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Hydrodynamic processes play a fundamental role in the distribution of salt within mangrove-fringed estuaries and mangrove forests. In this thesis, two hydrodynamic processes and their ecological implications were examined. (1) Passive Irrigation and Functional Morphology of Crustacean Burrows in Rhizophora-forests. The mangrove Rhizophora excludes more than 90% of the seawater salt at water intake at the roots. By means of conductivity methods and resin casting, it was found that crustacean burrows play a key role in the removal of excess salt from the root zone. Salt diffuses from the roots into the burrows, and is efficiently flushed from the burrows by rainwater infiltration and tidal irrigation. The burrows contribute significantly to favourable conditions for the growth of Rhizophora trees. (2) Trapping of Mangrove Propagules due to Density-driven Secondary Circulation in Tropical Estuaries. In North East Australian estuaries, mangrove propagules are drifted upstream by density-driven axial surface convergences. Propagules accumulate in hydrodynamic traps upstream from suitable habitat, where they are trapped at least for the entire tropical dry season. Axial convergences may provide an efficient barrier for propagule exchange across estuaries. In such estuaries, mangrove populations can be regarded as floristically isolated, not unlike island communities, even though the populations lie on a continuous coastline. This effect may contribute to the disjunct distribution observed in some mangrove species. The outcomes of this work contribute to the understanding of the importance of salt as a growth and habitat-restricting factor in the mangrove environment.
During the last decade, anatomic and physiological neuroscience research has yielded extensive information on the physiological regulators of short-term satiety, visceral and interoceptive sensation. Distinct neural circuits regulate the elements of food ingestion physiologically. The general aim of the current studies is to elucidate the peripheral neural pathways to the brain in healthy subjects to establish the groundwork for the study of the pathophysiology of bulimia nervosa (BN). We aimed to define the central activation pattern during non-nutritive gastric distension in humans, and aimed to define the cognitive responses to this mechanical gastric distension. We estimated regional cerebral blood flow with 15O-water positron emission tomography during intragastric balloon inflation and deflation in 18 healthy young women of normal weight. The contrast between inflated minus deflated in the exploratory analysis revealed activation in more than 20 brain regions. The analysis confirmed several well known areas in the central nervous system that contribute to visceral processing: the inferior frontal cortex, representing a zone of convergence for food related stimuli; the insula and operculum referred to as "visceral cortex"; the anterior cingulate gyrus (and insula), processing affective information; and the brainstem, a site of vagal relay for visceral afferent stimuli. Brain activation in the left ventrolateral prefrontal cortex was reproducible. This area is well known for higher cognitive processing, especially reward-related stimuli. The ventrolateral prefrontal cortex with the insular regions may provide a link between the affective and rewarding components of eating and disordered eating as observed in BN and binge-eating obesity. Gastric distension caused a significant rapid, reversible, and reproducible increase in the feelings of fullness, sleepiness, and gastric discomfort as well as a significant rapid, reversible, and reproducible decrease in the feeling of hunger. We showed that mechanical activation of the neurocircuitry involved in meal termination led to the described phenomena. The current brain activation studies of non-painful, proximal gastric distension could provide groundwork in the field of abnormal eating behavior by suggesting a link between visceral sensation and abnormal eating patterns. A potential treatment for disordered eating and obesity could alter the conscious and unconscious perception and interoceptive awareness of gastric distension contributing to meal termination.
The main research question of this thesis was to set up a framework to allow for the identification of land use changes in drylands and reveal their underlying drivers. The concept of describing land cover change processes in a framework of global change syndrome was introduced by Schellnhuber et al. (1997). In a first step the syndrome approach was implemented for semi-natural areas of the Iberian Peninsula based on time series analysis of the MEDOKADS archive. In the subsequent study the approach was expanded and adapted to other land cover strata. Furthermore, results of an analysis of the relationship of annual NDVI and rainfall data were incorporated to designate areas that show a significant relationship indicating that at least a part of the variability found in NDVI time series was caused by precipitation. Additionally, a first step was taken towards the integration of socio-economic data into the analysis; population density changes between 1961 and 2008 were utilized to support the identification of processes related to land abandonment accompanied by cessation of agricultural practices on the one hand and urbanization on the other. The main findings of the studies comprise three major land cover change processes caused by human interaction: (i) shrub and woody vegetation encroachment in the wake of land abandonment of marginal areas, (ii) intensification of non-irrigated and irrigated, intensively used fertile regions and (iii) urbanization trends along the coastline caused by migration and the increase of mass tourism. Land abandonment of cultivated fields and the give-up of grazing areas in marginal mountainous areas often lead to the encroachment of shrubs and woody vegetation in the course of succession or reforestation. Whereas this cover change has positive effects concerning soil stabilization and carbon sequestration the increase of biomass involves also negative consequences for ecosystem goods and services; these include decreased water yield as a result of increased evapotranspiration, increasing fire risk, decreasing biodiversity due to landscape homogenization and loss of aesthetic value. Arable land in intensively used fertile zones of Spain was further intensified including the expansion of irrigated arable land. The intensification of agriculture has also generated land abandonment in these areas because less people are needed in the agricultural labour sector due to mechanization. Urbanization effects due to migration and the growth of the tourism sector were mapped along the eastern Mediterranean coast. Urban sprawl was only partly detectable by means of the MEDOKADS archive as the changes of urbanization are often too subtle to be detected by data with a spatial resolution of 1 km-². This is in line with a comparison of a Landsat TM time series and the NOAA AVHRR archive for a study area in the Greece that showed that small scale changes cannot be detected based on this approach, even though they might be of high relevance for local management of resources. This underlines the fact that land degradation processes are multi-scale problems and that data of several spatial and temporal scales are mandatory to build a comprehensive dryland observation system. Further land cover processes related to a decrease of greenness did not play an important role in the observation period. Thus, only few patches were identified, suggesting that no large-scale land degradation processes are taking place in the sense of decline of primary productivity after disturbances. Nevertheless, the land cover processes detected impact ecosystem functioning and using the example of shrub encroachment, bear risks for the provision of goods and services which can be valued as land degradation in the sense of a decline of important ecosystem goods and services. This risk is not only confined to the affected ecosystem itself but can also impact adjacent ecosystems due to inter-linkages. In drylands water availability is of major importance and the management of water resources is an important political issue. In view of climate change this topic will become even more important because aridity in Spain did increase within the last decades and is likely to further do so. In addition, the land cover changes detected by the syndrome approach could even augment water scarcity problems. Whereas the water yield of marginal areas, which often serve as headwaters of rivers, decreases with increasing biomass, water demand of agriculture and tourism is not expected to decline. In this context it will be of major importance to evaluate the trade-offs between different land uses and to take decisions that maintain the future functioning of the ecosystems for human well-being.
The human brain is characterised by two apparently symmetrical cerebral hemispheres. However, the functions attributed to each half of the brain are very distinct with a relative specialisation of the left hemisphere for language processing. Most laterality research has been performed on a behavioural level, using techniques such as visual half-field presentation. The visual half-field technique involves the presentation of stimuli in the left or right visual field for a very short time (about 200 ms). During the presentation of lateralized stimuli, the gaze of the participants is fixated on a centrally presented fixation cross. This technique takes advantage of the anatomy of the visual pathway as the temporal hemiretinae project ipsilateral, while the nasal hemiretinae project contralateral. Thus, stimuli presented in the left or right visual field are initially processed in the contralateral hemisphere. Language organisation can also be directly investigated using functional magnetic resonance imaging (fMRI). Both behavioural and neuroimaging studies showed that about 95% of right-handed men have a left hemispheric specialisation for language. In contrast, data on language organisation in women are ambiguous. It is supposed that this ambivalent picture might be associated with changes in gonadal steroid levels in blood during the menstrual cycle. However, gonadal steroid effects are complex and their role in functional cerebral lateralization is still open to discussion. The aim of this PhD project was to investigate, using fMRI: (1) the processing of linguistic information initially received in the specialised, non-specialised or both hemispheres; (2) linking the associated brain activation pattern with progesterone levels during the menstrual cycle. Firstly, brain activation was measured in 16 right-handed, healthy males during processing of different components of language (orthography, phonology and semantics) after reception in the left, right or both hemispheres. Secondly, to investigate changes in language organisation during the menstrual cycle, we conducted an event-related fMRI study during semantic and phonological processing also using visual half-field and central presentation of linguistic stimuli. Our results revealed higher BOLD signal intensity change in the visual cortex contralateral to the visual field of stimulus presentation compared to the ipsilateral visual cortex reflecting the crossing of visual pathways. We also found support for the hypothesis that the superiority of word recognition in the left VWFA is the result of a reduced activity in the right VWFA under left hemispheric control. Further, linguistic information received in the subdominant RH, is interhemispheric transferred to the left hemisphere for phonological processing. Semantic processing in contrast occurs in the specialised and in the non-specialised hemisphere. For the group of women, data analysis revealed that during semantic processing, salivary progesterone levels correlated positively with brain activity of the left superior frontal gyrus, left middle and inferior occipital gyri and bilateral fusiform gyrus. In contrast, the brain activation pattern for phonological processing did not change significantly across the menstrual cycle. In conclusion, the effect of serum progesterone levels on brain activity is task and region specific.
Today, usage of complex circuit designs in computers, in multimedia applications and communication devices is widespread and still increasing. At the same time, due to Moore's Law we do not expect to see an end in the growth of the complexity of digital circuits. The decreasing ability of common validation techniques -- like simulation -- to assure correctness of a circuit design enlarges the need for formal verification techniques. Formal verification delivers a mathematical proof that a given implementation of a design fulfills its specification. One of the basic and during the last years widely used data structure in formal verification are the so called Ordered Binary Decision Diagrams (OBDDs) introduced by R. Bryant in 1986. The topic of this thesis is integration of structural high-level information in the OBDD-based formal verification of sequential systems. This work consist of three major parts, covering different layers of formal verification applications: At the application layer, an assertion checking methodology, integrated in the verification flow of the high-level design and verification tool Protocol Compiler is presented. At the algorithmic layer, new approaches for partitioning of transition relations of complex finite state machines, that significantly improve the performance of OBDD-based sequential verification are introduced. Finally, at the data structure level, dynamic variable reordering techniques that drastically reduce the time required for reordering without a trade-off in OBDD-size are described. Overall, this work demonstrates how a tighter integration of applications by using structural information can significantly improve the efficiency of formal verification applications in an industrial setting.
This thesis presents a study of tsunami deposits created by the 2004 Indian Ocean tsunami at the Thai Andaman coast. The outcomes of a study are the characteristics of tsunami deposit for paleo-tsunami database, the identification of major sediment layers in tsunami deposit and the reconstructing tsunami run-ups from the characteristics of tsunami deposit for a coastal development program. The investigations of tsunami deposit are made almost 3 years after the event. Field investigations characterize the tsunami deposit as a distinct sediment layer variable in thickness of gray sand deposited with an erosional basis on a pre-existing soil. The best location for the observation of recent tsunami deposit is the area located about 50-200 m inland from the coastline. In most cases, the deposit layer is normally graded. In some cases, the deposit contains rip-up clasts of muddy soils and/or organic matters. The tsunami deposits are compared with three deposits from coastal sub-environments. The mean grain-size and standard deviation of deposits show that the shoreface deposits are fine to very fine sand, poorly to moderately well sorted; the swash zone deposits are coarse to fine sand, poorly to well sorted; the berm/dune deposits are medium to fine sand, poorly to well sorted; and the tsunami deposits are coarse to very fine sand, poorly to moderately well sorted. The plots of deposit mean grain-size versus sorting indicate that the tsunami deposits are composed of shoreface deposits, swash zone deposits and berm/dune deposits as well. The vertical variation of the texture of tsunami deposit shows that the mean grain-size fines upward and fining landward. The analysis and interpretation of the run-up numbers from the characteristics of tsunami deposits get three run-ups for the 2004 Indian Ocean tsunami at the Thai Andaman coast. It corresponds to field observations from the eye-witness reports and local people- affirmations. The total deposition is a major transportation pattern of onshore tsunami sediments. The sediments must fine in the direction of transport. In general, the major origins of the sediment are the swash zone and berm/dune zone where coarse to medium sand is a significant material, the minor origin of tsunami sediment is a shoreface where a significant material is fine to very fine sand. Only at an area with flat slope shorface, the major origin of tsunami sediment is the shoreface. The thicknesses, the mean grain-sizes, and the standard deviations of tsunami deposits are used to evaluate the influences of coastal morphology on the sediment characteristics. The evaluations show that the tsunami affected areas were attacked by the variable energy waves. Wave energies at the direct tsunami wave affected areas are higher than at the indirect tsunami wave affected areas. Tsunami wave energy is highly dissipated at an area with steep slope shoreface. In the same way, tsunami run-up energy is highly dissipated at an area with steep slope onshore. A channel paralleled to the coastline decreases the run-up velocity, slightly dissipates run-up energy. The road and pond highly influence the characteristics of tsunami deposit and tsunami run-up. A road obstructs the run-up velocity, dissipates run-up energy. A pond decreases run-up velocity, dissipates run-up energy. The characteristics of tsunami deposit can be interpreted for reconstructing the characteristics of tsunami run-up such as a run-up height and a flow velocity. Soulsby et al.(2007)- model is applied for reconstructing tsunami run-up at the study areas. The input parameters are sediment grain-size and sediment inundation distance. Ao Kheuy beach and Khuk Khak beach, Phang Nga province, Thailand are the areas listed for reconstructing tsunami run-up. The evaluated run-up heights are 4.2-4.9 m at Ao Kheuy beach, and 5.4-9.4 m at Khuk Khak beach. The evaluated run-up velocities are 12.8-19.2 m/s (maximum) and 0.2-1.9 m/s (mean) at the coastline and onshore, respectively. Hence, a reasonably good agreement between the evaluated and observed run-up is found. Tsunami run-up height and velocity can be used for coastal development and risk management in the tsunami affected areas. The case studies from the Thai Andaman coast suggest that in the area from coastline to about 70-140 m inland was flooded by the high velocity (high energy) run-ups, and those run-up energies were dissipated there. That area ought to be a non-residential area or a physical protection construction area (flood barrier, forest planting, etc.).
This meta-scientific dissertation comprises three research articles that investigated the reproducibility of psychological research. Specifically, they focused on the reproducibility of eye-tracking research on the one hand, and studying preregistration (i.e., the practice of publishing a study protocol before data collection or analysis) as one method to increase reproducibility on the other hand.
In Article I, it was demonstrated that eye-tracking data quality is influenced by both the utilized eye-tracker and the specific task it is measuring. That is, distinct strengths and weaknesses were identified in three devices (Tobii Pro X3-120, GP3 HD, EyeLink 1000+) in an extensive test battery. Consequently, both the device and specific task should be considered when designing new studies. Meanwhile, Article II focused on the current perception of preregistration in the psychological research community and future directions for improving this practice. The survey showed that many researchers intended to preregister their research in the future and had overall positive attitudes toward preregistration. However, various obstacles were identified currently hindering preregistration, which should be addressed to increase its adoption. These findings were supplemented by Article III, which took a closer look at one preregistration-specific tool: the PRP-QUANT Template. In a simulation trial and a survey, the template demonstrated high usability and emerged as a valuable resource to support researchers in using preregistration. Future revisions of the template could help to further facilitate this open science practice.
In this dissertation, the findings of the three articles are summarized and discussed regarding their implications and potential future steps that could be implemented to improve the reproducibility of psychological research.
The economic growth theory analyses which factors affect economic growth and tries to analyze how it can last. A popular neoclassical growth model is the Ramsey-Cass-Koopmans model, which aims to determine how much of its income a nation or an economy should save in order to maximize its welfare. In this thesis, we present and analyze an extended capital accumulation equation of a spatial version of the Ramsey model, balancing diffusive and agglomerative effects. We model the capital mobility in space via a nonlocal diffusion operator which allows for jumps of the capital stock from one location to an other. Moreover, this operator smooths out heterogeneities in the factor distributions slower, which generated a more realistic behavior of capital flows. In addition to that, we introduce an endogenous productivity-production operator which depends on time and on the capital distribution in space. This operator models the technological progress of the economy. The resulting mathematical model is an optimal control problem under a semilinear parabolic integro-differential equation with initial and volume constraints, which are a nonlocal analog to local boundary conditions, and box-constraints on the state and the control variables. In this thesis, we consider this problem on a bounded and unbounded spatial domain, in both cases with a finite time horizon. We derive existence results of weak solutions for the capital accumulation equations in both settings and we proof the existence of a Ramsey equilibrium in the unbounded case. Moreover, we solve the optimal control problem numerically and discuss the results in the economic context.
Hybrid Modelling in general, describes the combination of at least two different methods to solve one specific task. As far as this work is concerned, Hybrid Models describe an approach to combine sophisticated, well-studied mathematical methods with Deep Neural Networks to solve parameter estimation tasks. To combine these two methods, the data structure of artifi- cially generated acceleration data of an approximate vehicle model, the Quarter-Car-Model, is exploited. Acceleration of individual components within a coupled dynamical system, can be described as a second order ordinary differential equation, including velocity and dis- placement of coupled states, scaled by spring - and damping-coefficient of the system. An appropriate numerical integration scheme can then be used to simulate discrete acceleration profiles of the Quarter-Car-Model with a random variation of the parameters of the system. Given explicit knowledge about the data structure, one can then investigate under which con- ditions it is possible to estimate the parameters of the dynamical system for a set of randomly generated data samples. We test, if Neural Networks are capable to solve parameter estima- tion problems in general, or if they can be used to solve several sub-tasks, which support a state-of-the-art parameter estimation method. Hybrid Models are presented for parameter estimation under uncertainties, including for instance measurement noise or incompleteness of measurements, which combine knowledge about the data structure and several Neural Networks for robust parameter estimation within a dynamical system.
Service innovation has increasingly gained acknowledgement to contribute to economic growth and well-being. Despite this increased relevance in practice, service innovation is a developing research field. To advance literature on service innovation, this work analyzes with a qualitative study how firms manage service innovation activities in their organization differently. In addition, it evaluates the influence of top management commitment and corporate service innovativeness on service innovation capabilities of a firm and their implications for firm-level performance by conducting a quantitative study. Accordingly, the main overall research questions of this dissertation are: 1.) How and why do firms manage service innovation activities in their organization differently? 2.) What influence do top management commitment and corporate service innovativeness have on service innovation capabilities of a firm and what are the implications for firm-level performance? To respond to the first research question the way firms manage service innovation activities in their organization is investigated and by whom and how service innovations are developed. Moreover, it is examined why firms implement their service innovation activities differently. To achieve this a qualitative empirical study is conducted which included 22 semi-structured interviews with 15 firms in the sectors of construction, financial services, IT services, and logistics. Addressing the second research question, the aim is to improve the understanding about factors that enhance firm-level performance through service innovations. Deploying a dynamic capabilities perspective, a quantitative study is performed which underlines the importance of service innovation capabilities. More specifically, a theoretical framework is developed that proposes a positive relationship of top management commitment and corporate service innovativeness with service innovation capabilities and a positive relationship between service innovation capabilities and the firm-level performance indicators market performance, competitive advantage, and efficiency. A survey with double respondents from 87 companies from the sectors construction, financial services, IT services, and logistics was conducted to test the proposed theoretical framework by applying partial least squares structural equation modeling (PLS-SEM).
This thesis presents a study of the visual change detection mechanism. This mechanism is thought to be responsible for the detection of sudden and unexpected changes in our visual environment. As the brain is a capacity limited system and has to deal with a continuous stream of information from its surroundings only a part of the vast amount of information can be completely processed and be brought to conscious awareness. This information, which passes through attentional filters, is used for goal-directed behaviour. Therefore, the change detection mechanism is a very useful aid to cope with important information which is outside the focus of our attention. rnIt is thought that a neural memory trace of repetitive visual information is stored. Each new information input is compared to this existing memory trace by a so-called change or mismatch detection system. Following a sudden change, the comparison process leads to a mismatch and the detection system elicits a warning signal, to which an orienting response can follow. This involves a change in the focus of attention towards this sudden environmental change which can then be evaluated for potential danger and allows for a behavioural adaptation to the new situation. rnTo this purpose a paradigm was developed combining a 2-choice response time task with in the background a mismatch detection task of which the subjects were not aware. This paradigm was implemented in an ERP and an fMRI study and was used to study the the change detection mechanism and its relationship with impulsivity.rnIn previous studies a change detection system for auditory information had already been established. As the brain is a very efficient system it was thought to be unlikely that this change detection system is only available for the processing of auditory information. rnIndeed, a modality specific mismatch response at the sensory specific occipital cortex and a more general response at the frontocentral midline, both resembling the components shown in auditory research, were found in the ERP study.rnAdditionally, magnetic resonance imaging revealed a possible functional network of regions, which responded specifically to the processing of a deviant. These regions included the occipital gyrus, premotor cortex, inferior frontal cortex, thalamas, insula, and parts of the cingular cortex. rnThe relationship between impulsivity measures and visual change detection was established in an additional study. More impulsive subjects showed less detection of deviant stimuli, which was most likely due to too fast and imprecise information processing.rnIn summary it can be said, that the work presented in this thesis demonstrates that visual mismatch negativity was established, a number of regions could be associated with change detection and additionally the relevance of change detection in information processing was shown.rn
At any given moment, our senses are assaulted with a flood of information from the environment around us. We need to pick our way through all this information in order to be able to effectively respond to that what is relevant to us. In most cases we are usually able to select information relevant to our intentions from what is not relevant. However, what happens to the information that is not relevant to us? Is this irrelevant information completely ignored so that it does not affect our actions? The literature suggests that even though we mayrnignore an irrelevant stimulus, it may still interfere with our actions. One of the ways in which irrelevant stimuli can affect actions is by retrieving a response with which it was associated. An irrelevant stimulus that is presented in close temporal contiguity with a relevant stimulus can be associated with the response made to the relevant stimulus " an observation termed distractor-response binding (Rothermund, Wentura, & De Houwer, 2005). The studies presented in this work take a closer look at such distractor-response bindings, and therncircumstances in which they occur. Specifically, the study reported in chapter 6 examined whether only an exact repetition of the distractor can retrieve the response with which it was associated, or whether even similar distractors may cause retrieval. The results suggested that even repeating a similar distractor caused retrieval, albeit less than an exact repetition. In chapter 7, the existence of bindings between a distractor and a response were tested beyond arnperceptual level, to see whether they exist at an (abstract) conceptual level. Similar to perceptual repetition, distractor-based retrieval of the response was observed for the repetition of concepts. The study reported in chapter 8 of this work examined the influence of attention on the feature-response binding of irrelevant features. The results pointed towards a stronger binding effects when attention was directed towards the irrelevant feature compared to whenrnit was not. The study in chapter 9 presented here looked at the processes underlying distractor-based retrieval and distractor inhibition. The data suggest that motor processes underlie distractor-based retrieval and cognitive process underlie distractor inhibition. Finally, the findings of all four studies are also discussed in the context of learning.
The search for relevant determinants of knowledge acquisition has a long tradition in educational research, with systematic analyses having started over a century ago. To date, a variety of relevant environmental and learner-related characteristics have been identified, providing a wide body of empirical evidence. However, there are still some gaps in the literature, which are highlighted in the current dissertation. The dissertation includes two meta-analyses summarizing the evidence on the effectiveness of electrical brain stimulation and the effects of prior knowledge on later learning outcomes and one empirical study employing latent profile transition analysis to investigate the changes in conceptual knowledge over time. The results from the three studies demonstrate how learning outcomes can be advanced by input from the environment and that they are highly related to the students" level of prior knowledge. It is concluded that the effects of environmental and learner-related variables impact both the biological and cognitive processes underlying knowledge acquisition. Based on the findings from the three studies, methodological and practical implications are provided, followed by an outline of four recommendations for future research on knowledge acquisition.
Our goal is to approximate energy forms on suitable fractals by discrete graph energies and certain metric measure spaces, using the notion of quasi-unitary equivalence. Quasi-unitary equivalence generalises the two concepts of unitary equivalence and norm resolvent convergence to the case of operators and energy forms defined in varying Hilbert spaces.
More precisely, we prove that the canonical sequence of discrete graph energies (associated with the fractal energy form) converges to the energy form (induced by a resistance form) on a finitely ramified fractal in the sense of quasi-unitary equivalence. Moreover, we allow a perturbation by magnetic potentials and we specify the corresponding errors.
This aforementioned approach is an approximation of the fractal from within (by an increasing sequence of finitely many points). The natural step that follows this realisation is the question whether one can also approximate fractals from outside, i.e., by a suitable sequence of shrinking supersets. We partly answer this question by restricting ourselves to a very specific structure of the approximating sets, namely so-called graph-like manifolds that respect the structure of the fractals resp. the underlying discrete graphs. Again, we show that the canonical (properly rescaled) energy forms on such a sequence of graph-like manifolds converge to the fractal energy form (in the sense of quasi-unitary equivalence).
From the quasi-unitary equivalence of energy forms, we conclude the convergence of the associated linear operators, convergence of the spectra and convergence of functions of the operators – thus essentially the same as in the case of the usual norm resolvent convergence.
The ability to acquire knowledge helps humans to cope with the demands of the environment. Supporting knowledge acquisition processes is among the main goals of education. Empirical research in educational psychology has identified several processes mediated through that prior knowledge affects learning. However, the majority of studies investigated cognitive mechanisms mediating between prior knowledge and learning and neglected that motivational processes might also mediate the influence. In addition, the impact of successful knowledge acquisition on patients’ health has not been comprehensively studied. This dissertation aims at closing knowledge gaps on these topics with the use of three studies. The first study is a meta-analysis that examined motivation as a mediator of individual differences in knowledge before and after learning. The second study investigated in greater detail the extent to which motivation mediated the influence of prior knowledge on knowledge gains in a sample of university students. The third study is a second-order meta-analysis synthesizing the results of previous meta-analyses on the effects of patient education on several health outcomes. The findings of this dissertation show that (a) motivation mediates individual differences in knowledge before and after learning; (b) interest and academic self-concept stabilize individual differences in knowledge more than academic self-efficacy, intrinsic motivation, and extrinsic motivation; (c) test-oriented instruction closes knowledge gaps between students; (d) students’ motivation can be independent of prior knowledge in high aptitude students; (e) knowledge acquisition affects motivational and health-related outcomes; and (f) evidence on prior knowledge and motivation can help develop effective interventions in patient education. The results of the dissertation provide insights into prerequisites, processes, and outcomes of knowledge acquisition. Future research should address covariates of learning and environmental impacts for a better understanding of knowledge acquisition processes.
The subject of this thesis is a homological approach to the splitting theory of PLS-spaces, i.e. to the question for which topologically exact short sequences 0->X->Y->Z->0 of PLS-spaces X,Y,Z the right-hand map admits a right inverse. We show that the category (PLS) of PLS-spaces and continuous linear maps is an additive category in which every morphism admits a kernel and a cokernel, i.e. it is pre-abelian. However, we also show that it is neither quasi-abelian nor semi-abelian. As a foundation for our homological constructions we show the more general result that every pre-abelian category admits a largest exact structure in the sense of Quillen. In the pre-abelian category (PLS) this exact structure consists precisely of the topologically exact short sequences of PLS-spaces. Using a construction of Ext-functors due to Yoneda, we show that one can define for each PLS-space A and every natural number k the k-th abelian-group valued covariant and contravariant Ext-functors acting on the category (PLS) of PLS-spaces, which induce for every topologically exact short sequence of PLS-spaces a long exact sequence of abelian groups and group morphisms. These functors are studied in detail and we establish a connection between the Ext-functors of PLS-spaces and the Ext-functors for LS-spaces. Through this connection we arrive at an analogue of a result for Fréchet spaces which connects the first derived functor of the projective limit with the first Ext-functor and also gives sufficient conditions for the vanishing of the higher Ext-functors. Finally, we show that Ext^k(E,F) = 0 for a k greater or equal than 1, whenever E is a closed subspace and F is a Hausdorff-quotient of the space of distributions, which generalizes a result of Wengenroth that is itself a generalization of results due to Domanski and Vogt.
This work investigates the industrial applicability of graphics and stream processors in the field of fluid simulations. For this purpose, an explicit Runge-Kutta discontinuous Galerkin method in arbitrarily high order is implemented completely for the hardware architecture of GPUs. The same functionality is simultaneously realized for CPUs and compared to GPUs. Explicit time steppings as well as established implicit methods are under consideration for the CPU. This work aims at the simulation of inviscid, transsonic flows over the ONERA M6 wing. The discontinuities which typically arise in hyperbolic equations are treated with an artificial viscosity approach. It is further investigated how this approach fits into the explicit time stepping and works together with the special architecture of the GPU. Since the treatment of artificial viscosity is close to the simulation of the Navier-Stokes equations, it is reviewed how GPU-accelerated methods could be applied for computing viscous flows. This work is based on a nodal discontinuous Galerkin approach for linear hyperbolic problems. Here, it is extended to non-linear problems, which makes the application of numerical quadrature obligatory. Moreover, the representation of complex geometries is realized using isoparametric mappings. Higher order methods are typically very sensitive with respect to boundaries which are not properly resolved. For this purpose, an approach is presented which fits straight-sided DG meshes to curved geometries which are described by NURBS surfaces. The mesh is modeled as an elastic body and deformed according to the solution of closest point problems in order to minimize the gap to the original spline surface. The sensitivity with respect to geometry representations is reviewed in the end of this work in the context of shape optimization. Here, the aerodynamic drag of the ONERA M6 wing is minimized according to the shape gradient which is implicitly smoothed within the mesh deformation approach. In this context a comparison to the classical Laplace-Beltrami operator is made in a Stokes flow situation.
Issues in Price Measurement
(2022)
This thesis focuses on the issues in price measurement and consists of three chapters. Due to outdated weighting information, a Laspeyres-based consumer price index (CPI) is prone to accumulating upward bias. Therefore, chapter 1 introduces and examines simple and transparent revision approaches that retrospectively address the source of the bias. They provide a consistent long-run time series of the CPI and require no additional information. Furthermore, a coherent decomposition of the bias into the contributions of individual product groups is developed. In a case study, the approaches are applied to a Laspeyres-based CPI. The empirical results confirm the theoretical predictions. The proposed revision approaches are adoptable not only to most national CPIs but also to other price-level measures such as the producer price index or the import and export price indices.
Chapter 2 is dedicated to the measurement of import and export price indices. Such indices are complicated by the impact of exchange rates. These indices are usually also compiled by some Laspeyres type index. Therefore, substitution bias is an issue. The terms of trade (ratio of export and import price index) are therefore also likely to be distorted. The underlying substitution bias accumulates over time. The present article applies a simple and transparent retroactive correction approach that addresses the source of the substitution bias and produces meaningful long-run time series of import and export price levels and, therefore, of the terms of trade. Furthermore, an empirical case study is conducted that demonstrates the efficacy and versatility of the correction approach.
Chapter 3 leaves the field of index revision and studies another issue in price measurement, namely, the economic evaluation of digital products in monetary terms that have zero market prices. This chapter explores different methods of economic valuation and pricing of free digital products and proposes an alternative way to calculate the economic value and a shadow price of free digital products: the Usage Cost Model (UCM). The goal of the chapter is, first of all, to formulate a theoretical framework and incorporate an alternative measure of the value of free digital products. However, an empirical application is also made to show the work of the theoretical model. Some conclusions on applicability are drawn at the end of the chapter.
Modern decision making in the digital age is highly driven by the massive amount of
data collected from different technologies and thus affects both individuals as well as
economic businesses. The benefit of using these data and turning them into knowledge
requires appropriate statistical models that describe the underlying observations well.
Imposing a certain parametric statistical model goes along with the need of finding
optimal parameters such that the model describes the data best. This often results in
challenging mathematical optimization problems with respect to the model’s parameters
which potentially involve covariance matrices. Positive definiteness of covariance matrices
is required for many advanced statistical models and these constraints must be imposed
for standard Euclidean nonlinear optimization methods which often results in a high
computational effort. As Riemannian optimization techniques proved efficient to handle
difficult matrix-valued geometric constraints, we consider optimization over the manifold
of positive definite matrices to estimate parameters of statistical models. The statistical
models treated in this thesis assume that the underlying data sets used for parameter
fitting have a clustering structure which results in complex optimization problems. This
motivates to use the intrinsic geometric structure of the parameter space. In this thesis,
we analyze the appropriateness of Riemannian optimization over the manifold of positive
definite matrices on two advanced statistical models. We establish important problem-
specific Riemannian characteristics of the two problems and demonstrate the importance
of exploiting the Riemannian geometry of covariance matrices based on numerical studies.
Every action we perform, no matter how simple or complex, has a cognitive representation. It is commonly assumed that these are organized hierarchically. Thus, the representation of a complex action consists of multiple simpler actions. The representation of a simple action, in turn, consists of stimulus, response, and effect features. These are integrated into one representation upon the execution of an action and can be retrieved if a feature is repeated. Depending on whether retrieved features match or only partially match the current action episode, this might benefit or impair the execution of a subsequent action. This pattern of costs and benefits results in binding effects that indicate the strength of common representation between features. Binding effects occur also in more complex actions: Multiple simple actions seem to form representations on a higher level through the integration and retrieval of sequentially given responses, resulting in so-called response-response binding effects. This dissertation aimed to investigate what factors determine whether simple actions form more complex representations. The first line of research (Articles 1-3) focused on dissecting the internal structure of simple actions. Specifically, I investigated whether the spatial relation of stimuli, responses, or effects, that are part of two different simple actions, influenced whether these simple actions are represented as one more complex action. The second line of research (Articles 2, 4, and 5) investigated the role of context on the formation and strength of more complex action representations. Results suggest that spatial separation of responses as well as context might affect the strength of more complex action representations. In sum, findings help to specify assumptions on the structure of complex action representations. However, it may be important to distinguish factors that influence the strength and structure of action representations from factors that terminate action representations.
In addition to the well-recognised effects of both, genes and adult environment, it is now broadly accepted that adverse conditions during pregnancy contribute to the development of mental and somatic disorders in the offspring, such as cardiovascular disorders, endocrinological disorders, metabolic disorders, schizophrenia, anxious and depressive behaviour and attention deficit hyperactivity disorder (ADHD). Early life events may have long lasting impact on tissue structure and function and these effects appear to underlie the developmental origins of vulnerability to chronic diseases. The assumption that prenatal adversity, such as maternal emotional states during pregnancy, may have adverse effects on the developing infant is not new. Accordant references can be found in an ancient Indian text (ca. 1050 before Christ), in biblical texts and in documents originating during the Middle Ages. Even Hippocrates stated possible effects of maternal emotional states on the developing fetus. Since the mid-1950s, research examining the effects of maternal psychosocial stress during pregnancy appeared in the literature. Extensive research in this field has been conducted since the early 1990s. Thus, the relationship between early life events and long-term health outcomes was already postulated over 20 years ago. David Barker and colleagues demonstrated that children of lower birth weight - which represents a crude marker of an adverse intrauterine environment - were at increased risk of high blood pressure, cardiovascular disorders, and type-2 diabetes later in life. These provocative findings led to a large amount of subsequent research, initially focussing on the role of undernutrition in determining fetal outcomes. The phenomenon of prenatal influences that determine in part the risk of suffering from chronic disease later in life has been named the "fetal origins of health and disease" paradigm. The concept of "prenatal programming" has now been extended to many other domains, such as the effects of prenatal maternal stress, prenatal tobacco exposure, alcohol intake, medication, toxins, as well as maternal infection and diseases. During the process of prenatal programming, environmental agents are transmitted across the placenta and act on specific fetal tissues during sensitive periods of development. Thus, developmental trajectories are changed and the organisation and function of tissue structure and organ system is altered. The biological purpose of those "early life programming" may consist in evolutionary advantages. The offspring adapts its development to the expected extrauterine environment which is forecast by the clues available during fetal life. If the fetus receives signals of a challenging environment, e.g. due to maternal stress hormones or maternal undernutrition, its survival may be promoted due to developmental adaptation processes. However, if the expected environment does not match with the real environment, maladapation and later disease risk may result. For example, a possible indicator of a "response ready" trait, such as hyperactivity/inattention may have been advantageous in an adverse ancient environment. However, it is of disadvantage when the postnatal environment demands oppositional skills, such as attention and concentration " e.g. in the classroom, at school, to achieve academic success. Borderline personality disorder (BPD) is a prevalent psychiatric disorder, characterized by impulsivity, affective instability, dysfunctional interpersonal relationships and identity disturbance. Although many studies report different risk factors, the exact etiologic mechanisms are not yet understood. In addition to the well-recognised effects of genetic components and adverse childhood experiences, BPD may potentially be co-determined by further environmental influences, acting very early in life: during pre- and perinatal period. There are several hints that may suggest possible prenatal programming processes in BPD. For example, patients with BPD are characterized by elevated stress sensitivity and reactivity and dysfunctions of the neuroendocrine stress system, such as the hypothalamic pituitary adrenal (HPA) axis. Furthermore, patients with BPD show a broad range of somatic comorbidities " especially those disorders for which prenatal programming processes have been described. During infancy and childhood, BPD patients already show behavioural and emotional abnormalities as well as pronounced temperamental traits, such as impulsivity, emotional dysregulation and inattention that may potentially be co-determined by prenatal programming processes. Such temperamental traits - similar to those, seen in patients with ADHD - have been described to be associated with low birthweight which indicates a suboptimal intrauterine environment. Moreover, the functional and structural alterations in the central nervous system (CNS) in patients with BPD might also be mediated in part by prenatal agents, such as prenatal tobacco exposure. Prenatal adversity may thus constitute a further, additional component in the multifactorial genesis of BPD. The association between BPD and prenatal risk factors has not yet been studied in such detail. We are not aware of any further study that assessed pre- and perinatal risk factors, such as maternal psychoscocial stress, smoking, alcohol intake, obstetric complications and lack of breastfeeding in patients with BPD.
In this thesis we focus on the development and investigation of methods for the computation of confluent hypergeometric functions. We point out the relations between these functions and parabolic boundary value problems and demonstrate applications to models of heat transfer and fluid dynamics. For the computation of confluent hypergeometric functions on compact (real or complex) intervals we consider a series expansion based on the Hadamard product of power series. It turnes out that the partial sums of this expansion are easily computable and provide a better rate of convergence in comparison to the partial sums of the Taylor series. Regarding the computational accuracy the problem of cancellation errors is reduced considerably. Another important tool for the computation of confluent hypergeometric functions are recurrence formulae. Although easy to implement, such recurrence relations are numerically unstable e.g. due to rounding errors. In order to circumvent these problems a method for computing recurrence relations in backward direction is applied. Furthermore, asymptotic expansions for large arguments in modulus are considered. From the numerical point of view the determination of the number of terms used for the approximation is a crucial point. As an application we consider initial-boundary value problems with partial differential equations of parabolic type, where we use the method of eigenfunction expansion in order to determine an explicit form of the solution. In this case the arising eigenfunctions depend directly on the geometry of the considered domain. For certain domains with some special geometry the eigenfunctions are of confluent hypergeometric type. Both a conductive heat transfer model and an application in fluid dynamics is considered. Finally, the application of several heat transfer models to certain sterilization processes in food industry is discussed.
Memory consists of multiple anatomically and functionally distinct systems. Animal studies suggest that stress modulates multiple memory systems in a manner that favors nucleus caudatus-based stimulus-response learning at the expense of hippocampus-based spatial learning. The present work aimed (i) to translate these findings to humans, (ii) to determine the involvement of the stress hormone cortisol in this effect, and (iii) to assess whether the use of stimulus-response and spatial strategies is a long lasting person characteristic. To address these issues we developed a new paradigm that differentiates the use of spatial and stimulus-response learning in humans. Our findings indicate that (i) psychosocial stress (Trier Social Stress Test) modulates the use of spatial and stimulus-response learning in humans, (ii) cortisol plays a key role in this modulatory effect of stress, and (iii) the use of spatial and stimulus-response learning is affected by situational rather than long lasting person factors.
In this thesis, we study the convergence behavior of an efficient optimization method used for the identification of parameters for underdetermined systems. The research is motivated by optimization problems arising from the estimation of parameters in neural networks as well as in option pricing models. In the first application, we are concerned with neural networks used to forecasting stock market indices. Since neural networks are able to describe extremely complex nonlinear structures they are used to improve the modelling of the nonlinear dependencies occurring in the financial markets. Applying neural networks to the forecasting of economic indicators, we are confronted with a nonlinear least squares problem of large dimension. Furthermore, in this application the number of parameters of the neural network to be determined is usually much larger than the number of patterns which are available for the determination of the unknowns. Hence, the residual function of our least squares problem is underdetermined. In option pricing, an important but usually not known parameter is the volatility of the underlying asset of the option. Assuming that the underlying asset follows a one-factor continuous diffusion model with nonconstant drift and volatility term, the value of an European call option satisfies a parabolic initial value problem with the volatility function appearing in one of the coefficients of the parabolic differential equation. Using this system equation, the estimation of the volatility function is described by a nonlinear least squares problem. Since the adaption of the volatility function is based only on a small number of observed market data these problems are naturally ill-posed. For the solution of these large-scale underdetermined nonlinear least squares problems we use a fully iterative inexact Gauss-Newton algorithm. We show how the structure of a neural network as well as that of the European call price model can be exploited using iterative methods. Moreover, we present theoretical statements for the convergence of the inexact Gauss-Newton algorithm applied to the less examined case of underdetermined nonlinear least squares problems. Finally, we present numerical results for the application of neural networks to the forecasting of stock market indices as well as for the construction of the volatility function in European option pricing models. In case of the latter application, we discretize the parabolic differential equation using a finite difference scheme and we elucidate convergence problems of the discrete scheme when the initial condition is not everywhere differentiable.
The present thesis addresses the validity of Binge Eating Disorder (BED) as well as underlying mechanisms of BED from three different angles. Three studies provide data discriminating obesity with BED from obesity without BED. Study 1 demonstrates differences between obese individuals with and without BED regarding eating in the natural environment, psychiatric comorbidity, negative affect as well as self reported tendencies in eating behavior. Evidence for possible psychological mechanisms explaining increased intake of BED individuals in the natural environment was given by analyzing associations of negative affect, emotional eating, restrained eating and caloric intake in obese BED compared to NBED controls. Study 2 demonstrated stress-induced changes in the eating behavior of obese individuals with BED. The impact of a psychosocial stressor, the Trier Social Stress Test (TSST, Kirschbaum, Pirke, & Hellhammer, 1993), on behavioral patterns of eating behavior in laboratory was investigated. Special attention was given to stress-induced changes in variables that reflect mechanisms of appetite regulation in obese BED individuals compared to controls. To further explore by which mechanisms stress might trigger binge eating, study 3 investigated differences in stress-induced cortisol secretion after a socially evaluated cold pressure test (SECPT, Schwabe, Haddad, & Schachinger, 2008) in obese BED as compared to obese NBED individuals.
The present work considers the normal approximation of the binomial distribution and yields estimations of the supremum distance of the distribution functions of the binomial- and the corresponding standardized normal distribution. The type of the estimations correspond to the classical Berry-Esseen theorem, in the special case that all random variables are identically Bernoulli distributed. In this case we state the optimal constant for the Berry-Esseen theorem. In the proof of these estimations several inequalities regarding the density as well as the distribution function of the binomial distribution are presented. Furthermore in the estimations mentioned above the distribution function is replaced by the probability of arbitrary, not only unlimited intervals and in this new situation we also present an upper bound.
Interoception - the perception of bodily processes - plays a crucial role in the subjective experience of emotion, consciousness and symptom genesis. As an alternative to interoceptive paradigms that depend on the participants" active cooperation, five studies are presented to show that startle methodology may be employed to study visceral afferent processing. Study 1 (38 volunteers) showed that startle responses to acoustic stimuli of 105 dB(A) intensity were smaller when elicited during the cardiac systole (R-wave +230 ms) as compared to the diastole (R +530 ms). In Study 2, 31 diabetic patients were divided into two groups with normal or diminished (< 6 ms/mmHg) baroreflex sensitivity (BRS) of heart rate control. Patients with normal BRS showed a startle inhibition during the cardiac systole as was found for healthy volunteers. Diabetic patients with diminished BRS did not show this pattern. Because diminished BRS is an indicator of impaired baro-afferent signal transmission, we concluded that cardiac modulation of startle is associated with intact arterial baro-afferent feedback. Thus, pre-attentive startle methodology is feasible to study visceral afferent processing. rnVisceral- and baro-afferent information has been found to be mainly processed in the right hemisphere. To explore whether cardiac modulation of startle eye blink is lateralized as well, in Study 3, 37 healthy volunteers received 160 unilateral acoustic startle stimuli presented to both ears, one at a time (R +0, 100, 230, 530 ms). Startle response magnitude was only diminished at R +230 ms and for left-ear presentation. This lateralization effect in the cardiac modulation of startle eye blink may reflect the previously described advantages of right-hemispheric brain structures in relaying viscero- and baro-afferent signal transmission. rnThis lateralization effect implies that higher cognitive processes may also play a role in the cardiac modulation of startle. To address this question, in Study 4, 25 volunteers responded first by 'fast as possible' button pushes (reaction time, RT), and second, rated perceived intensity of 60 acoustic startle stimuli (85, 95, or 105 dB; R +230, 530 ms). RT was divided into evaluation and motor response time. Increasing stimulus intensity enhanced startle eye blink, intensity ratings, and RT components. Eye blinks and intensity judgments were lower when startle was elicited at a latency of R +230 ms, but RT components were differentially affected. It is concluded that the cardiac cycle affects the attentive processing of acoustic startle stimuli. rnBeside the arterial baroreceptors, the cardiopulmonary baroreceptors represent another important system of cardiovascular perception that may have similar effects on startle responsiveness. To clarify this issue, in Study 5, Lower Body Negative Pressure at gradients of 0, -10, -20, and -30 mmHg was applied to unload cardiopulmonary baroreceptors in 12 healthy males, while acoustic startle stimuli were presented (R +230, 530 ms). Unloading of cardiopulmonary baroreceptors increased startle eye blink responsiveness. Furthermore, the effect of relative loading/unloading of arterial baroreceptors on startle eye blink responsiveness was replicated. These results demonstrate that the loading status of cardiopulmonary baroreceptors also has an impact on brainstem-based CNS processes. rnThus, the cardiac modulation of acoustic startle is feasible to reflect baro-afferent signal transmission of multiple neural sources, it represents a pre-attentive method that is independent of active cooperation, but its modulatory effects also reach higher cognitive, attentive processes.rn
This thesis comprises of four research papers on the economics of education and industrial relations, which contribute to the field of empirical economic research. All of the corresponding papers focus on analysing how much time individuals spend on specific activities. The allocation of available time resources is a decision that individuals make throughout their lifetime. In this thesis, we consider individuals at different stages of their lives - students at school, university students, and dependent employees at the workplace.
Part I includes two research studies on student's behaviour in secondary and tertiary education.
Chapter 2 explores whether students who are relatively younger or older within the school year exhibit differential time allocation. Building on previous findings showing that relatively younger students perform worse in school, the study shows that relatively younger students are aware of their poor performance in school and feel more strain as a result. Nevertheless, there are no clear differences to be found in terms of time spent on homework, while relatively younger students spend more time watching television and less time on sports activities. Thus, the results suggest that the lower learning outcomes are not associated with different time allocations between school-related activities and non-school-related activities.
Chapter 3 analyses how individual ability and labour market prospects affect study behaviour. The theoretical modelling predicts that both determinants increase study effort. The empirical investigation is based on cross-sectional data from the National Educational Panel Study (NEPS) and includes thousands of students in Germany. The analyses show that more gifted students exhibit lower subjective effort levels and invest less time in self-study. In contrast, very good labour market prospects lead to more effort exerted by the student, both qualitatively and quantitatively. The potential endogeneity problem is taken into account by using regional unemployment data as an instrumental variable.
Part II includes two labour economic studies on determinants of overtime. Both studies belong to the field of industrial relations, as they focus on union membership on the one hand and the interplay of works councils and collective bargaining coverage on the other.
Chapter 4 shows that union members work less overtime than non-members do. The econometric approach takes the problem of unobserved heterogeneity into account; but provides no evidence that this issue affects the results. Different channels that could lead to this relationship are analysed by examining relevant subgroups separately. For example, this effect of union membership can also be observed in establishments with works councils and for workers who are very likely to be covered by collective bargaining agreements. The study concludes that the observed effect is due to the fact that union membership can protect workers from corresponding increased working time demands by employers.
Chapter 5 builds on previous studies showing a negative effect of works councils on overtime. In addition to co-determination by works councils at the firm level, collective bargaining coverage is an important factor in the German industrial relations system. Corresponding data was not available in the SOEP for quite some time. Therefore, the study uses recent SOEP data, which also contains information on collective bargaining coverage. A cross-sectional analysis is conducted to examine the effects of works councils in establishments with and without collective bargaining coverage. Similar to studies analysing other outcome variables, the results show that the effect of works councils exists only for employees covered by a collective bargaining agreement.
Chemical communication in the reproductive behaviour of Neotropical poison frogs (Dendrobatidae)
(2013)
Chemical communication is the evolutionary oldest communication system in the animal kingdom that triggers intra- and interspecific interactions. It is initiated by the emitter releasing either a signal or a cue that causes a reaction of the receiving individual. Compared to other animals there are relatively few studies regarding chemical communication in anurans. In this thesis the impact of chemical communication on the behaviour of the poison frog Ranitomeya variabilis (Dendrobatidae) and its parental care performance was investigated. This species uses phytotelmata (small water bodies in plants) for both clutch and tadpole depositions. Since tadpoles are cannibalistic, adult frogs do not only avoid conspecifics when depositing their eggs but also transport their tadpoles individually into separated phytotelmata. The recognition of already occupied phytotelmata was shown to be due to chemical substances released by the conspecific tadpoles. In order to gain a deeper comprehension about the ability of adult R. variabilis to generally recognize and avoid tadpoles, in-situ pool choice experiments were conducted, offering chemical substances of tadpole of different species to the frogs (Chapter I). It turned out that they were able to recognize all species and avoid their chemical substances for clutch depositions. However, for tadpole depositions only dendrobatid tadpoles occurring in phytotelmata were avoided, while those species living in rivers were not. Additionally, the chemical substances of a treefrog tadpole (Hylidae) were recognized by R. variabilis. Yet, they were not avoided but preferred for tadpole depositions; thus these tadpoles might be recognized as a potential prey for the predatory poison frog larvae. One of the poison frog species which was avoided for both tadpole and clutch depositions, was the phytotelmata breeding Hyloxalus azureiventris. The chemical substances released by its tadpoles were analysed together with those of the R. variabilis tadpoles (Chapter II). After finding a suitable solid-phase extraction sorbent (DSC-18), the active chemical compounds from the water of both tadpole species were extracted and fractionated. In order to determine which fractions triggered the avoidance behaviour of the frogs, in-situ bioassays were conducted. It was found that the biologically active compounds differed between both species. Since the avoidance of the conspecific tadpoles is not advantageous to the releaser tadpoles (losing a potential food resource) the chemicals released by them might be defined as chemical cues. However, as it turned out that the avoidance of the heterospecific tadpoles was not triggered by a mere byproduct based on the close evolutionary relationship between the two species, the chemical compounds released by H. azureiventris tadpoles might be defined as chemical signals (being advantageous to the releasing tadpoles) or, more specifically as synomones, interspecificly acting chemicals that are advantageous for both emitter and receiver (since R. variabilis avoids a competition situation for its offspring, too). Another interspecific communication system investigated in this thesis was the avoidance of predator kairomones (Chapter III). Using chemical substances from damselfly larvae, it could be shown that R. variabilis was unable to recognize and avoid kairomones of these tadpole predators. However, when physically present, damselfly larvae were avoided by the frogs. For the recognition of conspecific tadpoles in contrast, chemical substances were necessary, since purely visible artificial tadpole models were not avoided. If R. variabilis is also capable to chemically communicate with adult conspecifics was investigated by presenting chemical cues/signals of same-sex or opposite-sex conspecifics to the frogs (Chapter IV). It was suggested that males would be attracted to chemical substances of females and repelled by those of conspecific males. But instead all individuals showed avoidance behaviour towards the conspecific chemicals. This was suggested to be an artefact due to confinement stress of the releaser animals, emitting disturbance cues that triggered avoidance behaviour in their conspecifics. The knowledge gained about chemical communication in parental care thus far, was used to further investigate a possible provisioning behaviour in R. variabilis. In-situ pool-choice experiments with chemical cues of conspecific tadpoles were carried out throughout the change from rainy to dry season (Chapter V). With a changepoint analysis, the exact seasonal change was defined and differences between frogs" choices were analysed. It turned out that R. variabilis does not avoid but prefer conspecific cues during the dry season for tadpole depositions, what might be interpreted as a way to provide their tadpoles with food (i.e. younger tadpoles) in order to accelerate their development when facing desiccation risk. That tadpoles were also occasionally fed with fertilized eggs could be shown in a comparative study, where phytotelmata that contained a tadpole deposited by the frogs themselves received more clutch depositions than freshly erected artificial phytotelmata containing unfamiliar tadpoles (i.e. their chemical cues; Chapter VI). Conducting home range calculations with ArcGIS, it turned out that R. variabilis males showed unexpectedly strong site fidelity, leading to the suggestion that they recognize their offspring by phytotelmata location. However, in order to test if R. variabilis is furthermore able to perform chemical offspring recognition, frogs were confronted in in-situ pool-choice experiments with chemical cues of single tadpoles that were found in their home ranges (Chapter VII). Genetic kinship analyses were conducted between those tadpoles emitting the chemical cues and those deposited together with or next to them. The results, however, indicated that frogs did not choose to deposit their offspring with or without another tadpole due to relatedness, i.e. kin recognition by chemical cues could not be confirmed in R. variabilis.
In this psycho-neuro-endocrine study the molecular basis of different variants of steroid receptors as well as highly conserved non steroidal receptors was investigated. These nuclear receptors (NRs) are important key regulators of a wide variety of different physiological and pathophysiological challenges ranging from inflammation and stress to complex behaviour and disease. NRs control gene transcription in a ligand dependent manner and are embedded in the huge interaction network of the neuroendocrine and immune system. Two receptors, the glucocorticoid receptor (GR) and the chicken ovalbumin upstream promoter-transcription factorII (Coup-TFII), both expressed in the immune and nervous system, were investigated regarding possible splice variants and their implication in the control of gene transcription. Both NRs are known to interact and modulate each other- target gene regulation. This study could be shown that both NRs have different splice variants that are expressed in a tissue specific manner. The different 5-´alternative transcript variants of the human GR were in silico identified in other species and evidence for a highly conserved and tightly controlled function was provided. Investigations of the N-terminal transactivation domain of the GR showed a deletion suggesting an altered glucocorticoid-dependent transactivation profile. The newly identified alternative transcript variant of Coup-TFII leads to a DNA binding deficient Coup-TFII isoform that is highly expressed in the brain. This Coup-TFII isoform alters Coup-TFII target gene expression and is suggested to interact with GR via its ligand binding domain resulting in an impaired GR target gene regulation in the nervous system. In this thesis it was demonstrated that NR variants are important for the understanding of the enormous regulatory potential of this receptor family and have to be taken into account for the development of therapeutic strategies for complex diseases such as stress related and neurodegenerative disorders.
We are living in a connected world, surrounded by interwoven technical systems. Since they pervade more and more aspects of our everyday lives, a thorough understanding of the structure and dynamics of these systems is becoming increasingly important. However - rather than being blueprinted and constructed at the drawing board - many technical infrastructures like for example the Internet's global router network, the World Wide Web, large scale Peer-to-Peer systems or the power grid - evolve in a distributed fashion, beyond the control of a central instance and influenced by various surrounding conditions and interdependencies. Hence, due to this increase in complexity, making statements about the structure and behavior of tomorrow's networked systems is becoming increasingly complicated. A number of failures has shown that complex structures can emerge unintentionally that resemble those which can be observed in biological, physical and social systems. In this dissertation, we investigate how such complex phenomena can be controlled and actively used. For this, we review methodologies stemming from the field of random and complex networks, which are being used for the study of natural, social and technical systems, thus delivering insights into their structure and dynamics. A particularly interesting finding is the fact that the efficiency, dependability and adaptivity of natural systems can be related to rather simple local interactions between a large number of elements. We review a number of interesting findings about the formation of complex structures and collective dynamics and investigate how these are applicable in the design and operation of large scale networked computing systems. A particular focus of this dissertation are applications of principles and methods stemming from the study of complex networks in distributed computing systems that are based on overlay networks. Here we argue how the fact that the (virtual) connectivity in such systems is alterable and widely independent from physical limitations facilitates a design that is based on analogies between complex network structures and phenomena studied in statistical physics. Based on results about the properties of scale-free networks, we present a simple membership protocol by which scale-free overlay networks with adjustable degree distribution exponent can be created in a distributed fashion. With this protocol we further exemplify how phase transition phenomena - as occurring frequently in the domain of statistical physics - can actively be used to quickly adapt macroscopic statistical network parameters which are known to massively influence the stability and performance of networked systems. In the case considered in this dissertation, the adaptation of the degree distribution exponent of a random, scale-free overlay allows - within critical regions - a change of relevant structural and dynamical properties. As such, the proposed scheme allows to make sound statements about the relation between the local behavior of individual nodes and large scale properties of the resulting complex network structures. For systems in which the degree distribution exponent cannot easily be derived for example from local protocol parameters, we further present a distributed, probabilistic mechanism which can be used to monitor a network's degree distribution exponent and thus to reason about important structural qualities. Finally, the dissertation shifts its focus towards the study of complex, non-linear dynamics in networked systems. We consider a message-based protocol which - based on the Kuramoto model for coupled oscillators - achieves a stable, global synchronization of periodic heartbeat events. The protocol's performance and stability is evaluated in different network topologies. We further argue that - based on existing findings about the interrelation between spectral network properties and the dynamics of coupled oscillators - the proposed protocol allows to monitor structural properties of networked computing systems. An important aspect of this dissertation is its interdisciplinary approach towards a sensible and constructive handling of complex structures and collective dynamics in networked systems. The associated investigation of distributed systems from the perspective of non-linear dynamics and statistical physics highlights interesting parallels both to biological and physical systems. This foreshadows systems whose structures and dynamics can be analyzed and understood in the conceptual frameworks of statistical physics and complex systems.
Traditionell werden Zufallsstichprobenerhebungen so geplant, dass nationale Statistiken zuverlässig mit einer adäquaten Präzision geschätzt werden können. Hierbei kommen vorrangig designbasierte, Modell-unterstützte (engl. model assisted) Schätzmethoden zur Anwendung, die überwiegend auf asymptotischen Eigenschaften beruhen. Für kleinere Stichprobenumfänge, wie man sie für Small Areas (Domains bzw. Subpopulationen) antrifft, eignen sich diese Schätzmethoden eher nicht, weswegen für diese Anwendung spezielle modellbasierte Small Area-Schätzverfahren entwickelt wurden. Letztere können zwar Verzerrungen aufweisen, besitzen jedoch häufig einen kleineren mittleren quadratischen Fehler der Schätzung als dies für designbasierte Schätzer der Fall ist. Den Modell-unterstützten und modellbasierten Methoden ist gemeinsam, dass sie auf statistischen Modellen beruhen; allerdings in unterschiedlichem Ausmass. Modell-unterstützte Verfahren sind in der Regel so konstruiert, dass der Beitrag des Modells bei sehr grossen Stichprobenumfängen gering ist (bei einer Grenzwertbetrachtung sogar wegfällt). Bei modellbasierten Methoden nimmt das Modell immer eine tragende Rolle ein, unabhängig vom Stichprobenumfang. Diese Überlegungen veranschaulichen, dass das unterstellte Modell, präziser formuliert, die Güte der Modellierung für die Qualität der Small Area-Statistik von massgeblicher Bedeutung ist. Wenn es nicht gelingt, die empirischen Daten durch ein passendes Modell zu beschreiben und mit den entsprechenden Methoden zu schätzen, dann können massive Verzerrungen und / oder ineffiziente Schätzungen resultieren.
Die vorliegende Arbeit beschäftigt sich mit der zentralen Frage der Robustheit von Small Area-Schätzverfahren. Als robust werden statistische Methoden dann bezeichnet, wenn sie eine beschränkte Einflussfunktion und einen möglichst hohen Bruchpunkt haben. Vereinfacht gesprochen zeichnen sich robuste Verfahren dadurch aus, dass sie nur unwesentlich durch Ausreisser und andere Anomalien in den Daten beeinflusst werden. Die Untersuchung zur Robustheit konzentriert sich auf die folgenden Modelle bzw. Schätzmethoden:
i) modellbasierte Schätzer für das Fay-Herriot-Modell (Fay und Herrot, 1979, J. Amer. Statist. Assoc.) und das elementare Unit-Level-Modell (vgl. Battese et al., 1988, J. Amer. Statist. Assoc.).
ii) direkte, Modell-unterstützte Schätzer unter der Annahme eines linearen Regressionsmodells.
Das Unit-Level-Modell zur Mittelwertschätzung beruht auf einem linearen gemischten Gauss'schen Modell (engl. mixed linear model, MLM) mit blockdiagonaler Kovarianzmatrix. Im Gegensatz zu bspw. einem multiplen linearen Regressionsmodell, besitzen MLM-Modelle keine nennenswerten Invarianzeigenschaften, so dass eine Kontamination der abhängigen Variablen unvermeidbar zu verzerrten Parameterschätzungen führt. Für die Maximum-Likelihood-Methode kann die resultierende Verzerrung nahezu beliebig groß werden. Aus diesem Grund haben Richardson und Welsh (1995, Biometrics) die robusten Schätzmethoden RML 1 und RML 2 entwickelt, die bei kontaminierten Daten nur eine geringe Verzerrung aufweisen und wesentlich effizienter sind als die Maximum-Likelihood-Methode. Eine Abwandlung von Methode RML 2 wurde Sinha und Rao (2009, Canad. J. Statist.) für die robuste Schätzung von Unit-Level-Modellen vorgeschlagen. Allerdings erweisen sich die gebräuchlichen numerischen Verfahren zur Berechnung der RML-2-Methode (dies gilt auch für den Vorschlag von Sinha und Rao) als notorisch unzuverlässig. In dieser Arbeit werden zuerst die Konvergenzprobleme der bestehenden Verfahren erörtert und anschließend ein numerisches Verfahren vorgeschlagen, das sich durch wesentlich bessere numerische Eigenschaften auszeichnet. Schließlich wird das vorgeschlagene Schätzverfahren im Rahmen einer Simulationsstudie untersucht und anhand eines empirischen Beispiels zur Schätzung von oberirdischer Biomasse in norwegischen Kommunen illustriert.
Das Modell von Fay-Herriot kann als Spezialfall eines MLM mit blockdiagonaler Kovarianzmatrix aufgefasst werden, obwohl die Varianzen des Zufallseffekts für die Small Areas nicht geschätzt werden müssen, sondern als bereits bekannte Größen betrachtet werden. Diese Eigenschaft kann man sich nun zunutze machen, um die von Sinha und Rao (2009) vorgeschlagene Robustifizierung des Unit-Level-Modells direkt auf das Fay-Herriot Model zu übertragen. In der vorliegenden Arbeit wird jedoch ein alternativer Vorschlag erarbeitet, der von der folgenden Beobachtung ausgeht: Fay und Herriot (1979) haben ihr Modell als Verallgemeinerung des James-Stein-Schätzers motiviert, wobei sie sich einen empirischen Bayes-Ansatz zunutze machen. Wir greifen diese Motivation des Problems auf und formulieren ein analoges robustes Bayes'sches Verfahren. Wählt man nun in der robusten Bayes'schen Problemformulierung die ungünstigste Verteilung (engl. least favorable distribution) von Huber (1964, Ann. Math. Statist.) als A-priori-Verteilung für die Lokationswerte der Small Areas, dann resultiert als Bayes-Schätzer [=Schätzer mit dem kleinsten Bayes-Risk] die Limited-Translation-Rule (LTR) von Efron und Morris (1971, J. Amer. Statist. Assoc.). Im Kontext der frequentistischen Statistik kann die Limited-Translation-Rule nicht verwendet werden, weil sie (als Bayes-Schätzer) auf unbekannten Parametern beruht. Die unbekannten Parameter können jedoch nach dem empirischen Bayes-Ansatz an der Randverteilung der abhängigen Variablen geschätzt werden. Hierbei gilt es zu beachten (und dies wurde in der Literatur vernachlässigt), dass die Randverteilung unter der ungünstigsten A-priori-Verteilung nicht einer Normalverteilung entspricht, sondern durch die ungünstigste Verteilung nach Huber (1964) beschrieben wird. Es ist nun nicht weiter erstaunlich, dass es sich bei den Maximum-Likelihood-Schätzern von Regressionskoeffizienten und Modellvarianz unter der Randverteilung um M-Schätzer mit der Huber'schen psi-Funktion handelt.
Unsere theoriegeleitete Herleitung von robusten Schätzern zum Fay-Herriot-Modell zeigt auf, dass bei kontaminierten Daten die geschätzte LTR (mit Parameterschätzungen nach der M-Schätzmethodik) optimal ist und, dass die LTR ein integraler Bestandteil der Schätzmethodik ist (und nicht als ``Zusatz'' o.Ä. zu betrachten ist, wie dies andernorts getan wird). Die vorgeschlagenen M-Schätzer sind robust bei Vorliegen von atypischen Small Areas (Ausreissern), wie dies auch die Simulations- und Fallstudien zeigen. Um auch Robustheit bei Vorkommen von einflussreichen Beobachtungen in den unabhängigen Variablen zu erzielen, wurden verallgemeinerte M-Schätzer (engl. generalized M-estimator) für das Fay-Herriot-Modell entwickelt.
The Role of Dopamine and Acetylcholine as Modulators of Selective Attention and Response Speed
(2015)
The principles of top-down and bottom-up processing are essential to cognitive psychology. At their broadest, most general definition, they denote that processing can be driven either by the salience of the stimulus input or by individual goals and strategies. Selective top-down attention, specifically, consists in the deliberate prioritizing of stimuli that are deemed goal-relevant, while selective bottom-up attention relies on the automatic allocation of attention to salient stimuli (Connor, Egeth, & Yantis, 2004; Schneider, Schote, Meyer, & Frings, 2014). Variations within neurotransmitter systems can modulate cognitive performance in a domain-specific fashion (Greenwood, Fossella, & Parasuraman, 2005). Noudoost and Moore (2011a) proposed that the influence of the dopaminergic neurotransmitter system on selective top-down attention might be greater than the influence of this system on selective bottom-up attention; likewise, they assumed that the cholinergic neurotransmitter system might be more important for selective bottom-up than top-down attention. To test this hypothesis, naturally occurring variations within the two neurotransmitter systems were assessed. Five polymorphisms were selected; two of the dopaminergic system (the COMT Val158Met polymorphism and the DAT1 polymorphism) and three of the cholinergic system (the CHRNA4 rs1044396 polymorphism, the CHRNA5 rs3841324 polymorphism, and the CHRNA5 rs16969968 polymorphism). It was tested whether these polymorphisms modulated the performance in tasks of selective top-down attention (a Stroop task and a Negative priming task) and in a task of selective bottom-up attention (a Posner-Cuing task). Indeed, the dopaminergic polymorphisms influenced selective top-down attention, but exerted no effects on bottom-up attention. This aligned with the hypothesis proposed by Noudoost and Moore (2011a). In contrast, the cholinergic polymorphisms were not found to modulate selective bottom-up attention. The three cholinergic polymorphisms, however, affected the general response speed in the Stroop task, Negative priming task, and Posner-Cuing task (irrespective of attentional processing). In sum, the findings of this study provide strong indications that the dopaminergic system modulates selective top-down attention, while the cholinergic system is highly relevant for the general speed of information processing.
Dry tropical forests are facing massive conversion and degradation processes and they are the most endangered forest type worldwide. One of the largest dry forest types are Miombo forests that stretch across the Southern African subcontinent and the proportionally largest part of this type can be found in Angola. The study site of this thesis is located in south-central Angola. The country still suffers from the consequences of the 27 years of civil war (1975-2002) that provides a unique socio-economic setting. The natural characteristics are a representative cross section which proved ideal to study underlying drivers as well as current and retrospective land use change dynamics. The major land change dynamic of the study area is the conversion of Miombo forests to cultivation areas as well as modification of forest areas, i.e. degradation, due to the extraction of natural resources. With future predictions of population growth, climate change and large scale investments, land pressure is expected to further increase. To fully understand the impacts of these dynamics, both, conversion and modification of forest areas were assessed. By using the conceptual framework of ecosystem services, the predominant trade-off between food and timber in the study area was analyzed, including retrospective dynamics and impacts. This approach accounts for products that contribute directly or indirectly to human well-being. For this purpose, data from the Landsat archive since 1989 until 2013 was applied in different study area adapted approaches. The objectives of these approaches were (I) to detect underlying drivers and their temporal and spatial extent of impact, (II) to describe modification and conversion processes that reach from times of armed conflicts over the ceasefire and the post-war period and (III) to provide an assessment of drivers and impacts in a comparative setting. It could be shown that major underlying drivers for the conversion processes are resettlement dynamics as well as the location and quality of streets and settlements. Furthermore, forests that are selectively used for resource extraction have a higher chance of being converted to a field. Drivers of forest degradation are on one hand also strongly connected to settlement and infrastructural structures. But also to a large extent to fire dynamics that occur mostly in more remote and presumably undisturbed forest areas. The loss of woody biomass as well as its slow recovery after the abandonment of fields could be quantified and stands in large contrast to the amount of potentially cultivated food that is necessarily needed. The results of the thesis support the fundamental understanding of drivers and impacts in the study area and can thus contribute to a sustainable resource management.
A phenomenon of recent decades is that digital marketplaces on the Internet are establishing themselves for a wide variety of products and services. Recently, it has become possible for private individuals to invest in young and innovative companies (so-called "start-ups"). Via Internet portals, potential investors can examine various start-ups and then directly invest in their chosen start-up. In return, investors receive a share in the firm- profit, while companies can use the raised capital to finance their projects. This new way of financing is called "Equity Crowdfunding" (ECF) or "Crowdinvesting". The aim of this dissertation is to provide empirical findings about the characteristics of ECF. In particular, the question of whether ECF is able to overcome geographic barriers, the interdependence of ECF and capital structure, and the risk of failure for funded start-ups and their chances of receiving follow-up funding by venture capitalists or business angels will be analyzed. The results of the first part of this dissertation show that investors in ECF prefer local companies. In particular, investors who invest larger amounts have a stronger tendency to invest in local start-ups. The second part of the dissertation provides first indications of the interdependencies between capital structure and ECF. The analysis makes clear that the capital structure is not a determinant for undertaking an ECF campaign. The third part of the dissertation analyzes the success of companies financed by ECF in a country comparison. The results show that after a successful ECF campaign German companies have a higher chance of receiving follow-up funding by venture capitalists compared to British companies. The probability of survival, however, is slightly lower for German companies. The results provide relevant implications for theory and practice. The existing literature in the area of entrepreneurial finance will be extended by insights into investor behavior, additions to the capital structure theory and a country comparison in ECF. In addition, implications are provided for various actors in practice.
This doctoral thesis examines intergenerational knowledge, its antecedents as well as how participation in intergenerational knowledge transfer is related to the performance evaluation of employees. To answer these questions, this doctoral thesis builds on a literature review and quantitative research methods. A systematic literature study shows that empirical evidence on intergenerational knowledge transfer is limited. Building on prior literature, effects of various antecedents at the interpersonal and organizational level regarding their effects on intergenerational and intragenerational knowledge transfer are postulated. By questioning 444 trainees and trainers, this doctoral thesis also demonstrates that interpersonal antecedents impact how trainees participate in intergenerational knowledge transfer with their trainers. Thereby, the results of this study provide support that interpersonal antecedents are relevant for intergenerational knowledge transfer, yet, also emphasize the implications attached to the assigned roles in knowledge transfer (i.e., whether one is a trainee or trainer). Moreover, the results of an experimental vignette study reveal that participation in intergenerational knowledge transfer is linked to the performance evaluation of employees, yet, is susceptible to whether the employee is sharing or seeking knowledge. Overall, this doctoral thesis provides insights into this topic by covering a multitude of antecedents of intergenerational knowledge transfer, as well as how participation in intergenerational knowledge transfer may be associated with the performance evaluation of employees.
Large scale non-parametric applied shape optimization for computational fluid dynamics is considered. Treating a shape optimization problem as a standard optimal control problem by means of a parameterization, the Lagrangian usually requires knowledge of the partial derivative of the shape parameterization and deformation chain with respect to input parameters. For a variety of reasons, this mesh sensitivity Jacobian is usually quite problematic. For a sufficiently smooth boundary, the Hadamard theorem provides a gradient expression that exists on the surface alone, completely bypassing the mesh sensitivity Jacobian. Building upon this, the gradient computation becomes independent of the number of design parameters and all surface mesh nodes are used as design unknown in this work, effectively allowing a free morphing of shapes during optimization. Contrary to a parameterized shape optimization problem, where a smooth surface is usually created independently of the input parameters by construction, regularity is not preserved automatically in the non-parametric case. As part of this work, the shape Hessian is used in an approximative Newton method, also known as Sobolev method or gradient smoothing, to ensure a certain regularity of the updates, and thus a smooth shape is preserved while at the same time the one-shot optimization method is also accelerated considerably. For PDE constrained shape optimization, the Hessian usually is a pseudo-differential operator. Fourier analysis is used to identify the operator symbol both analytically and discretely. Preconditioning the one-shot optimization by an appropriate Hessian symbol is shown to greatly accelerate the optimization. As the correct discretization of the Hadamard form usually requires evaluating certain surface quantities such as tangential divergence and curvature, special attention is also given to discrete differential geometry on triangulated surfaces for evaluating shape gradients and Hessians. The Hadamard formula and Hessian approximations are applied to a variety of flow situations. In addition to shape optimization of internal and external flows, major focus lies on aerodynamic design such as optimizing two dimensional airfoils and three dimensional wings. Shock waves form when the local speed of sound is reached, and the gradient must be evaluated correctly at discontinuous states. To ensure proper shock resolution, an adaptive multi-level optimization of the Onera M6 wing is conducted using more than 36, 000 shape unknowns on a standard office workstation, demonstrating the applicability of the shape-one-shot method to industry size problems.
This work is concerned with arbitrage bounds for prices of contingent claims under transaction costs, but regardless of other conceivable market frictions. Assumptions on the underlying market are held as weak as convenient for the deduction of meaningful results that make good economic sense. In discrete time we also allow for underlying price processes with uncountable state space. In continuous time the underlying price process is modeled by a semimartingale. For the most part we could avoid any stronger assumptions. The main problems with which we deal in this work are the modelling of (proportional) transaction costs, Fundamental Theorems of Asset Pricing under transaction costs, dual characterizations of arbitrage bounds under transaction costs, Quantile-Hedging under transaction costs, alternatives to the Black-Scholes model in continuous time (under transaction costs). The results apply to stock and currency markets.
Fostering positive and realistic self-concepts of individuals is a major goal in education worldwide (Trautwein & Möller, 2016). Individuals spend most of their childhood and adolescence in school. Thus, schools are important contexts for individuals to develop positive self-perceptions such as self-concepts. In order to enhance positive self-concepts in educational settings and in general, it is indispensable to have a comprehensive knowledge about the development and structure of self-concepts and their determinants. To date, extensive empirical and theoretical work on antecedents and change processes of self-concept has been conducted. However, several research gaps still exist, and several of these are the focus of the present dissertation. Specifically, these research gaps encompass (a) the development of multiple self-concepts from multiple perspectives regarding stability and change, (b) the direction of longitudinal interplay between self-concept facets over the entire time period from childhood to late adolescence, and (c) the evidence that a recently developed structural model of academic self-concept (nested Marsh/Shavelson model [Brunner et al., 2010]) fits the data in elementary school students, (d) the investigation of structural changes in academic self-concept profile formation within this model, (e) the investigation of dimensional comparison processes as determinants of academic self-concept profile formation in elementary school students within the internal/external frame of reference model (I/E model; Marsh, 1986), (f) the test of moderating variables for dimensional comparison processes in elementary school, (g) the test of the key assumptions of the I/E model that effects of dimensional comparisons depend to a large degree on the existence of achievement differences between subjects, and (h) the generalizability of the findings regarding the I/E model over different statistical analytic methods. Thus, the aim of the present dissertation is to contribute to close these gaps with three studies. Thereby, data from German students enrolled in elementary school to secondary school education were gathered in three projects comprising the developmental time span from childhood to adolescence (ages 6 to 20). Three vital self-concept areas in childhood and adolescence were in-vestigated: general self-concept (i.e., self-esteem), academic self-concepts (general, math, reading, writing, native language), and social self-concepts (of acceptance and assertion). In all studies, data were analyzed within a latent variable framework. Findings are discussed with respect to the research aims of acquiring more comprehensive knowledge on the structure and development of significant self-concept in childhood and adolescence and their determinants. In addition, theoretical and practical implications derived from the findings of the present studies are outlined. Strengths and limitations of the present dissertation are discussed. Finally, an outlook for future research on self-concepts is given.
The demand for reliable statistics has been growing over the past decades, because more and more political and economic decisions are based on statistics, e.g. regional planning, allocation of funds or business decisions. Therefore, it has become increasingly important to develop and to obtain precise regional indicators as well as disaggregated values in order to compare regions or specific groups. In general, surveys provide the information for these indicators only for larger areas like countries or administrative divisions. However, in practice, it is more interesting to obtain indicators for specific subdivisions like on NUTS 2 or NUTS 3 levels. The Nomenclature of Units for Territorial Statistics (NUTS) is a hierarchical system of the European Union used in statistics to refer to subdivisions of countries. In many cases, the sample information on such detailed levels is not available. Thus, there are projects such as the European Census, which have the goal to provide precise numbers on NUTS 3 or even community level. The European Census is conducted amongst others in Germany and Switzerland in 2011. Most of the participating countries use sample and register information in a combined form for the estimation process. The classical estimation methods of small areas or subgroups, such as the Horvitz-Thompson (HT) estimator or the generalized regression (GREG) estimator, suffer from small area-specific sample sizes which cause high variances of the estimates. The application of small area methods, for instance the empirical best linear unbiased predictor (EBLUP), reduces the variance of the estimates by including auxiliary information to increase the effective sample size. These estimation methods lead to higher accuracy of the variables of interest. Small area estimation is also used in the context of business data. For example during the estimation of the revenues of specific subgroups like on NACE 3 or NACE 4 levels, small sample sizes can occur. The Nomenclature statistique des activités économiques dans la Communauté européenne (NACE) is a system of the European Union which defines an industry standard classification. Besides small sample sizes, business data have further special characteristics. The main challenge is that business data have skewed distributions with a few large companies and many small businesses. For instance, in the automotive industry in Germany, there are many small suppliers but only few large original equipment manufacturers (OEM). Altogether, highly influential units and outliers can be observed in business statistics. These extreme values in connection with small sample sizes cause severe problems when standard small area models are applied. These models are generally based on the normality assumption, which does not hold in the case of outliers. One way to solve these peculiarities is to apply outlier robust small area methods. The availability of adequate covariates is important for the accuracy of the above described small area methods. However, in business data, the auxiliary variables are hardly available on population level. One of several reasons for that is the fact that in Germany a lot of enterprises are not reflected in business registers due to truncation limits. Furthermore, only listed enterprises or companies which trespass specific thresholds are obligated to publish their results. This limits the number of potential auxiliary variables for the estimation. Even though there are issues with available covariates, business data often include spatial dependencies which can be used to enhance small area methods. Next to spatial information based on geographic characteristics, group-specific similarities like related industries based on NACE codes can be used. For instance, enterprises from the same NACE 2 level, e.g. sector 47 retail trade, behave more similar than two companies from different NACE 2 levels, e.g. sector 05 mining of coal and sector 64 financial services. This spatial correlation can be incorporated by extending the general linear mixed model trough the integration of spatially correlated random effects. In business data, outliers as well as geographic or content-wise spatial dependencies between areas or domains are closely linked. The coincidence of these two factors and the resulting consequences have not been fully covered in the relevant literature. The only approach that combines robust small area methods with spatial dependencies is the M-quantile geographically weighted regression model. In the context of EBLUP-based small area models, the combination of robust and spatial methods has not been considered yet. Therefore, this thesis provides a theoretical approach to this scientific and practical problem and shows its relevance in an empirical study.
In order to classify smooth foliated manifolds, which are smooth maifolds equipped with a smooth foliation, we introduce the de Rham cohomologies of smooth foliated manifolds. These cohomologies are build in a similar way as the de Rham cohomologies of smooth manifolds. We develop some tools to compute these cohomologies. For example we proof a Mayer Vietoris theorem for foliated de Rham cohomology and show that these cohomologys are invariant under integrable homotopy. A generalization of a known Künneth formula, which relates the cohomologies of a product foliation with its factors, is discussed. In particular, this envolves a splitting theory of sequences between Frechet spaces and a theory of projective spectrums. We also prove, that the foliated de Rham cohomology is isomorphic to the Cech-de Rham cohomology and the Cech cohomology of leafwise constant functions of an underlying so called good cover.
It has been the overall aim of this research work to assess the potential of hyperspectral remote sensing data for the determination of forest attributes relevant to forest ecosystem simulation modeling and forest inventory purposes. A number of approaches for the determination of structural and chemical attributes from hyperspectral remote sensing have been applied to the collected data sets. Many of the methods to be found in the literature were up to now just applied to broadband multispectral data, applied to vegetation canopies other than forests, reported to work on the leaf level or with modelled data, not validated with ground truth data, or not systematically compared to other methods. Attributes that describe the properties of the forest canopy and that are potentially open to remote sensing were identified, appropriate methods for their retrieval were implemented and field, laboratory and image data (HyMap sensor) were acquired over a number of forest plots. The study on structural attributes compared statistical and physical approaches. In the statistical section, linear predictive models between vegetation indices derived from HyMap data and field measurements of structural forest stand attributes were systematically evaluated. The study demonstrates that for hyperspectral image data, linear regression models can be applied to quantify leaf area index and crown volume with good accuracy. For broadband multispectral data, the accuracy was generally lower. The physically-based approach used the invertible forest reflectance model (INFORM), a combination of well established sub-models FLIM, SAIL and LIBERTY. The model was inverted with HyMap data using a neural network approach. In comparison to the statistical approach, it could be shown that the reflectance model inversion works equally well. In opposition to empirically derived prediction functions that are generally limited to the local conditions at a certain point in time and to a specified sensor type, the calibrated reflectance model can be applied more easily to different optical remote sensing data acquired over central European forests. The study on chemical forest attributes evaluated the information content of HyMap data for the estimation of nitrogen, chlorophyll and water concentration. A number of needle samples of Norway spruce were analysed for their total chlorophyll, nitrogen and water concentrations. The chemical data was linked to needle spectra measured in the laboratory and canopy spectra measured by the HyMap sensor. Wavebands selected in statistical models were often located in spectral regions that are known to be important for chlorophyll detection (red edge, green peak). Predictive models were applied on the HyMap image to compute maps of chlorophyll concentration and nitrogen concentration. Results of map overlay operations revealed coherence between total chlorophyll and zones of stand development stage and between total chlorophyll and zones of soil type. Finally, it can be stated that the hyperspectral remote sensing data generally contains more information relevant to the estimation of the forest attributes compared to multispectral data. Structural forest attributes, except biomass, can be determined with good accuracy from a hyperspectral sensor type like HyMap. Among the chemical attributes, chlorophyll concentration can be determined with good accuracy and nitrogen concentration with moderate accuracy. For future research, additional dimensions have to be taken into account, for instance through exploitation of multi-view angle data. Additionally, existing forest canopy reflectance models should be further improved.
Coastal erosion describes the displacement of land caused by destructive sea waves,
currents or tides. Due to the global climate change and associated phenomena such as
melting polar ice caps and changing current patterns of the oceans, which result in rising
sea levels or increased current velocities, the need for countermeasures is continuously
increasing. Today, major efforts have been made to mitigate these effects using groins,
breakwaters and various other structures.
This thesis will find a novel approach to address this problem by applying shape optimization
on the obstacles. Due to this reason, results of this thesis always contain the
following three distinct aspects:
The selected wave propagation model, i.e. the modeling of wave propagation towards
the coastline, using various wave formulations, ranging from steady to unsteady descriptions,
described from the Lagrangian or Eulerian viewpoint with all its specialties. More
precisely, in the Eulerian setting is first a steady Helmholtz equation in the form of a
scattering problem investigated and followed subsequently by shallow water equations,
in classical form, equipped with porosity, sediment portability and further subtleties.
Secondly, in a Lagrangian framework the Lagrangian shallow water equations form the
center of interest.
The chosen discretization, i.e. dependent on the nature and peculiarity of the constraining
partial differential equation, we choose between finite elements in conjunction
with a continuous Galerkin and discontinuous Galerkin method for investigations in the
Eulerian description. In addition, the Lagrangian viewpoint offers itself for mesh-free,
particle-based discretizations, where smoothed particle hydrodynamics are used.
The method for shape optimization w.r.t. the obstacle’s shape over an appropriate
cost function, constrained by the solution of the selected wave-propagation model. In
this sense, we rely on a differentiate-then-discretize approach for free-form shape optimization
in the Eulerian set-up, and reverse the order in Lagrangian computations.
Recently, optimization has become an integral part of the aerodynamic design process chain. However, because of uncertainties with respect to the flight conditions and geometrical uncertainties, a design optimized by a traditional design optimization method seeking only optimality may not achieve its expected performance. Robust optimization deals with optimal designs, which are robust with respect to small (or even large) perturbations of the optimization setpoint conditions. The resulting optimization tasks become much more complex than the usual single setpoint case, so that efficient and fast algorithms need to be developed in order to identify, quantize and include the uncertainties in the overall optimization procedure. In this thesis, a novel approach towards stochastic distributed aleatory uncertainties for the specific application of optimal aerodynamic design under uncertainties is presented. In order to include the uncertainties in the optimization, robust formulations of the general aerodynamic design optimization problem based on probabilistic models of the uncertainties are discussed. Three classes of formulations, the worst-case, the chance-constrained and the semi-infinite formulation, of the aerodynamic shape optimization problem are identified. Since the worst-case formulation may lead to overly conservative designs, the focus of this thesis is on the chance-constrained and semi-infinite formulation. A key issue is then to propagate the input uncertainties through the systems to obtain statistics of quantities of interest, which are used as a measure of robustness in both robust counterparts of the deterministic optimization problem. Due to the highly nonlinear underlying design problem, uncertainty quantification methods are used in order to approximate and consequently simplify the problem to a solvable optimization task. Computationally demanding evaluations of high dimensional integrals resulting from the direct approximation of statistics as well as from uncertainty quantification approximations arise. To overcome the curse of dimensionality, sparse grid methods in combination with adaptive refinement strategies are applied. The reduction of the number of discretization points is an important issue in the context of robust design, since the computational effort of the numerical quadrature comes up in every iteration of the optimization algorithm. In order to efficiently solve the resulting optimization problems, algorithmic approaches based on multiple-setpoint ideas in combination with one-shot methods are presented. A parallelization approach is provided to overcome the amount of additional computational effort involved by multiple-setpoint optimization problems. Finally, the developed methods are applied to 2D and 3D Euler and Navier-Stokes test cases verifying their industrial usability and reliability. Numerical results of robust aerodynamic shape optimization under uncertain flight conditions as well as geometrical uncertainties are presented. Further, uncertainty quantification methods are used to investigate the influence of geometrical uncertainties on quantities of interest in a 3D test case. The results demonstrate the significant effect of uncertainties in the context of aerodynamic design and thus the need for robust design to ensure a good performance in real life conditions. The thesis proposes a general framework for robust aerodynamic design attacking the additional computational complexity of the treatment of uncertainties, thus making robust design in this sense possible.
Fast and Slow Effects of Cortisol on Several Functions of the Central Nervous System in Humans
(2014)
Cortisol is one of the key substances released during stress to restore homeostasis. Our knowledge of the impact of this glucocorticoid on cognition and behavior in humans is, however, still limited. Two modes of action of cortisol are known, a rapid, nongenomic and a slow, genomic mode. Both mechanisms appear to be involved in mediating the various effects of stress on cognition. Here, three experiments are presented that investigated fast and slow effects of cortisol on several functions of the human brain. The first experiment investigated the interaction between insulin and slow, genomic cortisol effects on resting regional cerebral blood flow (rCBF) in 48 young men. A bilateral, locally distinct increase in rCBF in the insular cortex was observed 37 to 58 minutes after intranasal insulin admission. Cortisol did not influence rCBF, neither alone nor in interaction with insulin. This finding suggests that cortisol does not influence resting cerebral blood flow within a genomic timeframe. The second experiment examined fast cortisol effects on memory retrieval. 40 participants (20 of them female) learned associations between neutral male faces and social descriptions and were tested for recall one week later. Cortisol administered intravenously 8 minutes before retrieval influenced recall performance in an inverted U-shaped dose-response relationship. This study demonstrates a rapid, presumably nongenomic cortisol effect on memory retrieval in humans. The third experiment studied rapid cortisol effects on early multisensory integration. 24 male participants were tested twice in a focused cross-modal choice reaction time paradigm, once after cortisol and once after placebo infusion. Cortisol acutely enhanced the integration of visual targets and startling auditory distractors, when both stimuli appeared in the same sensory hemi-field. The rapidity of effect onset strongly suggests that cortisol changes multisensory integration by a nongenomic mechanism. The work presented in this thesis highlights the essential role of cortisol as a fast acting agent during the stress response. Both the second and the third experiment provide new evidence of nongenomic cortisol effects on human cognition and behavior. Future studies should continue to investigate the impact of rapid cortisol effects on the functioning of the human brain.
Theoretical and empirical research assumes a negative development of student achievement motivation over the course of their school careers (i.e., mean-level declines of achievement motivation). However, the exact magnitude of this motivational change remains elusive and it is unclear whether different motivational constructs show similar developmental trends. Furthermore, it is unknown whether motivational declines are related to a particular school stage (i.e., elementary, middle, or high school) or the school transition, and which additional changes are associated with motivational decreases (e.g., changes in student achievement). Finally, previous research has remained inconsistent regarding the question whether ability grouping of students helps prevent motivational declines or results in additional motivational “costs” for students.
This dissertation presents three articles that were designed to address these research questions. In Article 1, a meta-analysis based on 107 independent longitudinal studies investigated student mean-level changes in self-esteem, academic self-concept, academic self-efficacy, intrinsic motivation, and achievement goals from first to 13th grade. Article 2 comprised two longitudinal studies with German adolescents (Study: n = 745 students assessed in four waves in grades 5-7; Study 2: n = 1420 students assessed in four waves in grades 5-8). Both longitudinal studies investigated the separate and the joint development of achievement goals, interest, and achievement in math. In Article 3, a longitudinal study (n = 296 high-ability students assessed in four waves in grades 5-7) investigated the effects of full-time ability grouping on student development of academic self-concept and achievement in math.
The meta-analysis revealed significant decreases in math and language academic self-concept, intrinsic motivation, and mastery and performance-approach goals, whereas no significant changes in self-esteem, general academic self-concept, academic self-efficacy, and performance-avoidance goals were found. Interestingly, motivational declines were not related to school stage or school transition. In Article 2, decreases in interest and mastery, performance-approach, and performance-avoidance goals were indicated by both longitudinal studies. Development of mastery and performance-approach goals was positively related or unrelated to development in interest and achievement, whereas development of performance-avoidance goals was negatively related or unrelated to development of interest and achievement. Finally, the longitudinal study in Article 3 revealed no significant change in student academic self-concept in math over time. Ability grouping showed no positive or negative effects on student academic self-concept. However, high-ability students that were grouped together demonstrated greater gains in their achievement than high-ability students in regular classes.
This thesis contains four parts that are all connected by their contributions to the Efficient Market Hypothesis and decision-making literature. Chapter two investigates how national stock market indices reacted to the news of national lockdown restrictions in the period from January to May 2020. The results show that lockdown restrictions led to different reactions in a sample of OECD and BRICS countries: there was a general negative effect resulting from the increase in lockdown restrictions, but the study finds strong evidence for underreaction during the lockdown announcement, followed by some overreaction that is corrected subsequently. This under-/overreaction pattern, however, is observed mostly during the first half of our time series, pointing to learning effects. Relaxation of the lockdown restrictions, on the other hand, had a positive effect on markets only during the second half of our sample, while for the first half of the sample, the effect was negative. The third chapter investigates the gender differences in stock selection preferences on the Taiwan Stock Exchange. By utilizing trading data from the Taiwan Stock Exchange over a span of six years, it becomes possible to analyze trading behavior while minimizing the self-selection bias that is typically present in brokerage data. To study gender differences, this study uses firm-level data. The percentage of male traders in a company is the dependent variable, while the company’s industry and fundamental/technical aspects serve as independent variables. The results show that the percentage of women trading a company rises with a company’s age, market capitalization, a company’s systematic risk, and return. Men trade more frequently and show a preference for dividend-paying stocks and for industries with which they are more familiar. The fourth chapter investigated the relationship between regret and malicious and benign envy. The relationship is analyzed in two different studies. In experiment 1, subjects had to fill out psychological scales that measured regret, the two types of envy, core self-evaluation and the big 5 personality traits. In experiment 2, felt regret is measured in a hypothetical scenario, and the subject’s felt regret was regressed on the other variables mentioned above. The two experiments revealed that there is a positive direct relationship between regret and benign envy. The relationship between regret and malicious envy, on the other hand, is mostly an artifact of core self-evaluation and personality influencing both malicious envy and regret. The relationship can be explained by the common action tendency of self-improvement for regret and benign envy. Chapter five discusses the differences in green finance regulation and implementation between the EU and China. China introduced the Green Silk Road, while the EU adopted the Green Deal and started working with its own green taxonomy. The first difference comes from the definition of green finance, particularly with regard to coal-fired power plants. Especially the responsibility of nation-states’ emissions abroad. China is promoting fossil fuel projects abroad through its Belt and Road Initiative, but the EU’s Green Deal does not permit such actions. Furthermore, there are policies in both the EU and China that create contradictory incentives for economic actors. On the one hand, the EU and China are improving the framework conditions for green financing while, on the other hand, still allowing the promotion of conventional fuels. The role of central banks is also different between the EU and China. China’s central bank is actively working towards aligning the financial sector with green finance. A possible new role of the EU central bank or the priority financing of green sectors through political decision-making is still being debated.
Industrial companies mainly aim for increasing their profit. That is why they intend to reduce production costs without sacrificing the quality. Furthermore, in the context of the 2020 energy targets, energy efficiency plays a crucial role. Mathematical modeling, simulation and optimization tools can contribute to the achievement of these industrial and environmental goals. For the process of white wine fermentation, there exists a huge potential for saving energy. In this thesis mathematical modeling, simulation and optimization tools are customized to the needs of this biochemical process and applied to it. Two different models are derived that represent the process as it can be observed in real experiments. One model takes the growth, division and death behavior of the single yeast cell into account. This is modeled by a partial integro-differential equation and additional multiple ordinary integro-differential equations showing the development of the other substrates involved. The other model, described by ordinary differential equations, represents the growth and death behavior of the yeast concentration and development of the other substrates involved. The more detailed model is investigated analytically and numerically. Thereby existence and uniqueness of solutions are studied and the process is simulated. These investigations initiate a discussion regarding the value of the additional benefit of this model compared to the simpler one. For optimization, the process is described by the less detailed model. The process is identified by a parameter and state estimation problem. The energy and quality targets are formulated in the objective function of an optimal control or model predictive control problem controlling the fermentation temperature. This means that cooling during the process of wine fermentation is controlled. Parameter and state estimation with nonlinear economic model predictive control is applied in two experiments. For the first experiment, the optimization problems are solved by multiple shooting with a backward differentiation formula method for the discretization of the problem and a sequential quadratic programming method with a line search strategy and a Broyden-Fletcher-Goldfarb-Shanno update for the solution of the constrained nonlinear optimization problems. Different rounding strategies are applied to the resulting post-fermentation control profile. Furthermore, a quality assurance test is performed. The outcomes of this experiment are remarkable energy savings and tasty wine. For the next experiment, some modifications are made, and the optimization problems are solved by using direct transcription via orthogonal collocation on finite elements for the discretization and an interior-point filter line-search method for the solution of the constrained nonlinear optimization problems. The second experiment verifies the results of the first experiment. This means that by the use of this novel control strategy energy conservation is ensured and production costs are reduced. From now on tasty white wine can be produced at a lower price and with a clearer conscience at the same time.
The main objective of the present thesis was to investigate whether antibody effects observed in earlier in vitro studies can translate into the protection against chemical carcinogenesis in vivo as the basis of an immunoprophylactic approach against carcinogens. As model for chemical carcinogenesis, we selected B[a]P the prototype polycyclic aromatic hydrocarbon (PAH), an environmental pollutant emanating from both natural and anthropogenic sources. Many in vivo models conveniently use high doses of carcinogens mostly given as single bolus, which provides simple surrogate readouts, but poorly reflects chronic exposure to the low concentrations found in the environment. In addition, these concentrations cannot be matched with equimolar antibody concentrations obtained by immunisation. However, low B[a]P concentrations do not permit to directly measure chemical carcinogenesis. Therefore, in the present thesis, the pharmacokinetic, metabolism and B[a]P mediated immunotoxicity were chosen as experimental read-outs. B[a]P conjugate vaccines based on ovalbumin, tetanus toxoid and diphtheria toxoid (DT) as carrier proteins were developed to actively immunise mice against B[a]P. B[a]P-DT conjugate induced the most robust immune response. The antibodies reacted not only with B[a]P but also with the proximate carcinogen 7,8-diol-B[a]P. Antibodies modulated the bioavailability of B[a]P and its metabolic activation in a dose-dependent manner by sequestration in the blood. In order to further improve the vaccination, we replaced the protein carrier by promiscuous T-helper cell epitopes to induce higher antibody titer with increased specificity for the B[a]P hapten. We hypothesised that a reduction of B cell binding sites on the carrier, compared to whole protein carrier, should favour the activation of B cells recognising the hapten instead of the carrier protein. An internal processing of the carrier and cleavage of the B[a]P-BA and subsequent presentation of the carrier peptide by MHC II molecules to T cell receptor should induce a B cell dependent immune response by activating B cells capable to recognise B[a]P. We demonstrated that a vaccination against B[a]P using promiscuous T-helper cell epitopes as a carrier is feasible and some tested peptide conjugates were more immunogenic as whole protein conjugates with increased specificity. We showed that vaccination against B[a]P reduces immunotoxicity. B[a]P suppressed the proliferative response of both T and B cells after a sub-acute administration, an effect that was completely reversed by vaccination. In immunized mice the immunotoxic effect of B[a]P on IFN-γ, Il-12, TNF-ï¡ production and B cell activation was restored. In addition, specific antibodies inhibited the induction of Cyp1a1 by B[a]P in lymphocytes and Cyp1b1 in the liver, enzymes that are known to convert the procarcinogen B[a]P to the ultimate DNA-adduct forming metabolite, a major risk factor of chemical carcinogenesis. In order to replace Freund adjuvant and to improve the immunisation strategy in terms of antibody quantity and quality, several adjuvants that are potentially compatible with their use in humans were tested. In combination with Freund adjuvant, the conjugate-vaccine induced high levels of B[a]P-specific antibodies. We showed that all adjuvants tested induced specific antibodies against B[a]P and 7,8-diol-B[a]P, its carcinogenic metabolite. The highest antibody levels were obtained with Quil A, MF-59 and Alum. Biological activity in terms of enhanced retention of B[a]P was confirmed in mice immunised with Quil A, Montanide, Alum and MF-59. Our findings demonstrate that a vaccination against B[a]P is feasible in combination with adjuvants licensed in humans. Based on these results and with the current understanding of the mechanisms of chemical carcinogenesis of the ubiquitous carcinogen B[a]P and of the effects of specific antibodies, an immunoprophylactic approach against chemical carcinogenesis is absolutely warranted. Nevertheless, the direct effects of B[a]P-specific antibodies on the different stages of carcinogenesis (e.g. adduct formation) and whether these effects may translate into long-term protective effect against tumourigenesis needs to be proven in further experiments.
No Longer Printing the Legend: The Aporia of Heteronormativity in the American Western (1903-1969)
(2023)
This study critically investigates the U.S.-American Western and its construction of sexuality and gender, revealing that the heteronormative matrix that is upheld and defended in the genre is consistently preceded by the exploration of alternative sexualities and ways to think gender beyond the binary. The endeavor to naturalize heterosexuality seems to be baked in the formula of the U.S.-Western. However, as I show in this study, this endeavor relies on an aporia, because the U.S.-Western can only ever attempt to naturalize gender by constructing it first, hence inevitably and simultaneously construct evidence that supports the opposite: the unnaturalness and contingency of gender and sexuality.
My study relies on the works of Raewyn Connell, Pierre Bourdieu, and Judith Butler, and amalgamates in its methodology established approaches from film and literary studies (i.e., close readings) with a Foucaultian understanding of discourse and discourse analysis, which allows me to relate individual texts to cultural, socio-political and economical contexts that invariably informed the production and reception of any filmic text. In an analysis of 14 U.S.-Westerns (excluding three excursions) that appeared between 1903 and 1969 I give ample and minute narrative and film-aesthetical evidence to reveal the complex and contradictory construction of gender and sexuality in the U.S.-Western, aiming to reveal both the normative power of those categories and its structural instability and inconsistency.
This study proofs that the Western up until 1969 did not find a stable pattern to represent the gender binary. The U.S.-Western is not necessarily always looking to confirm or stabilize governing constructs of (gendered) power. However, it without fail explores and negotiates its legitimacy. Heterosexuality and male hegemony are never natural, self-evident, incontestable, or preordained. Quite conversely: the U.S.-Western repeatedly – and in a surprisingly diverse and versatile way – reveals the illogical constructedness of the heteronormative matrix.
My study therefore offers a fresh perspective on the genre and shows that the critical exploration and negotiation of the legitimacy of heteronormativity as a way to organize society is constitutive for the U.S.-Western. It is the inquiry – not necessarily the affirmation – of the legitimacy of this model that gives the U.S.-Western its ideological currency and significance as an artifact of U.S.-American popular culture.