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My study attempts to illustrate the generic development of the family novel in the second half of the twentieth century. At its beginning stands a preliminary classification of the various types of family fiction as they are referred to in secondary literature, which is then followed by a definition of the family novel proper. With its microscopic approach to novels featuring the American family and its (post-)postmodern variations, my study marks a first step into as yet uncharted territory. Assuming that the family novel has emerged as a result of the twentieth century's emphasis on the modern nuclear family, focuses on the family as a gestalt rather than on a single protagonist, and is concerned with issues of social and cultural significance, this study examines how the family, its forms and its conflicts are functionalized for the respective author's cultural critique. From post-war to post-millennium, family novelists have sketched the American family in various precarious conditions, and their texts are critical assessments of contemporary socioeconomic and cultural conditions. My close reading of John Cheever's The Wapshot Chronicle (1957), Don DeLillo's White Noise (1985) and Jonathan Franzen's The Corrections (2001) intends to reveal, shared values as well as significant differences on a formal as well as on a thematic level. As my examination of the respective novel shows, authors react to social and cultural change with new functionalizations of the family in fiction. Unlike the general assumption of literary crticism, family novels do not approach new cultural developments in a conventional or even traditionalist manner. A comparison of White Noise with The Wapshot Chronicle demonstrates that DeLillo's postmodern family novel transcends the rather nostalgic perspective of Cheever's 1950s work. Similarly, Jonathan Franzen's fin de millennium family novel The Corrections holds a post-postmodern position, which can be aptly described by Franzen's own term 'tragical realism'. The significant changes and developments of the family novel in the past five decades demonstrate the need for a continuous reassessment of the genre, and in this respect, my study is merely a beginning.
Objective: Only 20-25% of the variance for the two to four-fold increased risk of developing breast cancer among women with family histories of the disease can be explained by known gene mutations. Other factors must exist. Here, a familial breast cancer model is proposed in which overestimation of risk, general distress, and cancer-specific distress constitute the type of background stress sufficient to increase unrelated acute stress reactivity in women at familial risk for breast cancer. Furthermore, these stress reactions are thought to be associated with central adiposity, an independent well-established risk factor for breast cancer. Hence, stress through its hormonal correlates and possible associations with central adiposity may play a crucial role in the etiology of breast cancer in women at familial risk for the disease. Methods: Participants were 215 healthy working women with first-degree relatives diagnosed before (high familial risk) or after age 50 (low familial risk), or without breast cancer in first-degree relatives (no familial risk). Participants completed self-report measures of perceived lifetime breast cancer risk, intrusive thoughts and avoidance about breast cancer (Impact of Event Scale), negative affect (Profile of Mood States), and general distress (Brief Symptom Inventory). Anthropometric measurements were taken. Urine samples during work, home, and sleep were collected for assessment of cortisol responses in the naturalistic setting where work was conceptualized as the stressful time of the day. Results: A series of analyses indicated a gradient increase of cortisol levels in response to the work environment from no, low, to high familial risk of breast cancer. When adding breast cancer intrusions to the model with familial risk status predicting work cortisol levels, significant intrusion effects emerged rendering the familial risk group non-significant. However, due to a lack of association between intrusions and cortisol in the low and high familial risk group separately, as well as a significant difference between low and high familial risk on intrusions, but not on work cortisol levels, full mediation of familial risk group effects on work cortisol by intrusions could not be established. A separate analysis indicated increased levels of central but not general adiposity in women at high familial risk of breast cancer compared to the low and no risk groups. There were no significant associations between central adiposity and cortisol excretion. Conclusion: A hyperactive hypothalamus-pituitary-adrenal axis with a more pronounced excretion of its end product cortisol, as well as elevated levels of central but not overall adiposity in women at high familial risk for breast cancer may indicate an increased health risk which expands beyond that of increased breast cancer risk for these women.
The startle response in psychophysiological research: modulating effects of contextual parameters
(2013)
Startle reactions are fast, reflexive, and defensive responses which protect the body from injury in the face of imminent danger. The underlying reflex is basic and can be found in many species. Even though it consists of only a few synapses located in the brain stem, the startle reflex offers a valuable research method for human affective, cognitive, and psychological research. This is because of moderating effects of higher mental processes such as attention and emotion on the response magnitude: affective foreground stimulation and directed attention are validated paradigms in startle-related research. This work presents findings from three independent research studies that deal with (1) the application of the established "affective modulation of startle"-paradigm to the novel setting of attractiveness and human mating preferences, (2) the question of how different components of the startle response are affected by a physiological stressor and (3) how startle stimuli affect visual attention towards emotional stimuli. While the first two studies treat the startle response as a dependent variable by measuring its response magnitude, the third study uses startle stimuli as an experimental manipulation and investigates its potential effects on a behavioural measure. The first chapter of this thesis describes the basic mechanisms of the startle response as well as the body of research that sets the foundation of startle research in psychophysiology. It provides the rationale for the presented studies, and offers a short summary of the obtained results. Chapter two to four represent primary research articles that are published or in press. At the beginning of each chapter the contribution of all authors is explained. The references for all chapters are listed at the end of this thesis. The overall scope of this thesis is to show how the human startle response is modulated by a variety of factors, such as the attractiveness of a potential mating partner or the exposure to a stressor. In conclusion, the magnitude of the startle response can serve as a measure for such psychological states and processes. Beyond the involuntary, physiological startle reflex, startle stimuli also affect intentional behavioural responses, which we could demonstrate for eye movements in a visual attention paradigm.
Der digitale Fortschritt der vergangenen Jahrzehnte beruht zu einem großen Teil auf der Innovationskraft junger aufstrebender Unternehmen. Während diese Unternehmen auf der einen Seite ihr hohes Maß an Innovativität eint, entsteht für diese zeitgleich auch ein hoher Bedarf an finanziellen Mitteln, um ihre geplanten Innovations- und Wachstumsziele auch in die Tat umsetzen zu können. Da diese Unternehmen häufig nur wenige bis keine Unternehmenswerte, Umsätze oder auch Profitabilität vorweisen können, gestaltet sich die Aufnahme von externem Kapital häufig schwierig bis unmöglich. Aus diesem Umstand entstand in der Mitte des zwanzigsten Jahrhunderts das Geschäftsmodell der Risikofinanzierung, des sogenannten „Venture Capitals“. Dabei investieren Risikokapitalgeber in aussichtsreiche junge Unternehmen, unterstützen diese in ihrem Wachstum und verkaufen nach einer festgelegten Dauer ihre Unternehmensanteile, im Idealfall zu einem Vielfachen ihres ursprünglichen Wertes. Zahlreiche junge Unternehmen bewerben sich um Investitionen dieser Risikokapitalgeber, doch nur eine sehr geringe Zahl erhält diese auch. Um die aussichtsreichsten Unternehmen zu identifizieren, sichten die Investoren die Bewerbungen anhand verschiedener Kriterien, wodurch bereits im ersten Schritt der Bewerbungsphase zahlreiche Unternehmen aus dem Kreis potenzieller Investmentobjekte ausscheiden. Die bisherige Forschung diskutiert, welche Kriterien Investoren zu einer Investition bewegen. Daran anschließend verfolgt diese Dissertation das Ziel, ein tiefergehendes Verständnis darüber zu erlangen, welche Faktoren die Entscheidungsfindung der Investoren beeinflussen. Dabei wird vor allem auch untersucht, wie sich persönliche Faktoren der Investoren, sowie auch der Unternehmensgründer, auf die Investitionsentscheidung auswirken. Ergänzt werden diese Untersuchungen zudem durch die Analyse der Wirkung des digitalen Auftretens von Unternehmensgründern auf die Entscheidungsfindung von Risikokapitalgebern. Des Weiteren verfolgt diese Dissertation als zweites Ziel einen Erkenntnisgewinn über die Auswirkungen einer erfolgreichen Investition auf den Unternehmensgründer. Insgesamt umfasst diese Dissertation vier Studien, die im Folgenden näher beschrieben werden.
In Kapitel 2 wird untersucht, inwiefern sich bestimmte Humankapitaleigenschaften des Investors auf dessen Entscheidungsverhalten auswirken. Mithilfe vorangegangener Interviews und Literaturrecherchen wurden insgesamt sieben Kriterien identifiziert, die Risikokapitalinvestoren in ihrer Entscheidungsfindung nutzen. Daraufhin nahmen 229 Investoren an einem Conjoint Experiment teil, mithilfe dessen gezeigt werden konnte, wie wichtig die jeweiligen Kriterien im Rahmen der Entscheidung sind. Von besonderem Interesse ist dabei, wie sich die Wichtigkeit der Kriterien in Abhängigkeit der Humankapitaleigenschaften der Investoren unterscheiden. Dabei kann gezeigt werden, dass sich die Wichtigkeit der Kriterien je nach Bildungshintergrund und Erfahrung der Investoren unterscheidet. So legen beispielsweise Investoren mit einem höheren Bildungsabschluss und Investoren mit unternehmerischer Erfahrung deutlich mehr Wert auf die internationale Skalierbarkeit der Unternehmen. Zudem unterscheidet sich die Wichtigkeit der Kriterien auch in Abhängigkeit der fachlichen Ausbildung. So legen etwa Investoren mit einer fachlichen Ausbildung in Naturwissenschaften einen deutlich stärkeren Fokus auf den Mehrwert des Produktes beziehungsweise der Dienstleistung. Zudem kann gezeigt werden, dass Investoren mit mehr Investitionserfahrung die Erfahrung des Managementteams wesentlich wichtiger einschätzen als Investoren mit geringerer Investitionserfahrung. Diese Ergebnisse ermöglichen es Unternehmensgründern ihre Bewerbungen um eine Risikokapitalfinanzierung zielgenauer auszurichten, etwa durch eine Analyse des beruflichen Hintergrunds der potentiellen Investoren und eine damit einhergehende Anpassung der Bewerbungsunterlagen, zum Beispiel durch eine stärkere Schwerpunktsetzung besonders relevanter Kriterien.
Die in Kapitel 3 vorgestellte Studie bedient sich der Daten des gleichen Conjoint Experiments aus Kapitel 2, legt hierbei allerdings einen Fokus auf den Unterschied zwischen Investoren aus den USA und Investoren aus Kontinentaleuropa. Dazu wurden Subsamples kreiert, in denen 128 Experimentteilnehmer in den USA angesiedelt sind und 302 in Kontinentaleuropa. Die Analyse der Daten zeigt, dass US-amerikanische Investoren, im Vergleich zu Investoren in Kontinentaleuropa, einen signifikant stärkeren Fokus auf das Umsatzwachstum der Unternehmen legen. Zudem legen kontinentaleuropäische Investoren einen deutlich stärkeren Fokus auf die internationale Skalierbarkeit der Unternehmen. Um die Ergebnisse der Analyse besser interpretieren zu können, wurden diese im Anschluss mit vier amerikanischen und sieben europäischen Investoren diskutiert. Dabei bestätigen die europäischen Investoren die Wichtigkeit der hohen internationalen Skalierbarkeit aufgrund der teilweise geringen Größe europäischer Länder und dem damit zusammenhängenden Zwang, schnell international skalieren zu können, um so zufriedenstellende Wachstumsraten zu erreichen. Des Weiteren wurde der vergleichsweise geringere Fokus auf das Umsatzwachstum in Europa mit fehlenden Mitteln für eine schnelle Expansion begründet. Gleichzeitig wird der starke Fokus der US-amerikanischen Investoren auf Umsatzwachstum mit der höheren Tendenz zu einem Börsengang in den USA begründet, bei dem hohe Umsätze als Werttreiber dienen. Die Ergebnisse dieses Kapitels versetzen Unternehmensgründer in die Lage, ihre Bewerbung stärker an die wichtigsten Kriterien der potenziellen Investoren auszurichten, um so die Wahrscheinlichkeit einer erfolgreichen Investitionsentscheidung zu erhöhen. Des Weiteren bieten die Ergebnisse des Kapitels Investoren, die sich an grenzüberschreitenden syndizierten Investitionen beteiligen, die Möglichkeit, die Präferenzen der anderen Investoren besser zu verstehen und die Investitionskriterien besser auf potenzielle Partner abzustimmen.
Kapitel 4 untersucht ob bestimmte Charaktereigenschaften des sogenannten Schumpeterschen Entrepreneurs einen Einfluss auf die Wahrscheinlichkeit eines zweiten Risikokapitalinvestments haben. Dazu wurden von Gründern auf Twitter gepostete Nachrichten sowie Information von Investitionsrunden genutzt, die auf der Plattform Crunchbase zur Verfügung stehen. Insgesamt wurden mithilfe einer Textanalysesoftware mehr als zwei Millionen Tweets von 3313 Gründern analysiert. Die Ergebnisse der Studie deuten an, dass einige Eigenschaften, die typisch für Schumpetersche Gründer sind, die Chancen für eine weitere Investition erhöhen, während andere keine oder negative Auswirkungen haben. So erhöhen Gründer, die auf Twitter einen starken Optimismus sowie ihre unternehmerische Vision zur Schau stellen die Chancen auf eine zweite Risikokapitalfinanzierung, gleichzeitig werden diese aber durch ein zu starkes Streben nach Erfolg reduziert. Diese Ergebnisse haben eine hohe praktische Relevanz für Unternehmensgründer, die sich auf der Suche nach Risikokapital befinden. Diese können dadurch ihr virtuelles Auftreten („digital identity“) zielgerichteter steuern, um so die Wahrscheinlichkeit einer weiteren Investition zu erhöhen.
Abschließend wird in Kapitel 5 untersucht, wie sich die digitale Identität der Gründer verändert, nachdem diese eine erfolgreiche Risikokapitalinvestition erhalten haben. Dazu wurden sowohl Twitter-Daten als auch Crunchbase-Daten genutzt, die im Rahmen der Erstellung der Studie in Kapitel 4 erhoben wurden. Mithilfe von Textanalyse und Paneldatenregressionen wurden die Tweets von 2094 Gründern vor und nach Erhalt der Investition untersucht. Dabei kann gezeigt werden, dass der Erhalt einer Risikokapitalinvestition das Selbstvertrauen, die positiven Emotionen, die Professionalisierung und die Führungsqualitäten der Gründer erhöhen. Gleichzeitig verringert sich allerdings die Authentizität der von den Gründern verfassten Nachrichten. Durch die Verwendung von Interaktionseffekten kann zudem gezeigt werden, dass die Steigerung des Selbstvertrauens positiv durch die Reputation des Investors moderiert wird, während die Höhe der Investition die Authentizität negativ moderiert. Investoren haben durch diese Erkenntnisse die Möglichkeit, den Weiterentwicklungsprozess der Gründer nach einer erfolgreichen Investition besser nachvollziehen zu können, wodurch sie in die Lage versetzt werden, die Aktivitäten ihrer Gründer auf Social Media Plattformen besser zu kontrollieren und im Bedarfsfall bei ihrer Anpassung zu unterstützen.
Die in den Kapiteln 2 bis 5 vorgestellten Studien dieser Dissertation tragen damit zu einem besseren Verständnis der Entscheidungsfindung im Venture Capital Prozess bei. Der bisherige Stand der Forschung wird um Erkenntnisse erweitert, die sowohl den Einfluss der Eigenschaften der Investoren als auch der Gründer betreffen. Zudem wird auch gezeigt, wie sich die Investition auf den Gründer selbst auswirken kann. Die Implikationen der Ergebnisse, sowie Limitationen und Möglichkeiten künftiger Forschung werden in Kapitel 6 näher beschrieben. Da die in dieser Dissertation verwendeten Methoden und Daten erst seit wenigen Jahren im Kontext der Venture Capital Forschung genutzt werden, beziehungsweise überhaupt verfügbar sind, bietet sie sich als eine Grundlage für weitere Forschung an.
Stress has been considered one of the most relevant factors promoting aggressive behavior. Animal and human pharmacological studies revealed the stress hormones corticosterone in rodents and cortisol in humans to constitute a particularly important neuroendocrine determinate in facilitating aggression and beyond that, assumedly in its continuation and escalation. Moreover, cortisol-induced alterations of social information processing, as well as of cognitive control processes, have been hypothesized as possible influencing factors in the stress-aggression link. So far, the immediate impact of a preceding stressor and thereby stress-induced rise of cortisol on aggressive behavior as well as higher-order cognitive control processes and social information processing in this context have gone mostly unheeded. The present thesis aimed to extend the hitherto findings of stress and aggression in this regard. For this purpose two psychophysiological studies with healthy adults were carried out, both using the socially evaluated-cold pressor test as an acute stress induction. Additionally to behavioral data and subjective reports, event related potentials were measured and acute levels of salivary cortisol were collected on the basis of which stressed participants were divided into cortisol-responders and "nonresponders. Study 1 examined the impact of acute stress-induced cortisol increase on inhibitory control and its neural correlates. 41 male participants were randomly assigned to the stress procedure or to a non-stressful control condition. Beforehand and afterwards, participants performed a Go Nogo task with visual letters to measure response inhibition. The effect of acute stress-induced cortisol increase on covert and overt aggressive behavior and on the processing of provoking stimuli within the aggressive encounter was investigated in study 2. Moreover, this experiment examined the combined impact of stress and aggression on ensuing affective information processing. 71 male and female participants were either exposed to the stress or to the control condition. Following this, half of each group received high or low levels of provocation during the Taylor Aggression Paradigm. At the end of the experiment, a passive viewing paradigm with affective pictures depicting positive, negative, or aggressive scenes with either humans or objects was realized. The results revealed that men were not affected by a stress-induced rise in cortisol on a behavioral level, showing neither impaired response inhibition nor enhanced aggressive behavior. In contrast, women showed enhanced overt and covert aggressive behavior under a surge of endogenous cortisol, confirming previous results, albeit only in case of high provocation and only up to the level of the control group. Unlike this rather moderate impact on behavior, cortisol showed a distinct impact on neural correlates of information processing throughout inhibitory control, aggression-eliciting stimuli, and emotional pictures for both men and women. At this, stress-induced increase of cortisol resulted in enhanced N2 amplitudes to Go stimuli, whereas P2 amplitudes to both and N2 to Nogo amplitudes retained unchanged, indicating an overcorrection and caution of the response activation in favor of successful inhibitory control. The processing of aggression-eliciting stimuli during the aggressive encounter was complexly altered by stress differently for women and men. Under increased cortisol levels, the frontal or parietal P3 amplitude patterns were either diminished or reversed in the case of high provocation compared to the control group and to cortisol-nonresponders, indicating a desensitization towards aggression-eliciting stimuli in males, but a more elaborate processing of those in women. Moreover, stress-induced cortisol and provocation jointly altered subsequent affective information processing at early as well as later stages of the information processing stream. Again, increased levels of cortisol led opposite directed amplitudes in the case of high provocation relative to the control group and cortisol-nonresponders, with enhanced N2 amplitudes in men and reduced P3 and LPP amplitudes in men and women for all affective pictures, suggesting initially enhanced emotional reactivity in men, but ensuing reduced motivational attention and enhanced emotion regulation in both, men and women. As a result, these present findings confirm the relevance of HPA activity in the elicitation and persistence of human aggressive behavior. Moreover, they reveal the significance of compensatory and emotion regulatory strategies and mechanisms in response to stress and provocation, indorsing the relevance of social information and cognitive control processes. Still, more research is needed to clarify the conditions which lead to the facilitation of aggression and by which compensatory mechanisms this is prevented.
In splitting theory of locally convex spaces we investigate evaluable characterizations of the pairs (E, X) of locally convex spaces such that each exact sequence 0 -> X -> G -> E -> 0 of locally convex spaces splits, i.e. either X -> G has a continuous linear left inverse or G -> E has a continuous linear right inverse. In the thesis at hand we deal with splitting of short exact sequences of so-called PLH spaces, which are defined as projective limits of strongly reduced spectra of strong duals of Fréchet-Hilbert spaces. This class of locally convex spaces contains most of the spaces of interest for application in the theory of partial differential operators as the space of Schwartz distributions , the space of real analytic functions and various spaces of ultradifferentiable functions and ultradistributions. It also contains non-Schwartz spaces as B(2,k,loc)(Ω) and spaces of smooth and square integrable functions that are not covered by the current theory for PLS spaces. We prove a complete characterizations of the above problem in the case of X being a PLH space and E either being a Fréchet-Hilbert space or a strong dual of one by conditions of type (T ). To this end, we establish the full homological toolbox of Yoneda Ext functors in exact categories for the category of PLH spaces including the long exact sequence, which in particular involves a thorough discussion of the proper concept of exactness. Furthermore, we exhibit the connection to the parameter dependence problem via the Hilbert tensor product for hilbertizable locally convex spaces. We show that the Hilbert tensor product of two PLH spaces is again a PLH space which in particular proves the positive answer to Grothendieck- problème des topologies. In addition to that we give a complete characterization of the vanishing of the first derivative of the functor proj for tensorized PLH spectra if one of the PLH spaces E and X meets some nuclearity assumptions. To apply our results to concrete cases we establish sufficient conditions of (DN)-(Ω) type and apply them to the parameter dependence problem for partial differential operators with constant coefficients on B(2,k,loc)(Ω) spaces as well as to the smooth and square integrable parameter dependence problem. Concluding we give a complete solution of all the problems under consideration for PLH spaces of Köthe type.
Chapter 2: Using data from the German Socio-Economic Panel, this study examines the relation-ship between immigrant residential segregation and immigrants" satisfaction with the neighbor-hood. The estimates show that immigrants living in segregated areas are less satisfied with the neighborhood. This is consistent with the hypothesis that housing discrimination rather than self-selection plays an important role in immigrant residential segregation. Our result holds true even when controlling for other influences such as household income and quality of the dwelling. It also holds true in fixed effects estimates that account for unobserved time-invariant influences. Chapter 3: Using survey data from the German Socio-Economic Panel, this study shows that immigrants living in segregated residential areas are more likely to report discrimination because of their ethnic background. This applies to both segregated areas where most neighbors are immigrants from the same country of origin as the surveyed person and segregated areas where most neighbors are immigrants from other countries of origin. The results suggest that housing discrimination rather than self-selection plays an important role in immigrant residential segregation. Chapter 4: Using data from the German Socio-Economic Panel (SOEP) and administrative data from 1996 to 2009, I investigate the question whether or not right-wing extremism of German residents is affected by the ethnic concentration of foreigners living in the same residential area. My results show a positive but insignificant relationship between ethnic concentration at the county level and the probability of extreme right-wing voting behavior for West Germany. However, due to potential endogeneity issues, I additionally instrument the share of foreigners in a county with the share of foreigners in each federal state (following an approach of Dustmann/Preston 2001). I find evidence for the interethnic contact theory, predicting a negative relationship between foreign-ers" share and right-wing voting. Moreover, I analyze the moderating role of education and the influence of cultural traits on this relationship. Chapter 5: Using data from the Socio-Economic Panel from 1998 to 2009 and administrative data on regional ethnic diversity, I show that ethnic diversity inhibits significantly people- political interest and participation in political organizations in West Germany. People seem to isolate themselves from political participation if exposed to more ethnic diversity which is particularly relevant with respect to the ongoing integration process of the European Union and the increasing transfer of legislative power from the national to European level. The results are robust if an instrumental variable strategy suggested by Dustmann and Preston (2001) is used to take into account that ethnic diversity measured on a local spatial level could be endogenous due to residential sorting. Interestingly, participation in non-political organizations is positively affected by ethnic diversity if selection bias is corrected for.
The main achievement of this thesis is an analysis of the accuracy of computations with Loader's algorithm for the binomial density. This analysis in later progress of work could be used for a theorem about the numerical accuracy of algorithms that compute rectangle probabilities for scan statistics of a multinomially distributed random variable. An example that shall illustrate the practical use of probabilities for scan statistics is the following, which arises in epidemiology: Let n patients arrive at a clinic in d = 365 days, each of the patients with probability 1/d at each of these d days and all patients independently from each other. The knowledge of the probability, that there exist 3 adjacent days, in which together more than k patients arrive, helps deciding, after observing data, if there is a cluster which we would not suspect to have occurred randomly but for which we suspect there must be a reason. Formally, this epidemiological example can be described by a multinomial model. As multinomially distributed random variables are examples of Markov increments, which is a fact already used implicitly by Corrado (2011) to compute the distribution function of the multinomial maximum, we can use a generalized version of Corrado's Algorithm to compute the probability described in our example. To compute its result, the algorithm for rectangle probabilities for Markov increments always uses transition probabilities of the corresponding Markov Chain. In the multinomial case, the transition probabilities of the corresponding Markov Chain are binomial probabilities. Therefore, we start an analysis of accuracy of Loader's algorithm for the binomial density, which for example the statistical software R uses. With the help of accuracy bounds for the binomial density we would be able to derive accuracy bounds for the computation of rectangle probabilities for scan statistics of multinomially distributed random variables. To figure out how sharp derived accuracy bounds are, in examples these can be compared to rigorous upper bounds and rigorous lower bounds which we obtain by interval-arithmetical computations.
In the first part of this work we generalize a method of building optimal confidence bounds provided in Buehler (1957) by specializing an exhaustive class of confidence regions inspired by Sterne (1954). The resulting confidence regions, also called Buehlerizations, are valid in general models and depend on a designated statistic'' that can be chosen according to some desired monotonicity behaviour of the confidence region. For a fixed designated statistic, the thus obtained family of confidence regions indexed by their confidence level is nested. Buehlerizations have furthermore the optimality property of being the smallest (w.r.t. set inclusion) confidence regions that are increasing in their designated statistic. The theory is eventually applied to normal, binomial, and exponential samples. The second part deals with the statistical comparison of pairs of diagnostic tests and establishes relations 1. between the sets of lower confidence bounds, 2. between the sets of pairs of comparable lower confidence bounds, and 3. between the sets of admissible lower confidence bounds in various models for diverse parameters of interest.
Knowledge acquisition comprises various processes. Each of those has its dedicated research domain. Two examples are the relations between knowledge types and the influences of person-related variables. Furthermore, the transfer of knowledge is another crucial domain in educational research. I investigated these three processes through secondary analyses in this dissertation. Secondary analyses comply with the broadness of each field and yield the possibility of more general interpretations. The dissertation includes three meta-analyses: The first meta-analysis reports findings on the predictive relations between conceptual and procedural knowledge in mathematics in a cross-lagged panel model. The second meta-analysis focuses on the mediating effects of motivational constructs on the relationship between prior knowledge and knowledge after learning. The third meta-analysis deals with the effect of instructional methods in transfer interventions on knowledge transfer in school students. These three studies provide insights into the determinants and processes of knowledge acquisition and transfer. Knowledge types are interrelated; motivation mediates the relation between prior and later knowledge, and interventions influence knowledge transfer. The results are discussed by examining six key insights that build upon the three studies. Additionally, practical implications, as well as methodological and content-related ideas for further research, are provided.