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Left ventricular assist devices (LVADs) have become a valuable treatment for patients with advanced heart failure. Women appear to be disadvantaged in the usage of LVADs and concerning clinical outcomes such as death and adverse events after LVAD implant. Contrary to typical clinical characteristics (e.g., disease severity), device-related factors such as the intended device strategy, bridge to a heart transplantation or destination therapy, are often not considered in research on gender differences. In addition, the relevance of pre-implant psychosocial risk factors, such as substance abuse and limited social support, for LVAD outcomes is currently unclear. Thus, the aim of this dissertation is to explore the role of pre-implant psychosocial risk factors for gender differences in clinical outcomes, accounting for clinical and device-related risk factors.
In the first article, gender differences in pre-implant characteristics of patients registered in The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) were investigated. It was found that women and men differed in multiple pre-implant characteristics depending on device strategy. In the second article, gender differences in major clinical outcomes (i.e., death, heart transplant, device explant due to cardiac recovery, device replacement due to complications) were evaluated for patients in the device strategy destination therapy in the Interagency Registry for Mechanically Assisted Circulation (INTERMACS). Additionally, the association of gender and psychosocial risk factors with the major outcomes were analyzed. Women had similar probabilities to die on LVAD support, and even higher probabilities to experience explant of the device due to cardiac recovery compared with men in the destination therapy subgroup. Pre-implant psychosocial risk factors were not associated with major outcomes. The third article focused on gender differences in 10 adverse events (e.g., device malfunction, bleeding) after LVAD implant in INTERMACS. The association of a psychosocial risk indicator with gender and adverse events after LVAD implantation was evaluated. Women were less likely to have psychosocial risk pre-implant but more likely to experience seven out of 10 adverse events compared with men. Pre-implant psychosocial risk was associated with adverse events, even suggesting a dose response-relationship. These associations appeared to be more pronounced in women.
In conclusion, women appear to have similar survival to men when accounting for device strategy. They have higher probabilities of recovery, but higher probabilities of device replacement and adverse events compared with men. Regarding these adverse events, women may be more susceptible to psychosocial risk factors than men. The results of this dissertation illustrate the importance of gender-sensitive research and suggest considering device strategy when studying gender differences in LVAD recipients. Further research is warranted to elucidate the role of specific psychosocial risk factors that lead to higher probabilities of adverse events, to intervene early and improve patient care in both, women and men
In einer empirischen Neuroimaging Studie an einer Gruppe von 141 rechts- und linkshändigen Probanden beiderlei Geschlechts wurden fMRT-Korrelate der funktionalen Sprachrepräsentation untersucht. Es fanden sich bedeutsame Unter-schiede in der Sprachverarbeitungskompetenz der beiden Hemisphären sowohl zwischen Rechts- und Linkshändern als auch zwischen Männern und Frauen.
Diese Arbeit hat das Ziel, die Kategorie "Frau", ihre Situation und ihre Konstitution sowohl auf symbolischer als auch soziostruktureller Ebene innerhalb der mexikanischen Kultur und Gesellschaft zu ergründen. Die Konstruktion von Weiblichkeit in Mexiko erfolgt entlang der bedeutungsstiftenden Strukturen einer Vielzahl von Kulturen (zumindest: die "indigen/traditionelle", die hispanisch-europäische und die mestizisch/mexikanische), gesellschaftlicher und politischer Institutionen (wie das staatliche Entwicklungsprojekt, Bildungsinitiativen, Kirchen und Religion) und weiterer, diffuser Einflüsse (etwa die Massenmedien in ihren populären Formen). Gerade deshalb gewinnt die Weiblichkeit der mexikanischen Mestizinnen eine besondere Qualität, die eine Möglichkeit bieten kann, nicht nur eine "fremde" Kultur, sondern auch die eigene Wahrnehmung zu analysieren.
While women's evolving contribution to entrepreneurship is irrefutable, in almost all nations, gender disparity is an existing reality of entrepreneurship. Social and economic outcomes make women entrepreneurship an important area for scholars and governments. In attempts to find reasons for this gender disparity, academic scholars evaluated various factors and recognised perceptual variables as having outstanding explanatory value in understanding women's entrepreneurship. To advance our knowledge of gender disparity in entrepreneurship, the present study explores the influence of entrepreneurial perceptual variables on women's entrepreneurship and considers the critical role of country-level institutional contexts on the women's entrepreneurial propensity. Therefore, this study examines the impact of perceptual variables in different nations. It also offers connections between entrepreneurial perceptions, women entrepreneurship, and institutional contexts as a critical topic for future studies.
Drawing on the importance of perceptual factors, this dissertation investigates whether and how their perception of entrepreneurial networks influences the individuals' decision to initiate a new venture. Prior scholars considered exposure to entrepreneurial role models as one of the most influential factors on the women's inclination towards entrepreneurship; thus, a systemized analysis makes it possible to identify existing research gaps related to this perception. Hence, to draw a clear picture of the relationship between entrepreneurial role models and entrepreneurship, this dissertation provides a systemized overview of prior studies. Subsequently, Chapter 2 structures the existing literature on entrepreneurial role models and reveals that past literature has focused on the different types of role models, the stage of life at which the exposure to role models occurs, and the context of the exposure. Current discourse argues that the women's lower access to entrepreneurial role models negatively influences their inclination towards entrepreneurship.
Additionally, although the research on women entrepreneurship has proliferated in recent years, little is known about how entrepreneurial perceptual variables form women's propensity towards entrepreneurship in various institutional contexts. The work of Koellinger et al. (2013), hereafter KMS, is one of the most influential papers that investigated the influence of perceptual variables, and it showed that a lower rate of women entrepreneurship is associated with a lower level of their entrepreneurial network, perceived entrepreneurial capability, and opportunity evaluation and with a higher fear of entrepreneurial failure. Thus, this dissertation replicates the work of KMS. Chapter 3 explicitly investigates the influence of the above perceptions on women's entrepreneurial propensity. This research has drawn data from the Global Entrepreneurship Monitor, a cross-national individual-level data set (2001-2006) covering 236,556 individuals across 17 countries. The results of this chapter suggest that gender disparities in entrepreneurial propensity are conditioned by differences in entrepreneurial perceptual variables. Women's lower levels of perceived entrepreneurial capability, entrepreneurial role models and opportunity evaluation and their higher fear of failure lead to lower entrepreneurial propensity.
To extend and generalise the relationship between perceptions and women's entrepreneurial propensity, in Chapter 4, two studies are conducted based on replicated research. Extension 1 generalises the results of KMS by using the same analysis on more recent data. Accordingly, this research implemented the same analysis on 372,069 individuals across the same countries (2011-2016). The recent data show that although gender disparity became significantly weaker, the gender gap is still in men's favour. However, similarly to the replicated study, this research revealed that perceptual factors explain a larger part of the gender disparity. To strengthen prior empirical evidence, in extension 2, utilising a sample of 1,029,863 individuals from 71 countries (2011-2016), the study conducted the same measures and analysis in a more global setting. By including developing countries, gender disparity in entrepreneurial propensity decreased significantly. The study revealed that the relative significance of the influences of perceptions' differs significantly across nations; however, perceptions have a worldwide effect. Moreover, this research found that the ratio of nascent women entrepreneurs in less developed countries to those in more developed nations is 2. More precisely, a higher level of economic development negatively influences the impact of perceptions on women's entrepreneurial propensity.
Whereas prior scholars increasingly underlined the importance of perceptions in explaining a large part of gender disparities in entrepreneurship, most of the prior investigations focused on nascent (early-stage) entrepreneurship, and evidence on the relationship between perceptions and other types of self-employment, such as innovative entrepreneurship, is scant. Innovation is a confirmed key driver of a firm's sustainability, higher competitive capability, and growth. Therefore, Chapter 5 investigates the influence of perceptions on women's innovative entrepreneurship. The chapter points out that entrepreneurial perceptions are the main determinants of the women's decision to offer a new product or service. This chapter also finds that women's innovative entrepreneurship is associated with the country's specific economic setting.
Overall, by underlining the critical role of institutional contexts, this dissertation provides considerable insights into the interaction between perceptions and women entrepreneurship, and its results have implications for policymakers and practitioners, who may find it helpful to consider women entrepreneurship in systemized challenges. Formal and informal barriers affect women's entrepreneurial perceptions and can differ from one country to the other. In this sense, it is crucial to design operational plans to mitigate formal and stereotypical challenges, and thus, more women will be able to start a business, particularly in developing countries in which women significantly comprise a smaller portion of the labour markets. This type of policy could write the "rules of the game" such that these rules enhance the women's propensity towards entrepreneurship.
The following dissertation contains three studies examining academic boredom development in five high-track German secondary schools (AVG-project data; Study 1: N = 1,432; Study 2: N = 1,861; Study 3: N = 1,428). The investigation period spanned 3.5 years, with four waves of measurement from grades 5 to 8 (T1: 5th grade, after transition to secondary school; T2: 5th grade, after mid-term evaluations; T3: 6th grade, after mid-term evaluations; T4: 8th grade, after mid-term evaluations). All three studies featured cross-sectional and longitudinal analyses, separating, and comparing the subject domains of mathematics and German.
Study 1 provided an investigation of academic boredom’s factorial structure alongside correlational and reciprocal relations of different forms of boredom and academic self-concept. Analyses included reciprocal effects models and latent correlation analyses. Results indicated separability of boredom intensity, boredom due to underchallenge and boredom due to overchallenge, as separate, correlated factors. Evidence for reciprocal relations between boredom and academic self-concept was limited.
Study 2 examined the effectiveness and efficacy of full-time ability grouping for as a boredom intervention directed at the intellectually gifted. Analyses included propensity score matching, and latent growth curve modelling. Results pointed to limited effectiveness and efficacy for full-time ability grouping regarding boredom reduction.
Study 3 explored gender differences in academic boredom development, mediated by academic interest, academic self-concept, and previous academic achievement. Analyses included measurement invariance testing, and multiple-indicator-multi-cause-models. Results showed one-sided gender differences, with boys reporting less favorable boredom development compared to girls, even beyond the inclusion of relevant mediators.
Findings from all three studies were embedded into the theoretical framework of control-value theory (Pekrun, 2006; 2019; Pekrun et al., 2023). Limitations, directions for future research, and practical implications were acknowledged and discussed.
Overall, this dissertation yielded important insights into boredom’s conceptual complexity. This concerned factorial structure, developmental trajectories, interrelations to other learning variables, individual differences, and domain specificities.
Keywords: Academic boredom, boredom intensity, boredom due to underchallenge, boredom due to overchallenge, ability grouping, gender differences, longitudinal data analysis, control-value theory