Social virtual environments allow their users to meet and collaborate in a shared three-dimensional space, even when far apart from each other in the real world. Within these spaces, the appearance and interaction capabilities of both users and environments can be adapted and changed in a myriad of ways. To enable virtual environments to fulfill their potential of supporting a wide variety of collaboration use-cases, both the impacts of basic interaction design decisions and the individual needs of specific usage areas need to be explored further. This thesis approaches this topic in two ways. First, the basic building blocks of collaboration in social virtual environments are explored by asking the question: "How can social virtual spaces that allow interaction beyond real-world constraints utilize the potential of mutual assistance and shared workflows between multiple users?". Going into further detail for a serious use-case in which direct collaborative interactions and their effect on the included users are especially important, it then explores the potential of collaborative virtual spaces in the therapy domain by asking "How can the potential of social virtual spaces be utilized to support and improve therapy encounters?" With regards to the first research question, the thesis presents two theoretical frameworks detailing different aspects of supporting smooth and varied collaboration processes. In addition, several user studies on the topic of collaborative virtual interaction are described, focusing on the role that different users can play during shared interaction and the effects that this distribution of roles and responsibilities has on both the performance and experience of the involved user pairs. The results presented for this first research question show that social virtual spaces have the potential to provide dedicated support for collaborative workflows. To enable users to adapt their working mode individually and as a team, interaction techniques should complement a team's natural interaction and communication. When presenting novel interactions to users, providing them with a way to support each other can ease their adaptation to these interactions. In these cases, the inclusion of all interested collaborators as active participators should be prioritized in order to let all users benefit from being immersed in a virtual environment. Addressing the combination of social virtual spaces with therapy in relation to the second research question, this thesis presents the result of a series of interviews with practicing physio- and psychotherapists. Motivated by the recorded expert feedback, it also reports on two more detailed explorations of specific areas of interest. The work presented for the second research question demonstrated the promise of using virtual environments in both exercise- and conversation-based therapy practice. Investigating the potential of shared interactions, the exploration of virtual recordings and the adaptation of virtual appearances, the presented work uncovered several topic areas that could be further explored regarding their possible use in the treatment of patients. Taken together, the six research articles presented in this thesis show both the value of supporting and understanding shared interactions in virtual spaces and their potential place in serious use-cases like the therapy domain. When introducing shared virtual environments to new user groups, the opportunity for mutual support through shared interaction techniques could be a crucial building block towards making virtual spaces both accessible and attractive to a variety of users.