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- Fachbereich 2 (7)
- Fachbereich 6 (7)
Left ventricular assist devices (LVADs) have become a valuable treatment for patients with advanced heart failure. Women appear to be disadvantaged in the usage of LVADs and concerning clinical outcomes such as death and adverse events after LVAD implant. Contrary to typical clinical characteristics (e.g., disease severity), device-related factors such as the intended device strategy, bridge to a heart transplantation or destination therapy, are often not considered in research on gender differences. In addition, the relevance of pre-implant psychosocial risk factors, such as substance abuse and limited social support, for LVAD outcomes is currently unclear. Thus, the aim of this dissertation is to explore the role of pre-implant psychosocial risk factors for gender differences in clinical outcomes, accounting for clinical and device-related risk factors.
In the first article, gender differences in pre-implant characteristics of patients registered in The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) were investigated. It was found that women and men differed in multiple pre-implant characteristics depending on device strategy. In the second article, gender differences in major clinical outcomes (i.e., death, heart transplant, device explant due to cardiac recovery, device replacement due to complications) were evaluated for patients in the device strategy destination therapy in the Interagency Registry for Mechanically Assisted Circulation (INTERMACS). Additionally, the association of gender and psychosocial risk factors with the major outcomes were analyzed. Women had similar probabilities to die on LVAD support, and even higher probabilities to experience explant of the device due to cardiac recovery compared with men in the destination therapy subgroup. Pre-implant psychosocial risk factors were not associated with major outcomes. The third article focused on gender differences in 10 adverse events (e.g., device malfunction, bleeding) after LVAD implant in INTERMACS. The association of a psychosocial risk indicator with gender and adverse events after LVAD implantation was evaluated. Women were less likely to have psychosocial risk pre-implant but more likely to experience seven out of 10 adverse events compared with men. Pre-implant psychosocial risk was associated with adverse events, even suggesting a dose response-relationship. These associations appeared to be more pronounced in women.
In conclusion, women appear to have similar survival to men when accounting for device strategy. They have higher probabilities of recovery, but higher probabilities of device replacement and adverse events compared with men. Regarding these adverse events, women may be more susceptible to psychosocial risk factors than men. The results of this dissertation illustrate the importance of gender-sensitive research and suggest considering device strategy when studying gender differences in LVAD recipients. Further research is warranted to elucidate the role of specific psychosocial risk factors that lead to higher probabilities of adverse events, to intervene early and improve patient care in both, women and men
Knowledge acquisition comprises various processes. Each of those has its dedicated research domain. Two examples are the relations between knowledge types and the influences of person-related variables. Furthermore, the transfer of knowledge is another crucial domain in educational research. I investigated these three processes through secondary analyses in this dissertation. Secondary analyses comply with the broadness of each field and yield the possibility of more general interpretations. The dissertation includes three meta-analyses: The first meta-analysis reports findings on the predictive relations between conceptual and procedural knowledge in mathematics in a cross-lagged panel model. The second meta-analysis focuses on the mediating effects of motivational constructs on the relationship between prior knowledge and knowledge after learning. The third meta-analysis deals with the effect of instructional methods in transfer interventions on knowledge transfer in school students. These three studies provide insights into the determinants and processes of knowledge acquisition and transfer. Knowledge types are interrelated; motivation mediates the relation between prior and later knowledge, and interventions influence knowledge transfer. The results are discussed by examining six key insights that build upon the three studies. Additionally, practical implications, as well as methodological and content-related ideas for further research, are provided.
When humans encounter attitude objects (e.g., other people, objects, or constructs), they evaluate them. Often, these evaluations are based on attitudes. Whereas most research focuses on univalent (i.e., only positive or only negative) attitude formation, little research exists on ambivalent (i.e., simultaneously positive and negative) attitude formation. Following a general introduction into ambivalence, I present three original manuscripts investigating ambivalent attitude formation. The first manuscript addresses ambivalent attitude formation from previously univalent attitudes. The results indicate that responding to a univalent attitude object incongruently leads to ambivalence measured via mouse tracking but not ambivalence measured via self-report. The second manuscript addresses whether the same number of positive and negative statements presented block-wise in an impression formation task leads to ambivalence. The third manuscript also used an impression formation task and addresses the question of whether randomly presenting the same number of positive and negative statements leads to ambivalence. Additionally, the effect of block size of the same valent statements is investigated. The results of the last two manuscripts indicate that presenting all statements of one valence and then all statements of the opposite valence leads to ambivalence measured via self-report and mouse tracking. Finally, I discuss implications for attitude theory and research as well as future research directions.
This thesis contains four parts that are all connected by their contributions to the Efficient Market Hypothesis and decision-making literature. Chapter two investigates how national stock market indices reacted to the news of national lockdown restrictions in the period from January to May 2020. The results show that lockdown restrictions led to different reactions in a sample of OECD and BRICS countries: there was a general negative effect resulting from the increase in lockdown restrictions, but the study finds strong evidence for underreaction during the lockdown announcement, followed by some overreaction that is corrected subsequently. This under-/overreaction pattern, however, is observed mostly during the first half of our time series, pointing to learning effects. Relaxation of the lockdown restrictions, on the other hand, had a positive effect on markets only during the second half of our sample, while for the first half of the sample, the effect was negative. The third chapter investigates the gender differences in stock selection preferences on the Taiwan Stock Exchange. By utilizing trading data from the Taiwan Stock Exchange over a span of six years, it becomes possible to analyze trading behavior while minimizing the self-selection bias that is typically present in brokerage data. To study gender differences, this study uses firm-level data. The percentage of male traders in a company is the dependent variable, while the company’s industry and fundamental/technical aspects serve as independent variables. The results show that the percentage of women trading a company rises with a company’s age, market capitalization, a company’s systematic risk, and return. Men trade more frequently and show a preference for dividend-paying stocks and for industries with which they are more familiar. The fourth chapter investigated the relationship between regret and malicious and benign envy. The relationship is analyzed in two different studies. In experiment 1, subjects had to fill out psychological scales that measured regret, the two types of envy, core self-evaluation and the big 5 personality traits. In experiment 2, felt regret is measured in a hypothetical scenario, and the subject’s felt regret was regressed on the other variables mentioned above. The two experiments revealed that there is a positive direct relationship between regret and benign envy. The relationship between regret and malicious envy, on the other hand, is mostly an artifact of core self-evaluation and personality influencing both malicious envy and regret. The relationship can be explained by the common action tendency of self-improvement for regret and benign envy. Chapter five discusses the differences in green finance regulation and implementation between the EU and China. China introduced the Green Silk Road, while the EU adopted the Green Deal and started working with its own green taxonomy. The first difference comes from the definition of green finance, particularly with regard to coal-fired power plants. Especially the responsibility of nation-states’ emissions abroad. China is promoting fossil fuel projects abroad through its Belt and Road Initiative, but the EU’s Green Deal does not permit such actions. Furthermore, there are policies in both the EU and China that create contradictory incentives for economic actors. On the one hand, the EU and China are improving the framework conditions for green financing while, on the other hand, still allowing the promotion of conventional fuels. The role of central banks is also different between the EU and China. China’s central bank is actively working towards aligning the financial sector with green finance. A possible new role of the EU central bank or the priority financing of green sectors through political decision-making is still being debated.
Social entrepreneurship is a successful activity to solve social problems and economic
challenges. Social entrepreneurship uses for-profit industry techniques and tools to build
financially sound businesses that provide nonprofit services. Social entrepreneurial activities
also lead to the achievement of sustainable development goals. However, due to the complex,
hybrid nature of the business, social entrepreneurial activities are typically supported by macrolevel
determinants. To expand our knowledge of how beneficial macro-level determinants can
be, this work examines empirical evidence about the impact of macro-level determinants on
social entrepreneurship. Another aim of this dissertation is to examine the impact at the micro
level, as the growth ambitions of social and commercial entrepreneurs differ. At the beginning,
the introductory section is explained in Chapter 1, which contains the motivation for the
research, the research question, and the structure of the work.
There is an ongoing debate about the origin and definition of social entrepreneurship.
Therefore, the numerous phenomena of social entrepreneurship are examined theoretically in
the previous literature. To determine the common consensus on the topic, Chapter 2 presents
the theoretical foundations and definition of social entrepreneurship. The literature shows that
a variety of determinants at the micro and macro levels are essential for the emergence of social
entrepreneurship as a distinctive business model (Hartog & Hoogendoorn, 2011; Stephan et
al., 2015; Hoogendoorn, 2016). It is impossible to create a society based on a social mission without the support of micro and macro-level-level determinants. This work examines the
determinants and consequences of social entrepreneurship from different methodological
perspectives. The theoretical foundations of the micro- and macro-level determinants
influencing social entrepreneurial activities were discussed in Chapter 3
The purpose of reproducibility in research is to confirm previously published results
(Hubbard et al., 1998; Aguinis & Solarino, 2019). However, due to the lack of data, lack of
transparency of methodology, reluctance to publish, and lack of interest from researchers, there
is a lack of promoting replication of the existing research study (Baker, 2016; Hedges &
Schauer, 2019a). Promoting replication studies has been regularly emphasized in the business
and management literature (Kerr et al., 2016; Camerer et al., 2016). However, studies that
provide replicability of the reported results are considered rare in previous research (Burman
et al., 2010; Ryan & Tipu, 2022). Based on the research of Köhler and Cortina (2019), an
empirical study on this topic is carried out in Chapter 4 of this work.
Given this focus, researchers have published a large body of research on the impact of microand
macro-level determinants on social inclusion, although it is still unclear whether these
studies accurately reflect reality. It is important to provide conceptual underpinnings to the
field through a reassessment of published results (Bettis et al., 2016). The results of their
research make it abundantly clear that the macro determinants support social entrepreneurship.
In keeping with the more narrative approach, which is a crucial concern and requires attention,
Chapter 5 considered the reproducibility of previous results, particularly on the topic of social
entrepreneurship. We replicated the results of Stephan et al. (2015) to establish the trend of
reproducibility and validate the specific conclusions they drew. The literal and constructive
replication in the dissertation inspired us to explore technical replication research on social
entrepreneurship. Chapter 6 evaluates the fundamental characteristics that have proven to be key factors in the
growth of social ventures. The current debate reviews and references literature that has
specifically focused on the development of social entrepreneurship. An empirical analysis of
factors directly related to the ambitious growth of social entrepreneurship is also carried out.
Numerous social entrepreneurial groups have been studied concerning this association. Chapter
6 compares the growth ambitions of social and traditional (commercial) entrepreneurship as
consequences at the micro level. This study examined many characteristics of social and
commercial entrepreneurs' growth ambitions. Scholars have claimed to some extent that the
growth of social entrepreneurship differs from commercial entrepreneurial activities due to
objectivity differences (Lumpkin et al., 2013; Garrido-Skurkowicz et al., 2022). Qualitative
research has been used in studies to support the evidence on related topics, including Gupta et
al (2020) emphasized that research needs to focus on specific concepts of social
entrepreneurship for the field to advance. Therefore, this study provides a quantitative,
analysis-based assessment of facts and data. For this purpose, a data set from the Global
Entrepreneurship Monitor (GEM) 2015 was used, which examined 12,695 entrepreneurs from
38 countries. Furthermore, this work conducted a regression analysis to evaluate the influence
of various social and commercial characteristics of entrepreneurship on economic growth in
developing countries. Chapter 7 briefly explains future directions and practical/theoretical
implications.
Data fusions are becoming increasingly relevant in official statistics. The aim of a data fusion is to combine two or more data sources using statistical methods in order to be able to analyse different characteristics that were not jointly observed in one data source. Record linkage of official data sources using unique identifiers is often not possible due to methodological and legal restrictions. Appropriate data fusion methods are therefore of central importance in order to use the diverse data sources of official statistics more effectively and to be able to jointly analyse different characteristics. However, the literature lacks comprehensive evaluations of which fusion approaches provide promising results for which data constellations. Therefore, the central aim of this thesis is to evaluate a concrete plethora of possible fusion algorithms, which includes classical imputation approaches as well as statistical and machine learning methods, in selected data constellations.
To specify and identify these data contexts, data and imputation-related scenario types of a data fusion are introduced: Explicit scenarios, implicit scenarios and imputation scenarios. From these three scenario types, fusion scenarios that are particularly relevant for official statistics are selected as the basis for the simulations and evaluations. The explicit scenarios are the fulfilment or violation of the Conditional Independence Assumption (CIA) and varying sample sizes of the data to be matched. Both aspects are likely to have a direct, that is, explicit, effect on the performance of different fusion methods. The summed sample size of the data sources to be fused and the scale level of the variable to be imputed are considered as implicit scenarios. Both aspects suggest or exclude the applicability of certain fusion methods due to the nature of the data. The univariate or simultaneous, multivariate imputation solution and the imputation of artificially generated or previously observed values in the case of metric characteristics serve as imputation scenarios.
With regard to the concrete plethora of possible fusion algorithms, three classical imputation approaches are considered: Distance Hot Deck (DHD), the Regression Model (RM) and Predictive Mean Matching (PMM). With Decision Trees (DT) and Random Forest (RF), two prominent tree-based methods from the field of statistical learning are discussed in the context of data fusion. However, such prediction methods aim to predict individual values as accurately as possible, which can clash with the primary objective of data fusion, namely the reproduction of joint distributions. In addition, DT and RF only comprise univariate imputation solutions and, in the case of metric variables, artificially generated values are imputed instead of real observed values. Therefore, Predictive Value Matching (PVM) is introduced as a new, statistical learning-based nearest neighbour method, which could overcome the distributional disadvantages of DT and RF, offers a univariate and multivariate imputation solution and, in addition, imputes real and previously observed values for metric characteristics. All prediction methods can form the basis of the new PVM approach. In this thesis, PVM based on Decision Trees (PVM-DT) and Random Forest (PVM-RF) is considered.
The underlying fusion methods are investigated in comprehensive simulations and evaluations. The evaluation of the various data fusion techniques focusses on the selected fusion scenarios. The basis for this is formed by two concrete and current use cases of data fusion in official statistics, the fusion of EU-SILC and the Household Budget Survey on the one hand and of the Tax Statistics and the Microcensus on the other. Both use cases show significant differences with regard to different fusion scenarios and thus serve the purpose of covering a variety of data constellations. Simulation designs are developed from both use cases, whereby the explicit scenarios in particular are incorporated into the simulations.
The results show that PVM-RF in particular is a promising and universal fusion approach under compliance with the CIA. This is because PVM-RF provides satisfactory results for both categorical and metric variables to be imputed and also offers a univariate and multivariate imputation solution, regardless of the scale level. PMM also represents an adequate fusion method, but only in relation to metric characteristics. The results also imply that the application of statistical learning methods is both an opportunity and a risk. In the case of CIA violation, potential correlation-related exaggeration effects of DT and RF, and in some cases also of RM, can be useful. In contrast, the other methods induce poor results if the CIA is violated. However, if the CIA is fulfilled, there is a risk that the prediction methods RM, DT and RF will overestimate correlations. The size ratios of the studies to be fused in turn have a rather minor influence on the performance of fusion methods. This is an important indication that the larger dataset does not necessarily have to serve as a donor study, as was previously the case.
The results of the simulations and evaluations provide concrete implications as to which data fusion methods should be used and considered under the selected data and imputation constellations. Science in general and official statistics in particular benefit from these implications. This is because they provide important indications for future data fusion projects in order to assess which specific data fusion method could provide adequate results along the data constellations analysed in this thesis. Furthermore, with PVM this thesis offers a promising methodological innovation for future data fusions and for imputation problems in general.
Semantic-Aware Coordinated Multiple Views for the Interactive Analysis of Neural Activity Data
(2024)
Visualizing brain simulation data is in many aspects a challenging task. For one, data used in brain simulations and the resulting datasets is heterogeneous and insight is derived by relating all different kinds of it. Second, the analysis process is rapidly changing while creating hypotheses about the results. Third, the scale of data entities in these heterogeneous datasets is manifold, reaching from single neurons to brain areas interconnecting millions. Fourth, the heterogeneous data consists of a variety of modalities, e.g.: from time series data to connectivity data, from single parameters to a set of parameters spanning parameter spaces with multiple possible and biological meaningful solutions; from geometrical data to hierarchies and textual descriptions, all on mostly different scales. Fifth, visualizing includes finding suitable representations and providing real-time interaction while supporting varying analysis workflows. To this end, this thesis presents a scalable and flexible software architecture for visualizing, integrating and interacting with brain simulations data. The scalability and flexibility is achieved by interconnected services forming in a series of Coordinated Multiple View (CMV) systems. Multiple use cases are presented, introducing views leveraging this architecture, extending its ecosystem and resulting in a Problem Solving Environment (PSE) from which custom-tailored CMV systems can be build. The construction of such CMV system is assisted by semantic reasoning hence the term semantic-aware CMVs.
Allocating scarce resources efficiently is a major task in mechanism design. One of the most fundamental problems in mechanism design theory is the problem of selling a single indivisible item to bidders with private valuations for the item. In this setting, the classic Vickrey auction of~\citet{vickrey1961} describes a simple mechanism to implement a social welfare maximizing allocation.
The Vickrey auction for a single item asks every buyer to report its valuation and allocates the item to the highest bidder for a price of the second highest bid. This auction features some desirable properties, e.g., buyers cannot benefit from misreporting their true value for the item (incentive compatibility) and the auction can be executed in polynomial time.
However, when there is more than one item for sale and buyers' valuations for sets of items are not additive or the set of feasible allocations is constrained, then constructing mechanisms that implement efficient allocations and have polynomial runtime might be very challenging. Consider a single seller selling $n\in \N$ heterogeneous indivisible items to several bidders. The Vickrey-Clarke-Groves auction generalizes the idea of the Vickrey auction to this multi-item setting. Naturally, every bidder has an intrinsic value for every subset of items. As in in the Vickrey auction, bidders report their valuations (Now, for every subset of items!). Then, the auctioneer computes a social welfare maximizing allocation according to the submitted bids and charges buyers the social cost of their winning that is incurred by the rest of the buyers. (This is the analogue to charging the second highest bid to the winning bidder in the single item Vickrey auction.) It turns out that the Vickrey-Clarke-Groves auction is also incentive compatible but it poses some problems: In fact, say for $n=40$, bidders would have to submit $2^{40}-1$ values (one value for each nonempty subset of the ground set) in total. Thus, asking every bidder for its valuation might be impossible due to time complexity issues. Therefore, even though the Vickrey-Clarke-Groves auction implements a social welfare maximizing allocation in this multi-item setting it might be impractical and there is need for alternative approaches to implement social welfare maximizing allocations.
This dissertation represents the results of three independent research papers all of them tackling the problem of implementing efficient allocations in different combinatorial settings.
This cumulative thesis encompass three studies focusing on the Weddell Sea region in the Antarctic. The first study produces and evaluates a high quality data set of wind measurements for this region. The second study produces and evaluates a 15 year regional climate simulation for the Weddell Sea region. And the third study produces and evaluates a climatology of low level jets (LLJs) from the simulation data set. The evaluations were done in the attached three publications and the produced data sets are published online.
In 2015/2016, the RV Polarstern undertook an Antarctic expedition in the Weddell Sea. We operated a Doppler wind lidar on board during that time running different scan patterns. The resulting data was evaluated, corrected, processed and we derived horizontal wind speed and directions for vertical profiles with up to 2 km height. The measurements cover 38 days with a temporal resolution of 10-15 minutes. A comparisons with other radio sounding data showed only minor differences.
The resulting data set was used alongside other measurements to evaluate temperature and wind of simulation data. The simulation data was produced with the regional climate model CCLM for the period of 2002 to 2016 for the Weddell Sea region. Only smaller biases were found except for a strong warm bias during winter near the surface of the Antarctic Plateau. Thus we adapted the model setup and were able to remove the bias in a second simulation.
This new simulation data was then used to derive a climatology of low level jets (LLJs). Statistics of occurrence frequency, height and wind speed of LLJs for the Weddell Sea region are presented along other parameters. Another evaluation with measurements was also performed in the last study.
Official business surveys form the basis for national and regional business statistics and are thus of great importance for analysing the state and performance of the economy. However, both the heterogeneity of business data and their high dynamics pose a particular challenge to the feasibility of sampling and the quality of the resulting estimates. A widely used sampling frame for creating the design of an official business survey is an extract from an official business register. However, if this frame does not accurately represent the target population, frame errors arise. Amplified by the heterogeneity and dynamics of business populations, these errors can significantly affect the estimation quality and lead to inefficiencies and biases. This dissertation therefore deals with design-based methods for optimising business surveys with respect to different types of frame errors.
First, methods for adjusting the sampling design of business surveys are addressed. These approaches integrate auxiliary information about the expected structures of frame errors into the sampling design. The aim is to increase the number of sampled businesses that are subject to frame errors. The element-specific frame error probability is estimated based on auxiliary information about frame errors observed in previous samples. The approaches discussed consider different types of frame errors and can be incorporated into predefined designs with fixed strata.
As the second main pillar of this work, methods for adjusting weights to correct for frame errors during estimation are developed and investigated. As a result of frame errors, the assumptions under which the original design weights were determined based on the sampling design no longer hold. The developed methods correct the design weights taking into account the errors identified for sampled elements. Case-number-based reweighting approaches, on the one hand, attempt to reconstruct the unknown size of the individual strata in the target population. In the context of weight smoothing methods, on the other hand, design weights are modelled and smoothed as a function of target or auxiliary variables. This serves to avoid inefficiencies in the estimation due to highly scattering weights or weak correlations between weights and target variables. In addition, possibilities of correcting frame errors by calibration weighting are elaborated. Especially when the sampling frame shows over- and/or undercoverage, the inclusion of external auxiliary information can provide a significant improvement of the estimation quality. For those methods whose quality cannot be measured using standard procedures, a procedure for estimating the variance based on a rescaling bootstrap is proposed. This enables an assessment of the estimation quality when using the methods in practice.
In the context of two extensive simulation studies, the methods presented in this dissertation are evaluated and compared with each other. First, in the environment of an experimental simulation, it is assessed which approaches are particularly suitable with regard to different data situations. In a second simulation study, which is based on the structural survey in the services sector, the applicability of the methods in practice is evaluated under realistic conditions.