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Semantic-Aware Coordinated Multiple Views for the Interactive Analysis of Neural Activity Data
(2024)
Visualizing brain simulation data is in many aspects a challenging task. For one, data used in brain simulations and the resulting datasets is heterogeneous and insight is derived by relating all different kinds of it. Second, the analysis process is rapidly changing while creating hypotheses about the results. Third, the scale of data entities in these heterogeneous datasets is manifold, reaching from single neurons to brain areas interconnecting millions. Fourth, the heterogeneous data consists of a variety of modalities, e.g.: from time series data to connectivity data, from single parameters to a set of parameters spanning parameter spaces with multiple possible and biological meaningful solutions; from geometrical data to hierarchies and textual descriptions, all on mostly different scales. Fifth, visualizing includes finding suitable representations and providing real-time interaction while supporting varying analysis workflows. To this end, this thesis presents a scalable and flexible software architecture for visualizing, integrating and interacting with brain simulations data. The scalability and flexibility is achieved by interconnected services forming in a series of Coordinated Multiple View (CMV) systems. Multiple use cases are presented, introducing views leveraging this architecture, extending its ecosystem and resulting in a Problem Solving Environment (PSE) from which custom-tailored CMV systems can be build. The construction of such CMV system is assisted by semantic reasoning hence the term semantic-aware CMVs.
Physically-based distributed rainfall-runoff models as the standard analysis tools for hydro-logical processes have been used to simulate the water system in detail, which includes spa-tial patterns and temporal dynamics of hydrological variables and processes (Davison et al., 2015; Ek and Holtslag, 2004). In general, catchment models are parameterized with spatial information on soil, vegetation and topography. However, traditional approaches for eval-uation of the hydrological model performance are usually motivated with respect to dis-charge data alone. This may thus cloud model realism and hamper understanding of the catchment behavior. It is necessary to evaluate the model performance with respect to in-ternal hydrological processes within the catchment area as well as other components of wa-ter balance rather than runoff discharge at the catchment outlet only. In particular, a consid-erable amount of dynamics in a catchment occurs in the processes related to interactions of the water, soil and vegetation. Evapotranspiration process, for instance, is one of those key interactive elements, and the parameterization of soil and vegetation in water balance mod-eling strongly influences the simulation of evapotranspiration. Specifically, to parameterize the water flow in unsaturated soil zone, the functional relationships that describe the soil water retention and hydraulic conductivity characteristics are important. To define these functional relationships, Pedo-Transfer Functions (PTFs) are common to use in hydrologi-cal modeling. Opting the appropriate PTFs for the region under investigation is a crucial task in estimating the soil hydraulic parameters, but this choice in a hydrological model is often made arbitrary and without evaluating the spatial and temporal patterns of evapotran-spiration, soil moisture, and distribution and intensity of runoff processes. This may ulti-mately lead to implausible modeling results and possibly to incorrect decisions in regional water management. Therefore, the use of reliable evaluation approaches is continually re-quired to analyze the dynamics of the current interactive hydrological processes and predict the future changes in the water cycle, which eventually contributes to sustainable environ-mental planning and decisions in water management.
Remarkable endeavors have been made in development of modelling tools that provide insights into the current and future of hydrological patterns in different scales and their im-pacts on the water resources and climate changes (Doell et al., 2014; Wood et al., 2011). Although, there is a need to consider a proper balance between parameter identifiability and the model's ability to realistically represent the response of the natural system. Neverthe-less, tackling this issue entails investigation of additional information, which usually has to be elaborately assembled, for instance, by mapping the dominant runoff generation pro-cesses in the intended area, or retrieving the spatial patterns of soil moisture and evapotran-spiration by using remote sensing methods, and evaluation at a scale commensurate with hydrological model (Koch et al., 2022; Zink et al., 2018). The present work therefore aims to give insights into the modeling approaches to simulate water balance and to improve the soil and vegetation parameterization scheme in the hydrological model subject to producing more reliable spatial and temporal patterns of evapotranspiration and runoff processes in the catchment.
An important contribution to the overall body of work is a book chapter included among publications. The book chapter provides a comprehensive overview of the topic and valua-ble insights into the understanding the water balance and its estimation methods.
Moreover, the first paper aimed to evaluate the hydrological model behavior with re-spect to contribution of various sources of information. To do so, a multi-criteria evaluation metric including soft and hard data was used to define constraints on outputs of the 1-D hydrological model WaSiM-ETH. Applying this evaluation metric, we could identify the optimal soil and vegetation parameter sets that resulted in a “behavioral” forest stand water balance model. It was found out that even if simulations of transpiration and soil water con-tent are consistent with measured data, but still the dominant runoff generation processes or total water balance might be wrongly calculated. Therefore, only using an evaluation scheme which looks over different sources of data and embraces an understanding of the local controls of water loss through soil and plant, allowed us to exclude the unrealistic modeling outputs. The results suggested that we may need to question the generally accept-ed soil parameterization procedures that apply default parameter sets.
The second paper attempts to tackle the pointed model evaluation hindrance by getting down to the small-scale catchment (in Bavaria). Here, a methodology was introduced to analyze the sensitivity of the catchment water balance model to the choice of the Pedo-Transfer Functions (PTF). By varying the underlying PTFs in a calibrated and validated model, we could determine the resulting effects on the spatial distribution of soil hydraulic properties, total water balance in catchment outlet, and the spatial and temporal variation of the runoff components. Results revealed that the water distribution in the hydrologic system significantly differs amongst various PTFs. Moreover, the simulations of water balance components showed high sensitivity to the spatial distribution of soil hydraulic properties. Therefore, it was suggested that opting the PTFs in hydrological modeling should be care-fully tested by looking over the spatio-temporal distribution of simulated evapotranspira-tion and runoff generation processes, whether they are reasonably represented.
To fulfill the previous studies’ suggestions, the third paper then aims to focus on evalu-ating the hydrological model through improving the spatial representation of dominant run-off processes. It was implemented in a mesoscale catchment in southwestern Germany us-ing the hydrological model WaSiM-ETH. Dealing with the issues of inadequate spatial ob-servations for rigorous spatial model evaluation, we made use of a reference soil hydrologic map available for the study area to discern the expected dominant runoff processes across a wide range of hydrological conditions. The model was parameterized by applying 11 PTFs and run by multiple synthetic rainfall events. To compare the simulated spatial patterns to the patterns derived by digital soil map, a multiple-component spatial performance metric (SPAEF) was applied. The simulated DRPs showed a large variability with regard to land use, topography, applied rainfall rates, and the different PTFs, which highly influence the rapid runoff generation under wet conditions.
The three published manuscripts proceeded towards the model evaluation viewpoints that ultimately attain the behavioral model outputs. It was performed through obtaining information about internal hydrological processes that lead to certain model behaviors, and also about the function and sensitivity of some of the soil and vegetation parameters that may primarily influence those internal processes in a catchment. Accordingly, using this understanding on model reactions, and by setting multiple evaluation criteria, it was possi-ble to identify which parameterization could lead to behavioral model realization. This work, in fact, will contribute to solving some of the issues (e.g., spatial variability and modeling methods) identified as the 23 unsolved problems in hydrology in the 21st century (Blöschl et al., 2019). The results obtained in the present work encourage the further inves-tigations toward a comprehensive model calibration procedure considering multiple data sources simultaneously. This will enable developing the new perspectives to the current parameter estimation methods, which in essence, focus on reproducing the plausible dy-namics (spatio-temporal) of the other hydrological processes within the watershed.
Information in der vorvertraglichen Phase – das heißt, Informationspflichten sowie Rechtsfolgen von Informationserteilung und -nichterteilung – in Bezug auf Kaufvertrag und Wahl des optionalen Instruments hat im Vorschlag der Europäischen Kommission für ein Gemeinsames Europäisches Kaufrecht (GEK; KOM(2011) 635) vielfältige Regelungen erfahren. Die vorliegende Arbeit betrachtet diese Regelungen auch in ihrem Verhältnis zu den Textstufen des Europäischen Privatrechts – Modellregeln und verbraucherschützende EU-Richtlinien – und misst sie an ökonomischen Rahmenbedingungen, die die Effizienz von Transaktionen gebieten und Grenzen des Nutzens von (Pflicht-)Informationen aufzeigen.
Vom Grundsatz der Vertragsfreiheit ausgehend ist jeder Partei das Risiko zugewiesen, unzureichend informiert zu sein, während die Gegenseite nur punktuell zur Information verpflichtet ist. Zwischen Unternehmern bleibt es auch nach dem GEK hierbei, doch zwischen Unternehmer und Verbraucher wird dieses Verhältnis umgekehrt. Dort gelten, mit Differenzierung nach Vertragsschlusssituationen, umfassende Kataloge von Informationspflichten hinsichtlich des Kaufvertrags. Als Konzept ist dies grundsätzlich sinnvoll; die Pflichten dienen dem Verbraucherschutz, insbesondere der Informiertheit und Transparenz vor der Entscheidung über den Vertragsschluss. Teilweise gehen die Pflichten aber zu weit. Die Beeinträchtigung der Vertragsfreiheit des Unternehmers durch die Pflichten und die Folgen ihrer Verletzung lässt sich nicht vollständig mit dem Ziel des Verbraucherschutzes rechtfertigen. Durch das Übermaß an Information fördern die angeordneten Pflichten den Verbraucherschutz nur eingeschränkt; sie genügen nicht verhaltensökonomischen Maßstäben. Es empfiehlt sich daher, zwischen Unternehmern und Verbrauchern bestimmte verpflichtende Informationsinhalte ganz zu streichen, auf im konkreten Fall nicht erforderliche Information zu verzichten, erst nach Vertragsschluss relevante Informationen auf diese Zeit zu verschieben und die verbleibenden vorvertraglichen Pflichtinformationen in einer für den Verbraucher besser zu verarbeitenden Weise zu präsentieren. Von den einem Verbraucher zu erteilenden Informationen sollte stets verlangt werden, dass sie klar und verständlich sind; die Beweislast für ihre ordnungsgemäße Erteilung sollte generell dem Unternehmer obliegen.
Neben die ausdrücklich angeordneten Informationspflichten treten ungeachtet der Verbraucher- oder Unternehmereigenschaft sowie der Käufer- oder Verkäuferrolle stark einzelfallabhängige Informationspflichten nach Treu und Glauben, die im Recht der Willensmängel niedergelegt sind. Hier ist der Grundsatz verwirklicht, dass mangelnde Information zunächst das eigene Risiko jeder Partei ist; berechtigtes Vertrauen und freie Willensbildung werden geschützt. Diese Pflichten berücksichtigen auch das Ziel der Effizienz und achten die Vertragsfreiheit. Das Vertrauen auf jegliche erteilten Informationen wird zudem dadurch geschützt, dass sie den Vertragsinhalt – allerdings in Verbraucherverträgen nicht umfassend genug – mitbestimmen können und dass ihre Unrichtigkeit sanktioniert wird.
Die Verletzung jeglicher Arten von Informationspflichten kann insbesondere einen Schadensersatzanspruch sowie – über das Recht der Willensmängel – die Möglichkeit zur Lösung vom Vertrag nach sich ziehen. Das Zusammenspiel der unterschiedlichen Mechanismen führt allerdings zu Friktionen sowie zu Lücken in den Rechtsfolgen von Informationspflichtverletzungen. Daher empfiehlt sich die Schaffung eines Schadensersatzanspruchs für jede treuwidrig unterlassene Informationserteilung; hierdurch wird das Gebot von Treu und Glauben auch außerhalb des Rechts der Willensmängel zu einer eigentlichen einzelfallabhängigen Informationspflicht aufgewertet.
Left ventricular assist devices (LVADs) have become a valuable treatment for patients with advanced heart failure. Women appear to be disadvantaged in the usage of LVADs and concerning clinical outcomes such as death and adverse events after LVAD implant. Contrary to typical clinical characteristics (e.g., disease severity), device-related factors such as the intended device strategy, bridge to a heart transplantation or destination therapy, are often not considered in research on gender differences. In addition, the relevance of pre-implant psychosocial risk factors, such as substance abuse and limited social support, for LVAD outcomes is currently unclear. Thus, the aim of this dissertation is to explore the role of pre-implant psychosocial risk factors for gender differences in clinical outcomes, accounting for clinical and device-related risk factors.
In the first article, gender differences in pre-implant characteristics of patients registered in The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) were investigated. It was found that women and men differed in multiple pre-implant characteristics depending on device strategy. In the second article, gender differences in major clinical outcomes (i.e., death, heart transplant, device explant due to cardiac recovery, device replacement due to complications) were evaluated for patients in the device strategy destination therapy in the Interagency Registry for Mechanically Assisted Circulation (INTERMACS). Additionally, the association of gender and psychosocial risk factors with the major outcomes were analyzed. Women had similar probabilities to die on LVAD support, and even higher probabilities to experience explant of the device due to cardiac recovery compared with men in the destination therapy subgroup. Pre-implant psychosocial risk factors were not associated with major outcomes. The third article focused on gender differences in 10 adverse events (e.g., device malfunction, bleeding) after LVAD implant in INTERMACS. The association of a psychosocial risk indicator with gender and adverse events after LVAD implantation was evaluated. Women were less likely to have psychosocial risk pre-implant but more likely to experience seven out of 10 adverse events compared with men. Pre-implant psychosocial risk was associated with adverse events, even suggesting a dose response-relationship. These associations appeared to be more pronounced in women.
In conclusion, women appear to have similar survival to men when accounting for device strategy. They have higher probabilities of recovery, but higher probabilities of device replacement and adverse events compared with men. Regarding these adverse events, women may be more susceptible to psychosocial risk factors than men. The results of this dissertation illustrate the importance of gender-sensitive research and suggest considering device strategy when studying gender differences in LVAD recipients. Further research is warranted to elucidate the role of specific psychosocial risk factors that lead to higher probabilities of adverse events, to intervene early and improve patient care in both, women and men
Differential equations yield solutions that necessarily contain a certain amount of regularity and are based on local interactions. There are various natural phenomena that are not well described by local models. An important class of models that describe long-range interactions are the so-called nonlocal models, which are the subject of this work.
The nonlocal operators considered here are integral operators with a finite range of interaction and the resulting models can be applied to anomalous diffusion, mechanics and multiscale problems.
While the range of applications is vast, the applicability of nonlocal models can face problems such as the high computational and algorithmic complexity of fundamental tasks. One of them is the assembly of finite element discretizations of truncated, nonlocal operators.
The first contribution of this thesis is therefore an openly accessible, documented Python code which allows to compute finite element approximations for nonlocal convection-diffusion problems with truncated interaction horizon.
Another difficulty in the solution of nonlocal problems is that the discrete systems may be ill-conditioned which complicates the application of iterative solvers. Thus, the second contribution of this work is the construction and study of a domain decomposition type solver that is inspired by substructuring methods for differential equations. The numerical results are based on the abstract framework of nonlocal subdivisions which is introduced here and which can serve as a guideline for general nonlocal domain decomposition methods.
Anmerkung: Es handelt sich um die 2. überarbeitete Auflage der Dissertation.
1. Auflage siehe:
"https://ubt.opus.hbz-nrw.de/frontdoor/index/index/docId/2083".
Ausgangspunkt der politisch-ikonographischen Untersuchung, in deren
Zentrum zwei Staatsporträts König Maximilians II. von Bayern stehen, ist die Beobachtung, dass diese beiden Bildnisse grundsätzlich unterschiedliche Inszenierungsformen wählen. Das erste von Max Hailer gefertigte Werk zeigt Maximilian II. im vollen bayerischen Krönungsornat und greift eine tradierte Darstellungsweise im Staatsporträt auf. Es entstand zwei Jahre nach Maximilians II. Thronbesteigung und damit nach den revolutionären Unruhen der Jahre 1848/49 im Jahr 1850. Das zweite wurde von Joseph Bernhardt 1857 bis 1858 gemalt und im Jahr 1858 zum zehnjährigen Thronjubiläum des Monarchen erstmals präsentiert. Die Inszenierung ändert sich im zweiten Bildnis: Das bayerische Krönungsornat ist der Generalsuniform gewichen, ebenso weitere Details, die sich noch in der ersten Darstellung finden: Draperie und Wappen fehlen, der übliche bayerisch-königliche Thronsessel ist durch einen anderen ersetzt. In den Hintergrund gedrängt ist die Verfassung, immerhin seit 1818 staatliche Rechtsgrundlage des bayerischen Königreichs. Die beiden Staatsporträts Maximilians II. leiten offensichtlich von den Herrscherbildnissen im vollen bayerischen Krönungsornat seines Großvaters Maximilian I. und Vaters Ludwig I. über zu einer solchen in Uniform mit Krönungsmantel wie sie sich bei Napoleon III. und Friedrich Wilhelm IV. finden und wie sie sein Sohn Ludwig II. weiterführte. Es stellt sich somit die Frage, welche Faktoren zu diesem prägnanten Wandel in der Inszenierung Maximilians II. als König von Bayern führten. Die Arbeit geht der These nach, dass beide Darstellungen grundlegend auf eine reaktionäre, gegen die Revolution 1848/49 gerichtete Politik ausgelegt sind, wobei dieser reaktionäre Charakter in Maximilians II. Bildnis von 1858 noch eine Steigerung im Vergleich zu derjenigen von 1850 erfährt. Zudem wandelt sich die innenpolitisch-historische Ausrichtung des ersten Porträts bei der zweiten Darstellung des bayerischen Monarchen in eine außenpolitisch-progressive. Die Legitimation Maximilians II. begründet sich nicht mehr, wie bei ersterem, in der Geschichte und der Herrschaft der Wittelsbacher, sondern in seinen eigenen Errungenschaften und seiner eigenen Herrschaft. Dieser Wechsel der politischen Bildaussage fußt sowohl auf den politischen Veränderungen und Entwicklungen innerhalb und außerhalb Bayerns als auch auf der Entwicklung des Staatsporträts in der Mitte des 19. Jahrhunderts. Nach nur zehn Jahren wird so eine veränderte Botschaft über Maximilians II. Position und Machtanspruch ausgesendet.
Der zentrale Gegenstand der Untersuchung ist die Rechtsfigur des Indigenats im Kontext der württembergischen und preußischen Staatenlandschaft. Das Indigenat lässt sich als ein Recht bestimmen, das seine potenziellen Rechtsträger maßgeblich über das Abstammungsprinzip definiert und ein Verhältnis zwischen Rechtsträger und einem übergeordneten Rechtssubjekt zum Ausdruck bringt, sei es lehns- oder standes-, staats- oder auch bundes- beziehungsweise reichsrechtlicher Natur. Der zeitliche Schwerpunkt der Betrachtung liegt auf dem 19. Jahrhundert. Es werden jedoch auch Rückblicke in die Frühe Neuzeit geworfen, weil Wandel und Kontinuität in der Entwicklung des Indigenats in einer solch langen Perspektive besonders klar hervortreten können. Die zentrale These dieser Arbeit ist, dass ein enger Zusammenhang zwischen der im 19. Jahrhundert entstehenden und bis heute geläufigen Form der Zuordnung von Menschen zum Staat und den aus diesem Verhältnis entspringenden Rechten einerseits und dem frühneuzeitlichen Indigenat andererseits besteht. Dabei kann gezeigt werden, dass Gesellschaften ihre politischen Machtpositionen gegenüber „fremdstämmigen“, etwa zuwandernden Personen abschirmten, indem sie sich auf indigenatrechtliche, ethnische Bestimmungen beriefen.
Social entrepreneurship is a successful activity to solve social problems and economic challenges. Social entrepreneurship uses for-profit industry techniques and tools to build financially sound businesses that provide nonprofit services. Social entrepreneurial activities also lead to the achievement of sustainable development goals. However, due to the complex, hybrid nature of the business, social entrepreneurial activities are typically supported by macrolevel determinants. To expand our knowledge of how beneficial macro-level determinants can be, this work examines empirical evidence about the impact of macro-level determinants on social entrepreneurship. Another aim of this dissertation is to examine the impact at the micro level, as the growth ambitions of social and commercial entrepreneurs differ. At the beginning, the introductory section is explained in Chapter 1, which contains the motivation for the research, the research question, and the structure of the work.
There is an ongoing debate about the origin and definition of social entrepreneurship. Therefore, the numerous phenomena of social entrepreneurship are examined theoretically in the previous literature. To determine the common consensus on the topic, Chapter 2 presents
the theoretical foundations and definition of social entrepreneurship. The literature shows that a variety of determinants at the micro and macro levels are essential for the emergence of social entrepreneurship as a distinctive business model (Hartog & Hoogendoorn, 2011; Stephan et al., 2015; Hoogendoorn, 2016). It is impossible to create a society based on a social mission without the support of micro and macro-level-level determinants. This work examines the determinants and consequences of social entrepreneurship from different methodological perspectives. The theoretical foundations of the micro- and macro-level determinants influencing social entrepreneurial activities were discussed in Chapter 3. The purpose of reproducibility in research is to confirm previously published results (Hubbard et al., 1998; Aguinis & Solarino, 2019). However, due to the lack of data, lack of transparency of methodology, reluctance to publish, and lack of interest from researchers, there is a lack of promoting replication of the existing research study (Baker, 2016; Hedges & Schauer, 2019a). Promoting replication studies has been regularly emphasized in the business and management literature (Kerr et al., 2016; Camerer et al., 2016). However, studies that provide replicability of the reported results are considered rare in previous research (Burman et al., 2010; Ryan & Tipu, 2022). Based on the research of Köhler and Cortina (2019), an empirical study on this topic is carried out in Chapter 4 of this work.
Given this focus, researchers have published a large body of research on the impact of microand macro-level determinants on social inclusion, although it is still unclear whether these studies accurately reflect reality. It is important to provide conceptual underpinnings to the field through a reassessment of published results (Bettis et al., 2016). The results of their research make it abundantly clear that the macro determinants support social entrepreneurship.
In keeping with the more narrative approach, which is a crucial concern and requires attention, Chapter 5 considered the reproducibility of previous results, particularly on the topic of social entrepreneurship. We replicated the results of Stephan et al. (2015) to establish the trend of reproducibility and validate the specific conclusions they drew. The literal and constructive replication in the dissertation inspired us to explore technical replication research on social entrepreneurship. Chapter 6 evaluates the fundamental characteristics that have proven to be key factors in the growth of social ventures. The current debate reviews and references literature that has specifically focused on the development of social entrepreneurship. An empirical analysis of factors directly related to the ambitious growth of social entrepreneurship is also carried out.
Numerous social entrepreneurial groups have been studied concerning this association. Chapter 6 compares the growth ambitions of social and traditional (commercial) entrepreneurship as consequences at the micro level. This study examined many characteristics of social and commercial entrepreneurs' growth ambitions. Scholars have claimed to some extent that the growth of social entrepreneurship differs from commercial entrepreneurial activities due to objectivity differences (Lumpkin et al., 2013; Garrido-Skurkowicz et al., 2022). Qualitative research has been used in studies to support the evidence on related topics, including Gupta et al (2020) emphasized that research needs to focus on specific concepts of social entrepreneurship for the field to advance. Therefore, this study provides a quantitative, analysis-based assessment of facts and data. For this purpose, a data set from the Global Entrepreneurship Monitor (GEM) 2015 was used, which examined 12,695 entrepreneurs from 38 countries. Furthermore, this work conducted a regression analysis to evaluate the influence of various social and commercial characteristics of entrepreneurship on economic growth in developing countries. Chapter 7 briefly explains future directions and practical/theoretical implications.