B/ordering the Anthropocene: Inter- and Transdisciplinary Perspectives on Nature-Culture Relations
(2020)
In and with this thematic issue we would like to invite you to engage in productive boundary work and to critically examine the relationship between nature and culture in the Anthropocene. A few years ago, the term Anthropocene was proposed by Paul Crutzen as a term for the current geological epoch, in which humankind (the ‘anthropos’) is seen as the central driving force for global changes in ecological systems. This epoch is characterized by the blurring of boundaries between society and nature, science and politics, as well as by the increased drawing of boundaries between social groups, lifestyles, and the Global North and Global South. With this issue, we would like to give an impetus to explore boundary phenomena in the relationship between nature and society, which up to now have not been the focus of Border Studies. The challenges and problems of the Anthropocene require cross-border thinking and research that stimulates a new reflexivity and commitment, to which the multidisciplinary field of Border Studies can contribute.
Fast and Slow Effects of Cortisol on Several Functions of the Central Nervous System in Humans
(2014)
Cortisol is one of the key substances released during stress to restore homeostasis. Our knowledge of the impact of this glucocorticoid on cognition and behavior in humans is, however, still limited. Two modes of action of cortisol are known, a rapid, nongenomic and a slow, genomic mode. Both mechanisms appear to be involved in mediating the various effects of stress on cognition. Here, three experiments are presented that investigated fast and slow effects of cortisol on several functions of the human brain. The first experiment investigated the interaction between insulin and slow, genomic cortisol effects on resting regional cerebral blood flow (rCBF) in 48 young men. A bilateral, locally distinct increase in rCBF in the insular cortex was observed 37 to 58 minutes after intranasal insulin admission. Cortisol did not influence rCBF, neither alone nor in interaction with insulin. This finding suggests that cortisol does not influence resting cerebral blood flow within a genomic timeframe. The second experiment examined fast cortisol effects on memory retrieval. 40 participants (20 of them female) learned associations between neutral male faces and social descriptions and were tested for recall one week later. Cortisol administered intravenously 8 minutes before retrieval influenced recall performance in an inverted U-shaped dose-response relationship. This study demonstrates a rapid, presumably nongenomic cortisol effect on memory retrieval in humans. The third experiment studied rapid cortisol effects on early multisensory integration. 24 male participants were tested twice in a focused cross-modal choice reaction time paradigm, once after cortisol and once after placebo infusion. Cortisol acutely enhanced the integration of visual targets and startling auditory distractors, when both stimuli appeared in the same sensory hemi-field. The rapidity of effect onset strongly suggests that cortisol changes multisensory integration by a nongenomic mechanism. The work presented in this thesis highlights the essential role of cortisol as a fast acting agent during the stress response. Both the second and the third experiment provide new evidence of nongenomic cortisol effects on human cognition and behavior. Future studies should continue to investigate the impact of rapid cortisol effects on the functioning of the human brain.