Primary focal hyperhidrosis (PFH, OMIM %144110) is a genetically influenced condition characterised by excessive sweating. Prevalence varies between 1.0–6.1% in the general population, dependent on ethnicity. The aetiology of PFH remains unclear but an autosomal dominant mode of inheritance, incomplete penetrance and variable phenotypes have been reported. In our study, nine pedigrees (50 affected, 53 non-affected individuals) were included. Clinical characterisation was performed at the German Hyperhidrosis Centre, Munich, by using physiological and psychological questionnaires. Genome-wide parametric linkage analysis with GeneHunter was performed based on the Illumina genome-wide SNP arrays. Haplotypes were constructed using easyLINKAGE and visualised via HaploPainter. Whole-exome sequencing (WES) with 100x coverage in 31 selected members (24 affected, 7 non-affected) from our pedigrees was achieved by next generation sequencing. We identified four genome-wide significant loci, 1q41-1q42.3, 2p14-2p13.3, 2q21.2-2q23.3 and 15q26.3-15q26.3 for PFH. Three pedigrees map to a shared locus at 2q21.2-2q23.3, with a genome-wide significant LOD score of 3.45. The chromosomal region identified here overlaps with a locus at chromosome 2q22.1-2q31.1 reported previously. Three families support 1q41-1q42.3 (LOD = 3.69), two families share a region identical by descent at 2p14-2p13.3 (LOD = 3.15) and another two families at 15q26.3 (LOD = 3.01). Thus, our results point to considerable genetic heterogeneity. WES did not reveal any causative variants, suggesting that variants or mutations located outside the coding regions might be involved in the molecular pathogenesis of PFH. We suggest a strategy based on whole-genome or targeted next generation sequencing to identify causative genes or variants for PFH.

Currently, new business models created in the sharing economy differ considerably and they differ in the formation of trust as well. If and how trust can be created is shown by a comparison of two examples which diverge in their founding philosophy. The chosen example of community-based economy, Community Supported Agriculture (CSA), no longer trusts the capitalist system and therefore distances itself and creates its own environment including a new business model. It is implemented within rather small groups where trust is created by personal relations and face-to-face communication. On the contrary, the example of a platform economy, the accommodation-provider company Airbnb, shows trust in the system and pushes technological innovations through the use of platform applications. It promotes trust and confidence in the progress of technology. For the conceptual analysis, the distinction between personal trust and system trust defined by Niklas Luhmann is adopted. The analysis describes two different modes of trust formation and how they push distrust or improve trust. Grounded on these analyses, assumptions on the process of trust formation within varying models of the sharing economy are formulated as well as a hypothesis about possible developments is introduced for further research.

Although gravitropism forces trees to grow vertically, stems have shown to prefer specific orientations. Apart from wind deforming the tree shape, lateral light can result in prevailing inclination directions. In recent years a species dependent interaction between gravitropism and phototropism, resulting in trunks leaning down-slope, has been confirmed, but a terrestrial investigation of such factors is limited to small scale surveys. ALS offers the opportunity to investigate trees remotely. This study shall clarify whether ALS detected tree trunks can be used to identify prevailing trunk inclinations. In particular, the effect of topography, wind, soil properties and scan direction are investigated empirically using linear regression models. 299.000 significantly inclined stems were investigated. Species-specific prevailing trunk orientations could be observed. About 58% of the inclination and 19% of the orientation could be explained by the linear models, while the tree species, tree height, aspect and slope could be identified as significant factors. The models indicate that deciduous trees tend to lean down-slope, while conifers tend to lean leeward. This study has shown that ALS is suitable to investigate the trunk orientation on larger scales. It provides empirical evidence for the effect of phototropism and wind on the trunk orientation.

Up-to-date information about the type and spatial distribution of forests is an essential element in both sustainable forest management and environmental monitoring and modelling. The OpenStreetMap (OSM) database contains vast amounts of spatial information on natural features, including forests (landuse=forest). The OSM data model includes describing tags for its contents, i.e., leaf type for forest areas (i.e., leaf_type=broadleaved). Although the leaf type tag is common, the vast majority of forest areas are tagged with the leaf type mixed, amounting to a total area of 87% of landuse=forests from the OSM database. These areas comprise an important information source to derive and update forest type maps. In order to leverage this information content, a methodology for stratification of leaf types inside these areas has been developed using image segmentation on aerial imagery and subsequent classification of leaf types. The presented methodology achieves an overall classification accuracy of 85% for the leaf types needleleaved and broadleaved in the selected forest areas. The resulting stratification demonstrates that through approaches, such as that presented, the derivation of forest type maps from OSM would be feasible with an extended and improved methodology. It also suggests an improved methodology might be able to provide updates of leaf type to the OSM database with contributor participation.

A lack of ability to inhibit prepotent responses, or more generally a lack of impulse control, is associated with several disorders such as attention-deficit/hyperactivity disorder and schizophrenia as well as general damage to the prefrontal cortex. A stop-signal task (SST) is a reliable and established measure of response inhibition. However, using the SST as an objective assessment in diagnostic or research-focused settings places significant stress on participants as the task itself requires concentration and cognitive effort and is not particularly engaging. This can lead to decreased motivation to follow task instructions and poor data quality, which can affect assessment efficacy and might increase drop-out rates. Gamification—the application of game-based elements in nongame settings—has shown to improve engaged attention to a cognitive task, thus increasing participant motivation and data quality.

The presence of sea ice leads in the sea ice cover represents a key feature in polar regions by controlling the heat exchange between the relatively warm ocean and cold atmosphere due to increased fluxes of turbulent sensible and latent heat. Sea ice leads contribute to the sea ice production and are sources for the formation of dense water which affects the ocean circulation. Atmospheric and ocean models strongly rely on observational data to describe the respective state of the sea ice since numerical models are not able to produce sea ice leads explicitly. For the Arctic, some lead datasets are available, but for the Antarctic, no such data yet exist. Our study presents a new algorithm with which leads are automatically identified in satellite thermal infrared images. A variety of lead metrics is used to distinguish between true leads and detection artefacts with the use of fuzzy logic. We evaluate the outputs and provide pixel-wise uncertainties. Our data yield daily sea ice lead maps at a resolution of 1 km2 for the winter months November– April 2002/03–2018/19 (Arctic) and April–September 2003–2019 (Antarctic), respectively. The long-term average of the lead frequency distributions show distinct features related to bathymetric structures in both hemispheres.

Roof and wall slates are fine-grained rocks with slaty cleavage, and it is often difficult to determine their mineral composition. A new norm mineral calculation called slatecalculation allows the determination of a virtual mineral composition based on full chemical analysis, including the amounts of carbon dioxide (CO2), carbon (C), and sulfur (S). Derived norm minerals include feldspars, carbonates, micas, hydro-micas, chlorites, ore-minerals, and quartz. The mineral components of the slate are assessed with superior accuracy compared to the petrographic analysis based on the European Standard EN 12326. The inevitable methodical inaccuracies in the calculations are limited and transparent. In the present paper, slates, shales, and phyllites from worldwide occurrences were examined. This also gives an overview of the rocks used for discontinuous roofing and external cladding.

The nonhydrostatic regional climate model CCLM was used for a long-term hindcast run (2002–2016) for the Weddell Sea region with resolutions of 15 and 5 km and two different turbulence parametrizations. CCLM was nested in ERA-Interim data and used in forecast mode (suite of consecutive 30 h long simulations with 6 h spin-up). We prescribed the sea ice concentration from satellite data and used a thermodynamic sea ice model. The performance of the model was evaluated in terms of temperature and wind using data from Antarctic stations, automatic weather stations (AWSs), an operational forecast model and reanalyses data, and lidar wind profiles. For the reference run we found a warm bias for the near-surface temperature over the Antarctic Plateau. This bias was removed in the second run by adjusting the turbulence parametrization, which results in a more realistic representation of the surface inversion over the plateau but resulted in a negative bias for some coastal regions. A comparison with measurements over the sea ice of the Weddell Sea by three AWS buoys for 1 year showed small biases for temperature around ±1 K and for wind speed of 1 m s−1. Comparisons of radio soundings showed a model bias around 0 and a RMSE of 1–2 K for temperature and 3–4 m s−1 for wind speed. The comparison of CCLM simulations at resolutions down to 1 km with wind data from Doppler lidar measurements during December 2015 and January 2016 yielded almost no bias in wind speed and a RMSE of ca. 2 m s−1. Overall CCLM shows a good representation of temperature and wind for the Weddell Sea region. Based on these encouraging results, CCLM at high resolution will be used for the investigation of the regional climate in the Antarctic and atmosphere–ice–ocean interactions processes in a forthcoming study.

Estimation and therefore prediction -- both in traditional statistics and machine learning -- encounters often problems when done on survey data, i.e. on data gathered from a random subset of a finite population. Additional to the stochastic generation of the data in the finite population (based on a superpopulation model), the subsetting represents a second randomization process, and adds further noise to the estimation. The character and impact of the additional noise on the estimation procedure depends on the specific probability law for subsetting, i.e. the survey design. Especially when the design is complex or the population data is not generated by a Gaussian distribution, established methods must be re-thought. Both phenomena can be found in business surveys, and their combined occurrence poses challenges to the estimation. This work introduces selected topics linked to relevant use cases of business surveys and discusses the role of survey design therein: First, consider micro-econometrics using business surveys. Regression analysis under the peculiarities of non-normal data and complex survey design is discussed. The focus lies on mixed models, which are able to capture unobserved heterogeneity e.g. between economic sectors, when the dependent variable is not conditionally normally distributed. An algorithm for survey-weighted model estimation in this setting is provided and applied to business data. Second, in official statistics, the classical sampling randomization and estimators for finite population totals are relevant. The variance estimation of estimators for (finite) population totals plays a major role in this framework in order to decide on the reliability of survey data. When the survey design is complex, and the number of variables is large for which an estimated total is required, generalized variance functions are popular for variance estimation. They allow to circumvent cumbersome theoretical design-based variance formulae or computer-intensive resampling. A synthesis of the superpopulation-based motivation and the survey framework is elaborated. To the author's knowledge, such a synthesis is studied for the first time both theoretically and empirically. Third, the self-organizing map -- an unsupervised machine learning algorithm for data visualization, clustering and even probability estimation -- is introduced. A link to Markov random fields is outlined, which to the author's knowledge has not yet been established, and a density estimator is derived. The latter is evaluated in terms of a Monte-Carlo simulation and then applied to real world business data.

Retirement, fertility and sexuality are three key life stage events that are embedded in the framework of population economics in this dissertation. Each topic implies economic relevance. As retirement entry shifts labour supply of experienced workers to zero, this issue is particularly relevant for employers, retirees themselves as well as policymakers who are in charge of the design of the pension system. Giving birth has comprehensive economic relevance for women. Parental leave and subsequent part-time work lead to a direct loss of income. Lower levels of employment, work experience, training and career opportunities result in indirect income losses. Sexuality has decisive influence on the quality of partnerships, subjective well-being and happiness. Well-being and happiness, in turn, are significant key determinants not only in private life but also in the work domain, for example in the area of job performance. Furthermore, partnership quality determines the duration of a partnership. And in general, partnerships enable the pooling of (financial) resources - compared to being single. The contribution of this dissertation emerges from the integration of social and psychological concepts into economic analysis as well as the application of economic theory in non-standard economic research topics. The results of the three chapters show that the multidisciplinary approach yields better prediction of human behaviour than the single disciplines on their own. The results in the first chapter show that both interpersonal conflict with superiors and the individual’s health status play a significant role in retirement decisions. The chapter further contributes to existing literature by showing the moderating role of health within the retirement decision-making: On the one hand, all employees are more likely to retire when they are having conflicts with their superior. On the other hand, among healthy employees, the same conflict raises retirement intentions even more. That means good health is a necessary, but not a sufficient condition for continued working. It may be that conflicts with superiors raise retirement intentions more if the worker is healthy. The key findings of the second chapter reveal significant influence of religion on contraceptive and fertility-related decisions. A large part of research on religion and fertility is originated in evidence from the US. This chapter contrasts evidence from Germany. Additionally, the chapter contributes by integrating miscarriages and abortions, rather than limiting the analysis to births and it gains from rich prospective data on fertility biography of women. The third chapter provides theoretical insights on how to incorporate psychological variables into an economic framework which aims to analyse sexual well-being. According to this theory, personality may play a dual role by shaping a person’s preferences for sex as well as the person’s behaviour in a sexual relationship. Results of econometric analysis reveal detrimental effects of neuroticism on sexual well-being while conscientiousness seems to create a win-win situation for a couple. Extraversions and Openness have ambiguous effects on romantic relationships by enhancing sexual well-being on the one hand but raising commitment problems on the other. Agreeable persons seem to gain sexual satisfaction even if they perform worse in sexual communication.