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This thesis considers the general task of computing a partition of a set of given objects such that each set of the partition has a cardinality of at least a fixed number k. Among such kinds of partitions, which we call k-clusters, the objective is to find the k-cluster which minimises a certain cost derived from a given pairwise difference between objects which end up the same set. As a first step, this thesis introduces a general problem, denoted by (||.||,f)-k-cluster, which models the task to find a k-cluster of minimum cost given by an objective function computed with respect to specific choices for the cost functions f and ||.||. In particular this thesis considers three different choices for f and also three different choices for ||.|| which results in a total of nine different variants of the general problem. Especially with the idea to use the concept of parameterised approximation, we first investigate the role of the lower bound on the cluster cardinalities and find that k is not a suitable parameter, due to remaining NP-hardness even for the restriction to the constant 3. The reductions presented to show this hardness yield the even stronger result which states that polynomial time approximations with some constant performance ratio for any of the nine variants of (||.||,f)-k-cluster require a restriction to instances for which the pairwise distance on the objects satisfies the triangle inequality. For this restriction to what we informally refer to as metric instances, constant-factor approximation algorithms for eight of the nine variants of (||.||,f)-k-cluster are presented. While two of these algorithms yield the provably best approximation ratio (assuming P!=NP), others can only guarantee a performance which depends on the lower bound k. With the positive effect of the triangle inequality and applications to facility location in mind, we discuss the further restriction to the setting where the given objects are points in the Euclidean metric space. Considering the effect of computational hardness caused by high dimensionality of the input for other related problems (curse of dimensionality) we check if this is also the source of intractability for (||.||,f)-k-cluster. Remaining NP-hardness for restriction to small constant dimensionality however disproves this theory. We then use parameterisation to develop approximation algorithms for (||.||,f)-k-cluster without restriction to metric instances. In particular, we discuss structural parameters which reflect how much the given input differs from a metric. This idea results in parameterised approximation algorithms with parameters such as the number of conflicts (our name for pairs of objects for which the triangle inequality is violated) or the number of conflict vertices (objects involved in a conflict). The performance ratios of these parameterised approximations are in most cases identical to those of the approximations for metric instances. This shows that for most variants of (||.||,f)-k-cluster efficient and reasonable solutions are also possible for non-metric instances.

Reptiles belong to a taxonomic group characterized by increasing worldwide population declines. However, it has not been until comparatively recent years that public interest in these taxa has increased, and conservation measures are starting to show results. While many factors contribute to these declines, environmental pollution, especially in form of pesticides, has seen a strong increase in the last few decades, and is nowadays considered a main driver for reptile diversity loss. In light of the above, and given that reptiles are extremely underrepresented in ecotoxicological studies regarding the effects of plant protection products, this thesis aims at studying the impacts of pesticide exposure in reptiles, by using the Common wall lizard (Podarcis muralis) as model species. In a first approach, I evaluated the risk of pesticide exposure for reptile species within the European Union, as a means to detect species with above average exposure probabilities and to detect especially sensitive reptile orders. While helpful to detect species at risk, a risk evaluation is only the first step towards addressing this problem. It is thus indispensable to identify effects of pesticide exposure in wildlife. For this, the use of enzymatic biomarkers has become a popular method to study sub-individual responses, and gain information regarding the mode of action of chemicals. However, current methodologies are very invasive. Thus, in a second step, I explored the use of buccal swabs as a minimally invasive method to detect changes in enzymatic biomarker activity in reptiles, as an indicator for pesticide uptake and effects at the sub-individual level. Finally, the last part of this thesis focuses on field data regarding pesticide exposure and its effects on reptile wildlife. Here, a method to determine pesticide residues in food items of the Common wall lizard was established, as a means to generate data for future dietary risk assessments. Subsequently, a field study was conducted with the aim to describe actual effects of pesticide exposure on reptile populations at different levels.

The Harmonic Faber Operator
(2018)

P. K. Suetin points out in the beginning of his monograph "Faber
Polynomials and Faber Series" that Faber polynomials play an important
role in modern approximation theory of a complex variable as they
are used in representing analytic functions in simply connected domains,
and many theorems on approximation of analytic functions are proved
with their help [50].
In 1903, the Faber polynomials were firstly discovered by G. Faber. It was Faber's aim to find a generalisation of Taylor
series of holomorphic functions in the open unit disc D
in the following way. As any holomorphic function in D
has a Taylor series representation
f(z)=\sum_{\nu=0}^{\infty}a_{\nu}z^{\nu} (z\in\D)
converging locally uniformly inside D, for a simply connected
domain G, Faber wanted to determine a system of polynomials (Q_n)
such that each function f being holomorphic in G can be expanded
into a series
f=\sum_{\nu=0}^{\infty}b_{\nu}Q_{\nu}
converging locally uniformly inside G. Having this goal in mind,
Faber considered simply connected domains bounded by an analytic Jordan
curve. He constructed a system of polynomials (F_n)
with this property. These polynomials F_n were named after him
as Faber polynomials. In the preface of [50],
a detailed summary of results concerning Faber polynomials and results
obtained by the aid of them is given.
An important application of Faber polynomials is e.g. the transfer
of known assertions concerning polynomial approximation of functions
belonging to the disc algebra to results of the approximation of functions
being continuous on a compact continuum K which contains at least
two points and has a connected complement and being holomorphic in
the interior of K. In this field, the Faber operator
denoted by T turns out to be a powerful tool (for
an introduction, see e.g. D. Gaier's monograph). It
assigns a polynomial of degree at most n given in the monomial
basis \sum_{\nu=0}^{n}a_{\nu}z^{\nu} with a polynomial of degree
at most n given in the basis of Faber polynomials \sum_{\nu=0}^{n}a_{\nu}F_{\nu}.
If the Faber operator is continuous with respect to the uniform norms,
it has a unique continuous extension to an operator mapping the disc
algebra onto the space of functions being continuous on the whole
compact continuum and holomorphic in its interior. For all f being
element of the disc algebra and all polynomials P, via the obvious
estimate for the uniform norms
||T(f)-T(P)||<= ||T|| ||f-P||,
it can be seen that the original task of approximating F=T(f)
by polynomials is reduced to the polynomial approximation of the function
f. Therefore, the question arises under which conditions the Faber
operator is continuous and surjective. A fundamental result in this
regard was established by J. M. Anderson and J. Clunie who showed
that if the compact continuum is bounded by a rectifiable Jordan curve
with bounded boundary rotation and free from cusps, then the Faber
operator with respect to the uniform norms is a topological isomorphism.
Now, let f be a harmonic function in D.
Similar as above, we find that f has a uniquely determined representation
f=\sum_{\nu=-\infty}^{\infty}a_{\nu}p_{\nu}
converging locally uniformly inside D where p_{n}(z)=z^{n}
for n\in\N_{0} and p_{-n}(z)=\overline{z}^{n}
for n\in\N}. One may ask whether there is an analogue for
harmonic functions on simply connected domains G. Indeed, for a
domain G bounded by an analytic Jordan curve, the conjecture that
each function f being harmonic in G has a uniquely determined
representation
f=\sum_{\nu=-\infty}^{\infty}b_{\nu}F_{\nu}
where F_{-n}(z)=\overline{F_{n}(z\)} for n\inN,
converging locally uniformly inside G, holds true.
Let now K be a compact continuum containing at least two points
and having a connected complement. A main component of this thesis
will be the examination of the harmonic Faber operator mapping a harmonic
polynomial given in the basis of the harmonic monomials \sum_{\nu=-n}^{n}a_{\nu}p_{\nu}
to a harmonic polynomial given as \sum_{\nu=-n}^{n}a_{\nu}F_{\nu}.
If this operator, which is based on an idea of J. Müller,
is continuous with respect to the uniform norms, it has a unique continuous
extension to an operator mapping the functions being continuous on
\partial\D onto the continuous functions on K being
harmonic in the interior of K. Harmonic Faber polynomials and the
harmonic Faber operator will be the objects accompanying us throughout
our whole discussion.
After having given an overview about notations and certain tools we
will use in our consideration in the first chapter, we begin our studies
with an introduction to the Faber operator and the harmonic Faber
operator. We start modestly and consider domains bounded by an analytic
Jordan curve. In Section 2, as a first
result, we will show that, for such a domain G, the harmonic Faber
operator has a unique continuous extension to an operator mapping
the space of the harmonic functions in D onto the space
of the harmonic functions in G, and moreover, the harmonic Faber
operator is an isomorphism with respect to the topologies of locally
uniform convergence. In the further sections of this chapter, we illumine
the behaviour of the (harmonic) Faber operator on certain function
spaces.
In the third chapter, we leave the situation of compact continua bounded
by an analytic Jordan curve. Instead we consider closures of domains
bounded by Jordan curves having a Dini continuous curvature. With
the aid of the concept of compact operators and the Fredholm alternative,
we are able to show that the harmonic Faber operator is a topological
isomorphism.
Since, in particular, the main result of the third chapter holds true
for closures K of domains bounded by analytic Jordan curves, we
can make use of it to obtain new results concerning the approximation
of functions being continuous on K and harmonic in the interior
of K by harmonic polynomials. To do so, we develop techniques applied
by L. Frerick and J. Müller in [11] and adjust them to
our setting. So, we can transfer results about the classic Faber operator
to the harmonic Faber operator.
In the last chapter, we will use the theory of harmonic Faber polynomials
to solve certain Dirichlet problems in the complex plane. We pursue
two different approaches: First, with a similar philosophy as in [50],
we develop a procedure to compute the coefficients of a series \sum_{\nu=-\infty}^{\infty}c_{\nu}F_{\nu}
converging uniformly to the solution of a given Dirichlet problem.
Later, we will point out how semi-infinite programming with harmonic
Faber polynomials as ansatz functions can be used to get an approximate
solution of a given Dirichlet problem. We cover both approaches first
from a theoretical point of view before we have a focus on the numerical
implementation of concrete examples. As application of the numerical
computations, we considerably obtain visualisations of the concerned
Dirichlet problems rounding out our discussion about the harmonic
Faber polynomials and the harmonic Faber operator.

Optimal Control of Partial Integro-Differential Equations and Analysis of the Gaussian Kernel
(2018)

An important field of applied mathematics is the simulation of complex financial, mechanical, chemical, physical or medical processes with mathematical models. In addition to the pure modeling of the processes, the simultaneous optimization of an objective function by changing the model parameters is often the actual goal. Models in fields such as finance, biology or medicine benefit from this optimization step.
While many processes can be modeled using an ordinary differential equation (ODE), partial differential equations (PDEs) are needed to optimize heat conduction and flow characteristics, spreading of tumor cells in tissue as well as option prices. A partial integro-differential equation (PIDE) is a parital differential equation involving an integral operator, e.g., the convolution of the unknown function with a given kernel function. PIDEs occur for example in models that simulate adhesive forces between cells or option prices with jumps.
In each of the two parts of this thesis, a certain PIDE is the main object of interest. In the first part, we study a semilinear PIDE-constrained optimal control problem with the aim to derive necessary optimality conditions. In the second, we analyze a linear PIDE that includes the convolution of the unknown function with the Gaussian kernel.

The economic growth theory analyses which factors affect economic growth
and tries to analyze how it can last. A popular neoclassical growth model
is the Ramsey-Cass-Koopmans model, which aims to determine how much
of its income a nation or an economy should save in order to maximize its
welfare.
In this thesis, we present and analyze an extended capital accumulation equation of a spatial version of the Ramsey model, balancing diffusive and agglomerative effects. We model the capital mobility in space via a nonlocal
diffusion operator which allows for jumps of the capital stock from one lo-
cation to an other. Moreover, this operator smooths out heterogeneities in
the factor distributions slower, which generated a more realistic behavior of
capital flows. In addition to that, we introduce an endogenous productivity-
production operator which depends on time and on the capital distribution
in space. This operator models the technological progress of the economy.
The resulting mathematical model is an optimal control problem under a
semilinear parabolic integro-differential equation with initial and volume constraints, which are a nonlocal analog to local boundary conditions, and box-constraints on the state and the control variables. In this thesis, we consider
this problem on a bounded and unbounded spatial domain, in both cases with
a finite time horizon. We derive existence results of weak solutions for the
capital accumulation equations in both settings and we proof the existence
of a Ramsey equilibrium in the unbounded case. Moreover, we solve the
optimal control problem numerically and discuss the results in the economic
context.

The implicit power motive is one of the most researched motives in motivational
psychology—at least in adults. Children have rarely been subject to investigation and there
are virtually no results on behavioral and affective correlates of the implicit power motive in
children. As behavior and affect are important components of conceptual validation, the
empirical data in this dissertation focused on identifying three correlates, namely resource
control behavior (study 1), power stress (study 2), and persuasive behavior (study 3). In each
study, the implicit power motive was measured via the Picture Story Exercise, using an
adapted version for children. Children across samples were between 4 and 11 years old.
Results from study 1 and 2 showed that children’s power-related behavior corresponded with
evidence from adult samples: children with a high implicit power motive secure attractive
resources and show negative reactions to a thwarted attempt to exert influence. Study 3
contradicted existing evidence with adults in that children’s persuasive behavior was not
associated with nonverbal, but with verbal strategies of persuasion. Despite this inconsistency,
these results are, together with the validation of a child-friendly Picture Story Exercise
version, an important step into further investigating and confirming the concept of the implicit
power motive and how to measure it in children.

Early life adversity (ELA) poses a high risk for developing major health problems in adulthood including cardiovascular and infectious diseases and mental illness. However, the fact that ELA-associated disorders first become manifest many years after exposure raises questions about the mechanisms underlying their etiology. This thesis focuses on the impact of ELA on startle reflexivity, physiological stress reactivity and immunology in adulthood.
The first experiment investigated the impact of parental divorce on affective processing. A special block design of the affective startle modulation paradigm revealed blunted startle responsiveness during presentation of aversive stimuli in participants with experience of parental divorce. Nurture context potentiated startle in these participants suggesting that visual cues of childhood-related content activates protective behavioral responses. The findings provide evidence for the view that parental divorce leads to altered processing of affective context information in early adulthood.
A second investigation was conducted to examine the link between aging of the immune system and long-term consequences of ELA. In a cohort of healthy young adults, who were institutionalized early in life and subsequently adopted, higher levels of T cell senescence were observed compared to parent-reared controls. Furthermore, the results suggest that ELA increases the risk of cytomegalovirus infection in early childhood, thereby mediating the effect of ELA on T cell-specific immunosenescence.
The third study addresses the effect of ELA on stress reactivity. An extended version of the Cold Pressor Test combined with a cognitive challenging task revealed blunted endocrine response in adults with a history of adoption while cardiovascular stress reactivity was similar to control participants. This pattern of response separation may best be explained by selective enhancement of central feedback-sensitivity to glucocorticoids resulting from ELA, in spite of preserved cardiovascular/autonomic stress reactivity.

Fostering positive and realistic self-concepts of individuals is a major goal in education worldwide (Trautwein & Möller, 2016). Individuals spend most of their childhood and adolescence in school. Thus, schools are important contexts for individuals to develop positive self-perceptions such as self-concepts. In order to enhance positive self-concepts in educational settings and in general, it is indispensable to have a comprehensive knowledge about the development and structure of self-concepts and their determinants. To date, extensive empirical and theoretical work on antecedents and change processes of self-concept has been conducted. However, several research gaps still exist, and several of these are the focus of the present dissertation. Specifically, these research gaps encompass (a) the development of multiple self-concepts from multiple perspectives regarding stability and change, (b) the direction of longitudinal interplay between self-concept facets over the entire time period from childhood to late adolescence, and (c) the evidence that a recently developed structural model of academic self-concept (nested Marsh/Shavelson model [Brunner et al., 2010]) fits the data in elementary school students, (d) the investigation of structural changes in academic self-concept profile formation within this model, (e) the investigation of dimensional comparison processes as determinants of academic self-concept profile formation in elementary school students within the internal/external frame of reference model (I/E model; Marsh, 1986), (f) the test of moderating variables for dimensional comparison processes in elementary school, (g) the test of the key assumptions of the I/E model that effects of dimensional comparisons depend to a large degree on the existence of achievement differences between subjects, and (h) the generalizability of the findings regarding the I/E model over different statistical analytic methods. Thus, the aim of the present dissertation is to contribute to close these gaps with three studies. Thereby, data from German students enrolled in elementary school to secondary school education were gathered in three projects comprising the developmental time span from childhood to adolescence (ages 6 to 20). Three vital self-concept areas in childhood and adolescence were in-vestigated: general self-concept (i.e., self-esteem), academic self-concepts (general, math, reading, writing, native language), and social self-concepts (of acceptance and assertion). In all studies, data were analyzed within a latent variable framework. Findings are discussed with respect to the research aims of acquiring more comprehensive knowledge on the structure and development of significant self-concept in childhood and adolescence and their determinants. In addition, theoretical and practical implications derived from the findings of the present studies are outlined. Strengths and limitations of the present dissertation are discussed. Finally, an outlook for future research on self-concepts is given.

Industrial companies mainly aim for increasing their profit. That is why they intend to reduce production costs without sacrificing the quality. Furthermore, in the context of the 2020 energy targets, energy efficiency plays a crucial role. Mathematical modeling, simulation and optimization tools can contribute to the achievement of these industrial and environmental goals. For the process of white wine fermentation, there exists a huge potential for saving energy. In this thesis mathematical modeling, simulation and optimization tools are customized to the needs of this biochemical process and applied to it. Two different models are derived that represent the process as it can be observed in real experiments. One model takes the growth, division and death behavior of the single yeast cell into account. This is modeled by a partial integro-differential equation and additional multiple ordinary integro-differential equations showing the development of the other substrates involved. The other model, described by ordinary differential equations, represents the growth and death behavior of the yeast concentration and development of the other substrates involved. The more detailed model is investigated analytically and numerically. Thereby existence and uniqueness of solutions are studied and the process is simulated. These investigations initiate a discussion regarding the value of the additional benefit of this model compared to the simpler one. For optimization, the process is described by the less detailed model. The process is identified by a parameter and state estimation problem. The energy and quality targets are formulated in the objective function of an optimal control or model predictive control problem controlling the fermentation temperature. This means that cooling during the process of wine fermentation is controlled. Parameter and state estimation with nonlinear economic model predictive control is applied in two experiments. For the first experiment, the optimization problems are solved by multiple shooting with a backward differentiation formula method for the discretization of the problem and a sequential quadratic programming method with a line search strategy and a Broyden-Fletcher-Goldfarb-Shanno update for the solution of the constrained nonlinear optimization problems. Different rounding strategies are applied to the resulting post-fermentation control profile. Furthermore, a quality assurance test is performed. The outcomes of this experiment are remarkable energy savings and tasty wine. For the next experiment, some modifications are made, and the optimization problems are solved by using direct transcription via orthogonal collocation on finite elements for the discretization and an interior-point filter line-search method for the solution of the constrained nonlinear optimization problems. The second experiment verifies the results of the first experiment. This means that by the use of this novel control strategy energy conservation is ensured and production costs are reduced. From now on tasty white wine can be produced at a lower price and with a clearer conscience at the same time.

Given a compact set K in R^d, the theory of extension operators examines the question, under which conditions on K, the linear and continuous restriction operators r_n:E^n(R^d)→E^n(K),f↦(∂^α f|_K)_{|α|≤n}, n in N_0 and r:E(R^d)→E(K),f↦(∂^α f|_K)_{α in N_0^d}, have a linear and continuous right inverse. This inverse is called extension operator and this problem is known as Whitney's extension problem, named after Hassler Whitney. In this context, E^n(K) respectively E(K) denote spaces of Whitney jets of order n respectively of infinite order. With E^n(R^d) and E(R^d), we denote the spaces of n-times respectively infinitely often continuously partially differentiable functions on R^d. Whitney already solved the question for finite order completely. He showed that it is always possible to construct a linear and continuous right inverse E_n for r_n. This work is concerned with the question of how the existence of a linear and continuous right inverse of r, fulfilling certain continuity estimates, can be characterized by properties of K. On E(K), we introduce a full real scale of generalized Whitney seminorms (|·|_{s,K})_{s≥0}, where |·|_{s,K} coincides with the classical Whitney seminorms for s in N_0. We equip also E(R^d) with a family (|·|_{s,L})_{s≥0} of those seminorms, where L shall be a a compact set with K in L-°. This family of seminorms on E(R^d) suffices to characterize the continuity properties of an extension operator E, since we can without loss of generality assume that E(E(K)) in D^s(L).
In Chapter 2, we introduce basic concepts and summarize the classical results of Whitney and Stein.
In Chapter 3, we modify the classical construction of Whitney's operators E_n and show that |E_n(·)|_{s,L}≤C|·|_{s,K} for s in[n,n+1).
In Chapter 4, we generalize a result of Frerick, Jordá and Wengenroth and show that LMI(1) for K implies the existence of an extension operator E without loss of derivatives, i.e. we have it fulfils |E(·)|_{s,L}≤C|·|_{s,K} for all s≥0. We show that a large class of self similar sets, which includes the Cantor set and the Sierpinski triangle, admits an extensions operator without loss of derivatives.
In Chapter 5 we generalize a result of Frerick, Jordá and Wengenroth and show that WLMI(r) for r≥1 implies the existence of a tame linear extension operator E having a homogeneous loss of derivatives, such that |E(·)|_{s,L}≤C|·|_{(r+ε)s,K} for all s≥0 and all ε>0.
In the last chapter we characterize the existence of an extension operator having an arbitrary loss of derivatives by the existence of measures on K.