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Auf der Grundlage einer Fragebogenstudie wurden unterschiedliche Elemente eines förderlichen Umgangs mit Gesundheitsinformationen betrachtet und ihre Zusammenhänge mit personspezifischen Merkmalen analysiert. Als zentrale Aspekte der Informationsprozesse wurden die drei Elemente Gesundheitsinformationskompetenz, Gesundheitsinteresse und gesundheitsspezifische Informationsgewohnheiten konzeptuell voneinander getrennt. Auf der Basis des bisherigen Forschungsstands wurde zunächst ein theoretisches Modell des Umgangs mit Gesundheitsinformationen entwickelt, das die Bedeutung der Kompetenz und des Interesses für gesundheitsbezogene Informationsgewohnheiten hervorhebt, individuelle Ausprägungen dieser drei Elemente mit soziodemografischen Faktoren, Persönlichkeitseigenschaften, Überzeugungen und dem Gesundheitszustand in Beziehung setzt sowie Verbindungen zu gesundheitsrelevanten Verhaltensweisen beschreibt. Dieses Modell wurde anschließend an einer Stichprobe von 352 Berufsschülerinnen und -schülern aus drei Berufsbereichen (Wirtschaft/Verwaltung, Technik und Gesundheit) empirisch überprüft. Über multiple Regressionsanalysen wurden bedeutsame Prädiktoren für die drei Hauptelemente Kompetenz, Interesse und Informationsgewohnheiten identifiziert, über logistische Regressionen und Korrelationen ihre Zusammenhänge mit dem Gesundheitsverhalten überprüft. Darüber hinaus wurden lineare Strukturgleichungsmodelle zur Vorhersage des Informationsverhaltens entwickelt. Die Ergebnisse bestätigen die konzeptionelle Trennung der drei Faktoren, die jeweils mit unterschiedlichen Prädiktoren verbunden waren. Auf der Basis der Befunde werden Ansatzpunkte für die weitere Forschung und die Förderung eines kompetenten Umgangs mit Gesundheitsinformationen diskutiert.
Die publikationsbasierte Dissertation untersucht die Bedeutung sozialer Bewegungen für die Entwicklung der Sozialen Arbeit am Ende des 19. und den ersten Jahrzehnten des 20. Jahrhunderts als Profession und Disziplin in den USA und in Deutschland. Dabei wird die entstehende Soziale Arbeit als ‚Formbildung‘ sozialer Bewegungen verstanden und gefragt, wie sich die Bewegungen in die sich etablierende und institutionalisierende Profession und Wissenschaft Soziale Arbeit einschreiben, welche Anliegen dabei verfolgt werden und wie dadurch Wissen in der Sozialen Arbeit auch über nationalstaatliche Grenzen hinweg zirkuliert.
Die Untersuchung konzentriert sich auf Prozesse der Pädagogisierung, also unterschiedliche ‚Formbildungen des Pädagogischen‘, die die Bewegungsanliegen zum Thema von Aufklärung, (Selbst)Bildung und Pädagogik machen, und auf solche der Verwissenschaftlichung, die sich auf den Aufbau einer Wissensgrundlage zur Bearbeitung von sozialen Problemen richten und dabei alternative Formen der Wissensproduktion ausbilden. Diese Prozesse werden in drei Teilstudien – zur Charity Organization Movement und der Settlement House Movement in den USA sowie der bürgerlichen Frauenbewegung in Deutschland – in sieben Einzelbeiträgen näher untersucht. Im Mittelpunkt stehen dabei die Handlungsmethoden und das Praxisverständnis sowie Forschungskonzepte und –projekte exemplarisch ausgewählter sozialbewegter Initiativen der Sozialen Arbeit. Dabei werden unter anderem nicht-intendierte Effekte untersucht, die zum Beispiel in Konservierungen normativer Vorstellungen und Ideologien in als demokratisierend angelegten Ansätzen, aber auch in ‚differenzverstärkenden‘ Effekten bestehen können.
Hypothalamic-pituitary-adrenal (HPA) axis-related genetic variants influence the stress response
(2019)
The physiological stress system includes the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic-adrenal-medullary system (SAM). Parameters representing these systems such as cortisol, blood pressure or heart rate define the physiological reaction in response to a stressor. The main objective of the studies described in this thesis was to understand the role of the HPA-related genetic factors in these two systems. Genetic factors represent one of the components causing individual variations in physiological stress parameters. Five genes involved in the functioning of the HPA axis regarding stress responses are examined in this thesis. They are: corticotropin-releasing hormone (CRH), the glucocorticoid receptor (GR), the mineralocorticoid receptor (MR), the 5-hydroxytryptamine-transporter-linked polymorphic region (5-HTTLPR) in the serotonin transporter (5-HTT) and the brain-derived neurotrophic factor (BDNF) gene. Two hundred thirty-two healthy participants were genotyped. The influence of genetic factors on physiological parameters, such as post-awakening cortisol and blood pressure was assessed, as well as the influence of genetic factors on stress reactivity in response to a socially evaluated cold pressor test (SeCPT). Three studies tested the HPA-related genes each on three different levels. The first study examined the influences of genotypes and haplotypes of these five genes on physiological as well as psychological stress indicators (Chapter 2). The second study examined the effects of GR variants (genotypes and haplotypes) and promoter methylation level on both the SAM system and the HPA axis stress reactivity (Chapter 3). The third study comprised the characterization of CRH promoter haplotypes in an in-vitro study and the association of the CRH promoter with stress indicators in vivo (Chapter 4).
Computer simulation has become established in a two-fold way: As a tool for planning, analyzing, and optimizing complex systems but also as a method for the scientific instigation of theories and thus for the generation of knowledge. Generated results often serve as a basis for investment decisions, e.g., road construction and factory planning, or provide evidence for scientific theory-building processes. To ensure the generation of credible and reproducible results, it is indispensable to conduct systematic and methodologically sound simulation studies. A variety of procedure models exist that structure and predetermine the process of a study. As a result, experimenters are often required to repetitively but thoroughly carry out a large number of experiments. Moreover, the process is not sufficiently specified and many important design decisions still have to be made by the experimenter, which might result in an unintentional bias of the results.
To facilitate the conducting of simulation studies and to improve both replicability and reproducibility of the generated results, this thesis proposes a procedure model for carrying out Hypothesis-Driven Simulation Studies, an approach that assists the experimenter during the design, execution, and analysis of simulation experiments. In contrast to existing approaches, a formally specified hypothesis becomes the key element of the study so that each step of the study can be adapted and executed to directly contribute to the verification of the hypothesis. To this end, the FITS language is presented, which enables the specification of hypotheses as assumptions regarding the influence specific input values have on the observable behavior of the model. The proposed procedure model systematically designs relevant simulation experiments, runs, and iterations that must be executed to provide evidence for the verification of the hypothesis. Generated outputs are then aggregated for each defined performance measure to allow for the application of statistical hypothesis testing approaches. Hence, the proposed assistance only requires the experimenter to provide an executable simulation model and a corresponding hypothesis to conduct a sound simulation study. With respect to the implementation of the proposed assistance system, this thesis presents an abstract architecture and provides formal specifications of all required services.
To evaluate the concept of Hypothesis-Driven Simulation Studies, two case studies are presented from the manufacturing domain. The introduced approach is applied to a NetLogo simulation model of a four-tiered supply chain. Two scenarios as well as corresponding assumptions about the model behavior are presented to investigate conditions for the occurrence of the bullwhip effect. Starting from the formal specification of the hypothesis, each step of a Hypothesis-Driven Simulation Study is presented in detail, with specific design decisions outlined, and generated inter- mediate data as well as final results illustrated. With respect to the comparability of the results, a conventional simulation study is conducted which serves as reference data. The approach that is proposed in this thesis is beneficial for both practitioners and scientists. The presented assistance system allows for a more effortless and simplified execution of simulation experiments while the efficient generation of credible results is ensured.
This dissertation investigates corporate acquisition decisions that represent important corporate development activities for family and non-family firms. The main research objective of this dissertation is to generate insights into the subjective decision-making behavior of corporate decision-makers from family and non-family firms and their weighting of M&A decision-criteria during the early pre-acquisition target screening and selection process. The main methodology chosen for the investigation of M&A decision-making preferences and the weighting of M&A decision criteria is a choice-based conjoint analysis. The overall sample of this dissertation consists of 304 decision-makers from 264 private and public family and non-family firms from mainly Germany and the DACH-region. In the first empirical part of the dissertation, the relative importance of strategic, organizational and financial M&A decision-criteria for corporate acquirers in acquisition target screening is investigated. In addition, the author uses a cluster analysis to explore whether distinct decision-making patterns exist in acquisition target screening. In the second empirical part, the dissertation explores whether there are differences in investment preferences in acquisition target screening between family and non-family firms and within the group of family firms. With regards to the heterogeneity of family firms, the dissertation generated insights into how family-firm specific characteristics like family management, the generational stage of the firm and non-economic goals such as transgenerational control intention influences the weighting of different M&A decision criteria in acquisition target screening. The dissertation contributes to strategic management research, in specific to M&A literature, and to family business research. The results of this dissertation generate insights into the weighting of M&A decision-making criteria and facilitate a better understanding of corporate M&A decisions in family and non-family firms. The findings show that decision-making preferences (hence the weighting of M&A decision criteria) are influenced by characteristics of the individual decision-maker, the firm and the environment in which the firm operates.
In this thesis, we aim to study the sampling allocation problem of survey statistics under uncertainty. We know that the stratum specific variances are generally not known precisely and we have no information about the distribution of uncertainty. The cost of interviewing each person in a stratum is also a highly uncertain parameter as sometimes people are unavailable for the interview. We propose robust allocations to deal with the uncertainty in both stratum specific variances and costs. However, in real life situations, we can face such cases when only one of the variances or costs is uncertain. So we propose three different robust formulations representing these different cases. To the best of our knowledge robust allocation in the sampling allocation problem has not been considered so far in any research.
The first robust formulation for linear problems was proposed by Soyster (1973). Bertsimas and Sim (2004) proposed a less conservative robust formulation for linear problems. We study these formulations and extend them for the nonlinear sampling allocation problem. It is very unlikely to happen that all of the stratum specific variances and costs are uncertain. So the robust formulations are in such a way that we can select how many strata are uncertain which we refer to as the level of uncertainty. We prove that an upper bound on the probability of violation of the nonlinear constraints can be calculated before solving the robust optimization problem. We consider various kinds of datasets and compute robust allocations. We perform multiple experiments to check the quality of the robust allocations and compare them with the existing allocation techniques.
This thesis sheds light on the heterogeneous hedging behavior of airlines. The focus lies on financial hedging, operational hedging and selective hedging. The unbalanced panel data set includes 74 airlines from 39 countries. The period of analysis is 2005 until 2014, resulting in 621 firm years. The random effects probit and fixed effects OLS models provide strong evidence of a convex relation between derivative usage and a firm’s leverage, opposing the existing financial distress theory. Airlines with lower leverage had higher hedge ratios. In addition, the results show that airlines with interest rate and currency derivatives were more likely to engage in fuel price hedging. Moreover, the study results support the argument that operational hedging is a complement to financial hedging. Airlines with more heterogeneous fleet structures exhibited higher hedge ratios.
Also, airlines which were members of a strategic alliance were more likely to be hedging airlines. As alliance airlines are rather financially sound airlines, the positive relation between alliance membership and hedging reflects the negative results on the leverage
ratio. Lastly, the study presents determinants of an airlines’ selective hedging behavior. Airlines with prior-period derivative losses, recognized in income, changed their hedge portfolios more frequently. Moreover, the sample airlines acted in accordance with herd behavior theory. Changes in the regional hedge portfolios influenced the hedge portfolio of the individual airline in the same direction.
Entrepreneurship has become an essential phenomenon all over the world because it is a major driving force behind the economic growth and development of a country. It is widely accepted that entrepreneurship development in a country creates new jobs, pro-motes healthy competition through innovation, and benefits the social well being of individuals and societies. The policymakers in both developed and developing countries focus on entrepreneurship because it helps to alleviate impediments to economic development and social welfare. Therefore, policymakers and academic researchers consider the promotion of entrepreneurship as essential for the economy and research-based support is needed for further development of entrepreneurship activities.
The impact of entrepreneurial activities on economic and social development also varies from country to country. The effect of entrepreneurial activities on economic and social development also varies from country to country because the level of entrepreneur-ship activities also varies from one region to another or one country to another. To under-stand these variations, policymakers have investigated the determinants of entrepreneur-ship at different levels, such as the individual, industry, and country levels. Moreover, entrepreneurship behavior is influenced by various personal and environmental level factors. However, these personal-level factors cannot be separated from the surrounding environment.
The link between religion and entrepreneurship is well established and can be traced back to Weber (1930). Researchers have analyzed the relationship between religion and entrepreneurship from various perspectives, and the research related to religion and entrepreneurship is diversified and scattered across disciplines. This dissertation tries to explain the link between religion and entrepreneurship, specifically Islamic religion and entrepreneurship. Technically this dissertation comprises three parts. The first part of this dissertation consists of two chapters that discuss the definition and theories of entrepreneurship (Chapter 2) and the theoretical relationship between religion and entrepreneur-ship (Chapter 3).
The second part of this dissertation (Chapter 4) provides an overview of the field with a purpose to gain a better understanding of the field’s current state of knowledge to bridge the different views and perspectives. In order to provide an overview of the field, a systematic literature search leading to a descriptive overview of the field based on 270 articles published in 163 journals Subsequently, bibliometric methods are used to identify thematic clusters, the most influential authors and articles, and how they are connected.
The third part of this dissertation (Chapter 5) empirically evaluates the influence of Islamic values and Islamic religious practices on entrepreneurship intentions within the Islamic community. Using the theory of planned behavior as a theoretical lens, we also take into account that the relationship between religion and entrepreneurial intentions can be mediated by individual’s attitude towards entrepreneurship. A self-administrative questionnaire was used to collect the responses from a sample of 1895 Pakistani university students. A structured equation modeling was adopted to perform a nuanced assessment of the relationship between Islamic values and practices and entrepreneurship intentions and to account for mediating effect of attitude towards entrepreneurship.
The research on religion and entrepreneurship has increased sharply during the last years and is scattered across various academic disciplines and fields. The analysis identifies and characterize the most important publications, journals, and authors in the area and map the analyzed religions and regions. The comprehensive overview of previous studies allows us to identify research gaps and derive avenues for future research in a substantiated way. Moreover, this dissertation helps the research scholars to understand the field in its entirety, identify relevant articles, and to uncover parallels and differences across religions and regions. Besides, the study reveals a lack of empirical research related to specific religions and specific regions. Therefore, scholars can take these regions and religions into consideration when conducting empirical research.
Furthermore, the empirical analysis about the influence of Islamic religious values and Islamic religious practices show that Islamic values served as a guiding principle in shaping people’s attitudes towards entrepreneurship in an Islamic community; they had an indirect influence on entrepreneurship intention through attitude. Similarly, the relationship between Islamic religious practices and the entrepreneurship intentions of students was fully mediated by the attitude towards entrepreneurship. Furthermore, this dissertation contributes to prior research on entrepreneurship in Islamic communities by applying a more fine-grained approach to capture the link between religion and entrepreneurship. Moreover, it contributes to the literature on entrepreneurship intentions by showing that the influence of religion on entrepreneurship intentions is mainly due to religious values and practices, which shape the attitude towards entrepreneurship and thereby influence entrepreneurship intentions in religious communities. The entrepreneur-ship research has put a higher emphasis on assessing the influence of a diverse set of con-textual factors. This dissertation introduces Islamic values and Islamic religious practices as critical contextual factors that shape entrepreneurship in countries that are characterized by the Islamic religion.
Our goal is to approximate energy forms on suitable fractals by discrete graph energies and certain metric measure spaces, using the notion of quasi-unitary equivalence. Quasi-unitary equivalence generalises the two concepts of unitary equivalence and norm resolvent convergence to the case of operators and energy forms defined in varying Hilbert spaces.
More precisely, we prove that the canonical sequence of discrete graph energies (associated with the fractal energy form) converges to the energy form (induced by a resistance form) on a finitely ramified fractal in the sense of quasi-unitary equivalence. Moreover, we allow a perturbation by magnetic potentials and we specify the corresponding errors.
This aforementioned approach is an approximation of the fractal from within (by an increasing sequence of finitely many points). The natural step that follows this realisation is the question whether one can also approximate fractals from outside, i.e., by a suitable sequence of shrinking supersets. We partly answer this question by restricting ourselves to a very specific structure of the approximating sets, namely so-called graph-like manifolds that respect the structure of the fractals resp. the underlying discrete graphs. Again, we show that the canonical (properly rescaled) energy forms on such a sequence of graph-like manifolds converge to the fractal energy form (in the sense of quasi-unitary equivalence).
From the quasi-unitary equivalence of energy forms, we conclude the convergence of the associated linear operators, convergence of the spectra and convergence of functions of the operators – thus essentially the same as in the case of the usual norm resolvent convergence.
Nonlocal operators are used in a wide variety of models and applications due to many natural phenomena being driven by nonlocal dynamics. Nonlocal operators are integral operators allowing for interactions between two distinct points in space. The nonlocal models investigated in this thesis involve kernels that are assumed to have a finite range of nonlocal interactions. Kernels of this type are used in nonlocal elasticity and convection-diffusion models as well as finance and image analysis. Also within the mathematical theory they arouse great interest, as they are asymptotically related to fractional and classical differential equations.
The results in this thesis can be grouped according to the following three aspects: modeling and analysis, discretization and optimization.
Mathematical models demonstrate their true usefulness when put into numerical practice. For computational purposes, it is important that the support of the kernel is clearly determined. Therefore nonlocal interactions are typically assumed to occur within an Euclidean ball of finite radius. In this thesis we consider more general interaction sets including norm induced balls as special cases and extend established results about well-posedness and asymptotic limits.
The discretization of integral equations is a challenging endeavor. Especially kernels which are truncated by Euclidean balls require carefully designed quadrature rules for the implementation of efficient finite element codes. In this thesis we investigate the computational benefits of polyhedral interaction sets as well as geometrically approximated interaction sets. In addition to that we outline the computational advantages of sufficiently structured problem settings.
Shape optimization methods have been proven useful for identifying interfaces in models governed by partial differential equations. Here we consider a class of shape optimization problems constrained by nonlocal equations which involve interface-dependent kernels. We derive the shape derivative associated to the nonlocal system model and solve the problem by established numerical techniques.