachi period. He adopted the dance based on performances by the Ōmi troupe player Inuō in order to expand his own troupe’s repertoire to include a divinely powerful, feminine character. In the first chapter, I show how Zeami, informed by his success as a sexualized child in the service of the political elite (chigo), understood the relationship between performer and audience in gendered terms. In his treatises, he describes how a player must create a complementary relationship between patron and performer (feminine/masculine or yin/yang) that escalates to an ecstasy of successful communication between the two poles, resembling sexual union. Next, I look at how Zeami perceived Inuō’s relationships with patrons, the daimyo Sasaki Dōyo in chapter two and shogun Ashikaga Yoshimitsu in chapter three. Inuō was influenced by Dōyo’s masculine penchant for powerful, awe-inspiring art, but Zeami also recognized that Inuō was able to complement Dōyo’s masculinity with feminine elegance (kakari and yūgen). In his relationship with Yoshimitsu, Inuō used the performance of subversion, both in his public persona and in the aesthetic of his performances, to maintain a rebellious reputation appropriate within the climate of conflict among the martial elite. His play “Aoi no ue” draws on the aristocratic literary tradition of the Genji monogatari, giving Yoshimitsu the role of Prince Genji and confronting him with the consequences of betrayal in the form of a demonic, because jilted, Lady Rokujō. This performance challenged Zeami’s early notion that the extreme masculinity of demons and elegant femininity as exemplified by the aristocracy must be kept separate in character creation. In the fourth chapter, I show how Zeami also combined dominance (masculinity) and submission (femininity) in the corporal capacity of a single player when he adopted the heavenly woman dance. The heavenly woman dance thus complemented not only the masculinity of his male patrons with femininity but also the political power of his patrons with another dominant power, which plays featuring the heavenly woman dance label divine rather than masculine.
Theoretical and empirical research assumes a negative development of student achievement motivation over the course of their school careers (i.e., mean-level declines of achievement motivation). However, the exact magnitude of this motivational change remains elusive and it is unclear whether different motivational constructs show similar developmental trends. Furthermore, it is unknown whether motivational declines are related to a particular school stage (i.e., elementary, middle, or high school) or the school transition, and which additional changes are associated with motivational decreases (e.g., changes in student achievement). Finally, previous research has remained inconsistent regarding the question whether ability grouping of students helps prevent motivational declines or results in additional motivational “costs” for students.
This dissertation presents three articles that were designed to address these research questions. In Article 1, a meta-analysis based on 107 independent longitudinal studies investigated student mean-level changes in self-esteem, academic self-concept, academic self-efficacy, intrinsic motivation, and achievement goals from first to 13th grade. Article 2 comprised two longitudinal studies with German adolescents (Study: n = 745 students assessed in four waves in grades 5-7; Study 2: n = 1420 students assessed in four waves in grades 5-8). Both longitudinal studies investigated the separate and the joint development of achievement goals, interest, and achievement in math. In Article 3, a longitudinal study (n = 296 high-ability students assessed in four waves in grades 5-7) investigated the effects of full-time ability grouping on student development of academic self-concept and achievement in math.
The meta-analysis revealed significant decreases in math and language academic self-concept, intrinsic motivation, and mastery and performance-approach goals, whereas no significant changes in self-esteem, general academic self-concept, academic self-efficacy, and performance-avoidance goals were found. Interestingly, motivational declines were not related to school stage or school transition. In Article 2, decreases in interest and mastery, performance-approach, and performance-avoidance goals were indicated by both longitudinal studies. Development of mastery and performance-approach goals was positively related or unrelated to development in interest and achievement, whereas development of performance-avoidance goals was negatively related or unrelated to development of interest and achievement. Finally, the longitudinal study in Article 3 revealed no significant change in student academic self-concept in math over time. Ability grouping showed no positive or negative effects on student academic self-concept. However, high-ability students that were grouped together demonstrated greater gains in their achievement than high-ability students in regular classes.
This dissertation investigates corporate acquisition decisions that represent important corporate development activities for family and non-family firms. The main research objective of this dissertation is to generate insights into the subjective decision-making behavior of corporate decision-makers from family and non-family firms and their weighting of M&A decision-criteria during the early pre-acquisition target screening and selection process. The main methodology chosen for the investigation of M&A decision-making preferences and the weighting of M&A decision criteria is a choice-based conjoint analysis. The overall sample of this dissertation consists of 304 decision-makers from 264 private and public family and non-family firms from mainly Germany and the DACH-region. In the first empirical part of the dissertation, the relative importance of strategic, organizational and financial M&A decision-criteria for corporate acquirers in acquisition target screening is investigated. In addition, the author uses a cluster analysis to explore whether distinct decision-making patterns exist in acquisition target screening. In the second empirical part, the dissertation explores whether there are differences in investment preferences in acquisition target screening between family and non-family firms and within the group of family firms. With regards to the heterogeneity of family firms, the dissertation generated insights into how family-firm specific characteristics like family management, the generational stage of the firm and non-economic goals such as transgenerational control intention influences the weighting of different M&A decision criteria in acquisition target screening. The dissertation contributes to strategic management research, in specific to M&A literature, and to family business research. The results of this dissertation generate insights into the weighting of M&A decision-making criteria and facilitate a better understanding of corporate M&A decisions in family and non-family firms. The findings show that decision-making preferences (hence the weighting of M&A decision criteria) are influenced by characteristics of the individual decision-maker, the firm and the environment in which the firm operates.
In the modeling context, non-linearities and uncertainty go hand in hand. In fact, the utility function's curvature determines the degree of risk-aversion. This concept is exploited in the first article of this thesis, which incorporates uncertainty into a small-scale DSGE model. More specifically, this is done by a second-order approximation, while carrying out the derivation in great detail and carefully discussing the more formal aspects. Moreover, the consequences of this method are discussed when calibrating the equilibrium condition. The second article of the thesis considers the essential model part of the first paper and focuses on the (forward-looking) data needed to meet the model's requirements. A large number of uncertainty measures are utilized to explain a possible approximation bias. The last article keeps to the same topic but uses statistical distributions instead of actual data. In addition, theoretical (model) and calibrated (data) parameters are used to produce more general statements. In this way, several relationships are revealed with regard to a biased interpretation of this class of models. In this dissertation, the respective approaches are explained in full detail and also how they build on each other.
In summary, the question remains whether the exact interpretation of model equations should play a role in macroeconomics. If we answer this positively, this work shows to what extent the practical use can lead to biased results.
Internet interventions have gained popularity and the idea is to use them to increase the availability of psychological treatment. Research suggests that internet interventions are effective for a number of psychological disorders with effect sizes comparable to those found in face-to-face treatment. However, when provided as an add-on to treatment as usual, internet interventions do not seem to provide additional benefit. Furthermore, adherence and dropout rates vary greatly between studies, limiting the generalizability of the findings. This underlines the need to further investigate differences between internet interventions, participating patients, and their usage of interventions. A stronger focus on the processes of change seems necessary to better understand the varying findings regarding outcome, adherence and dropout in internet interventions. Thus, the aim of this dissertation was to investigate change processes in internet interventions and the factors that impact treatment response. This could help to identify important variables that should be considered in research on internet interventions as well as in clinical settings that make use of internet interventions.
Study I (Chapter 5) investigated early change patterns in participants of an internet intervention targeting depression. Data from 409 participants were analyzed using Growth Mixture Modeling. Specifically a piecewise model was applied to model change from screening to registration (pretreatment) and early change (registration to week four of treatment). Three early change patterns were identified; two were characterized by improvement and one by deterioration. The patterns were predictive of treatment outcome. The results therefore indicated that early change should be closely monitored in internet interventions, as early change may be an important indicator of treatment outcome.
Study II (Chapter 6) picked up on the idea of analyzing change patterns in internet interventions and extended it by using the Muthen-Roy model to identify change-dropout patterns. A sligthly bigger sample of the dataset from Study I was analyzed (N = 483). Four change-dropout patterns emerged; high risk of dropout was associated with rapid improvement and deterioration. These findings indicate that clinicians should consider how dropout may depend on patient characteristics as well as symptom change, as dropout is associated with both deterioration and a good enough dosage of treatment.
Study III (Chapter 7) compared adherence and outcome in different participant groups and investigated the impact of adherence to treatment components on treatment outcome in an internet intervention targeting anxiety symptoms. 50 outpatient participants waiting for face- to-face treatment and 37 self-referred participants were compared regarding adherence to treatment components and outcome. In addition, outpatient participants were compared to a matched sample of outpatients, who had no access to the internet intervention during the waiting period. Adherence to treatment components was investigated as a predictor of treatment outcome. Results suggested that especially adherence may vary depending on participant group. Also using specific measures of adherence such as adherence to treatment components may be crucial to detect change mechanisms in internet interventions. Fostering adherence to treatment components in participants may increase the effectiveness of internet interventions.
Results of the three studies are discussed and general conclusions are drawn.
Implications for future research as well as their utility for clinical practice and decision- making are presented.
Auf der Grundlage einer Fragebogenstudie wurden unterschiedliche Elemente eines förderlichen Umgangs mit Gesundheitsinformationen betrachtet und ihre Zusammenhänge mit personspezifischen Merkmalen analysiert. Als zentrale Aspekte der Informationsprozesse wurden die drei Elemente Gesundheitsinformationskompetenz, Gesundheitsinteresse und gesundheitsspezifische Informationsgewohnheiten konzeptuell voneinander getrennt. Auf der Basis des bisherigen Forschungsstands wurde zunächst ein theoretisches Modell des Umgangs mit Gesundheitsinformationen entwickelt, das die Bedeutung der Kompetenz und des Interesses für gesundheitsbezogene Informationsgewohnheiten hervorhebt, individuelle Ausprägungen dieser drei Elemente mit soziodemografischen Faktoren, Persönlichkeitseigenschaften, Überzeugungen und dem Gesundheitszustand in Beziehung setzt sowie Verbindungen zu gesundheitsrelevanten Verhaltensweisen beschreibt. Dieses Modell wurde anschließend an einer Stichprobe von 352 Berufsschülerinnen und -schülern aus drei Berufsbereichen (Wirtschaft/Verwaltung, Technik und Gesundheit) empirisch überprüft. Über multiple Regressionsanalysen wurden bedeutsame Prädiktoren für die drei Hauptelemente Kompetenz, Interesse und Informationsgewohnheiten identifiziert, über logistische Regressionen und Korrelationen ihre Zusammenhänge mit dem Gesundheitsverhalten überprüft. Darüber hinaus wurden lineare Strukturgleichungsmodelle zur Vorhersage des Informationsverhaltens entwickelt. Die Ergebnisse bestätigen die konzeptionelle Trennung der drei Faktoren, die jeweils mit unterschiedlichen Prädiktoren verbunden waren. Auf der Basis der Befunde werden Ansatzpunkte für die weitere Forschung und die Förderung eines kompetenten Umgangs mit Gesundheitsinformationen diskutiert.
