Filtern
Erscheinungsjahr
Dokumenttyp
- Dissertation (64)
- Wissenschaftlicher Artikel (30)
Sprache
- Englisch (94) (entfernen)
Volltext vorhanden
- ja (94) (entfernen)
Schlagworte
- Stress (22)
- Hydrocortison (13)
- Cortisol (9)
- cortisol (9)
- stress (7)
- Lernen (6)
- Physiologische Psychologie (6)
- Aufmerksamkeit (5)
- Depression (4)
- Elektroencephalographie (4)
- Funktionelle NMR-Tomographie (4)
- Kognition (4)
- Lebensmittel (4)
- Neuroendokrines System (4)
- Stressreaktion (4)
- fMRI (4)
- Affekt (3)
- Aggression (3)
- Gedächtnis (3)
- Langzeitgedächtnis (3)
- Memory (3)
- Psychotherapie (3)
- Schmerz (3)
- Selbstbild (3)
- episodic memory (3)
- long-term memory (3)
- Ambivalenz (2)
- Arbeitsgedächtnis (2)
- Augenfolgebewegung (2)
- Brustkrebs (2)
- Distractor-Response Binding (2)
- Dopamin (2)
- Einstellung (2)
- Elektroencephalogramm (2)
- Emotion (2)
- Emotionsregulation (2)
- Episodisches Gedächtnis (2)
- Ereigniskorreliertes Potenzial (2)
- Essstörung (2)
- Evaluation (2)
- Evaluative Konditionierung (2)
- Fibromyalgie (2)
- Gefühl (2)
- Gehirn (2)
- Genanalyse (2)
- Genexpression (2)
- Glucocorticosteroide (2)
- Glucocorticosteroidrezeptor (2)
- HPA axis (2)
- Humangenetik (2)
- Hypothalamus-Hypophysen-Nebennierenrinden-Achse (2)
- Insulin (2)
- Interaktion (2)
- Interozeption (2)
- Kognitive Psychologie (2)
- Learning (2)
- Partnerwahl (2)
- Persönlichkeitsstörung (2)
- Prognose (2)
- Psychobiologie (2)
- Psychological stress (2)
- Rückmeldung (2)
- Schizophrenie (2)
- Schreckreaktion (2)
- Selbstkontrolle (2)
- Stressor (2)
- Therapieerfolg (2)
- Vegetatives Nervensystem (2)
- Vergessen (2)
- academic self-concept (2)
- affective startle modulation (2)
- alternative Transkriptionsvarianten (2)
- alternative transcription variant (2)
- ambivalence (2)
- attitudes (2)
- behavioral genetics (2)
- directed forgetting (2)
- dopamine (2)
- evaluative conditioning (2)
- fibromyalgia (2)
- glucocorticoid receptor (2)
- intervention (2)
- mating preferences (2)
- pain (2)
- psychology (2)
- selective attention (2)
- (ADHD (1)
- 2D DIGE (1)
- 5' UTR (1)
- ACC (1)
- ANS (1)
- Abhängigkeit (1)
- Acetylcholin (1)
- Action control (1)
- Adaptives System (1)
- Affect (1)
- Affektive Schreckreiz-Modulation (1)
- Affektive Startle Modulation (1)
- Affektstörung (1)
- Alter (1)
- Ambivalence (1)
- Angststörung (1)
- Annäherungs-Vermeidungs-Motivation (1)
- Anthropometrie (1)
- Approach-avoidance motivation (1)
- Arbeit (1)
- Assoziatives Lernen (1)
- Aufmerksamkeits-Defizit-Syndrom (1)
- Ausdauer (1)
- Auswahl (1)
- Autismus (1)
- Baroreflex (1)
- Bauchfett (1)
- Beeinflussung (1)
- Begabtenförderung (1)
- Behalten (1)
- Behavioural methods (1)
- Beurteilungsfehler (1)
- Binge-eating Disorder (1)
- Bipolar Disorder (1)
- Bipolare Störung (1)
- Birth weight (1)
- Blinkreflex (1)
- Blinzelreflex (1)
- Borderline Personality Disorder (1)
- Borderline-Persönlichkeitsstörung (1)
- Brain (1)
- Bulimie (1)
- Burnout (1)
- Burnout-Syndrom (1)
- C15orf53 (1)
- CASL (1)
- CBG (1)
- CBT (1)
- COMT Val158Met (1)
- Care (1)
- Catecholmethyltransferase <Catechol-0-Methyltransferase> (1)
- Central Nervous System (1)
- Change (1)
- Chromosom 15 (1)
- Chromosom 22 (1)
- Cingulum (1)
- Cingulum Cerebri (1)
- Cognition (1)
- Cold Pressor Test (1)
- Coming-out (1)
- Conceptual Endophenotypes (1)
- Conduct disorder (1)
- Construal Level Theorie (1)
- Construal Level Theory (1)
- Consumer need for uniqueness (1)
- Continuity (1)
- Control theory (1)
- Corticosteroid-bindendes Globulin (1)
- Corticosteroidrezeptor (1)
- Cortisol-Aufwach-Reaktion (1)
- Cytokine (1)
- Das circadiane System (1)
- Diagnostische Urteilskompetenz (1)
- Differentielle Genexpression (1)
- Dissonance (1)
- Distraktor-Reaktionsbindung (1)
- Distraktor-Verarbeitung (1)
- Distraktorverarbeitung (1)
- EEG (1)
- ERP (1)
- Ecological Momentary Assessment (1)
- Einstellungsforschung (1)
- Elektroenzephalogramm (1)
- Elektrokardiogramm (1)
- Emotions (1)
- Empfindung (1)
- Encodierung (1)
- Entscheidung (1)
- Entwicklung (1)
- Enzym (1)
- Enzyme (1)
- Epigenetik (1)
- Ereigniskorreliertes Potential (1)
- Ergebnis (1)
- Erwartung (1)
- Erzählung (1)
- Essgewohnheit (1)
- Essverhalten (1)
- Event file (1)
- Event-File (1)
- Exekuitive Funktion (1)
- Exekutive Funktionen (1)
- Experiment (1)
- Extraversion (1)
- F0 (1)
- FKBP51 (1)
- Fahrassistenzsystem (1)
- Faktorenanalyse (1)
- Fear (1)
- Feedback (1)
- Feinkartierung (1)
- Fettsucht (1)
- Fetus (1)
- Fissurisation (1)
- Flexibilität (1)
- Fluoreszenzmikroskopie (1)
- Food pictures (1)
- Frequenzbandkopplungen (1)
- Funktionalität (1)
- Funktionelle Kernspintomographie (1)
- Furcht (1)
- Fähigkeitsselbstkonzepte (1)
- GR (1)
- Gamification (1)
- Gedächtnisrepräsentation (1)
- Gedächtnistest (1)
- Gegenstimulation (1)
- Genauigkeit (1)
- Generationsbeziehung (1)
- Genetik (1)
- Geneva Emotional Competence Test (1)
- Gesichtsfeld (1)
- Glucocorticoid Receptor (GR) (1)
- Glucocorticoidrezeptor (1)
- Glucocorticoids (1)
- Glukokortikoidrezeptor (1)
- Grundfrequenz (1)
- Grundschullehrer (1)
- Gyrifikation (1)
- HPA (1)
- HPA-Achse (1)
- Habituation (1)
- Handlungsregulation (1)
- Haushalt (1)
- Heart rate (1)
- Hemisphärendominanz (1)
- Herztransplantation (1)
- Hippocampus (1)
- Hippocampus Aktivierung (1)
- Hippocampus Atrophie (1)
- Hippocampus Volumen (1)
- Hirnforschung (1)
- Hirnfunktion (1)
- Human (1)
- Human behaviour (1)
- Hypothalamic-pituitary-adrenocortical axis (1)
- Immunsystem (1)
- Implizites Lernen (1)
- Implizites Sequenzlernen (1)
- Impulsivität (1)
- Individualisierte Medizin (1)
- Individualisierung (1)
- Information (1)
- Information Retrieval (1)
- Informationsverarbeitung (1)
- Infusion (1)
- Inhibition (1)
- Inhibitorische Kontrolle (1)
- Intelligence Structure Battery (1)
- Intelligence profiles (1)
- Intelligenz (1)
- Intelligenztest (1)
- Intention (1)
- Interoception (1)
- Interpersonale Kommunikation (1)
- Intranasal insulin (1)
- Intrusionen (1)
- Isolation <Soziologie> (1)
- Jugend (1)
- Kaltwasserstresstest (1)
- Kaltwasssertest (1)
- Kardiovaskuläre Krankheit (1)
- Kernspintomographie (1)
- Kind (1)
- Klassiche Lidschlagkonditionierung (1)
- Klassische Konditionierung (1)
- Knowledge (1)
- Koerperwahrnehmung (1)
- Kognitive Entwicklung (1)
- Kognitive Verhaltenstherapie (1)
- Konditionierung (1)
- Kontrollierte Therapiestudie (1)
- Konzeptuelle Endophänotypen (1)
- Kopplungs- und Mutationsanalysen (1)
- Kortex (1)
- Kunststoff (1)
- Körpertherapie (1)
- LG children (1)
- Leben (1)
- Lebensqualität (1)
- Lerntechnik (1)
- Literatur (1)
- Long-term memory (1)
- Lymphozyt (1)
- MALDI-TOF MS (1)
- MLC1 (1)
- MR (1)
- Makrophage (1)
- Mann (1)
- Mass Customization (1)
- Mathematik (1)
- Meat Consumption (1)
- Meat Paradox (1)
- Mensch (1)
- Menstruationszyklus (1)
- Meta-Analyse (1)
- Meta-Analysis (1)
- Metabolism (1)
- Methylierung und SNPs (1)
- Methylphenidat (1)
- Milde Depression (1)
- Mindesthaltbarkeitsdatum (1)
- Mineralokortikoidrezeptor (1)
- Moderator (1)
- Moderators and mediators (1)
- Modulation (1)
- Monozyt (1)
- Mortality Salience (1)
- Mortalitätssalienz (1)
- Motor mimicry (1)
- MouseTracker (1)
- Mutation (1)
- Männlichkeit (1)
- NMR-Spektroskopie (1)
- Netzwerkanalyse (1)
- Neuropattern (1)
- Nuklearrezeptoren (1)
- Orbicularis-oculi-Reflex (1)
- P-Glykoprotein (1)
- PERIOD Gene (1)
- PERIOD gene (1)
- PERIOD genes (1)
- PTSD (1)
- Patient (1)
- Patients (1)
- Perfektionismus (1)
- Perfusion (1)
- Personalisierte Psychotherapie (1)
- Personalisierung (1)
- Personalized Medicine (1)
- Personalized mental health (1)
- Phasen-Amplituden-Kopplung (1)
- Physical activity (1)
- Plazenta (1)
- Polymorphismus (1)
- Positive affect (1)
- Positiver Affekt (1)
- Posttraumatisches Stresssyndrom (1)
- Precision mental health (1)
- Pressorezeptor (1)
- Problemlösen (1)
- Prognosis (1)
- Programm (1)
- Promotorregion (1)
- Prosa (1)
- Prosocial behavior (1)
- Proteomanalyse (1)
- Provokation (1)
- Präferenz (1)
- Präpulsinhibierung (1)
- Psychiatric genetics (1)
- Psychische Störung (1)
- Psychisches Trauma (1)
- Psychologiestudierende (1)
- Psychologiestudium (1)
- Psychologische Diagnostik (1)
- Psychologische Distanz (1)
- Psychometrie (1)
- Psychometrischer Intelligenztest (1)
- Psychophysiology (1)
- Psychotherapeutische Versorgung (1)
- Pulsatilität (1)
- Pädagogische Diagnostik (1)
- RCT (1)
- Reaktion (1)
- Reiz-Reaktions Bindung (1)
- Reizverarbeitung (1)
- Reliabilität (1)
- Routine outcome monitoring (1)
- SNP (1)
- Sakkade (1)
- Schizophrenia (1)
- Schreckreflex (1)
- Schule (1)
- Schullaufbahnempfehlung (1)
- Schulleistung (1)
- Schulzeugnis (1)
- Schwangersch (1)
- Schwangerschaft (1)
- Schweißabsonderung (1)
- Sekundärkrankheit (1)
- Selbsteinschätzung (1)
- Selbstkonzept (1)
- Selbstregulation (1)
- Selbstwert (1)
- Selbstwertgefühl (1)
- Selbstwirksamkeit (1)
- Selbstwirksamkeitserwartung (1)
- Selective attention (1)
- Selektion (1)
- Selektivität (1)
- Self-Regulation (1)
- Smoking) (1)
- Social anxiety disorder (1)
- Somatic experiencing (1)
- Sozialangst (1)
- Sozialer Stress (1)
- Sozialpsychologie (1)
- Sozialverhalten (1)
- Spatial learning (1)
- Speichel (1)
- Sprachverarbeitung (1)
- Stability (1)
- Startle modulation (1)
- Startle reflex (1)
- Statistik (1)
- Stereotyp (1)
- Steroidhormonrezeptor (1)
- Stillen (1)
- Stimme (1)
- Stimulus-Response binding (1)
- Stimulus-response learning (1)
- Struktur (1)
- Subarachnoidalblutung (1)
- Sympathikus (1)
- Test-retest (1)
- Testen (1)
- Testergebnis (1)
- Testosteron (1)
- Thalamus (1)
- Therapieabbruch (1)
- Thermal stresses (1)
- Transkript (1)
- Transkription <Genetik> (1)
- Umweltbewusstsein (1)
- Universal Eating Monitor (1)
- Unsicherheit (1)
- Unterkörper Unterdruck (1)
- Unterrichtsfach (1)
- Vagus (1)
- Validierung (1)
- Vater (1)
- Vegetarianism (1)
- Verbesserung (1)
- Verbraucherverhalten (1)
- Verhaltensgenetik (1)
- Verhaltensmuster (1)
- Verhaltensstörung (1)
- Verlangen (1)
- Vermeidung (1)
- Verpackung (1)
- Verschwendung (1)
- Videospiel (1)
- Visceral perception (1)
- Visuelle Aufmerksamkeit (1)
- Viszerale Wahrnehmung (1)
- Vorsorge (1)
- Wandel (1)
- Wartezeit (1)
- Willenskraft (1)
- Wirkung (1)
- Wissen (1)
- Work Stress (1)
- Working memory (1)
- Zeit (1)
- Zentralnervensystem (1)
- Zuckergehalt (1)
- Zytokin (1)
- acetylcholine (1)
- action control (1)
- adaptive hypermedia (1)
- adolescents (1)
- affect (1)
- age stereotypes (1)
- akademisches Selbstkonzept (1)
- analysistransplantation (1)
- anterior cingulate (1)
- arterial spin labeling (1)
- associative learning (1)
- attitude formation (1)
- automatische Handlungsplanung (1)
- automatische Reizverarbeitung (1)
- baroreceptor (1)
- best before (1)
- biases in judgement (1)
- blood oxygen level dependent (BOLD) contrast (1)
- body composition (1)
- bottom-up-therapy (1)
- brain (1)
- bulimia (1)
- central adiposity (1)
- cerebral blood flow (1)
- chronic stress (1)
- chronischer Stress (1)
- circadian clock genes (1)
- circadian clock system (1)
- cognition (1)
- cognitive control (1)
- cold pressor (1)
- coming out (or disclosure) (1)
- cortex (1)
- corticosteroid receptor (1)
- cortisol response to awakening (1)
- counter-stimulation (1)
- cross-frequency coupling (1)
- crystallized abilities (1)
- customer loyalty (1)
- cytokine (1)
- cytokines (1)
- dACC (1)
- date labeling (1)
- decision making (1)
- depression (1)
- development (1)
- die circadiane Uhr-Gene (1)
- distractor processing (1)
- distress (1)
- domestic food waste (1)
- driver assistance system (1)
- dual task interference (1)
- early response (1)
- eating behavior (1)
- eating behaviour (1)
- ecological momentary assessment (1)
- educational assessment (1)
- effectiveness (1)
- efficacy (1)
- electrocardiogram (1)
- electroencephalogram (1)
- emotion regulation (1)
- emotional intelligence (1)
- empirical evaluation (1)
- encoding (1)
- epigenetic programming (1)
- evaluation (1)
- evaluation framework (1)
- event file (1)
- executive functions (1)
- exekutive Funktionen (1)
- eyeblink conditioning (1)
- fMRT (1)
- factor analysis (1)
- familial risk (1)
- fathers (1)
- fine mapping (1)
- fissurization (1)
- fluid abilities (1)
- food preference (1)
- functional MRI (1)
- functional specialisation of hemispheres (1)
- funktionelle NMR-Tomographie (1)
- games, experimental (1)
- gene expression (1)
- genetics (1)
- glucocorticoids (1)
- glycaemic index (1)
- growth mixture modeling (1)
- heart failure (1)
- hippocampal atrophy (1)
- hippocampal volume assessment (1)
- homosexuality (1)
- hypothalamic-pituitary-adrenal axis (1)
- hypothalamo-pituitary-adrenal-axis (1)
- hypothalamus-pituitary-adrenal axis (1)
- immune system (1)
- immunity (1)
- implicit learning (1)
- impulsivity (1)
- information processing (1)
- inhibitory control (1)
- interference (1)
- intergenerational programs (1)
- interoception (1)
- intrusions (1)
- judgement accuracy (1)
- kognitive Kontrolle (1)
- language processing (1)
- learning (1)
- linkage and mutational analysis (1)
- lower body negative pressure (1)
- lymphocytes (1)
- macrophages (1)
- maternal care (1)
- mean vector length (1)
- membrane glucocorticoid receptor (1)
- membraner Glucocorticoidrezeptor (1)
- memory (1)
- memory representation (1)
- menstrual cycle (1)
- methylation and SNPs (1)
- methylphenidate (1)
- midcingulate cortex (1)
- mineralocorticoid receptor (1)
- mismatch negativity (1)
- modulation (1)
- modulation index (1)
- monocytes (1)
- motion energy analysis (1)
- natural killer cells (1)
- natürliche Killerzellen (1)
- neuroendocrine system (1)
- neuroimaging (1)
- nicht-genomische Effekte (1)
- non-genomic effects (1)
- nonverbal synchrony (1)
- norepinephrine (1)
- nuclear receptor (1)
- nucleus accumbens (1)
- obesity (1)
- older adults (1)
- p-glycoprotein (1)
- patient-focused psychotherapy research (1)
- patienten-orientierte Psychotherapieforschung (1)
- perception (1)
- periodic catatonia (1)
- periodische Katatonie (1)
- personalized psychotherapy (1)
- phase-amplitude coupling (1)
- placenta (1)
- plastic (1)
- post-transcriptional regulation (1)
- post-transkriptionelle Regulierung (1)
- post-traumatic stress disorder (1)
- postnatal stress factors (1)
- postnatale Stressfaktoren (1)
- posttraumatic stress disorder (1)
- prenatal adversity (1)
- prenatal programming (1)
- prenatal stress (1)
- prenatal stress factors (1)
- prenatal tobacco exposure (1)
- prepulse inhibition (1)
- promoter region (1)
- proof of concept study (1)
- proteomics (1)
- provocation (1)
- pränatale Programmierung (1)
- pränatale Risikofaktoren (1)
- pränatale Stressfaktoren (1)
- pränatale Tabakexposition (1)
- pränataler Stress (1)
- psychological distance (1)
- psychology and behaviorsocial isolation (1)
- psychology students (1)
- psychometric validation (1)
- pulsatility (1)
- quantitative sensory testing (1)
- retrieval practice (1)
- risk factors (1)
- routine care (1)
- saccade (1)
- salivary alpha-amylase (1)
- school (1)
- school performance (1)
- school subject (1)
- selection (1)
- selective forgetting (1)
- selektive Aufmerksamkeit (1)
- self-concept (1)
- self-efficacy (1)
- self-esteem (1)
- self-perception (1)
- simulation study (1)
- social contactssurvival (1)
- social self-concept (1)
- somatische Komorbiditäten (1)
- soziale Selbstkonzepte (1)
- stress hyporesponsive period (1)
- stress reaction (1)
- structure (1)
- subarachnoid haemorrhage (1)
- substance abuse (1)
- teacher judgement (1)
- teachers (1)
- testing (1)
- text memory (1)
- trauma therapy (1)
- uncertainty (1)
- uniqueness seeking (1)
- user modeling (1)
- vagus (1)
- video games (1)
- visceral awareness (1)
- visual change detection (1)
- visuelle Wahrnehmung (1)
- visueller Mismatch (1)
- viszerale Empfindung (1)
- voice (1)
- zerebraler Blutfluss (1)
- Ätiologie (1)
- Überleben (1)
- Übung (1)
Institut
- Psychologie (94) (entfernen)
The present thesis addresses the validity of Binge Eating Disorder (BED) as well as underlying mechanisms of BED from three different angles. Three studies provide data discriminating obesity with BED from obesity without BED. Study 1 demonstrates differences between obese individuals with and without BED regarding eating in the natural environment, psychiatric comorbidity, negative affect as well as self reported tendencies in eating behavior. Evidence for possible psychological mechanisms explaining increased intake of BED individuals in the natural environment was given by analyzing associations of negative affect, emotional eating, restrained eating and caloric intake in obese BED compared to NBED controls. Study 2 demonstrated stress-induced changes in the eating behavior of obese individuals with BED. The impact of a psychosocial stressor, the Trier Social Stress Test (TSST, Kirschbaum, Pirke, &amp;amp; Hellhammer, 1993), on behavioral patterns of eating behavior in laboratory was investigated. Special attention was given to stress-induced changes in variables that reflect mechanisms of appetite regulation in obese BED individuals compared to controls. To further explore by which mechanisms stress might trigger binge eating, study 3 investigated differences in stress-induced cortisol secretion after a socially evaluated cold pressure test (SECPT, Schwabe, Haddad, &amp;amp; Schachinger, 2008) in obese BED as compared to obese NBED individuals.
There are large health, societal, and economic costs associated with attrition from psychological services. The recently emerged, innovative statistical tool of complex network analysis was used in the present proof-of-concept study to improve the prediction of attrition. Fifty-eight patients undergoing psychological treatment for mood or anxiety disorders were assessed using Ecological Momentary Assessments four times a day for two weeks before treatment (3,248 measurements). Multilevel vector autoregressive models were employed to compute dynamic symptom networks. Intake variables and network parameters (centrality measures) were used as predictors for dropout using machine-learning algorithms. Networks for patients differed significantly between completers and dropouts. Among intake variables, initial impairment and sex predicted dropout explaining 6% of the variance. The network analysis identified four additional predictors: Expected force of being excited, outstrength of experiencing social support, betweenness of feeling nervous, and instrength of being active. The final model with the two intake and four network variables explained 32% of variance in dropout and identified 47 out of 58 patients correctly. The findings indicate that patients" dynamic network structures may improve the prediction of dropout. When implemented in routine care, such prediction models could identify patients at risk for attrition and inform personalized treatment recommendations.
Many people are aware of the negative consequences of plastic use on the environment. Nevertheless, they use plastic due to its functionality. In the present paper, we hypothesized that this leads to the experience of ambivalence—the simultaneous existence of positive and negative evaluations of plastic. In two studies, we found that participants showed greater ambivalence toward plastic packed food than unpacked food. Moreover, they rated plastic packed food less favorably than unpacked food in response evaluations. In Study 2, we tested whether one-sided (only positive vs. only negative) information interventions could effectively influence ambivalence. Results showed that ambivalence is resistant to (social) influence. Directions for future research were discussed.
Cortisol exhibits typical ultradian and circadian rhythm and disturbances in its secretory pattern have been described in stress-related pathology. The aim of this thesis was to dissect the underlying structure of cortisol pulsatility and to develop tools to investigate the effects of this pulsatility on immune cell trafficking and the responsiveness of the neuroendocrine system and GR target genes to stress. Deconvolution modeling was set up as a tool for investigation of the pulsatile secretion underlying the ultradian cortisol rhythm. This further allowed us to investigate the role of the single cortisol pulses on the immune cell trafficking and the role of induced cortisol pulses on the kinetics of expression of GR target genes. The development of these three tools, would allow to induce and investigate in future the significance of single cortisol pulses for health and disease.
The complicated human alternative GR promoter region plays a pivotal role in the regulation of GR levels. In this thesis, both genomic and environmental factors linked with GR expression are covered. This research showed that GR promoters were susceptible to silencing by methylation and the activity of the individual promoters was also modulated by SNPs. E2F1 is a major element to drive the expression of GR 1F transcripts and single CpG dinucleotide methylation cannot mediate the inhibition of transcription in vitro. Also, the distribution of GR first exons and 3" splice variants (GRα and GR-P) is expressed throughout the human brain with no region-specific alternative first exon usage. These data mirrored the consistently low levels of methylation in the brain, and the observed homogeneity throughout the studied regions. Taken together, the research presented in this thesis explored several layers of complexity in GR transcriptional regulation.
The influence of affect on vocal parameters has been well investigated in speech portrayed by actors, but little is known about affect expression in more natural or authentic speech behavior. This is partly due to the difficulty of generating speech samples that represent authentic expression of speaker affect. The present work investigates the influence of speaker affect on the vocal fundamental frequency (F0) in comparatively authentic speech samples. Three well-documented psychophysiological research methods were applied for the induction of affective states in German native speakers in order to obtain speech samples with authentic affect expression: the Cold Pressor Test (CPT), the Stroop Color-Word Test (SCWT) and the presentation of slides from the International Affective Pictures System (IAPS). The here reported results show that the influence of affect on F0 is differentially modulated by psychophysiological processes as well as socio-cultural influences. They also indicate that this approach may be useful for future research and further to gain a deeper understanding of authentic vocal affect expression. Moreover, F0 may constitute an additional non-invasive, easy to obtain measure for the established psychophysiological research methodology.
The startle response in psychophysiological research: modulating effects of contextual parameters
(2013)
Startle reactions are fast, reflexive, and defensive responses which protect the body from injury in the face of imminent danger. The underlying reflex is basic and can be found in many species. Even though it consists of only a few synapses located in the brain stem, the startle reflex offers a valuable research method for human affective, cognitive, and psychological research. This is because of moderating effects of higher mental processes such as attention and emotion on the response magnitude: affective foreground stimulation and directed attention are validated paradigms in startle-related research. This work presents findings from three independent research studies that deal with (1) the application of the established "affective modulation of startle"-paradigm to the novel setting of attractiveness and human mating preferences, (2) the question of how different components of the startle response are affected by a physiological stressor and (3) how startle stimuli affect visual attention towards emotional stimuli. While the first two studies treat the startle response as a dependent variable by measuring its response magnitude, the third study uses startle stimuli as an experimental manipulation and investigates its potential effects on a behavioural measure. The first chapter of this thesis describes the basic mechanisms of the startle response as well as the body of research that sets the foundation of startle research in psychophysiology. It provides the rationale for the presented studies, and offers a short summary of the obtained results. Chapter two to four represent primary research articles that are published or in press. At the beginning of each chapter the contribution of all authors is explained. The references for all chapters are listed at the end of this thesis. The overall scope of this thesis is to show how the human startle response is modulated by a variety of factors, such as the attractiveness of a potential mating partner or the exposure to a stressor. In conclusion, the magnitude of the startle response can serve as a measure for such psychological states and processes. Beyond the involuntary, physiological startle reflex, startle stimuli also affect intentional behavioural responses, which we could demonstrate for eye movements in a visual attention paradigm.
Attitudes are "the most distinctive and indispensable concept in contemporary social psychology" (Allport, 1935, p. 798). This outstanding position of the attitude concept in social cognitive research is not only reflected in the innumerous studies focusing on this concept but also in the huge number of theoretical approaches that have been put forth since then. Yet, it is still an open question, what attitudes actually are. That is, the question of how attitude objects are represented in memory cannot be unequivocally answered until now (e.g., Barsalou, 1999; Gawronski, 2007; Pratkanis, 1989, Chapter 4). In particular, researchers strongly differ with respect to their assumptions on the content, format and structural nature of attitude representations (Ferguson & Fukukura, 2012). This prevailing uncertainty on what actually constitutes our likes and dislikes is strongly dovetailed with the question of which processes result in the formation of these representations. In recent years, this issue has mainly been addressed in evaluative conditioning research (EC). In a standard EC-paradigm a neutral stimulus (conditioned stimulus, CS) is repeatedly paired with an affective stimulus (unconditioned stimulus, US). The pairing of stimuli then typically results in changes in the evaluation of the CS corresponding to the evaluative response of the US (De Houwer, Baeyens, & Field, 2005). This experimental approach on the formation of attitudes has primarily been concerned with the question of how the representations underlying our attitudes are formed. However, which processes operate on the formation of such an attitude representation is not yet understood (Jones, Olson, & Fazio, 2010; Walther, Nagengast, & Trasselli, 2005). Indeed, there are several ideas on how CS-US pairs might be encoded in memory. Notwithstanding the importance of these theoretical ideas, looking at the existing empirical work within the research area of EC (for reviews see Hofmann, De Houwer, Perugini, Baeyens, & Crombez, 2010; De Houwer, Thomas, & Baeyens, 2001) leaves one with the impression that scientists have skipped the basic processes. Basic processes hereby especially refer to the attentional processes being involved in the encoding of CSs and USs as well as the relation between them. Against the background of this huge gap in current research on attitude formation, the focus of this thesis will be to highlight the contribution of selective attention processes to a better understanding of the representation underlying our likes and dislikes. In particular, the present thesis considers the role of selective attention processes for the solution of the representation issue from three different perspectives. Before illustrating these different perspectives, Chapter 1 is meant to envision the omnipresence of the representation problem in current theoretical as well as empirical work on evaluative conditioning. Likewise, it emphasizes the critical role of selective attention processes for the representation question in classical conditioning and how this knowledge might be used to put forth the uniqueness of evaluative conditioning as compared to classical conditioning. Chapter 2 then considers the differential influence of attentional resources and goal-directed attention on attitude learning. The primary objective of the presented experiment was thereby to investigate whether attentional resources and goal-directed attention exert their influence on EC via changes in the encoding of CS-US relations in memory (i.e., contingency memory). Taking the findings from this experiment into account, Chapter 3 focuses on the selective processing of the US relative to the CS. In particular, the two experiments presented in this chapter were meant to explore the moderating influence of the selective processing of the US in its relation to the CS on EC. In Chapter 4 the important role of the encoding of the US in relation to the CS, as outlined in Chapter 3, is illuminated in the context of different retrieval processes. Against the background of the findings from the two presented experiments, the interplay between the encoding of CS-US contingencies and the moderation of EC via different retrieval processes will be discussed. Finally, a general discussion of the findings, their theoretical implications and future research lines will be outlined in Chapter 5.
Phase-amplitude cross-frequency coupling is a mechanism thought to facilitate communication between neuronal ensembles. The mechanism could underlie the implementation of complex cognitive processes, like executive functions, in the brain. This thesis contributes to answering the question, whether phase-amplitude cross-frequency coupling - assessed via electroencephalography (EEG) - is a mechanism by which executive functioning is implemented in the brain and whether an assumed performance effect of stress on executive functioning is reflected in phase-amplitude coupling strength. A huge body of studies shows that stress can influence executive functioning, in essence having detrimental effects. In two independent studies, each being comprised of two core executive function tasks (flexibility and behavioural inhibition as well as cognitive inhibition and working memory), beta-gamma phase-amplitude coupling was robustly detected in the left and right prefrontal hemispheres. No systematic pattern of coupling strength modulation by either task demands or acute stress was detected. Beta-gamma coupling might also be present in more basic attention processes. This is the first investigation of the relationship between stress, executive functions and phase-amplitude coupling. Therefore, many aspects have not been explored yet. For example, studying phase precision instead of coupling strength as an indicator for phase-amplitude coupling modulations. Furthermore, data was analysed in source space (independent component analysis); comparability to sensor space has still to be determined. These as well as other aspects should be investigated, due to the promising finding of very robust and strong beta-gamma coupling for all executive functions. Additionally, this thesis tested the performance of two widely used phase-amplitude coupling measures (mean vector length and modulation index). Both measures are specific and sensitive to coupling strength and coupling width. The simulation study also drew attention to several confounding factors, which influence phase-amplitude coupling measures (e. g. data length, multimodality).
The Role of Dopamine and Acetylcholine as Modulators of Selective Attention and Response Speed
(2015)
The principles of top-down and bottom-up processing are essential to cognitive psychology. At their broadest, most general definition, they denote that processing can be driven either by the salience of the stimulus input or by individual goals and strategies. Selective top-down attention, specifically, consists in the deliberate prioritizing of stimuli that are deemed goal-relevant, while selective bottom-up attention relies on the automatic allocation of attention to salient stimuli (Connor, Egeth, & Yantis, 2004; Schneider, Schote, Meyer, & Frings, 2014). Variations within neurotransmitter systems can modulate cognitive performance in a domain-specific fashion (Greenwood, Fossella, & Parasuraman, 2005). Noudoost and Moore (2011a) proposed that the influence of the dopaminergic neurotransmitter system on selective top-down attention might be greater than the influence of this system on selective bottom-up attention; likewise, they assumed that the cholinergic neurotransmitter system might be more important for selective bottom-up than top-down attention. To test this hypothesis, naturally occurring variations within the two neurotransmitter systems were assessed. Five polymorphisms were selected; two of the dopaminergic system (the COMT Val158Met polymorphism and the DAT1 polymorphism) and three of the cholinergic system (the CHRNA4 rs1044396 polymorphism, the CHRNA5 rs3841324 polymorphism, and the CHRNA5 rs16969968 polymorphism). It was tested whether these polymorphisms modulated the performance in tasks of selective top-down attention (a Stroop task and a Negative priming task) and in a task of selective bottom-up attention (a Posner-Cuing task). Indeed, the dopaminergic polymorphisms influenced selective top-down attention, but exerted no effects on bottom-up attention. This aligned with the hypothesis proposed by Noudoost and Moore (2011a). In contrast, the cholinergic polymorphisms were not found to modulate selective bottom-up attention. The three cholinergic polymorphisms, however, affected the general response speed in the Stroop task, Negative priming task, and Posner-Cuing task (irrespective of attentional processing). In sum, the findings of this study provide strong indications that the dopaminergic system modulates selective top-down attention, while the cholinergic system is highly relevant for the general speed of information processing.
The role of cortisol and cortisol dynamics in patients after aneurysmal subarachnoid hemorrhage
(2011)
Spontaneous aneurysmal subarachnoid hemorrhage (SAH) is a form of stroke which constitutes a severe trauma to the brain and often leads to serious long-term medical and psychosocial sequels which persist for years after the acute event. Recently, adrenocorticotrophic hormone deficiency has been identified as one possible consequence of the bleeding and is assumed to occur in around 20% of all survivors. Additionally, a number of studies report a high prevalence of post-SAH symptoms such as lack of initiative, fatigue, loss of concentration, impaired quality of life and psychiatric symptoms such as depression. The overlap of these symptoms and those of patients with untreated partial or complete hypopituitarism lead to the suggestion that neuroendocrine dysregulations may contribute to the psychosocial sequels of SAH. Therefore, one of the aims of this work is to gain insights into the role of neuroendocrine dysfunction on quality of life and the prevalence of psychiatric sequels in SAH-patients. Additionally, as data on cortisol dynamics after SAH are scarce, diurnal cortisol profiles are investigated in patients in the acute and chronic phase, as well as the cortisol awakening response and feedback sensitivity in the chronic phase after SAH. As a result, it can be shown that some SAH patients exhibit lower serum cortisol levels but at the same time a higher cortisol awakening response in saliva than healthy controls. Also, patients in the chronic phase after SAH do have a stable diurnal cortisol rhythm while there are disturbances in around 50% of all patients in the acute phase, leading to the conclusion that a single baseline measurement of cortisol is of no substantial use for diagnosing cortisol dysregulations in the acute phase after SAH. It is assumed that in SAH patients endocrine changes occur over time and that a combination of adrenal exhaustion and a subsequent downregulation of corticosteroid binding globulin may be the most probable causes for the dissociation of serum cortisol concentrations and salivary cortisol profiles in the investigated SAH patients. These changes may be an emergency response after SAH and, as elevated free cortisol levels are connected to a better psychosocial outcome in patients in the chronic phase after SAH, this reaction may even be adaptive.
The stress hormone cortisol as the end-product of the hypothalamic-pituitary-adrenal (HPA) axis has been found to play a crucial role in the release of aggressive behavior (Kruk et al., 2004; Böhnke et al., 2010). In order to further explore potential mechanisms underlying the relationship between stress and aggression, such as changes in (social) information processing, we conducted two experimental studies that are presented in this thesis. In both studies, acute stress was induced by means of the Socially Evaluated Cold Pressor Test (SECP) designed by Schwabe et al. (2008). Stressed participants were classified as either cortisol responders or nonresponders depending on their rise in cortisol following the stressor. Moreover, basal HPA axis activity was measured prior to the experimental sessions and EEG was recorded throughout the experiments. The first study dealt with the influence of acute stress on cognitive control processes. 41 healthy male participants were assigned to either the stress condition or the non-stressful control procedure of the SECP. Before as well as after the stress induction, all participants performed a cued task-switching paradigm in order to measure cognitive control processes. Results revealed a significant influence of acute and basal cortisol levels, respectively, on the motor preparation of the upcoming behavioral response, that was reflected in changes in the magnitude of the terminal Contingent Negative Variation (CNV). In the second study, the effect of acute stress and subsequent social provocation on approach-avoidance motivation was examined. 72 healthy students (36 males, 36 females) took part in the study. They performed an approach-avoidance task, using emotional facial expressions as stimuli, before as well as after the experimental manipulation of acute stress (again via the SECP) and social provocation realized by means of the Taylor Aggression Paradigm (Taylor, 1967). Additionally to salivary cortisol, testosterone samples were collected at several points in time during the experimental session. Results indicated a positive relationship between acute testosterone levels and the motivation to approach social threat stimuli in highly provoked cortisol responders. Similar results were found when the testosterone-to-cortisol ratio at baseline was taken into account instead of acute testosterone levels. Moreover, brain activity during the approach-avoidance task was significantly influenced by acute stress and social provocation, as reflected in reductions of early (P2) as well as of later (P3) ERP components in highly provoked cortisol responders. This may indicate a less accurate, rapid processing of socially relevant stimuli due to an acute increase in cortisol and subsequent social provocation. In conclusion, the two studies presented in this thesis provide evidence for significant changes in information processing due to acute stress, basal cortisol levels and social provocation, suggesting an enhanced preparation for a rapid behavioral response in the sense of a fight-or-flight reaction. These results confirm the model of Kruk et al. (2004) proposing a mediating role of changed information processes in the stress-aggression-link.
Stress has been considered one of the most relevant factors promoting aggressive behavior. Animal and human pharmacological studies revealed the stress hormones corticosterone in rodents and cortisol in humans to constitute a particularly important neuroendocrine determinate in facilitating aggression and beyond that, assumedly in its continuation and escalation. Moreover, cortisol-induced alterations of social information processing, as well as of cognitive control processes, have been hypothesized as possible influencing factors in the stress-aggression link. So far, the immediate impact of a preceding stressor and thereby stress-induced rise of cortisol on aggressive behavior as well as higher-order cognitive control processes and social information processing in this context have gone mostly unheeded. The present thesis aimed to extend the hitherto findings of stress and aggression in this regard. For this purpose two psychophysiological studies with healthy adults were carried out, both using the socially evaluated-cold pressor test as an acute stress induction. Additionally to behavioral data and subjective reports, event related potentials were measured and acute levels of salivary cortisol were collected on the basis of which stressed participants were divided into cortisol-responders and "nonresponders. Study 1 examined the impact of acute stress-induced cortisol increase on inhibitory control and its neural correlates. 41 male participants were randomly assigned to the stress procedure or to a non-stressful control condition. Beforehand and afterwards, participants performed a Go Nogo task with visual letters to measure response inhibition. The effect of acute stress-induced cortisol increase on covert and overt aggressive behavior and on the processing of provoking stimuli within the aggressive encounter was investigated in study 2. Moreover, this experiment examined the combined impact of stress and aggression on ensuing affective information processing. 71 male and female participants were either exposed to the stress or to the control condition. Following this, half of each group received high or low levels of provocation during the Taylor Aggression Paradigm. At the end of the experiment, a passive viewing paradigm with affective pictures depicting positive, negative, or aggressive scenes with either humans or objects was realized. The results revealed that men were not affected by a stress-induced rise in cortisol on a behavioral level, showing neither impaired response inhibition nor enhanced aggressive behavior. In contrast, women showed enhanced overt and covert aggressive behavior under a surge of endogenous cortisol, confirming previous results, albeit only in case of high provocation and only up to the level of the control group. Unlike this rather moderate impact on behavior, cortisol showed a distinct impact on neural correlates of information processing throughout inhibitory control, aggression-eliciting stimuli, and emotional pictures for both men and women. At this, stress-induced increase of cortisol resulted in enhanced N2 amplitudes to Go stimuli, whereas P2 amplitudes to both and N2 to Nogo amplitudes retained unchanged, indicating an overcorrection and caution of the response activation in favor of successful inhibitory control. The processing of aggression-eliciting stimuli during the aggressive encounter was complexly altered by stress differently for women and men. Under increased cortisol levels, the frontal or parietal P3 amplitude patterns were either diminished or reversed in the case of high provocation compared to the control group and to cortisol-nonresponders, indicating a desensitization towards aggression-eliciting stimuli in males, but a more elaborate processing of those in women. Moreover, stress-induced cortisol and provocation jointly altered subsequent affective information processing at early as well as later stages of the information processing stream. Again, increased levels of cortisol led opposite directed amplitudes in the case of high provocation relative to the control group and cortisol-nonresponders, with enhanced N2 amplitudes in men and reduced P3 and LPP amplitudes in men and women for all affective pictures, suggesting initially enhanced emotional reactivity in men, but ensuing reduced motivational attention and enhanced emotion regulation in both, men and women. As a result, these present findings confirm the relevance of HPA activity in the elicitation and persistence of human aggressive behavior. Moreover, they reveal the significance of compensatory and emotion regulatory strategies and mechanisms in response to stress and provocation, indorsing the relevance of social information and cognitive control processes. Still, more research is needed to clarify the conditions which lead to the facilitation of aggression and by which compensatory mechanisms this is prevented.
People are increasingly concerned about how meat affects the environment, human health, and animal welfare, yet eating and enjoying meat remains a norm. Unsurprisingly, many people are ambivalent about meat—evaluating it as both positive and negative. Here, we propose that meat-related conflict is multidimensional and depends on people’s dietary group: Omnivores’ felt ambivalence relates to multiple negative associations that oppose a predominantly positive attitude towards meat, and veg*ans’ ambivalence relates to various positive associations that oppose a predominantly negative attitude. A qualitative study (N = 235; German) revealed that omnivores and veg*ans experience meat-related ambivalence due to associations with animals, sociability, sustainability, health, and sensory experiences. To quantify felt ambivalence in these domains, we developed the Meat Ambivalence Questionnaire (MAQ). We validated the MAQ in four pre-registered studies using self-report and behavioral data (N = 3,485; German, UK, representative US). Both omnivores and veg*ans reported meat-related ambivalence, but with differences across domains and their consequences for meat consumption. Specifically, ambivalence was associated with less meat consumption in omnivores (especially sensory-/animal-based ambivalence) and more meat consumption in veg*ans (especially sensory-/socially-based ambivalence). Network analyses shed further light on the nomological net of the MAQ while controlling for a comprehensive set of determinants of meat consumption. By introducing the MAQ, we hope to provide researchers with a tool to better understand how ambivalence accompanies behavior change and maintenance.
Stress represents a significant problem for Western societies inducing costs as high as 3-4 % of the European gross national products, a burden that is continually increasing (WHO Briefing, EUR/04/5047810/B6). The classical stress response system is the hypothalamic-pituitary-adrenal (HPA) axis which acts to restore homeostasis after disturbances. Two major components within the HPA axis system are the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). Cortisol, released from the adrenal glands at the end of the HPA axis, binds to MRs and with a 10 fold lower affinity to GRs. Both, impairment of the HPA axis and an imbalance in the MR/GR ratio enhances the risk for infection, inflammation and stress related psychiatric disorders. Major depressive disorder (MDD) is characterised by a variety of symptoms, however, one of the most consistent findings is the hyperactivity of the HPA axis. This may be the result of lower numbers or reduced activity of GRs and MRs. The GR gene consists of multiple alternative first exons resulting in different GR mRNA transcripts whereas for the MR only two first exons are known to date. Both, the human GR promoter 1F and the homologue rat Gr promoter 1.7 seem to be susceptible to methylation during stressful early life events resulting in lower 1F/1.7 transcript levels. It was proposed that this is due to methylation of a NGFI-A binding site in both, the rat promoter 1.7 and the human promoter 1F. The research presented in this thesis was undertaken to determine the differential expression and methylation patterns of GR and MR variants in multiple areas of the limbic brain system in the healthy and depressed human brain. Furthermore, the transcriptional control of the GR transcript 1F was investigated as expression changes of this transcript were associated with MDD, childhood abuse and early life stress. The role of NGFI-A and several other transcription factors on 1F regulation was studied in vitro and the effect of Ngfi-a overexpression on the rat Gr promoter 1.7 in vivo. The susceptibility to epigenetic programming of several GR promoters was investigated in MDD. In addition, changes in methylation levels have been determined in response to a single acute stressor in rodents. Our results showed that GR and MR first exon transcripts are differentially expressed in the human brain, but this is not due to epigenetic programming. We showed that NGFI-A has no effect on endogenous 1F/1.7 expression in vitro and in vivo. We provide evidence that the transcription factor E2F1 is a major element in the transcriptional complex necessary to drive the expression of GR 1F transcripts. In rats, highly individual methylation patterns in the paraventricular nucleus of the hypothalamus (PVN) suggest that this is not related to the stressor but can rather be interpreted as pre-existing differences. In contrast, the hippocampus showed a much more uniform epigenetic status, but still is susceptible to epigenetic modification even after a single acute stress suggesting a differential "state‟ versus "trait‟ regulation of the GR gene in different brain regions. The results of this thesis have given further insight in the complex transcriptional regulation of GR and MR first exons in health and disease. Epigenetic programming of GR promoters seems to be involved in early life stress and acute stress in adult rats; however, the susceptibility to methylation in response to stress seems to vary between brain regions.
The forward effect of testing refers to the finding that retrieval practice of previously studied information increases retention of subsequently studied other information. It has recently been hypothesized that the forward effect (partly) reflects the result of a reset-of-encoding (ROE) process. The proposal is that encoding efficacy decreases with an increase in study material, but testing of previously studied information resets the encoding process and makes the encoding of the subsequently studied information as effective as the encoding of the previously studied information. The goal of the present study was to verify the ROE hypothesis on an item level basis. An experiment is reported that examined the effects of testing in comparison to restudy on items’ serial position curves. Participants studied three lists of items in each condition. In the testing condition, participants were tested immediately on non-target lists 1 and 2, whereas in the restudy condition, they restudied lists 1 and 2. In both conditions, participants were tested immediately on target list 3. Influences of condition and items’ serial learning position on list 3 recall were analyzed. The results showed the forward effect of testing and furthermore that this effect varies with items’ serial list position. Early target list items at list primacy positions showed a larger enhancement effect than middle and late target list items at non-primacy positions. The results are consistent with the ROE hypothesis on an item level basis. The generalizability of the ROE hypothesis across different experimental tasks, like the list-method directed-forgetting task, is discussed.
The Firepower of Work Craving: When Self-Control Is Burning under the Rubble of Self-Regulation
(2017)
Work craving theory addresses how work-addicted individuals direct great emotion-regulatory efforts to weave their addictive web of working. They crave work for two main emotional incentives: to overcompensate low self-worth and to escape (i.e., reduce) negative affect, which is strategically achieved through neurotic perfectionism and compulsive working. Work-addicted individuals" strong persistence and self-discipline with respect to work-related activities suggest strong skills in volitional action control. However, their inability to disconnect from work implies low volitional skills. How can work-addicted individuals have poor and strong volitional skills at the same time? To answer this paradox, we elaborated on the relevance of two different volitional modes in work craving: self-regulation (self-maintenance) and self-control (goal maintenance). Four hypotheses were derived from Wojdylo- work craving theory and Kuhl- self-regulation theory: (H1) Work craving is associated with a combination of low self-regulation and high self-control. (H2) Work craving is associated with symptoms of psychological distress. (H3) Low self-regulation is associated with psychological distress symptoms. (H4) Work craving mediates the relationships between self-regulation deficits and psychological distress symptoms at high levels of self-control. Additionally, we aimed at supporting the discriminant validity of work craving with respect to work engagement by showing their different volitional underpinnings. Results of the two studies confirmed our hypotheses: whereas work craving was predicted by high self-control and low self-regulation and associated with higher psychological distress, work engagement was predicted by high self-regulation and high self-control and associated with lower symptoms of psychological distress. Furthermore, work styles mediated the relationship between volitional skills and symptoms of psychological distress. Based on these new insights, several suggestions for prevention and therapeutic interventions for work-addicted individuals are proposed.
The catechol-O-methyltransferase gene (COMT) plays a crucial role in the metabolism of catecholamines in the frontal cortex. A single nucleotide polymorphism (Val158Met SNP, rs4680) leads to either methionine (Met) or valine (Val) at codon 158, resulting in a three- to fourfold reduction in COMT activity. The aim of the present study was to assess the COMT Val158Met SNP as a risk factor for attention-deficit/hyperactivity disorder (ADHD), ADHD symptom severity and co-morbid conduct disorder (CD) in 166 children with ADHD. The main finding of the present study is that the Met allele of the COMT Val158Met SNP was associated with ADHD and increased ADHD symptom severity. No association with co-morbid CD was observed. In addition, ADHD symptom severity and early adverse familial environment were positive predictors of lifetime CD. These findings support previous results implicating COMT in ADHD symptom severity and early adverse familial environment as risk factors for co-morbid CD, emphasizing the need for early intervention to prevent aggressive and maladaptive behavior progressing into CD, reducing the overall severity of the disease burden in children with ADHD.
The last decades of stress research have yielded substantial advancements highlighting the importance of the phenomenon for basic psychological functions as well as physical health and well-being. Progress in stress research heavily relies on the availability of suitable and well validated laboratory stressors. Appropriate laboratory stressors need to be able to reliably provoke a response in the relevant parameters and be applicable in different research settings or experimental designs. This thesis focuses on the Cold Pressor Test (CPT) as a stress induction technique. Three published experiments are presented that show how the advantages of the CPT can be used to test stress effects on memory processes and how some of its disadvantages can be met by a simple modification that retains its feasibility and validity. The first experiment applies the CPT in a substantial sample to investigate the consolidation effects of post-learning sympathetic arousal. Stressed participants with high increases in heart rate during the CPT showed enhanced memory performance one day after learning compared to both the warm water control group and low heart rate responders. This finding suggests that beta-adrenergic activation elicited shortly after learning enhances memory consolidation and that the CPT induced heart rate response is a predictor for this effect. Moreover, the CPT proved to be an appropriate stressor to test hypothesis about endogenous adrenergic effects on memory processes. The second experiment addresses known practical limitations of the standard dominant hand CPT protocol. A bilateral feet CPT modification is presented, the elicited neuroendocrine stress response assessed and validated against the standard CPT in a within-subjects design. The bilateral feet CPT elicited a substantial neuroendocrine stress response. Moreover, with the exception of blood pressure responses, all stress parameters were enhanced compared to the standard CPT. This shows that the bilateral feet CPT is a valid alternative to the standard CPT. The third experiment further validates the bilateral feet CPT and its corresponding control procedure by employing it in a typical application scenario. Specifically, the bilateral feet CPT was used to modulate retrieval of event files in a distractor-response binding paradigm that required lateralized bimanual responses. Again, the bilateral feet CPT induced significant increases in heart rate, blood pressure and cortisol, no such increases could be observed in the warm water control condition. Moreover, stressed participants showed diminished retrieval compared to controls. These results provide further evidence for the feasibility and validity of the bilateral feet CPT and its warm water control procedure. Together the experiments presented here highlight the usefulness of the CPT as a tool in psychophysiological stress research. It is especially well suited to test hypothesis concerning stress effects on memory processes and its applicability can be further increased by the bilateral feet modification.
The benefits of prosocial power motivation in leadership: Action orientation fosters a win-win
(2023)
Power motivation is considered a key component of successful leadership. Based on its dualistic nature, the need for power (nPower) can be expressed in a dominant or a prosocial manner. Whereas dominant motivation is associated with antisocial behaviors, prosocial motivation is characterized by more benevolent actions (e.g., helping, guiding). Prosocial enactment of the power motive has been linked to a wide range of beneficial outcomes, yet less has been investigated what determines a prosocial enactment of the power motive. According to Personality Systems Interactions (PSI) theory, action orientation (i.e., the ability to self-regulate affect) promotes prosocial enactment of the implicit power motive and initial findings within student samples verify this assumption. In the present study, we verified the role of action orientation as an antecedent for prosocial power enactment in a leadership sample (N = 383). Additionally, we found that leaders personally benefited from a prosocial enactment strategy. Results show that action orientation through prosocial power motivation leads to reduced power-related anxiety and, in turn, to greater leader well-being. The integration of motivation and self-regulation research reveals why leaders enact their power motive in a certain way and helps to understand how to establish a win-win situation for both followers and leaders.