This doctoral thesis includes five studies that deal with the topics work, well-being, and family formation, as well as their interaction. The studies aim to find answers to the following questions: Do workers’ personality traits determine whether they sort into jobs with performance appraisals? Does job insecurity result in lower quality and quantity of sleep? Do public smoking bans affect subjective well-being by changing individuals’ use of leisure time? Can risk preferences help to explain non-traditional family forms? And finally, are differences in out-of-partnership birth rates between East and West Germany driven by cultural characteristics that have evolved in the two separate politico-economic systems? To answer these questions, the following chapters use basic economic subjects such as working conditions, income, and time use, but also employ a range of sociological and psychological concepts such as personality traits and satisfaction measures. Furthermore, all five studies use data from the German Socio-Economic Panel (SOEP), a representative longitudinal panel of private households in Germany, and apply state-of-the-art microeconometric methods. The findings of this doctoral thesis are important for individuals, employers, and policymakers. Workers and employers benefit from knowing the determinants of occupational sorting, as vacancies can be filled more accurately. Moreover, knowing which job-related problems lead to lower well-being and potentially higher sickness absence likely increases efficiency in the workplace. The research on smoking bans and family formation in chapters 4, 5, and 6 is particularly interesting for policymakers. The results on the effects of smoking bans on subjective well-being presented in chapter 4 suggest that the impacts of tobacco control policies could be weighed more carefully. Additionally, understanding why women are willing to take the risks associated with single motherhood can help to improve policies targeting single mothers.