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Left ventricular assist devices (LVADs) have become a valuable treatment for patients with advanced heart failure. Women appear to be disadvantaged in the usage of LVADs and concerning clinical outcomes such as death and adverse events after LVAD implant. Contrary to typical clinical characteristics (e.g., disease severity), device-related factors such as the intended device strategy, bridge to a heart transplantation or destination therapy, are often not considered in research on gender differences. In addition, the relevance of pre-implant psychosocial risk factors, such as substance abuse and limited social support, for LVAD outcomes is currently unclear. Thus, the aim of this dissertation is to explore the role of pre-implant psychosocial risk factors for gender differences in clinical outcomes, accounting for clinical and device-related risk factors.
In the first article, gender differences in pre-implant characteristics of patients registered in The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) were investigated. It was found that women and men differed in multiple pre-implant characteristics depending on device strategy. In the second article, gender differences in major clinical outcomes (i.e., death, heart transplant, device explant due to cardiac recovery, device replacement due to complications) were evaluated for patients in the device strategy destination therapy in the Interagency Registry for Mechanically Assisted Circulation (INTERMACS). Additionally, the association of gender and psychosocial risk factors with the major outcomes were analyzed. Women had similar probabilities to die on LVAD support, and even higher probabilities to experience explant of the device due to cardiac recovery compared with men in the destination therapy subgroup. Pre-implant psychosocial risk factors were not associated with major outcomes. The third article focused on gender differences in 10 adverse events (e.g., device malfunction, bleeding) after LVAD implant in INTERMACS. The association of a psychosocial risk indicator with gender and adverse events after LVAD implantation was evaluated. Women were less likely to have psychosocial risk pre-implant but more likely to experience seven out of 10 adverse events compared with men. Pre-implant psychosocial risk was associated with adverse events, even suggesting a dose response-relationship. These associations appeared to be more pronounced in women.
In conclusion, women appear to have similar survival to men when accounting for device strategy. They have higher probabilities of recovery, but higher probabilities of device replacement and adverse events compared with men. Regarding these adverse events, women may be more susceptible to psychosocial risk factors than men. The results of this dissertation illustrate the importance of gender-sensitive research and suggest considering device strategy when studying gender differences in LVAD recipients. Further research is warranted to elucidate the role of specific psychosocial risk factors that lead to higher probabilities of adverse events, to intervene early and improve patient care in both, women and men
Information in der vorvertraglichen Phase – das heißt, Informationspflichten sowie Rechtsfolgen von Informationserteilung und -nichterteilung – in Bezug auf Kaufvertrag und Wahl des optionalen Instruments hat im Vorschlag der Europäischen Kommission für ein Gemeinsames Europäisches Kaufrecht (GEK; KOM(2011) 635) vielfältige Regelungen erfahren. Die vorliegende Arbeit betrachtet diese Regelungen auch in ihrem Verhältnis zu den Textstufen des Europäischen Privatrechts – Modellregeln und verbraucherschützende EU-Richtlinien – und misst sie an ökonomischen Rahmenbedingungen, die die Effizienz von Transaktionen gebieten und Grenzen des Nutzens von (Pflicht-)Informationen aufzeigen.
Vom Grundsatz der Vertragsfreiheit ausgehend ist jeder Partei das Risiko zugewiesen, unzureichend informiert zu sein, während die Gegenseite nur punktuell zur Information verpflichtet ist. Zwischen Unternehmern bleibt es auch nach dem GEK hierbei, doch zwischen Unternehmer und Verbraucher wird dieses Verhältnis umgekehrt. Dort gelten, mit Differenzierung nach Vertragsschlusssituationen, umfassende Kataloge von Informationspflichten hinsichtlich des Kaufvertrags. Als Konzept ist dies grundsätzlich sinnvoll; die Pflichten dienen dem Verbraucherschutz, insbesondere der Informiertheit und Transparenz vor der Entscheidung über den Vertragsschluss. Teilweise gehen die Pflichten aber zu weit. Die Beeinträchtigung der Vertragsfreiheit des Unternehmers durch die Pflichten und die Folgen ihrer Verletzung lässt sich nicht vollständig mit dem Ziel des Verbraucherschutzes rechtfertigen. Durch das Übermaß an Information fördern die angeordneten Pflichten den Verbraucherschutz nur eingeschränkt; sie genügen nicht verhaltensökonomischen Maßstäben. Es empfiehlt sich daher, zwischen Unternehmern und Verbrauchern bestimmte verpflichtende Informationsinhalte ganz zu streichen, auf im konkreten Fall nicht erforderliche Information zu verzichten, erst nach Vertragsschluss relevante Informationen auf diese Zeit zu verschieben und die verbleibenden vorvertraglichen Pflichtinformationen in einer für den Verbraucher besser zu verarbeitenden Weise zu präsentieren. Von den einem Verbraucher zu erteilenden Informationen sollte stets verlangt werden, dass sie klar und verständlich sind; die Beweislast für ihre ordnungsgemäße Erteilung sollte generell dem Unternehmer obliegen.
Neben die ausdrücklich angeordneten Informationspflichten treten ungeachtet der Verbraucher- oder Unternehmereigenschaft sowie der Käufer- oder Verkäuferrolle stark einzelfallabhängige Informationspflichten nach Treu und Glauben, die im Recht der Willensmängel niedergelegt sind. Hier ist der Grundsatz verwirklicht, dass mangelnde Information zunächst das eigene Risiko jeder Partei ist; berechtigtes Vertrauen und freie Willensbildung werden geschützt. Diese Pflichten berücksichtigen auch das Ziel der Effizienz und achten die Vertragsfreiheit. Das Vertrauen auf jegliche erteilten Informationen wird zudem dadurch geschützt, dass sie den Vertragsinhalt – allerdings in Verbraucherverträgen nicht umfassend genug – mitbestimmen können und dass ihre Unrichtigkeit sanktioniert wird.
Die Verletzung jeglicher Arten von Informationspflichten kann insbesondere einen Schadensersatzanspruch sowie – über das Recht der Willensmängel – die Möglichkeit zur Lösung vom Vertrag nach sich ziehen. Das Zusammenspiel der unterschiedlichen Mechanismen führt allerdings zu Friktionen sowie zu Lücken in den Rechtsfolgen von Informationspflichtverletzungen. Daher empfiehlt sich die Schaffung eines Schadensersatzanspruchs für jede treuwidrig unterlassene Informationserteilung; hierdurch wird das Gebot von Treu und Glauben auch außerhalb des Rechts der Willensmängel zu einer eigentlichen einzelfallabhängigen Informationspflicht aufgewertet.
Physically-based distributed rainfall-runoff models as the standard analysis tools for hydro-logical processes have been used to simulate the water system in detail, which includes spa-tial patterns and temporal dynamics of hydrological variables and processes (Davison et al., 2015; Ek and Holtslag, 2004). In general, catchment models are parameterized with spatial information on soil, vegetation and topography. However, traditional approaches for eval-uation of the hydrological model performance are usually motivated with respect to dis-charge data alone. This may thus cloud model realism and hamper understanding of the catchment behavior. It is necessary to evaluate the model performance with respect to in-ternal hydrological processes within the catchment area as well as other components of wa-ter balance rather than runoff discharge at the catchment outlet only. In particular, a consid-erable amount of dynamics in a catchment occurs in the processes related to interactions of the water, soil and vegetation. Evapotranspiration process, for instance, is one of those key interactive elements, and the parameterization of soil and vegetation in water balance mod-eling strongly influences the simulation of evapotranspiration. Specifically, to parameterize the water flow in unsaturated soil zone, the functional relationships that describe the soil water retention and hydraulic conductivity characteristics are important. To define these functional relationships, Pedo-Transfer Functions (PTFs) are common to use in hydrologi-cal modeling. Opting the appropriate PTFs for the region under investigation is a crucial task in estimating the soil hydraulic parameters, but this choice in a hydrological model is often made arbitrary and without evaluating the spatial and temporal patterns of evapotran-spiration, soil moisture, and distribution and intensity of runoff processes. This may ulti-mately lead to implausible modeling results and possibly to incorrect decisions in regional water management. Therefore, the use of reliable evaluation approaches is continually re-quired to analyze the dynamics of the current interactive hydrological processes and predict the future changes in the water cycle, which eventually contributes to sustainable environ-mental planning and decisions in water management.
Remarkable endeavors have been made in development of modelling tools that provide insights into the current and future of hydrological patterns in different scales and their im-pacts on the water resources and climate changes (Doell et al., 2014; Wood et al., 2011). Although, there is a need to consider a proper balance between parameter identifiability and the model's ability to realistically represent the response of the natural system. Neverthe-less, tackling this issue entails investigation of additional information, which usually has to be elaborately assembled, for instance, by mapping the dominant runoff generation pro-cesses in the intended area, or retrieving the spatial patterns of soil moisture and evapotran-spiration by using remote sensing methods, and evaluation at a scale commensurate with hydrological model (Koch et al., 2022; Zink et al., 2018). The present work therefore aims to give insights into the modeling approaches to simulate water balance and to improve the soil and vegetation parameterization scheme in the hydrological model subject to producing more reliable spatial and temporal patterns of evapotranspiration and runoff processes in the catchment.
An important contribution to the overall body of work is a book chapter included among publications. The book chapter provides a comprehensive overview of the topic and valua-ble insights into the understanding the water balance and its estimation methods.
Moreover, the first paper aimed to evaluate the hydrological model behavior with re-spect to contribution of various sources of information. To do so, a multi-criteria evaluation metric including soft and hard data was used to define constraints on outputs of the 1-D hydrological model WaSiM-ETH. Applying this evaluation metric, we could identify the optimal soil and vegetation parameter sets that resulted in a “behavioral” forest stand water balance model. It was found out that even if simulations of transpiration and soil water con-tent are consistent with measured data, but still the dominant runoff generation processes or total water balance might be wrongly calculated. Therefore, only using an evaluation scheme which looks over different sources of data and embraces an understanding of the local controls of water loss through soil and plant, allowed us to exclude the unrealistic modeling outputs. The results suggested that we may need to question the generally accept-ed soil parameterization procedures that apply default parameter sets.
The second paper attempts to tackle the pointed model evaluation hindrance by getting down to the small-scale catchment (in Bavaria). Here, a methodology was introduced to analyze the sensitivity of the catchment water balance model to the choice of the Pedo-Transfer Functions (PTF). By varying the underlying PTFs in a calibrated and validated model, we could determine the resulting effects on the spatial distribution of soil hydraulic properties, total water balance in catchment outlet, and the spatial and temporal variation of the runoff components. Results revealed that the water distribution in the hydrologic system significantly differs amongst various PTFs. Moreover, the simulations of water balance components showed high sensitivity to the spatial distribution of soil hydraulic properties. Therefore, it was suggested that opting the PTFs in hydrological modeling should be care-fully tested by looking over the spatio-temporal distribution of simulated evapotranspira-tion and runoff generation processes, whether they are reasonably represented.
To fulfill the previous studies’ suggestions, the third paper then aims to focus on evalu-ating the hydrological model through improving the spatial representation of dominant run-off processes. It was implemented in a mesoscale catchment in southwestern Germany us-ing the hydrological model WaSiM-ETH. Dealing with the issues of inadequate spatial ob-servations for rigorous spatial model evaluation, we made use of a reference soil hydrologic map available for the study area to discern the expected dominant runoff processes across a wide range of hydrological conditions. The model was parameterized by applying 11 PTFs and run by multiple synthetic rainfall events. To compare the simulated spatial patterns to the patterns derived by digital soil map, a multiple-component spatial performance metric (SPAEF) was applied. The simulated DRPs showed a large variability with regard to land use, topography, applied rainfall rates, and the different PTFs, which highly influence the rapid runoff generation under wet conditions.
The three published manuscripts proceeded towards the model evaluation viewpoints that ultimately attain the behavioral model outputs. It was performed through obtaining information about internal hydrological processes that lead to certain model behaviors, and also about the function and sensitivity of some of the soil and vegetation parameters that may primarily influence those internal processes in a catchment. Accordingly, using this understanding on model reactions, and by setting multiple evaluation criteria, it was possi-ble to identify which parameterization could lead to behavioral model realization. This work, in fact, will contribute to solving some of the issues (e.g., spatial variability and modeling methods) identified as the 23 unsolved problems in hydrology in the 21st century (Blöschl et al., 2019). The results obtained in the present work encourage the further inves-tigations toward a comprehensive model calibration procedure considering multiple data sources simultaneously. This will enable developing the new perspectives to the current parameter estimation methods, which in essence, focus on reproducing the plausible dy-namics (spatio-temporal) of the other hydrological processes within the watershed.
Today, almost every modern computing device is equipped with multicore processors capable of efficient concurrent and parallel execution of threads. This processor feature can be leveraged by concurrent programming, which is a challenge for software developers for two reasons: first, it introduces a paradigm shift that requires a new way of thinking. Second, it can lead to issues that are unique to concurrent programs due to the non-deterministic, interleaved execution of threads. Consequently, the debugging of concurrency and related performance issues is a rather difficult and often tedious task. Developers still lack on thread-aware programming tools that facilitate the understanding of concurrent programs. Ideally, these tools should be part of their daily working environment, which typically includes an Integrated Development Environment (IDE). In particular, the way source code is visually presented in traditional source-code editors does not convey much information on whether the source code is executed concurrently or in parallel in the first place.
With this dissertation, we pursue the main goal of facilitating and supporting the understanding and debugging of concurrent programs. To this end, we formulate and utilize a visualization paradigm that particularly includes the display of interactive glyph-based visualizations embedded in the source-code editor close to their corresponding artifacts (in-situ).
To facilitate the implementation of visualizations that comply with our paradigm as plugins for IDEs, we designed, implemented and evaluated a programming framework called CodeSparks. After presenting the design goals and the architecture of the framework, we demonstrate its versatility with a total of fourteen plugins realized by different developers using the CodeSparks framework (CodeSparks plugins). With focus group interviews, we empirically investigated how developers of the CodeSparks plugins experienced working with the framework. Based on the plugins, deliberate design decisions and the interview results, we discuss to what extent we achieved our design goals. We found that the framework is largely target programming-language independent and that it supports the development of plugins for a wide range of source-code-related tasks while hiding most of the details of the underlying plugin development API.
In addition, we applied our visualization paradigm to thread-related runtime data from concurrent programs to foster the awareness of source code being executed concurrently or in parallel. As a result, we developed and designed two in-situ thread visualizations, namely ThreadRadar and ThreadFork, with the latter building on the former. Both thread visualizations are based on a debugging approach, which combines statistical profiling, thread-aware runtime metrics, clustering of threads on the basis of these metrics, and finally interactive glyph-based in-situ visualizations. To address scalability issues of the ThreadRadar in terms of space required and the number of displayable thread clusters, we designed a revised thread visualization. This revision also involved the question of how many thread clusters k should be computed in the first place. To this end, we conducted experiments with the clustering of threads for artifacts from a corpus of concurrent Java programs that include real-world Java applications and concurrency bugs. We found that the maximum k on the one hand and the optimal k according to four cluster validation indices on the other hand rarely exceed three. However, occasionally thread clusterings with k > 3 are available and also optimal. Consequently, we revised both the clustering strategy and the visualization as parts of our debugging approach, which resulted in the ThreadFork visualization. Both in-situ thread visualizations, including their additional features that support the exploration of the thread data, are implemented in a tool called CodeSparks-JPT, i.e., as a CodeSparks plugin for IntelliJ IDEA.
With various empirical studies, including anecdotal usage scenarios, a usability test, web surveys, hands-on sessions, questionnaires and interviews, we investigated quality aspects of the in-situ thread visualizations and their corresponding tools. First, by a demonstration study, we illustrated the usefulness of the ThreadRadar visualization in investigating and fixing concurrency bugs and a performance bug. This was confirmed by a subsequent usability test and interview, which also provided formative feedback. Second, we investigated the interpretability and readability of the ThreadFork glyphs as well as the effectiveness of the ThreadFork visualization through anonymous web surveys. While we have found that the ThreadFork glyphs are correctly interpreted and readable, it remains unproven that the ThreadFork visualization effectively facilitates understanding the dynamic behavior of threads that concurrently executed portions of source code. Moreover, the overall usability of CodeSparks-JPT is perceived as "OK, but not acceptable" as the tool has issues with its learnability and memorability. However, all other usability aspects of CodeSparks-JPT that were examined are perceived as "above average" or "good".
Our work supports software-engineering researchers and practitioners in flexibly and swiftly developing novel glyph-based visualizations that are embedded in the source-code editor. Moreover, we provide in-situ thread visualizations that foster the awareness of source code being executed concurrently or in parallel. These in-situ thread visualizations can, for instance, be adapted, extended and used to analyze other use cases or to replicate the results. Through empirical studies, we have gradually shaped the design of the in-situ thread visualizations through data-driven decisions, and evaluated several quality aspects of the in-situ thread visualizations and the corresponding tools for their utility in understanding and debugging concurrent programs.
Semantic-Aware Coordinated Multiple Views for the Interactive Analysis of Neural Activity Data
(2024)
Visualizing brain simulation data is in many aspects a challenging task. For one, data used in brain simulations and the resulting datasets is heterogeneous and insight is derived by relating all different kinds of it. Second, the analysis process is rapidly changing while creating hypotheses about the results. Third, the scale of data entities in these heterogeneous datasets is manifold, reaching from single neurons to brain areas interconnecting millions. Fourth, the heterogeneous data consists of a variety of modalities, e.g.: from time series data to connectivity data, from single parameters to a set of parameters spanning parameter spaces with multiple possible and biological meaningful solutions; from geometrical data to hierarchies and textual descriptions, all on mostly different scales. Fifth, visualizing includes finding suitable representations and providing real-time interaction while supporting varying analysis workflows. To this end, this thesis presents a scalable and flexible software architecture for visualizing, integrating and interacting with brain simulations data. The scalability and flexibility is achieved by interconnected services forming in a series of Coordinated Multiple View (CMV) systems. Multiple use cases are presented, introducing views leveraging this architecture, extending its ecosystem and resulting in a Problem Solving Environment (PSE) from which custom-tailored CMV systems can be build. The construction of such CMV system is assisted by semantic reasoning hence the term semantic-aware CMVs.
Der vorliegende Beitrag greift die öffentliche Diskussion um den rechtspolitischen Umgang mit Hass, Hetze und Antisemitismus auf, die insbesondere nach dem Terroranschlag der Hamas am 07.10.2023 an Intensität und Dringlichkeit zugenommen hat. Dabei beleuchtet er einerseits das Straf- und Zivilrecht, legt andererseits einen besonderen Fokus auf öffentlich-rechtliche Konstellationen. Auf jedem dieser Gebiete werden Schwächen und Potenziale des Rechts und der Rechtsprechung aufgezeigt, zugleich aber auch die Grenzen staatlicher Gewalt verdeutlicht. Denn letztlich handelt es sich um ein gesellschaftliches Problem, dem – trotz aller Notwendigkeit staatlichen Handelns – in erster Linie durch Information, und erst in zweiter Linie durch das Recht begegnet werden muss.